CN108026590B - Park2作为用于鉴定免疫细胞特别是单核细胞的表观遗传标志物 - Google Patents

Park2作为用于鉴定免疫细胞特别是单核细胞的表观遗传标志物 Download PDF

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CN108026590B
CN108026590B CN201680052663.5A CN201680052663A CN108026590B CN 108026590 B CN108026590 B CN 108026590B CN 201680052663 A CN201680052663 A CN 201680052663A CN 108026590 B CN108026590 B CN 108026590B
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monocytes
cells
mammal
methylation
cpg
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CN108026590A (zh
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斯文·欧莱克
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Precision Medical Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
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  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Mechanical Control Devices (AREA)
CN201680052663.5A 2015-09-25 2016-09-22 Park2作为用于鉴定免疫细胞特别是单核细胞的表观遗传标志物 Active CN108026590B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1516975.8A GB201516975D0 (en) 2015-09-25 2015-09-25 PARK2 as epigenetic marker for the identification of immune cells, in particular monocytes
GB1516975.8 2015-09-25
PCT/EP2016/072594 WO2017050925A1 (en) 2015-09-25 2016-09-22 Park2 as epigenetic marker for the identification of immune cells, in particular monocytes

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CN108026590A CN108026590A (zh) 2018-05-11
CN108026590B true CN108026590B (zh) 2023-10-31

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CN201680052663.5A Active CN108026590B (zh) 2015-09-25 2016-09-22 Park2作为用于鉴定免疫细胞特别是单核细胞的表观遗传标志物
CN201921407627.3U Withdrawn - After Issue CN211582764U (zh) 2015-09-25 2019-08-28 拉动式的换挡传动系统及食物料理机

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US (1) US11761041B2 (https=)
EP (1) EP3353319B1 (https=)
JP (1) JP2018529346A (https=)
CN (2) CN108026590B (https=)
CA (1) CA2999614C (https=)
GB (1) GB201516975D0 (https=)
WO (1) WO2017050925A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102017125013B4 (de) * 2017-10-25 2019-10-17 Epiontis Gmbh MCC als epigenetischer Marker zur Identifizierung von Immunzellen, insbesondere basophiler Granulozyten
DE102017125150B4 (de) * 2017-10-26 2019-10-10 Epiontis Gmbh Endosialin (CD248) als epigenetischer Marker zur Identifizierung von Immunzellen, insbesondere naïver CD8+ T-Zellen
DE102017125335B4 (de) 2017-10-27 2019-10-17 Epiontis Gmbh Amplikon-Region als epigenetischer Marker zur Identifizierung von Immunzellen, insbesondere nicht-klassischer Monozyten
HK1256212A2 (zh) * 2018-12-27 2019-09-13 汪恩光 拉动式的换挡传动系统及食物料理机
JPWO2022191293A1 (https=) * 2021-03-12 2022-09-15

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011128820A2 (en) * 2010-04-16 2011-10-20 Koninklijke Philips Electronics N.V. Methods for the analysis of breast cancer disorders
WO2013033627A2 (en) * 2011-09-01 2013-03-07 The Regents Of The University Of California Diagnosis and treatment of arthritis using epigenetics
WO2014170497A2 (en) * 2013-04-19 2014-10-23 Epiontis Gmbh Method for identifying the quantitative cellular composition in a biological sample

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2367012T3 (es) * 2006-02-28 2011-10-27 Charite-Universitätsmedizin Berlin Detección y control de calidad de linfocitos t reguladores a través del análisis de metilación del adn del gen foxp3.
CA2671270A1 (en) * 2006-12-29 2008-07-17 Asuragen, Inc. Mir-16 regulated genes and pathways as targets for therapeutic intervention
PL2248913T3 (pl) * 2009-04-28 2017-04-28 Epiontis Gmbh GNLY jako marker epigenetyczny do identyfikacji komórek naturalnej cytotoksyczności ekspresjonujących CD56
WO2013067451A2 (en) * 2011-11-04 2013-05-10 Population Diagnostics Inc. Methods and compositions for diagnosing, prognosing, and treating neurological conditions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011128820A2 (en) * 2010-04-16 2011-10-20 Koninklijke Philips Electronics N.V. Methods for the analysis of breast cancer disorders
WO2013033627A2 (en) * 2011-09-01 2013-03-07 The Regents Of The University Of California Diagnosis and treatment of arthritis using epigenetics
WO2014170497A2 (en) * 2013-04-19 2014-10-23 Epiontis Gmbh Method for identifying the quantitative cellular composition in a biological sample

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia;Xabier Agirre等;《International Journal of Cancer》;20060415;第118卷(第8期);第1945-1953页 *
Circulating miRNAs as Biomarkers for Neurodegenerative Disorders;Margherita Grasso等;《Molecules》;20140523;第19卷;第6891-6910页 *
Homo sapiens parkin RBR E3 ubiquitin protein ligase (PARK2), RefSeqGene on chromosome 6;Bruggemann,N.等;《GenBank》;20140526;Accession No: NG_008289.1 *
Methylation and Hydroxymethylation Status of Tumor Suppressor Genes and Common Fragile Sites Genes in Acute Myeloid Leukemia I Blood Journal;Hiroshi Handa等;《Blood》;20141206;第124卷(第21期);3535 *
Parkin基因甲基化在鼻咽癌发生发展中的作用;倪海峰等;《2014年浙江省医学会耳鼻咽喉头颈外科学学术年会论文汇编》;20140905;第135页 *
散发性早发帕金森病PARK2基因突变及其临床特征;陈思等;《山东大学学报(医学版)》;20120731;第50卷(第7期);第55-59页 *
表观遗传学与糖尿病的研究进展;周娜等;《医学综述》;20120605(第11期);第130-132页 *

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Publication number Publication date
HK1257582A1 (en) 2019-10-25
US11761041B2 (en) 2023-09-19
WO2017050925A1 (en) 2017-03-30
EP3353319A1 (en) 2018-08-01
CN108026590A (zh) 2018-05-11
JP2018529346A (ja) 2018-10-11
US20180216184A1 (en) 2018-08-02
CN211582764U (zh) 2020-09-29
EP3353319B1 (en) 2020-10-21
CA2999614C (en) 2023-02-28
GB201516975D0 (en) 2015-11-11
CA2999614A1 (en) 2017-03-30

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