CN108030840A - A kind of Chinese medicine for treating diarrhea and preparation method thereof - Google Patents
A kind of Chinese medicine for treating diarrhea and preparation method thereof Download PDFInfo
- Publication number
- CN108030840A CN108030840A CN201810134100.1A CN201810134100A CN108030840A CN 108030840 A CN108030840 A CN 108030840A CN 201810134100 A CN201810134100 A CN 201810134100A CN 108030840 A CN108030840 A CN 108030840A
- Authority
- CN
- China
- Prior art keywords
- diarrhea
- chinese medicine
- parts
- taro
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a kind of Chinese medicine for treating diarrhea, its preparing raw material is made of the component of following parts by weight：5 10 parts of taro, 15 parts of umbellate pore furgus.In addition, present invention also offers a kind of preparation method for the Chinese medicine for treating diarrhea.The Chinese medicine of present invention treatment diarrhea is the diarrhea that the insufficiency of the spleen with overabundance of dampness is controlled according to theory of traditional Chinese medical science reasonable formula, taro energy bowl spares invigorating the spleen, moreover it is possible to which complement sun, middle benefit gas are cold to dissipate belly；The gas of umbellate pore furgus benefaction stomach and intestine and relieve pain, alleviate the abdominal pain caused by damp evil diarrhea and vomiting, the two combination can dispelling cold and dehumidification, it is warming spleen and stopping diarrha.The Chinese prescription compatibility of the invention for treating diarrhea is reasonable, strengthening spleen and tonifying lung, tonifying middle-Jiao and Qi, and spleen dampness elimination, and qi-regulating dissipate-swelling is with strong points, and security is good, and curative effect is good, can effectively treat diarrhea, be with a wide range of applications.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine for treating diarrhea and preparation method thereof.
Background technology
Diarrhea, the traditional Chinese medical science are known as diarrhea, are a kind of common symptons, refer to defecation frequency significantly more than the frequency being accustomed on ordinary days,
Excrement matter is thin, moisture increase, and daily feces volume is more than 200g, or containing not digesting food or purulence blood, mucus.Diarrhea is often accompanied by defecation
The symptoms such as sense of urgency, anus discomfort, incontinence.Diarrhea is divided to acute and chronic two class.Diarrhea is belonged to digestive system by modern medicine
Disease, clinic is common inflammatory bowel disease, Functional Gastrointestinal Disease and chronic diarrhea, such as：Acute gastroenteritis, functional digestive are not
Good, intestinal irritable syndrome etc..
Treatment is mainly using antibiotic medicine, sulfa drugs, aid digestion medicine etc..Western medicine diarrhea is taken easily to produce
Raw drug resistance, is repeatedly used for a long antibiotic and dysbacteriosis easily occurs, nonresponder can form chronic diarrhea and clinic is seen
Gastrointestinal dysfunction syndrome, and medical expense is high.
The traditional Chinese medical science thinks that this is sick the closest with insufficiency of the spleen relation, and insufficiency of the spleen to lose fortune, indigestion is precise and tiny, raw in muddiness, and paddy is anti-
To be stagnant, water instead to be wet, mix and under, and walk large intestine, and be diarrhea；It is multiple because of disorder of emotion if usually taste element is weak, so that irritability
Pent-up, perverse and unreasonable manner multiply spleen, and transporting mistake department, can also form diarrhea；If after prolonged illness, damaging kidney yang, or worn with age, YANG QI deficiency,
Dysfunction of the spleen in warming, dysfunction of the spleen in transportation and transformation, may also lead to diarrhea.According to theory of traditional Chinese medical science, for the pathogenesis of diarrhea, with tonifying spleen and kidney for base
This principle of reatment, carries out dialectical composition of prescription, to achieve the purpose that to treat both principal and secondary aspect of disease.
A variety of Chinese medicines for being used to treat diarrhea have been developed at present, and also achieve preferable therapeutic effect, but this
How more complicated a little Chinese medicine preparation components are, and preparation process is also numerous and diverse, simultaneously because Chinese medicine material is numerous, inevitably brings
Some side effects, affect the treatment to a certain extent, so as to limit its extensive use.So necessary one kind of developing is matched somebody with somebody
Simple, the eutherapeutic Chinese medicine in side is used for the treatment of diarrhea.
The content of the invention
The present invention provides a kind of Chinese medicine for treating diarrhea, solve and take western medicine diarrhea in the prior art and easily produce
Raw drug resistance, and the problem of medical expense is high, it is complicated to also solve the Chinese medicine preparation of existing treatment diarrhea, asking more than side effect
Topic.
First purpose of the present invention is to provide a kind of Chinese medicine for treating diarrhea, its preparing raw material is by following parts by weight
Component forms：5-10 parts of taro, 1-5 parts of umbellate pore furgus.
Preferably, the preparing raw material of the Chinese medicine of the treatment diarrhea is made of the component of following parts by weight：7 parts of taro,
3 parts of umbellate pore furgus.
Second object of the present invention is to provide a kind of preparation method for the Chinese medicine for treating diarrhea, specifically according to following steps
Implement：
Step 1,5-10 parts of taro, 1-5 parts of umbellate pore furgus are weighed by weight, it is spare；
Step 2, by the taro weighed in step 1, umbellate pore furgus clean, remove the peel, dry after cut into slices, obtain mixed material piece,
Water of 5 times equivalent to mixed material sheet weight is added into mixed material piece to soak 12-14 days, is filtered, is obtained after immersion
Soak medicinal material and soak；
Immersion medicinal material is dried and is placed in soak, immersion 1-2h is after decocting 15-30min, Ran Housheng at 60-80 DEG C
Temperature decocts 20-30min at 90 DEG C, is filtered after decoction, obtain filtrate and filter residue to 90 DEG C；
Step 3, stirred evenly rear close equivalent to the composite probiotics ferment bacterium solution of filter residue weight 1% toward addition in filter residue
Envelope, ferments 25-30 days at 20-25 DEG C, and fermentation finishes to obtain tunning, and tunning is filtered, obtains ferment filtrate；
Wherein, the composite probiotics ferment bacterium solution is by lactobacillus fermentation bacterium solution, saccharomycetes to make fermentation bacterium solution and withered grass bud
Born of the same parents' bacillus fermentation bacterium solution is according to 2：1：1 mass ratio mixes, and living bacteria count in the composite probiotics ferment bacterium solution
≥1010CFU/mL；
Step 4, the filtrate in step 2 is uniformly mixed with the ferment filtrate in step 3, it is 2g/ to be then concentrated into concentration
ML, then autoclaving, that is, obtain the Chinese medicine of the treatment diarrhea.
Preferably, the coolant-temperature gage that mixed material piece is soaked in the step 2 is 70-80 DEG C.
Preferably, filtered in the step 2, the step 3 using millipore filter.
Preferably, the step 4 mesohigh sterilising conditions are：Sterilize 5-10min under the pressure of 400-700MPa.
The pharmacological action of each raw material Chinese medicine and drug effect in the present invention：
1st, taro：Property is sweet pungent, flat, returns intestines, stomach.With beneficial stomach, swelling and pain relieving, wide intestines, removing toxic substances, bowl spares liver and kidney benefiting, dissipate
Gas, resolving sputum, defaecation, beneficial stomach invigorating the spleen, sperm adding and marrow healthing and other effects in knot, adjusting.Taro contains a kind of natural polysaccharide natural plant gum
Body, can improve a poor appetite, help digest, there is antidiarrheal；There is the function of dietary fiber again at the same time, can relax bowel, prevent just
It is secret；And body resistance against diseases can be improved, helps rehabilitation after being ill.Also contain a kind of mucus albumen in taro, after being absorbed by the body
Immunoglobulin, or antibody globulin can be produced, the resistance of body can be improved.Therefore the traditional Chinese medical science thinks that taro can detoxify, to people
The carbuncle swells poison pain of body, which includes cancer poison, suppression resolution effect, can be used to the illnesss such as anti-curing oncoma and scrofula.
2nd, umbellate pore furgus：It is sweet in flavor, light, flat, the thoughts of returning home, spleen, stomach, lung, kidney channel.Control difficult urination, oedema, diarrhea, stranguria with turbid discharge, with.
《Collected statements on the herbal foundation》Record：" this medicine slightly sweet flavor slight bitter, though bitter decline, and the sweet light profit that can ooze is wandered away, and is risen and can be dropped, and is dropped and can be risen,
Therefore the gas diuresis of kind loosing the interspaces of skin and muscles subscale Yangli the moon, therefore preceding Gu Zhu Zhu Jie malarias.”《Square arteries and veins man is precious》In just record and matched somebody with somebody with umbellate pore furgus
Radix bupleuri, Poria cocos, the tuber of pinellia, ginger etc. treat Xin Jiu Jie malarias.Again《LEI Feng is wet to rush down》Cloud：" disease of diarrhea, it is more to belong to wet.Immersion
In spleen, the dysfunction of the spleen in transport, it is impossible to which imbibition, causes ileocecal conjunction to be unable to secrete clear not turbid, trough enters large intestine and forms diarrhea ".The method rushed down is controlled,《Doctor
Learn introduction diarrheas》Medium cloud：" just preferably divide regulating the function of middle-JIAO, ooze burnt under profit." therefore controlled and rushed down with umbellate pore furgus, just urine can be divided, so that wet go
Rush down from only.
Compared with prior art, the beneficial effects of the present invention are：
The Chinese medicine of present invention treatment diarrhea is that taro energy bowl spares invigorating the spleen, controls the insufficiency of the spleen with overabundance of dampness according to theory of traditional Chinese medical science reasonable formula
Diarrhea, moreover it is possible to complement sun, middle benefit gas are cold to dissipate belly；The gas of umbellate pore furgus benefaction stomach and intestine and relieve pain, alleviate caused by damp evil diarrhea
Abdominal pain and vomiting.The two combination energy dispelling cold and dehumidification, it is warming spleen and stopping diarrha, it is thin for diarrhea to clinical manifestation, such as water sample, abdominal pain intestines
Ring, the vexed deficiency of food of gastral cavity, can have good efficacy with poisoning symptoms such as fever, nausea and vomiting, borborygmus abdominal pain.Inventive formulation is to be based on
The compound of instruction of Chinese Medicine theory, is an organic whole, the performance of its curative effect is nor a component or certain a herb institute
It can substitute completely, and experimental study shows, and its curative effect is optimal when inventive formulation is as an entirety, is used than simple
Effect has significant synergy to act on.
The Chinese prescription compatibility of the invention for treating diarrhea is reasonable, strengthening spleen and tonifying lung, tonifying middle-Jiao and Qi, and spleen dampness elimination, qi-regulating dissipate-swelling,
With strong points, security is good, and curative effect is good, can effectively treat diarrhea, be with a wide range of applications.
Embodiment
In order to enable those skilled in the art to more fully understand, technical scheme is practiced, with reference to specific
The invention will be further described for embodiment, but illustrated embodiment is not as a limitation of the invention.
Bacillus acidi lactici (Lactobacillus.crispatus) used is Chinese microorganism strain preservation management in the present invention
Committee's common micro-organisms center deposit number is the bacterial strain of CGMCC No.9468；Saccharomycete (Saccharomyces
Cerevisiae it is) that China Committee for Culture Collection of Microorganisms's common micro-organisms center's deposit number is CGMCC
The bacterial strain of No.4429；Bacillus subtillis (Bacillus subtilis) is general for China Committee for Culture Collection of Microorganisms
The bacterial strain that logical microorganism center deposit number is CGMCC No.9870.
Lactobacillus fermentation bacterium solution, saccharomycetes to make fermentation bacterium solution and Bacillus subtillis zymocyte liquid are to use in embodiment
Conventional method culture obtains, and experimental method described in following each embodiments, is conventional method unless otherwise specified.
Embodiment 1
A kind of Chinese medicine for treating diarrhea, its preparing raw material are made of the component of following parts by weight：7 parts of taro, umbellate pore furgus 3
Part.
Specifically implement according to following steps：
Step 1,7 parts of taro, 3 parts of umbellate pore furgus are weighed by weight, it is spare；
Step 2, by the taro weighed in step 1, umbellate pore furgus clean, remove the peel, dry after cut into slices, obtain mixed material piece,
Add in water equivalent to 5 times of mixed material sheet weight, that temperature is 70-80 DEG C and soak 12 days into mixed material piece, immersion
After filter, obtain immersion medicinal material and soak；
Immersion medicinal material is dried and is placed in soak, 1h at 80 DEG C after decocting 15min for immersion, then heats to 90
DEG C, 30min is decocted at 90 DEG C, is filtered after decoction, obtains filtrate and filter residue；
Step 3, stirred evenly rear close equivalent to the composite probiotics ferment bacterium solution of filter residue weight 1% toward addition in filter residue
Envelope, ferments 25 days at 20-25 DEG C, and fermentation finishes to obtain tunning, and tunning is filtered, obtains ferment filtrate；
Wherein, the composite probiotics ferment bacterium solution is by lactobacillus fermentation bacterium solution, saccharomycetes to make fermentation bacterium solution and withered grass bud
Born of the same parents' bacillus fermentation bacterium solution is according to 2：1：1 mass ratio mixes, and living bacteria count in composite probiotics ferment bacterium solution >=
1010CFU/mL；
Step 4, the filtrate in step 2 is uniformly mixed with the ferment filtrate in step 3, it is 2g/ to be then concentrated into concentration
ML, then autoclaving, that is, obtain the Chinese medicine of treated diarrhea.
Embodiment 2
A kind of Chinese medicine for treating diarrhea, its preparing raw material are made of the component of following parts by weight：5 parts of taro, umbellate pore furgus 5
Part.
Specifically implement according to following steps：
Step 1,5 parts of taro, 5 parts of umbellate pore furgus are weighed by weight, it is spare；
Step 2, by the taro weighed in step 1, umbellate pore furgus clean, remove the peel, dry after cut into slices, obtain mixed material piece,
Add in water equivalent to 5 times of mixed material sheet weight, that temperature is 70-80 DEG C and soak 13 days into mixed material piece, immersion
After filter, obtain immersion medicinal material and soak；
Immersion medicinal material is dried and is placed in soak, 1.5h at 70 DEG C after decocting 20min for immersion, then heats to 90
DEG C, 25min is decocted at 90 DEG C, is filtered after decoction, obtains filtrate and filter residue；
Step 3, stirred evenly rear close equivalent to the composite probiotics ferment bacterium solution of filter residue weight 1% toward addition in filter residue
Envelope, ferments 30 days at 20-25 DEG C, and fermentation finishes to obtain tunning, and tunning is filtered, obtains ferment filtrate；
Wherein, the composite probiotics ferment bacterium solution is by lactobacillus fermentation bacterium solution, saccharomycetes to make fermentation bacterium solution and withered grass bud
Born of the same parents' bacillus fermentation bacterium solution is according to 2：1：1 mass ratio mixes, and living bacteria count in composite probiotics ferment bacterium solution >=
1010CFU/mL；
Step 4, the filtrate in step 2 is uniformly mixed with the ferment filtrate in step 3, it is 2g/ to be then concentrated into concentration
ML, then autoclaving, that is, the Chinese medicine for the diarrhea that obtains medical treatment.
Embodiment 3
A kind of Chinese medicine for treating diarrhea, its preparing raw material are made of the component of following parts by weight：10 parts of taro, umbellate pore furgus 1
Part.
Specifically implement according to following steps：
Step 1,5-10 parts of taro, 1-5 parts of umbellate pore furgus are weighed by weight, it is spare；
Step 2, by the taro weighed in step 1, umbellate pore furgus clean, remove the peel, dry after cut into slices, obtain mixed material piece,
Add in water equivalent to 5 times of mixed material sheet weight, that temperature is 70-80 DEG C and soak 14 days into mixed material piece, immersion
After filter, obtain immersion medicinal material and soak；
Immersion medicinal material is dried and is placed in soak, 2h at 60 DEG C after decocting 30min for immersion, then heats to 90
DEG C, 20min is decocted at 90 DEG C, is filtered after decoction, obtains filtrate and filter residue；
Step 3, stirred evenly rear close equivalent to the composite probiotics ferment bacterium solution of filter residue weight 1% toward addition in filter residue
Envelope, ferments 28 days at 20-25 DEG C, and fermentation finishes to obtain tunning, and tunning is filtered, obtains ferment filtrate；
Wherein, the composite probiotics ferment bacterium solution is by lactobacillus fermentation bacterium solution, saccharomycetes to make fermentation bacterium solution and withered grass bud
Born of the same parents' bacillus fermentation bacterium solution is according to 2：1：1 mass ratio mixes, and living bacteria count in composite probiotics ferment bacterium solution >=
1010CFU/mL；
Step 4, the filtrate in step 2 is uniformly mixed with the ferment filtrate in step 3, it is 2g/ to be then concentrated into concentration
ML, then autoclaving, that is, the Chinese medicine for the diarrhea that obtains medical treatment.
It should be noted that filtered in step 2, step 3 using millipore filter.
Explanation is needed further exist for, step 4 mesohigh sterilising conditions are：Sterilize 5- under the pressure of 400-700MPa
10min。
In order to further be illustrated to the effect of the present invention, the present invention is also provided with comparative example.
Comparative example 1
For preparation method with embodiment 1, difference is that preparing raw material component only has taro.
Comparative example 2
For preparation method with embodiment 1, difference is that preparing raw material component only has umbellate pore furgus.
Comparative example 3
With embodiment 1, difference is no step 3, and directly raw material obtains medical treatment diarrhea after step 2 is handled
Chinese medicine.
Comparative example 4
With embodiment 1, difference is no step 2, after directly raw material is handled using the zymotechnique of step 3
To the Chinese medicine for the treatment of diarrhea.
Embodiment 1-3 has prepared the Chinese medicine of the treatment diarrhea to work well, to embodiment 1-3 and comparative example 1-4 systems
Performance for the Chinese medicine of the treatment diarrhea gone out is tested, and is illustrated with the effect to the present invention.
The effect of the present invention is illustrated using zoopery below.
1st, experiment material
1.1 medicines and reagent：The Chinese medicine of the treatment diarrhea of 1-3 of the embodiment of the present invention；In the treatment diarrhea of comparative example 1-4
Medicine, loperamide hydrochloride (Xian-Janssen Pharmaceutical Ltd.), Xianglian Wan (Wuhan Zhonglian Pharmaceutical Group Co. Ltd.), carboxylic
Sodium carboxymethylcellulose pyce (Wuxi flourishing age Hong Cheng bio tech ltd).
1.2 experimental animal：Healthy Kunming mouse, weight 20g ± 2g, half male and half female.
2nd, experimental method
2.1st, to the influence of diarrhea of mouse index
Take mouse 100, half male and half female, be randomly divided into experimental group, contrast groups, loperamide hydrochloride group, Xianglian Wan group with
And model group, experimental group there are three groups, every group 10, the Chinese medicine of the treatment diarrhea that embodiment 1-3 is prepared is given respectively；Contrast groups
There are four groups, every group 10, give the Chinese medicine of the treatment diarrhea that comparative example 1-4 is prepared respectively.
Mouse normally raising 3 days, the fasting for solids but not liquids 12h before administration, model group gives pure water 0.2mL gavages, experiment
Group and contrast groups give corresponding Chinese medicine (2g crude drugs/mL) 5g/kg gavages respectively, and loperamide hydrochloride group is to loperamide hydrochloride
(0.1g/mL) 1g/kg gavages, Xianglian Wan group give Xianglian Wan (0.1g/mL) 1g/kg gavages.After 0.5h, every group of mouse gives cassia angustifolia
Single mouse, is put into the mouse cage for being covered with filter paper by leaf (1g crude drugs/mL liquids) 10g/kg gavages afterwards, bio-occlusion food drinking-water,
Observe diarrhea mice general state, behavior and stool change.Record loose stools number, total bowel frequency number, the loose stools in each group mouse 6h
Level, calculates loose stool rate and Scours index.
Wherein, loose stool rate (%)=mouse passage of loose stools number/mouse defecation total degree × 100%, loose stools level are dirty with loose stools
The stain area diameter size deciding grade and level that filter paper is formed is contaminated, is specifically shown in Table 1；Scours index=loose stool rate × loose stools level.
1 loose stools size Scaling Standards of table
| Level-one | Two level | Three-level | Level Four | |
| Diameter | Diameter<1cm | 1.0≤diameter<2.0 | 2.0≤diameter<3.0 | 3.0≤diameter<4.0 |
2.2nd, to the influence of mouse Intestinal pushing
Each group mouse gives relative medicine, in addition to model group gives 5% sodium carboxymethylcellulose of isometric(al), other groups
Species and dosage is administered with above-mentioned 2.1, once a day, successive administration three days.0.5h gavages give ink after the last administration
0.4mL/ only, after 20min takes off neck and puts to death mouse, opens abdominal cavity and takes out small intestine, measure the length of small intestine, ink small intestine propulsion
Distance, calculates ink and promotes percentage.Wherein, ink promote distance/small intestine total length of percentage=ink front end and pylorus ×
100%
3rd, experimental result
Experimental result is shown in Table 2-3.
Table 2 influences experimental result to diarrhea of mouse
| Group | Loose stool rate (%) | Average loose stools level | Scours index |
| Embodiment 1 | 41.36±5.38** | 1.93±0.26** | 1.02±0.21** |
| Embodiment 2 | 39.03±5.22** | 2.07±0.18** | 0.98±0.19** |
| Embodiment 3 | 40.82±4.59** | 2.09±0.22** | 0.92±0.18** |
| Comparative example 1 | 44.36±6.37** | 2.21±0.16** | 1.16±0.21** |
| Comparative example 2 | 48.14±7.34** | 2.27±0.21** | 1.21±0.16** |
| Comparative example 3 | 56.53±7.41** | 2.32±0.22** | 1.36±0.22** |
| Comparative example 4 | 46.26±6.98** | 2.19±0.18** | 1.19±0.25** |
| Loperamide hydrochloride group | 36.85±4.21** | 1.87±0.52** | 1.46±0.21** |
| Xianglian Wan group | 43.57±4.33** | 2.37±0.31** | 0.96±0.16** |
| Model group | 62.64±7.46 | 2.42±0.36 | 1.43±0.25 |
Note：Compared with folium sennae model group, * P<0.05, * * P<0.01.
From table 2 it can be seen that compared with model group and comparative example 1-4, the Chinese medicine for the treatment diarrhea that embodiment 1-3 is prepared
There is therapeutic effect to diarrhea mouse, its Scours index decreases (* P<0.01).The treatment abdomen that embodiment 1-3 is prepared
The Chinese medicine rushed down is suitable with Xianglian Wan drug effect.
The Chinese medicine for the treatment of diarrhea, the preparation method used due to it and implementation are prepared in comparative example 1 only with taro
Example is identical, therefore the Chinese medicine effect that comparative example 1 is prepared is slightly worse than embodiment 1-3's；Made in comparative example 2 only with umbellate pore furgus
The Chinese medicine of standby treatment diarrhea, the preparation method that it is used is also identical with embodiment, and the Chinese medicine effect prepared is worse than comparative example 1
, illustrate under the preparation method of the present invention, taro is more preferable for the therapeutic effect of diarrhea.But taro and umbellate pore furgus are coordinated
Together, when and preparation method using the present invention prepares Chinese medicine, the two can act synergistically, and promote mutually, given play to more than two
The drug effect of person in itself.
Taro and umbellate pore furgus are simply mixed rear water and carried by comparative example 3, and the active ingredient in taro and umbellate pore furgus cannot be extracted fully
Out, therefore drug effect is poor.Comparative example 4 is by taro and umbellate pore furgus mixed fermentation, and not by aqueous extraction step, drug effect is compared with embodiment 1-
3 is less better.
Therefore, on the one hand the drug effect of the Chinese medicine for the treatment diarrhea that the present invention prepares comes from raw material in itself, on the other hand
Come from preparation method, raw material using the present invention and preparation method can prepare the Chinese medicine for the treatment of diarrhea evident in efficacy.
Influence of the table 3 to mouse Intestinal pushing
Note：Compared with folium sennae model group, * P<0.05, * * P<0.01.
The Intestinal pushing of table 3 test result indicates that, compared with model group and comparative example 1-4, treatment that embodiment 1-3 is prepared
The inhibition that the Chinese medicine of diarrhea wriggles diarrhea mouse small intestine is more preferable, so that antidiarrheal effect is more preferable.Embodiment 1-3 is prepared
The Chinese medicine for the treatment of diarrhea is suitable with loperamide hydrochloride drug effect, is slightly better than the drug effect of Xianglian Wan.
It should be noted that involved in claims of the present invention during number range, it is thus understood that each number range
Any one numerical value can be selected between two endpoints and two endpoints, due to step method and the embodiment 1-3 phases of use
Together, repeat in order to prevent, description of the invention preferred embodiment, but those skilled in the art once know substantially
Creative concept, then can make these embodiments other change and modification.So appended claims are intended to be construed to wrap
Include preferred embodiment and fall into all change and modification of the scope of the invention.
Obviously, various changes and modifications can be made to the invention without departing from essence of the invention by those skilled in the art
God and scope.In this way, if these modifications and changes of the present invention belongs to the scope of the claims in the present invention and its equivalent technologies
Within, then the present invention is also intended to comprising including these modification and variations.
Claims (6)
1. a kind of Chinese medicine for treating diarrhea, it is characterised in that its preparing raw material is made of the component of following parts by weight：Taro 5-
10 parts, 1-5 parts of umbellate pore furgus.
2. the Chinese medicine for the treatment of diarrhea according to claim 1, it is characterised in that its preparing raw material is by following parts by weight
Component forms：7 parts of taro, 3 parts of umbellate pore furgus.
3. the preparation method of the Chinese medicine for the treatment of diarrhea according to claim 1, it is characterised in that specifically according to following steps
Implement：
Step 1,5-10 parts of taro, 1-5 parts of umbellate pore furgus are weighed by weight, it is spare；
Step 2, by the taro weighed in step 1, umbellate pore furgus clean, remove the peel, dry after cut into slices, mixed material piece is obtained, toward mixed
The water for closing 5 times equivalent to mixed material sheet weight of addition in material piece soaks 12-14 days, filters, is soaked after immersion
Medicinal material and soak；
Immersion medicinal material is dried and is placed in soak, 1-2h at 60-80 DEG C after decocting 15-30min for immersion, then heats to
90 DEG C, 20-30min is decocted at 90 DEG C, is filtered after decoction, obtains filtrate and filter residue；
Step 3, toward the composite probiotics ferment bacterium solution added in filter residue equivalent to filter residue weight 1%, sealed after stirring evenly, in
Ferment 25-30 days at 20-25 DEG C, fermentation finishes to obtain tunning, and tunning is filtered, obtains ferment filtrate；
Wherein, the composite probiotics ferment bacterium solution is by lactobacillus fermentation bacterium solution, saccharomycetes to make fermentation bacterium solution and Ko subtilis bar
Bacterium zymocyte liquid is according to 2：1：1 mass ratio mixes, and living bacteria count in the composite probiotics ferment bacterium solution >=
1010CFU/mL；
Step 4, the filtrate in step 2 is uniformly mixed with the ferment filtrate in step 3, it is 2g/mL to be then concentrated into concentration, then
Autoclaving, that is, obtain the Chinese medicine of the treatment diarrhea.
4. the preparation method of the Chinese medicine for the treatment of diarrhea according to claim 3, it is characterised in that soaked in the step 2
The coolant-temperature gage of mixed material piece is 70-80 DEG C.
5. the preparation method of the Chinese medicine for the treatment of diarrhea according to claim 3, it is characterised in that the step 2, the step
Filtered in rapid 3 using millipore filter.
6. the preparation method of the Chinese medicine for the treatment of diarrhea according to claim 3, it is characterised in that step 4 mesohigh
Sterilising conditions are：Sterilize 5-10min under the pressure of 400-700MPa.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810134100.1A CN108030840A (en) | 2018-02-09 | 2018-02-09 | A kind of Chinese medicine for treating diarrhea and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810134100.1A CN108030840A (en) | 2018-02-09 | 2018-02-09 | A kind of Chinese medicine for treating diarrhea and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108030840A true CN108030840A (en) | 2018-05-15 |
Family
ID=62097379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810134100.1A Pending CN108030840A (en) | 2018-02-09 | 2018-02-09 | A kind of Chinese medicine for treating diarrhea and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108030840A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110810836A (en) * | 2018-08-10 | 2020-02-21 | 天津晶然科技有限公司 | Taro polysaccharide extraction method, taro polysaccharide extract and application |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1436545A (en) * | 2002-02-03 | 2003-08-20 | 路良宇 | Medicine and prepn for treating children's diarrhea |
-
2018
- 2018-02-09 CN CN201810134100.1A patent/CN108030840A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1436545A (en) * | 2002-02-03 | 2003-08-20 | 路良宇 | Medicine and prepn for treating children's diarrhea |
Non-Patent Citations (4)
| Title |
|---|
| 〔日〕阿部绚子 著: "《这样吃更健康》", 31 July 2009, 南海出版社 * |
| 林能明主编: "《科学用药：常见病临床药师用药答疑》", 30 November 2016, 浙江大学出版社 * |
| 祝之友 著: "《<神农本草经>药物古今临床应用解读》", 31 January 2014, 四川科学技术出版社 * |
| 谢莉敏 等: "益生菌及其在药学研究中的应用", 《药学研究》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110810836A (en) * | 2018-08-10 | 2020-02-21 | 天津晶然科技有限公司 | Taro polysaccharide extraction method, taro polysaccharide extract and application |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102198262B (en) | Chinese medicine preparation for treating infant rotavirus enteritis and preparation method thereof | |
| CN101347594B (en) | Method for preparing Chinese medicine for treating kidney-yang deficiency type diarrhea | |
| CN104771515B (en) | A kind of Wash-out medicine and preparation method thereof for treating eczema | |
| CN104173970B (en) | A kind of traditional Chinese powder medicine for treating baby diarrhea | |
| CN108030840A (en) | A kind of Chinese medicine for treating diarrhea and preparation method thereof | |
| CN103977372A (en) | Traditional Chinese medicine additive used for treating porcine epizootic diarrhea and preparing method thereof | |
| CN102631630B (en) | Method for preparing traditional Chinese medicine (TCM) for treating intestine and stomach dyspepsia type colitis | |
| CN102716458B (en) | It is a kind of to improve the healthy medicated wine and preparation method of rheumatic arthritis | |
| CN109771602A (en) | For treating external application type Traditional Chinese medicine composition patch, preparation and its application of diarrhea | |
| CN102178797B (en) | Preparation method of traditional Chinese medicine for treating acute pancreatitis caused by engorgement | |
| CN108403820A (en) | It is a kind of to be used to treat Chinese medical extract of gastrointestinal disease and preparation method thereof | |
| CN104547251B (en) | A kind of navel patch and preparation method for treating chordapsus | |
| CN104491629B (en) | A kind of external medicine composition for treating perianal eczema and preparation method thereof | |
| CN103239503B (en) | Chinese medicine preparation for treating itai-itai disease and preparation method of Chinese medicine preparation | |
| CN102188643B (en) | Medicament for treating damp-heat blockage syndrome and its preparation method | |
| CN101023988A (en) | Chinese medicine preparation for treating infant's diarrhea | |
| CN103816486A (en) | Traditional Chinese medicine preparation for treating acute and chronic hepatitis | |
| CN103751623B (en) | A kind of pharmaceutical composition for the treatment of diarrhoea and preparation method thereof | |
| CN107260823A (en) | A kind of Chinese medicine for treating incontinence of faces | |
| CN104116920A (en) | Viable bacteria mixture for treating diarrhea with flatulence and preparation method thereof | |
| CN100594927C (en) | Medicine for treating chronic enteritis, chronic bacterial diarrhea and intestine cancer | |
| CN104587060A (en) | Biological preparation for treating prostatitis and preparation method for biological preparation | |
| CN111346137A (en) | Traditional Chinese medicine formula for treating damp-heat diarrhea and preparation and use methods thereof | |
| CN104524443A (en) | Traditional Chinese medicine composition for hypomenorrhea | |
| CN104435327A (en) | Coptis-chinensis-containing pharmaceutical composition for treating diarrhea |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180515 |
|
| RJ01 | Rejection of invention patent application after publication |