CN108523124A - A kind of method of nanoscale food, drug and production nanoscale food, drug - Google Patents
A kind of method of nanoscale food, drug and production nanoscale food, drug Download PDFInfo
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- CN108523124A CN108523124A CN201710126267.9A CN201710126267A CN108523124A CN 108523124 A CN108523124 A CN 108523124A CN 201710126267 A CN201710126267 A CN 201710126267A CN 108523124 A CN108523124 A CN 108523124A
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- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
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- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A61K2236/10—Preparation or pretreatment of starting material
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The present invention provides a kind of methods of nanoscale food, drug and production nanoscale food, drug, are related to biology, physics and technical field of chemistry.A method of producing nanoscale food, drug comprising：The step of vegetable raw material is subjected to extraction and biological enzymolysis；Extraction includes：Supercritical extract, microwave abstracting, ultrasonic extraction, high hydrostatic pressure extraction and one or more combinations in nano-milled extraction extract mode.Party's forensic science is simple, food, drug process of manufacture in, the nanosizing degree of vegetable raw material is high and particle size range is stablized.A kind of nanoscale food, drug produce to obtain by the above method, and the ratio in the food or drug that produce shared by particle of the grain size less than 1000nm is more than 98%, and the ratio shared by particle of the grain size less than 900nm is more than 90%.
Description
Technical field
The present invention relates to biology, physics and technical field of chemistry, in particular to a kind of nanoscale food, drug and
The method for producing nanoscale food, drug.
Background technology
Nanotechnology (nanotechnology) is the technology based on numerous advanced science and technologies now, is 21
Century high and new technology and emerging scientific development basis.Food or drug nanosizing can make food or medicine particle more tiny
Change, for food or drug, a large amount of costs of material can be saved, greatly improve the utilization rate of raw material, it is considered that raw material nano
It will produce physics, the chemistry even change of biological property after changing, blocky thing become smaller through digestion via mouth to small intestine, then inhales
Receiving contributes to human body infant, the elderly or the bad patient of digestive system to absorb.
Existing vegetable food, the processing method of drug nanosizing are varied, but the degree of nanosizing is not high, and
Method is not unified enough.
Invention content
The first object of the present invention is the provision of a kind of method producing nanoscale food, drug, party's forensic science letter
It is single, food, drug process of manufacture in, the nanosizing degree of vegetable raw material is high and particle size range is stablized.
The second object of the present invention is the provision of a kind of nanoscale food, drug, produces to obtain by the above method, raw
It produces the ratio in obtained nanoscale food, drug shared by particle of the grain size less than 1000nm and is more than 98%, grain size is less than 900nm
Particle shared by ratio be more than 90%.
The present invention solves its technical problem using following technical scheme to realize.
The present invention provides a kind of methods producing nanoscale food, drug comprising extracts vegetable raw material
The step of with biological enzymolysis；Extraction includes：Supercritical extract, microwave abstracting, ultrasonic extraction, high hydrostatic pressure extraction with it is nano-milled
One or more combinations in extraction extract mode.
The present invention provides a kind of nanoscale food, drugs, are obtained by the above method, grain in nanoscale food, drug
Ratio shared by particle of the diameter less than 1000nm is more than 98%, and the ratio shared by particle of the grain size less than 900nm is more than 90%.
The advantageous effect of the method for a kind of nanoscale food proposed by the present invention, drug and production nanoscale food, drug
It is：
The method of the production nanoscale food, drug, first extracts vegetable raw material, is obtained after extraction more and complete
Whole active ingredient；Then biological enzymolysis is carried out again, and vegetable raw material generation is made chemically or physically to change, final getable production
Particle nanosizing degree in product is high, and the particle size range of particle is stablized.Ratio wherein shared by particle of the grain size less than 1000nm
Rate is more than 98%, and the ratio shared by particle of the grain size less than 900nm is more than 90%.
Description of the drawings
It, below will be to required use in embodiment in order to illustrate more clearly of the technical solution of embodiment of the present invention
Attached drawing be briefly described, it should be understood that the following drawings illustrates only certain embodiments of the present invention, therefore is not to be seen as
It is the restriction to range, it for those of ordinary skill in the art, without creative efforts, can be with root
Other relevant attached drawings are obtained according to these attached drawings.
Fig. 1 is the corresponding testing result figure of sample that the embodiment of the present invention 1 provides；
Fig. 2 is the corresponding testing result figure of sample that the embodiment of the present invention 2 provides；
Fig. 3 is the corresponding testing result figure of sample that the embodiment of the present invention 3 provides.
Specific implementation mode
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, builds according to normal condition or manufacturer
The condition of view carries out.Reagents or instruments used without specified manufacturer is the conventional production that can be obtained by commercially available purchase
Product.
Below to the side of a kind of nanoscale food provided in an embodiment of the present invention, drug and production nanoscale food, drug
Method is specifically described.
Firstly, it is necessary to illustrate, food, the drug of " nanoscale " in the embodiment of the present invention refer in food or drug
Particle be nanoscale, rather than the total volume of food or drug be nanoscale.
Include mainly by vegetable raw material an embodiment of the present invention provides a kind of method producing nanoscale food, drug
Extraction and biological enzymolysis.
Specifically, sorting is carried out first, and selection is ripe, goes mouldy without rotten, nothing, the edible or medicinal plant of no disease and pests harm
Physical property raw material is used as and processes raw material.Wherein, vegetable raw material refers to edible or medicinal plant.Food plant generally comprises grain and oil class
(such as paddy, wheat, corn, sorghum, buckwheat, oat, soybean, peanut, sesame etc.), greengrocery (such as tomato, cucumber, eggplant
Son, green pepper, carrot, spinach, Chinese yam, pueraria lobata, cucurbita pepo, watermelon, muskmelon, wax gourd, balsam pear, wild cabbage, celery, ginger, green onion, garlic
Deng), fruits (such as peach, Lee, apricot, ginkgo, apple, pineapple, grape, blueberry, walnut, matrimony vine, sea-buckthorn etc.), mushroom (ratio
Such as oyster mushroom, mushroom, Pleurotus eryngii, Pleurotus nebrodensis, needle mushroom, black fungus, white fungus) etc..Medicinal plant generally comprises Chinese Pharmacopoeia institute
All autonomic drugs recorded, nearly 11500 kinds, such as ginseng, Radix Astragali, Radix Notoginseng, Radix Glycyrrhizae, Radix Angelicae Sinensis, Rhizoma Atractylodis Macrocephalae, ganoderma lucidum, Reishi sporule etc..
Cleaning, vegetable raw material is cleaned up, it should be noted that also can directly select the vegetalitas cleaned up former
Material.
It crushes, the vegetable raw material for totally meeting edible conditions is crushed, it is preferable that be ground into that grain size is less than 5mm
Extraction efficiency can be improved when the vegetable raw material using grain size less than 5mm is extracted in grain.
Secondly, before being extracted, the product uniform in order to obtain, mouthfeel is relatively good, it is preferable that further include by powder
Vegetable raw material after broken carries out the step of defibrination is with allotment.
It is that (namely psychrometric ratio is 1 to the water measured of 1-8 times of raw material that defibrination, which refers to by vegetable raw material and weight after crushing,:1~
8) after mixing, the grain size for wearing into the particle in slurry is less than 30 μm, is ground using colloid mill or Cone crusher or grinding machine.
It refers to being uniformly mixed above-mentioned slurry to size mixing, and can be adjusted according to sugar-acid ratio or recipe ratio.
Then it is extracted, in the embodiment of the present invention, extraction includes supercritical extract, microwave abstracting, ultrasonic extraction, surpasses
One or more combinations in high pressure extraction or nano-milled extraction extract mode.
Wherein, the pressure that supercritical extract vegetable raw material uses is 25-80MPa, power 5-25Kw, temperature be≤
40 DEG C, fluid flow 1000-2000L/h；
The frequency that microwave abstracting vegetable raw material uses is 300-915MHz, power 5-25Kw, and temperature is≤40 DEG C, instead
It is 1000-3000L to answer tank volume；
The frequency that ultrasonic extraction vegetable raw material uses is 20-50KHz, power 5-25Kw, and temperature is≤40 DEG C, instead
It is 1000-3000L to answer tank volume；
The pressure that high hydrostatic pressure extraction vegetable raw material uses is 250-380MPa, power 5-25Kw, and temperature is≤40 DEG C,
Fluid flow is 1000-2000L/h；
For the pressure that nano-milled extraction vegetable raw material uses for 50-80MPa, power 5-25Kw, temperature is≤40 DEG C,
Reaction tank volume is 100-500L or fluid flow is 1000-5000L/h.
It should be noted that individually extracting vegetalitas by the way of supercritical extract, microwave abstracting or ultrasonic extraction
When raw material, extraction time 45-60min；When individually using high hydrostatic pressure extraction or nano-milled extraction vegetable raw material, when over-pressed
Between be 2-5min.
Under the parameter of above-mentioned different extraction modes, vegetable food or drug can be made to be fully used, retained more
More active ingredient.
Preferably, extractant selects water or carbon dioxide.
It should be noted that fixed-point value can be allocated parameters according to the difference of vegetable raw material formula really.
Preferably, extraction vegetable raw material is using any one of following extraction combination；
Extraction is combined：
The combination of supercritical extract and microwave abstracting；The combination of supercritical extract and ultrasonic extraction；Supercritical extract with
The combination of high hydrostatic pressure extraction；The combination of supercritical extract and nano-milled extraction；The combination of microwave abstracting and ultrasonic extraction；It is micro-
Wave extracts the combination with high hydrostatic pressure extraction；The combination of microwave abstracting and nano-milled extraction；Ultrasonic extraction and high hydrostatic pressure extraction
Combination；The combination of ultrasonic extraction and nano-milled extraction；The combination of supercritical extract, microwave abstracting and ultrasonic extraction；
The combination of supercritical extract, microwave abstracting and high hydrostatic pressure extraction；The group of supercritical extract, microwave abstracting and nano-milled extraction
It closes；The combination of microwave abstracting, ultrasonic extraction and high hydrostatic pressure extraction；Microwave abstracting, ultrasonic extraction and nano-milled extraction
Combination；The combination of ultrasonic extraction, high hydrostatic pressure extraction and nano-milled extraction.
Wherein, when the above extraction mode combines two-by-two or two-by-two, the supercritical extract time is 5-10min, when microwave abstracting
Between be 10-15min, time of ultrasonic extraction is 5-10min, and the time of high hydrostatic pressure extraction is 2-5min, nano-milled extraction
Time be 5-10min.
In other words, supercritical extract 5-10min is combined with microwave abstracting 10-15min；
Supercritical extract 5-10min is combined with ultrasonic extraction 5-10min；
Supercritical extract 5-10min is combined with high hydrostatic pressure extraction 2-5min；
Supercritical extract 5-10min is combined with nano-milled extraction 5-10min；
Microwave abstracting 10-15min is combined with ultrasonic wave 5-10min extractions；
Microwave abstracting 10-15min is combined with high hydrostatic pressure extraction 2-5min；
Microwave abstracting 10-15min is combined with nano-milled extraction 5-10min；
Ultrasonic extraction 5-10min is combined with high hydrostatic pressure extraction 2-5min；
Ultrasonic extraction 5-10min is combined with nano-milled 5-10min；
Supercritical extract 5-10min, microwave abstracting 10-15min are combined with ultrasonic extraction 5-10min；
Supercritical extract 5-10min, microwave abstracting 10-15min are combined with high hydrostatic pressure extraction 2-5min；
Supercritical extract 5-10min, microwave abstracting 10-15min are combined with nano-milled extraction 5-10min；
Microwave abstracting 10-15min, ultrasonic extraction 5-10min are combined with high hydrostatic pressure extraction 2-5min；
Microwave abstracting 10-15min, ultrasonic extraction 5-10min are combined with nano-milled extraction 5-10min；
Ultrasonic extraction 5-10min, high hydrostatic pressure extraction 2-5min are combined with nano-milled extraction 5-10min.
Extraction time is unsuitable long, within the scope of the extraction time, extraction yield can not only be made to reach highest, active ingredient
It not easily runs off, moreover it is possible to save the process cost.
It should be noted that when the above extraction is combined two-by-two or two-by-two, the sequencing that extraction mode is selected is unlimited.
Later, the extract liquor obtained after extraction is subjected to biological enzymolysis, fermentation enzymolysis is carried out to it by compound probiotic.
Compound probiotic includes at least two in lactic acid bacteria, bacillus, saccharomycete, cellulase and dextranase.Pass through biology
After enzymolysis the range of grain size can stablize, stablize in 1000nm or less.
Further, it purified after biological enzymolysis, be concentrated to give liquid nano food or drug.Or it is done again
It is dry to obtain solid nano food or drug.Preferably, concentration makes its water content control be preferred below 75%.Further, dry
It is that the liquid nano food, the drug that are obtained after concentration are dried, 15% solid nano food below of water content, medicine is made
Product.
Further include the steps that sterilization, filling and packaging finally before finished product is made.Preferably, the mode of sterilization is selected
Static ultrahigh pressure sterilization, microwave disinfection or ultrasonic sterilization.
The embodiment of the present invention additionally provides a kind of nanoscale food, drug, is obtained by the above method.Produce obtained food
Ratio in product or drug shared by particle of the grain size less than 1000nm is more than 98%, the ratio shared by particle of the grain size less than 900nm
Rate is more than 90%.And the range is relatively stablized.It will produce changing for physics, chemistry even biological property after food or drug nanosizing
Become, blocky thing becomes smaller through digestion via mouth to small intestine, reabsorbs to human body, contributes to infant, the elderly or Digestive
The patient for uniting bad absorbs.The bioavilability for improving raw material, enhances the metabolism of body.
The feature and performance of the present invention are described further with reference to embodiments.
1 compound fruit and vegetable juice of embodiment
1, primary raw material：Carrot, tomato, apple, nectarine, grape, honey.
2, sorting：Selection is ripe, without rot, without go mouldy, the carrot of no disease and pests harm, tomato, apple, nectarine, grape
Make raw material.
3, it cleans：Carrot after choosing, tomato, apple, nectarine, grape are cleaned, silt is washed away and other is miscellaneous
Object.
4, it crushes：Carrot after cleaned, tomato, apple, nectarine, grape are crushed respectively, crushed by wet feed
Machine is ground into 5mm or less particles.
5, defibrination：Defibrination is carried out respectively to the carrot after crushing, tomato, apple, nectarine, grape, by 1 ︰'s 1 of psychrometric ratio
Ratio adds water, is then worn into 20 μm of slurries below by colloid mill or Cone crusher.
6, it allocates：Carrot after defibrination, tomato, apple, nectarine, grape are allocated according to formula rate, bee is added
Honey adjusts sugar-acid ratio, and stirs evenly.
7, to deployed compound fruit and vegetable juice, it is extracted by high hydrostatic pressure extraction；
High hydrostatic pressure extraction is 250-380MPa, power 5-25Kw, temperature≤40 DEG C, fluid flow 1000- with pressure
2000L/h, over-pressed time are 2-5min.
8, biological enzymolysis is carried out to the liquid nano compound fruit and vegetable juice obtained after extraction, 0.5% compound probiotic is added
(lactic acid bacteria, bacillus, saccharomycete, cellulase and dextranase), closed ferment at constant temperature culture 8 is small under the conditions of 40 DEG C
When.
9, to the liquid nano compound fruit and vegetable juice obtained after biological enzymolysis, it is carried out by cryogenic vacuum concentrator dense
Contracting, makes its water content control below 50%.
10, the liquid nano compound fruit and vegetable juice obtained after being concentrated to cryogenic vacuum, fills it by dosing filling machine
Dress.
11, the finished product to quantitative filling after good sterilizes it by static ultrahigh pressure, makes finished product in high pressures such as static state
600MPa, to get compound fruit and vegetable juice after sterilizing 5min under the conditions of 40 DEG C of temperature.
2 Xiao Chaihu Tang of embodiment
1, primary raw material：Radix bupleuri, radix scutellariae, ginseng, the tuber of pinellia, honey-fried licorice root, ginger, jujube.
2, sorting：Selection is ripe, without rot, without go mouldy, the radix bupleuri of no disease and pests harm, radix scutellariae, ginseng, the tuber of pinellia, toast it is sweet
Grass, ginger, jujube make raw material.
3, it cleans：To radix bupleuri, radix scutellariae, ginseng, the tuber of pinellia, honey-fried licorice root, ginger, the jujube after choosing, is cleaned, wash away mud
Husky and other sundries.
4, it crushes：Radix bupleuri, radix scutellariae, ginseng, the tuber of pinellia, honey-fried licorice root, ginger, jujube after cleaned is crushed respectively,
It is ground into 5mm or less particles by wet-material disintegrator.
5, defibrination：Defibrination is carried out respectively to radix bupleuri, radix scutellariae, ginseng, the tuber of pinellia, honey-fried licorice root, ginger, the jujube after crushing, is pressed
The ratio of 1 ︰ 1 of psychrometric ratio adds water, is then worn into 20 μm of slurries below by colloid mill or Cone crusher.
6, it allocates：Radix bupleuri, radix scutellariae, ginseng, the tuber of pinellia, honey-fried licorice root, ginger, jujube after defibrination is carried out according to formula rate
Allotment adjusts sugar-acid ratio, and stirs evenly.
7, to deployed Xiao Chaihu Tang, it is extracted by supercritical extract；
The pressure of supercritical extract is 25-80MPa, power 5-25Kw, temperature≤40 DEG C, fluid flow 1000-
2000L/h extracts as time 45-60min；
8, biological enzymolysis is carried out to the liquid nano Xiao Chaihu Tang obtained after extraction, 0.5% compound probiotic (breast is added
Sour bacterium, bacillus, saccharomycete, cellulase and dextranase), closed ferment at constant temperature culture 8 hours under the conditions of 40 DEG C.
9, to the liquid nano Xiao Chaihu Tang obtained after biological enzymolysis, it is carried out by cryogenic vacuum concentrator dense
Contracting, makes its water content control below 50%.
10, the liquid nano Xiao Chaihu Tang obtained after being concentrated to cryogenic vacuum, carries out it by dosing filling machine filling.
11, the finished product to quantitative filling after good, sterilizes it by static ultrahigh pressure equipment, makes finished product in static state etc.
High pressure 600MPa, to get Xiao Chaihu Tang after sterilizing 5min under the conditions of 40 DEG C of temperature.
3 soy sauce of embodiment, vinegar brewing
1, primary raw material：Soybean, lima bean, the sort of quyi.
2, sorting：Selection is ripe, without rot, without go mouldy, the soybean of no disease and pests harm, lima bean make raw material.
3, it cleans：Soybean after choosing, lima bean are cleaned, silt and other sundries are washed away.
4, it crushes：Soybean after cleaned, lima bean are crushed respectively, 5mm is ground by wet-material disintegrator
Following particle.
5, defibrination：Defibrination is carried out respectively to the soybean after crushing, lima bean, 30 μm are worn by colloid mill or Cone crusher
Slurry below.
6, it allocates：Soybean after defibrination, lima bean are allocated according to formula rate, adjust sugar-acid ratio, and stir evenly.
7, to deployed soybean, lima bean slurry, it is extracted by ultrasonic extraction；
Ultrasonic extraction is 20-50KHz with frequency, and power 5-25Kw, temperature≤40 DEG C, reaction tank volume is 1000-
3000L, extraction time 45-60min.
8, to obtained after extraction liquid nano soybean, lima bean slurry carry out biological enzymolysis, 1% compound probiotic is added
(lactic acid bacteria, bacillus, saccharomycete, cellulase and dextranase) and 2% the special sort of quyi of soy sauce or vinegar, in natural epidemic disaster in booth
Closed or semi-hermetic fermented and cultured 3 months under the conditions of degree.
9, to the liquid nano soy sauce or vinegar that are obtained after biological enzymolysis, it is purified by isolating and purifying equipment.
10, to soy sauce or vinegar after purification, it is carried out by dosing filling machine filling.
11, the finished product to quantitative filling after good, sterilizes it by static ultrahigh pressure equipment, makes finished product in static state etc.
High pressure 600MPa, sterilize under the conditions of 40 DEG C of temperature 5min.
4 wine production of embodiment
1, primary raw material：Grape, distiller's yeast.
2, sorting：Selection is ripe, without rotten, nothing is gone mouldy, the grape of no disease and pests harm makees raw material.
3, it cleans：Grape after choosing is cleaned, silt and other sundries are washed away.
4, it crushes：Grape after cleaned is crushed, 5mm or less particles are ground by wet-material disintegrator.
5, defibrination：Defibrination is carried out to the grape after crushing, 30 μm of slurries below are worn by colloid mill or Cone crusher
Material.
6, it allocates：Grape after defibrination is allocated, adjusts sugar-acid ratio, and stir evenly.
7, to deployed grape slurry, it is extracted by microwave abstracting equipment；
Microwave abstracting is 300-915MHz with frequency, and power 5-25Kw, temperature≤40 DEG C, reaction tank volume is 1000-
3000L, extraction time 45-60min.
8, biological enzymolysis is carried out to the liquid nano grape slurry obtained after extraction, 1% compound probiotic (lactic acid is added
Bacterium, saccharomycete, cellulase and dextranase) and 2% the special wine brewing distiller's yeast of grape wine, closed constant temperature hair under the conditions of 40 DEG C
Ferment culture 7 days.
9, to the liquid nano grape wine obtained after biological enzymolysis, it is purified by isolating and purifying equipment.
10, to grape wine after purification, it is carried out by dosing filling machine filling.
11, the finished product to quantitative filling after good, sterilizes it by static ultrahigh pressure equipment, makes finished product in static state etc.
High pressure 600MPa, sterilizing 5min is to get grape wine under the conditions of 40 DEG C of temperature.
5 dachengqi decoction of embodiment
1, primary raw material：Rheum officinale, Cortex Magnoliae Officinalis, the dried immature fruit of citron orange, saltcake.
2, sorting：Maturation is selected, is gone mouldy without rotten, nothing, the rheum officinale of no disease and pests harm, Cortex Magnoliae Officinalis, the dried immature fruit of citron orange, saltcake work original
Material.
3, it cleans：Rheum officinale, Cortex Magnoliae Officinalis, the dried immature fruit of citron orange, saltcake after choosing is cleaned, silt and other sundries are washed away.
4, it crushes：Rheum officinale, Cortex Magnoliae Officinalis, the dried immature fruit of citron orange, saltcake after cleaned is crushed respectively, by wet-material disintegrator by its
It is ground into 5mm or less particles.
5, defibrination：Defibrination is carried out respectively to rheum officinale, Cortex Magnoliae Officinalis, the dried immature fruit of citron orange, the saltcake after crushing, is added in the ratio of 1 ︰ 1 of psychrometric ratio
Then water is worn into 20 μm of slurries below by colloid mill or Cone crusher.
6, it allocates：Rheum officinale, Cortex Magnoliae Officinalis, the dried immature fruit of citron orange, saltcake after defibrination is allocated according to formula rate, honey is added, is adjusted
Whole sugar-acid ratio, and stir evenly.
7, to deployed dachengqi decoction, it is extracted by nano-milled extraction；The pressure of nano-milled extraction
For 50-80MPa, power 5-25Kw, temperature≤40 DEG C, fluid flow 1000-5000L/h, the over-pressed time is 2-5min.
8, biological enzymolysis is carried out to the liquid nano dachengqi decoction of rear acquisition, 0.5% compound benefit is added in inoculation wherein
Raw bacterium (lactic acid bacteria, bacillus, saccharomycete, cellulase and dextranase), the closed ferment at constant temperature culture 8 under the conditions of 40 DEG C
Hour.
9, to the liquid nano dachengqi decoction obtained after biological enzymolysis, it is carried out by cryogenic vacuum concentrator dense
Contracting, makes its water content control below 50%.
10, the liquid nano dachengqi decoction obtained after being concentrated to cryogenic vacuum, carries out it by dosing filling machine filling.
11, the finished product to quantitative filling after good, sterilizes it by static ultrahigh pressure equipment, makes finished product in static state etc.
High pressure 600MPa, to get dachengqi decoction after sterilizing 5min under the conditions of 40 DEG C of temperature.
6 Siwu Tang of embodiment
1, primary raw material：Prepared rehmannia root, Radix Angelicae Sinensis, Radix Paeoniae Alba, Rhizoma Chuanxiong, honey.
2, sorting：Selection is gone mouldy without rotten, nothing, and prepared rehmannia root, Radix Angelicae Sinensis, Radix Paeoniae Alba, the Rhizoma Chuanxiong work for meeting Chinese Pharmacopoeia standard are former
Material.
3, it cleans：Prepared rehmannia root, Radix Angelicae Sinensis, Radix Paeoniae Alba, Rhizoma Chuanxiong after choosing is cleaned, silt and other sundries are washed away.
4, it crushes：Prepared rehmannia root, Radix Angelicae Sinensis, Radix Paeoniae Alba, Rhizoma Chuanxiong after cleaned is crushed respectively, passing through wet-material disintegrator will
It is ground into 5mm or less particles.
5, defibrination：Defibrination is carried out respectively to prepared rehmannia root, Radix Angelicae Sinensis, Radix Paeoniae Alba, the Rhizoma Chuanxiong after crushing, in the ratio of 1 ︰ 8 of psychrometric ratio
Add water, 30 μm of slurries below are then worn by colloid mill or Cone crusher.
6, it allocates：Prepared rehmannia root, Radix Angelicae Sinensis, Radix Paeoniae Alba, Rhizoma Chuanxiong after defibrination is allocated according to formula rate, honey is added,
And it stirs evenly.
7, to deployed Siwu Tang, extraction pair is combined with microwave abstracting 10-15min by supercritical extract 5-10min
It is extracted；
The pressure of supercritical extract is 25-80MPa, power 5-25Kw, temperature≤40 DEG C, fluid flow 1000-
2000L/h；
Microwave abstracting is 300-915MHz with frequency, and power 5-25Kw, temperature≤40 DEG C, reaction tank volume is 1000-
3000L。
8, biological enzymolysis is carried out to the liquid nano Siwu Tang obtained after extraction, 1% compound probiotic (lactic acid is added
Bacterium, bacillus, saccharomycete, cellulase and dextranase), closed ferment at constant temperature culture 10 hours under the conditions of 40 DEG C.
9, to the liquid nano Siwu Tang obtained after biological enzymolysis, it is concentrated by cryogenic vacuum concentrator,
Make its water content control below 50%.
10, the liquid nano Siwu Tang obtained after being concentrated to cryogenic vacuum, carries out it by Vacuum Drying Equipment
It is dry, make its water content control below 10%.
12, the finished product to quantitative package after good, sterilizes it by static ultrahigh pressure equipment, makes finished product in static state etc.
High pressure 600MPa, sterilize under the conditions of 40 DEG C of temperature 5min.
7 wenpi decoction of embodiment
1, primary raw material：Rheum officinale, Radix Angelicae Sinensis, rhizoma zingiberis, monkshood, ginseng, saltcake, Radix Glycyrrhizae.
2, sorting：Selection without rot, without going mouldy, meet the rheum officinale of Chinese Pharmacopoeia standard, Radix Angelicae Sinensis, rhizoma zingiberis, monkshood, ginseng,
Saltcake, Radix Glycyrrhizae make raw material.
3, it cleans：Rheum officinale after choosing, Radix Angelicae Sinensis, rhizoma zingiberis, monkshood, ginseng, saltcake, Radix Glycyrrhizae are cleaned, silt is washed away
With other sundries.
4, it crushes：Rheum officinale after cleaned, Radix Angelicae Sinensis, rhizoma zingiberis, monkshood, ginseng, saltcake, Radix Glycyrrhizae are crushed respectively, led to
It crosses wet-material disintegrator and is ground into 5mm or less particles.
5, defibrination：Defibrination is carried out respectively to the rheum officinale after crushing, Radix Angelicae Sinensis, rhizoma zingiberis, monkshood, ginseng, saltcake, Radix Glycyrrhizae, by dry
The wet ratio than 1 ︰ 7 adds water, is then worn into 30 μm of slurries below by colloid mill or Cone crusher.
6, it allocates：Rheum officinale after defibrination, Radix Angelicae Sinensis, rhizoma zingiberis, monkshood, ginseng, saltcake, Radix Glycyrrhizae are adjusted according to formula rate
Match, and stirs evenly.
7, to deployed wenpi decoction, extraction is combined with ultrasonic extraction 5-10min by supercritical extract 5-10min and is set
It is standby that it is extracted；
The pressure of supercritical extract is 25-80MPa, power 5-25Kw, temperature≤40 DEG C, fluid flow 1000-
2000L/h；
Ultrasonic extraction is 20-50KHz with frequency, and power 5-25Kw, temperature≤40 DEG C, reaction tank volume is 1000-
3000L。
8, biological enzymolysis is carried out to the liquid nano wenpi decoction obtained after extraction, 1% compound probiotic is added, at 40 DEG C
Under the conditions of closed ferment at constant temperature culture 10 hours.
9, to the liquid nano wenpi decoction obtained after biological enzymolysis, it is concentrated by cryogenic vacuum concentrator,
Make its water content control below 50%.
10, the liquid nano wenpi decoction obtained after being concentrated to cryogenic vacuum, carries out it by Vacuum Drying Equipment
It is dry, make its water content control below 10%.
12, the finished product to quantitative package after good, sterilizes it by static ultrahigh pressure equipment, makes finished product in static state etc.
High pressure 600MPa, sterilize under the conditions of 40 DEG C of temperature 5min.
8 Longdan Xiegan Tang of embodiment
1, primary raw material：Felwort, radix scutellariae, fructus gardeniae, rhizoma alismatis, akebi, plantain seed, Radix Angelicae Sinensis, radix rehmanniae recen, radix bupleuri, life are sweet
Grass.
2, sorting：Selection without rot, without going mouldy, meet the felwort of Chinese Pharmacopoeia standard, radix scutellariae, fructus gardeniae, rhizoma alismatis, wood
Logical, plantain seed, Radix Angelicae Sinensis, radix rehmanniae recen, radix bupleuri, licorice make raw material.
3, it cleans：To the felwort after choosing, radix scutellariae, fructus gardeniae, rhizoma alismatis, akebi, plantain seed, Radix Angelicae Sinensis, radix rehmanniae recen, bavin
Recklessly, licorice is cleaned, and washes away silt and other sundries.
4, it crushes：To the felwort after cleaned, radix scutellariae, fructus gardeniae, rhizoma alismatis, akebi, plantain seed, Radix Angelicae Sinensis, radix rehmanniae recen, bavin
Recklessly, licorice crushes respectively, and 5mm or less particles are ground by wet-material disintegrator.
5, defibrination：To the felwort after crushing, radix scutellariae, fructus gardeniae, rhizoma alismatis, akebi, plantain seed, Radix Angelicae Sinensis, radix rehmanniae recen, bavin
Recklessly, licorice carries out defibrination respectively, adds water in the ratio of 1 ︰ 8 of psychrometric ratio, is then worn into 30 μ by colloid mill or Cone crusher
M slurries below.
6, it allocates：To the felwort after defibrination, radix scutellariae, fructus gardeniae, rhizoma alismatis, akebi, plantain seed, Radix Angelicae Sinensis, radix rehmanniae recen, bavin
Recklessly, licorice is allocated according to formula rate, and is stirred evenly.
7, to deployed Longdan Xiegan Tang, extraction is combined with high hydrostatic pressure extraction 2-5min by supercritical extract 5-10min
It takes and it is extracted；
The pressure of supercritical extract is 25-80MPa, power 5-25Kw, temperature≤40 DEG C, fluid flow 1000-
2000L/h；
High hydrostatic pressure extraction is 250-380MPa, power 5-25Kw, temperature≤40 DEG C, fluid flow 1000- with pressure
2000L/h。
8, biological enzymolysis is carried out to the liquid nano Longdan Xiegan Tang obtained after extraction, 1% compound probiotic is added,
Closed ferment at constant temperature culture 10 hours under the conditions of 40 DEG C.
9, to the liquid nano Longdan Xiegan Tang obtained after biological enzymolysis, it is carried out by cryogenic vacuum concentrator dense
Contracting, makes its water content control below 50%.
10, the liquid nano Longdan Xiegan Tang obtained after being concentrated to cryogenic vacuum, by Vacuum Drying Equipment to it
It is dried, makes its water content control below 10%.
12, the finished product to quantitative package after good, sterilizes it by static ultrahigh pressure equipment, makes finished product in static state etc.
High pressure 600MPa, sterilize under the conditions of 40 DEG C of temperature 5min.
20 compound mushroom juice of embodiment 9- embodiments
1, primary raw material：Mushroom, needle mushroom, Hericium erinaceus, ganoderma lucidum, white fungus, golden ear, dictyophora phalloidea, cordyceps flower, grifola frondosus, Poria cocos,
Honey.
2, sorting：Selection is ripe, without rot, without go mouldy, the mushroom of no disease and pests harm, needle mushroom, Hericium erinaceus, ganoderma lucidum,
White fungus, golden ear, dictyophora phalloidea, cordyceps flower, grifola frondosus, Poria cocos make raw material.
3, it cleans：To mushroom, needle mushroom, Hericium erinaceus, ganoderma lucidum, white fungus, golden ear, dictyophora phalloidea, cordyceps flower, the ash tree after choosing
Flower, Poria cocos are cleaned, and silt and other sundries are washed away.
4, it crushes：To mushroom, needle mushroom, Hericium erinaceus, ganoderma lucidum, white fungus, golden ear, dictyophora phalloidea, cordyceps flower, the ash tree after cleaned
Flower, Poria cocos crush respectively, and 5mm or less particles are ground by wet-material disintegrator.
5, defibrination：To mushroom, needle mushroom, Hericium erinaceus, ganoderma lucidum, white fungus, golden ear, dictyophora phalloidea, cordyceps flower, the ash tree after crushing
Flower, Poria cocos carry out defibrination respectively, add water in the ratio of 1 ︰ 2 of psychrometric ratio, are then worn into 30 μm by colloid mill or Cone crusher
Slurry below.
6, it allocates：To mushroom, needle mushroom, Hericium erinaceus, ganoderma lucidum, white fungus, golden ear, dictyophora phalloidea, cordyceps flower, the ash tree after defibrination
Flower, Poria cocos are allocated according to formula rate, and honey is added, and adjust sugar-acid ratio, and stir evenly.
7, to deployed compound mushroom juice, it is extracted, the extraction process parameter of embodiment 9-20 is shown in Table 1.Its
In, the pressure of supercritical extract is 25-80MPa, power 5-25Kw, temperature≤40 DEG C, fluid flow 1000-2000L/h；
Microwave abstracting is 300-915MHz with frequency, and power 5-25Kw, temperature≤40 DEG C, reaction tank volume is 1000-3000L；It is super
Sound wave extraction is 20-50KHz with frequency, and power 5-25Kw, temperature≤40 DEG C, reaction tank volume is 1000-3000L；Superelevation
Pressure extraction is 250-380MPa, power 5-25Kw, temperature≤40 DEG C, fluid flow 1000-2000L/h with pressure；Nanometer
The pressure of grinding extraction is 50-80MPa, and power 5-25Kw, temperature≤40 DEG C, reaction tank volume is 100-500L or liquid flow
Amount is 1000-5000L/h.
8, biological enzymolysis is carried out to the compound mushroom juice of the liquid nano obtained after extraction, 1% compound probiotic is added,
Closed ferment at constant temperature culture 12 hours under the conditions of 40 DEG C.
9, to the compound mushroom juice of the liquid nano obtained after biological enzymolysis, it is carried out by cryogenic vacuum concentrator dense
Contracting, makes its water content control below 50%.
10, the compound mushroom juice of liquid nano obtained after being concentrated to cryogenic vacuum, fills it by dosing filling machine
Dress.
11, the finished product to quantitative filling after good, sterilizes it by static ultrahigh pressure equipment, makes finished product in static state etc.
High pressure 600MPa, sterilize under the conditions of 40 DEG C of temperature 5min.
The extraction process of 1 embodiment 9-20 of table combines
Test example 1
Droplet measurement is carried out to the sample that embodiment 1-3 is provided respectively.
1, the testing conditions and result of embodiment 1
The testing conditions of 2 embodiment 1 of table
The test result of 3 embodiment 1 of table
| Average grain diameter：Xav=849.59nm | Dispersion index：PI=0.4556 | Photon counting：21 |
| D10=209.88nm | D50=460.78nm | D90=1009.59nm |
Concrete outcome is shown in Fig. 1.
2, the testing conditions and result of embodiment 2 and embodiment 3
The test condition of table 4 embodiment 2 and embodiment 3
| Test temperature：25℃ | Decentralized medium：Water |
| Medium refraction index：1.330 | Dielectric viscosity (cP)：0.8872 |
The test result of 5 embodiment 2 of table
Concrete outcome is shown in Fig. 2.
The test result of 6 embodiment 3 of table
Concrete outcome is shown in Fig. 3.
According to table 3, table 5 and table 6 it is found that the average grain diameter for the sample that the method final production that Examples 1 to 3 provides obtains
For 849.59nm, 427.1nm and 428.3nm；And as can be seen from FIG. 1, particle size range is concentrated mainly on 100-1000nm, illustrates reality
The grain size for applying food or drug that example 1 is produced is smaller, and the ratio shared by particle of the grain size less than 1000nm is more than 98%.Root
According to Fig. 2 and Fig. 3 it is found that in food or drug that embodiment 2 and embodiment 3 are produced, shared by particle of the grain size less than 900nm
Ratio be more than 90%.
The foregoing is merely the preferred embodiment of the present invention, are not intended to restrict the invention, for this field
For technical staff, the invention may be variously modified and varied.All within the spirits and principles of the present invention, any made by
Modification, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of method producing nanoscale food, drug, which is characterized in that it includes：
The step of vegetable raw material is subjected to extraction and biological enzymolysis；Extraction includes：Supercritical extract, microwave abstracting, ultrasonic wave
Extraction, high hydrostatic pressure extraction and one or more combinations in nano-milled extraction extract mode.
2. the method for production nanoscale food according to claim 1, drug, which is characterized in that described in supercritical extract
The pressure that vegetable raw material uses is 25-80MPa, power 5-25Kw, and temperature is≤40 DEG C, fluid flow 1000-
2000L/h；
The frequency that vegetable raw material described in microwave abstracting uses is 300-915MHz, power 5-25Kw, and temperature is≤40 DEG C；
The frequency that vegetable raw material described in ultrasonic extraction uses is 20-50KHz, power 5-25Kw, and temperature is≤40 DEG C；
The pressure that vegetable raw material described in high hydrostatic pressure extraction uses is 250-380MPa, power 5-25Kw, and temperature is≤40 DEG C,
Fluid flow is 1000-2000L/h；
For the pressure that the nano-milled extraction vegetable raw material uses for 50-80MPa, power 5-25Kw, temperature is≤40 DEG C,
Fluid flow is 1000-5000L/h.
3. the method for production nanoscale food according to claim 2, drug, which is characterized in that extract the vegetalitas
Raw material is using any one of following extraction combination；
The extraction is combined：
The combination of supercritical extract and microwave abstracting；The combination of supercritical extract and ultrasonic extraction；Supercritical extract and superelevation
Press the combination of extraction；The combination of supercritical extract and nano-milled extraction；The combination of microwave abstracting and ultrasonic extraction；Microwave extracts
Take the combination with high hydrostatic pressure extraction；The combination of microwave abstracting and nano-milled extraction；The group of ultrasonic extraction and high hydrostatic pressure extraction
It closes；Or the combination of ultrasonic extraction and nano-milled extraction；The combination of supercritical extract, microwave abstracting and ultrasonic extraction；It is super
Critical extraction, the combination of microwave abstracting and high hydrostatic pressure extraction；The combination of supercritical extract, microwave abstracting and nano-milled extraction；
The combination of microwave abstracting, ultrasonic extraction and high hydrostatic pressure extraction；The group of microwave abstracting, ultrasonic extraction and nano-milled extraction
It closes；The combination of ultrasonic extraction, high hydrostatic pressure extraction and nano-milled extraction.
4. the method for production nanoscale food according to claim 3, drug, which is characterized in that in the extraction combination,
The time of extraction is respectively：
The supercritical extract time is 5-10min, and the microwave abstracting time is 10-15min, and the time of ultrasonic extraction is 5-10min,
The time of high hydrostatic pressure extraction is 2-5min, and the time of nano-milled extraction is 5-10min.
5. the method for production nanoscale food according to claim 3, drug, which is characterized in that ultrasonic extraction 5-
The combination of 10min and high hydrostatic pressure extraction 2-5min extracts.
6. the method for production nanoscale food according to claim 1, drug, which is characterized in that biological enzymolysis was selected
Compound probiotic includes at least two in lactic acid bacteria, bacillus, saccharomycete, cellulase and dextranase.
7. the method for production nanoscale food according to claim 1, drug, which is characterized in that before being extracted,
Further include the steps that the vegetable raw material is ground into grain size as the particle less than 5mm.
8. the method for production nanoscale food according to claim 1, drug, which is characterized in that before being extracted,
Further include the steps that the water that 1-8 times of the vegetable raw material is measured being added the vegetable raw material is ground into slurry, the slurry
In grain diameter be less than 30 μm.
9. a kind of nanoscale food, drug, which is characterized in that using the production nanoscale described in claim 1-8 any one
Food, drug method be made.
10. nanoscale food according to claim 9, drug, which is characterized in that grain in the nanoscale food, drug
Ratio shared by particle of the diameter less than 1000nm is more than 98%, and the ratio shared by particle of the grain size less than 900nm is more than 90%.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110477226A (en) * | 2019-08-19 | 2019-11-22 | 广东百草正元健康科技有限公司 | A kind of ginseng Chinese caterpillar fungus drink and preparation method thereof |
| CN112772926A (en) * | 2021-01-04 | 2021-05-11 | 江中食疗科技有限公司 | Edible fungus polysaccharide compound formula capable of improving organism immunity |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104286607A (en) * | 2014-07-14 | 2015-01-21 | Pac生命科技研发有限公司 | Preparation method of food additive and application of food additive |
| CN105232601A (en) * | 2015-09-30 | 2016-01-13 | 河南行知专利服务有限公司 | Preparation method and application of decoction-free traditional Chinese fruit medicine preparation |
-
2017
- 2017-03-03 CN CN201710126267.9A patent/CN108523124A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104286607A (en) * | 2014-07-14 | 2015-01-21 | Pac生命科技研发有限公司 | Preparation method of food additive and application of food additive |
| CN105232601A (en) * | 2015-09-30 | 2016-01-13 | 河南行知专利服务有限公司 | Preparation method and application of decoction-free traditional Chinese fruit medicine preparation |
Non-Patent Citations (2)
| Title |
|---|
| 吴宏富等: "《中国粉体工业通鉴》", 30 June 2006, 中国建材工业出版社 * |
| 范青生主编: "《保健食品注册申报实用指南》", 30 May 2006, 中国轻工业出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110477226A (en) * | 2019-08-19 | 2019-11-22 | 广东百草正元健康科技有限公司 | A kind of ginseng Chinese caterpillar fungus drink and preparation method thereof |
| CN112772926A (en) * | 2021-01-04 | 2021-05-11 | 江中食疗科技有限公司 | Edible fungus polysaccharide compound formula capable of improving organism immunity |
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