CN108026184A - 包含分散的酯化纤维素醚的水性组合物 - Google Patents
包含分散的酯化纤维素醚的水性组合物 Download PDFInfo
- Publication number
- CN108026184A CN108026184A CN201680053859.6A CN201680053859A CN108026184A CN 108026184 A CN108026184 A CN 108026184A CN 201680053859 A CN201680053859 A CN 201680053859A CN 108026184 A CN108026184 A CN 108026184A
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- China
- Prior art keywords
- waterborne compositions
- cellulose ether
- esterified cellulose
- group
- water
- Prior art date
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Classifications
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
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- A—HUMAN NECESSITIES
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- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
- B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
- B29C41/14—Dipping a core
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
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- A—HUMAN NECESSITIES
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- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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- B29L2031/00—Other particular articles
- B29L2031/712—Containers; Packaging elements or accessories, Packages
- B29L2031/7174—Capsules
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2201/00—Properties
- C08L2201/06—Biodegradable
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
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- C08L2203/02—Applications for biomedical use
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
- C08L2205/025—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group containing two or more polymers of the same hierarchy C08L, and differing only in parameters such as density, comonomer content, molecular weight, structure
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Food Science & Technology (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Mechanical Engineering (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- General Preparation And Processing Of Foods (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
Claims (15)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562236173P | 2015-10-02 | 2015-10-02 | |
US62/236173 | 2015-10-02 | ||
PCT/US2016/054271 WO2017058973A1 (en) | 2015-10-02 | 2016-09-29 | Aqueous composition comprising dispersed esterified cellulose ether |
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CN107849152B (zh) * | 2015-07-28 | 2020-12-01 | 陶氏环球技术有限责任公司 | 生产酯化纤维素醚分散体的方法 |
KR20190125334A (ko) * | 2017-03-17 | 2019-11-06 | 다우 글로벌 테크놀로지스 엘엘씨 | 반응 생성 혼합물로부터 에스테르화 셀룰로스 에테르를 회수하는 공정 |
WO2019022822A1 (en) * | 2017-07-26 | 2019-01-31 | Dow Global Technologies Llc | WATER-SOLUBLE POLYSACCHARIDES WITH IMPROVED PALABILITY |
JP7149885B2 (ja) * | 2019-03-22 | 2022-10-07 | 株式会社ダイセル | セルロース誘導体粒子、化粧品組成物及びセルロース誘導体粒子の製造方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005115330A2 (en) * | 2004-05-28 | 2005-12-08 | Pfizer Products Inc. | Pharmaceutical compositions with enhanced performance |
CN1934181A (zh) * | 2004-03-22 | 2007-03-21 | 沃纳-兰伯特有限公司 | 生物高分子组合物及其产品 |
US20130295188A1 (en) * | 2012-05-02 | 2013-11-07 | Capsugel France SAS | Bulk enteric capsule shells |
CN104427979A (zh) * | 2012-04-11 | 2015-03-18 | 陶氏环球技术有限责任公司 | 具有特定的取代基分布的酯化的纤维素醚 |
CN105007903A (zh) * | 2013-03-07 | 2015-10-28 | 陶氏环球技术有限责任公司 | 具有极高分子量的新颖酯化纤维素醚 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3499040A (en) * | 1964-06-29 | 1970-03-03 | Eastman Kodak Co | Copolymeric ether glycol and process for its manufacture |
US4226981A (en) | 1977-09-28 | 1980-10-07 | Shin-Etsu Chemical Co., Ltd. | Ether-ester derivatives of cellulose and their applications |
US4365060A (en) | 1979-04-28 | 1982-12-21 | Shin-Etsu Chemical Co. Ltd. | Enterosoluble capsules |
JPS6281402A (ja) | 1985-10-07 | 1987-04-14 | Shin Etsu Chem Co Ltd | セルロ−スエ−テル酸性ジカルボン酸エステルの製造方法 |
US5539021A (en) | 1995-06-05 | 1996-07-23 | The Dow Chemical Company | Process for preparing high internal phase ratio emulsions and latexes derived thereof |
US7763676B2 (en) | 2003-08-25 | 2010-07-27 | Dow Global Technologies Inc. | Aqueous polymer dispersions and products from those dispersions |
GB0706178D0 (en) | 2007-03-29 | 2007-05-09 | Univ Aston | Enteric pharmaceutical capsules |
JP5792807B2 (ja) * | 2010-06-14 | 2015-10-14 | ダウ グローバル テクノロジーズ エルエルシー | アセテートおよびサクシネートの置換が向上されたヒドロキシプロピルメチルセルロースアセテートサクシネート |
EP2831121B1 (en) | 2012-03-27 | 2018-10-10 | Dow Global Technologies LLC | A process of preparing an ester of a cellulose ether |
US9486532B2 (en) | 2013-03-07 | 2016-11-08 | Dow Global Technologies Llc | Esterified cellulose ethers of low viscosity |
EP2813218B1 (en) * | 2013-06-14 | 2022-08-24 | Shin-Etsu Chemical Co., Ltd. | Method for producing aqueous enteric coating liquid, solid preparation, and method for producing same |
CN106163564B (zh) | 2014-04-08 | 2018-10-09 | 陶氏环球技术有限责任公司 | 包含酯化纤维素醚的分散体 |
WO2016148977A1 (en) * | 2015-03-16 | 2016-09-22 | Dow Global Technologies Llc | Water-soluble esterified cellulose ethers having a low degree of neutralization |
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1934181A (zh) * | 2004-03-22 | 2007-03-21 | 沃纳-兰伯特有限公司 | 生物高分子组合物及其产品 |
WO2005115330A2 (en) * | 2004-05-28 | 2005-12-08 | Pfizer Products Inc. | Pharmaceutical compositions with enhanced performance |
CN104427979A (zh) * | 2012-04-11 | 2015-03-18 | 陶氏环球技术有限责任公司 | 具有特定的取代基分布的酯化的纤维素醚 |
US20130295188A1 (en) * | 2012-05-02 | 2013-11-07 | Capsugel France SAS | Bulk enteric capsule shells |
CN105007903A (zh) * | 2013-03-07 | 2015-10-28 | 陶氏环球技术有限责任公司 | 具有极高分子量的新颖酯化纤维素醚 |
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JP6795587B2 (ja) | 2020-12-02 |
US11142633B2 (en) | 2021-10-12 |
WO2017058973A1 (en) | 2017-04-06 |
JP2018532013A (ja) | 2018-11-01 |
CN108026184B (zh) | 2020-09-15 |
BR112018005463A2 (pt) | 2018-10-09 |
EP3356421A1 (en) | 2018-08-08 |
KR20180061234A (ko) | 2018-06-07 |
EP3356421B1 (en) | 2019-09-04 |
US20180282526A1 (en) | 2018-10-04 |
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