CN108026098B - 作为ido和tdo抑制剂的杂环化合物 - Google Patents

作为ido和tdo抑制剂的杂环化合物 Download PDF

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Publication number
CN108026098B
CN108026098B CN201680033890.3A CN201680033890A CN108026098B CN 108026098 B CN108026098 B CN 108026098B CN 201680033890 A CN201680033890 A CN 201680033890A CN 108026098 B CN108026098 B CN 108026098B
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CN
China
Prior art keywords
compound
cancer
mixture
stirred
ido
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Expired - Fee Related
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CN201680033890.3A
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English (en)
Chinese (zh)
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CN108026098A (zh
Inventor
张汉承
刘世峰
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Hangzhou Innogate Pharma Co Ltd
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Hangzhou Innogate Pharma Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201680033890.3A 2015-04-12 2016-04-12 作为ido和tdo抑制剂的杂环化合物 Expired - Fee Related CN108026098B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562146340P 2015-04-12 2015-04-12
US62/146,340 2015-04-12
US201662274292P 2016-01-02 2016-01-02
US62/274,292 2016-01-02
PCT/CN2016/079104 WO2016165613A1 (en) 2015-04-12 2016-04-12 Heterocycles useful as ido and tdo inhibitors

Publications (2)

Publication Number Publication Date
CN108026098A CN108026098A (zh) 2018-05-11
CN108026098B true CN108026098B (zh) 2019-09-03

Family

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Family Applications (1)

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CN201680033890.3A Expired - Fee Related CN108026098B (zh) 2015-04-12 2016-04-12 作为ido和tdo抑制剂的杂环化合物

Country Status (6)

Country Link
US (1) US10358451B2 (cg-RX-API-DMAC7.html)
EP (1) EP3283488A4 (cg-RX-API-DMAC7.html)
JP (1) JP2018511647A (cg-RX-API-DMAC7.html)
CN (1) CN108026098B (cg-RX-API-DMAC7.html)
AU (1) AU2016248366B2 (cg-RX-API-DMAC7.html)
WO (1) WO2016165613A1 (cg-RX-API-DMAC7.html)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105884828A (zh) * 2015-02-16 2016-08-24 上海迪诺医药科技有限公司 多环化合物、其药物组合物及应用
CN106715440B (zh) * 2015-04-21 2019-02-22 江苏恒瑞医药股份有限公司 咪唑并异吲哚类衍生物、其制备方法及其在医药上的应用
CN110072864B (zh) * 2015-12-24 2022-05-27 基因泰克公司 Tdo2抑制剂
CN107056785B (zh) * 2016-01-02 2021-06-22 杭州英创医药科技有限公司 作为ido和tdo抑制剂的杂环化合物
CN107556316B (zh) * 2016-06-30 2021-11-12 鲁南制药集团股份有限公司 含桥环的咪唑衍生物
WO2017198159A1 (zh) * 2016-05-16 2017-11-23 鲁南制药集团股份有限公司 含桥环的咪唑衍生物
WO2018028491A1 (zh) * 2016-08-09 2018-02-15 苏州国匡医药科技有限公司 吲哚胺2，3-双加氧酶抑制剂及其在药学中的用途
TW201815766A (zh) 2016-09-22 2018-05-01 美商普雷辛肯公司 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症
GB201701332D0 (en) * 2017-01-26 2017-03-15 Tc Biopharm Ltd Immune cells with modified metabolism and their use thereof
BR102018007822A2 (pt) * 2017-04-20 2018-11-06 Gilead Sciences, Inc. composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição
CN107176956B (zh) * 2017-05-31 2019-11-12 成都海博锐药业有限公司 一种ido抑制剂化合物、药用组合物、用途
EP3645533B1 (en) * 2017-06-28 2025-03-26 Genentech, Inc. Tdo2 and ido1 inhibitors
US11827639B2 (en) 2017-06-28 2023-11-28 Genentech, Inc. TDO2 and IDO1 inhibitors
CN107501272B (zh) * 2017-09-05 2020-03-31 中国药科大学 咪唑并异吲哚类ido1抑制剂、其制备方法及应用
CN108424414A (zh) * 2017-12-08 2018-08-21 苏州国匡医药科技有限公司 一类含杂环的吲哚胺2，3-双加氧酶调节化合物及其在药学中的用途
WO2019160882A1 (en) 2018-02-13 2019-08-22 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
US11149011B2 (en) 2018-03-20 2021-10-19 Plexxikon Inc. Compounds and methods for IDO and TDO modulation, and indications therefor
WO2019231870A1 (en) 2018-05-31 2019-12-05 Merck Sharp & Dohme Corp. Novel substituted [1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors
GB201809050D0 (en) 2018-06-01 2018-07-18 E Therapeutics Plc Modulators of tryptophan catabolism
PE20210642A1 (es) 2018-07-13 2021-03-23 Gilead Sciences Inc Inhibidores de pd-1/pd-l1
BR112023017582A2 (pt) 2021-03-05 2023-12-05 Univ Basel Composições para o tratamento de doenças ou condições associadas ao ebv
EP4052705A1 (en) 2021-03-05 2022-09-07 Universität Basel Vizerektorat Forschung Compositions for the treatment of ebv associated diseases or conditions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103547579A (zh) * 2011-04-15 2014-01-29 新联基因公司 用作ido抑制剂的稠合咪唑衍生物
WO2016037026A1 (en) * 2014-09-05 2016-03-10 Merck Patent Gmbh Cyclohexyl-ethyl substituted diaza- and triaza-tricyclic compounds as indole-amine-2,3-dioxygenase (ido) antagonists for the treatment of cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2902174A1 (en) 2013-03-14 2014-10-02 Newlink Genetics Corporation Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization
GB201417369D0 (en) * 2014-10-01 2014-11-12 Redx Pharma Ltd Compounds
CN105884828A (zh) * 2015-02-16 2016-08-24 上海迪诺医药科技有限公司 多环化合物、其药物组合物及应用
CN105037371A (zh) 2015-06-30 2015-11-11 西华大学 一种氘代的吲哚胺-2,3-双加氧酶抑制剂

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103547579A (zh) * 2011-04-15 2014-01-29 新联基因公司 用作ido抑制剂的稠合咪唑衍生物
WO2016037026A1 (en) * 2014-09-05 2016-03-10 Merck Patent Gmbh Cyclohexyl-ethyl substituted diaza- and triaza-tricyclic compounds as indole-amine-2,3-dioxygenase (ido) antagonists for the treatment of cancer

Also Published As

Publication number Publication date
WO2016165613A1 (en) 2016-10-20
EP3283488A4 (en) 2018-10-24
US10358451B2 (en) 2019-07-23
CN108026098A (zh) 2018-05-11
US20180127418A1 (en) 2018-05-10
AU2016248366A1 (en) 2017-11-30
EP3283488A1 (en) 2018-02-21
JP2018511647A (ja) 2018-04-26
AU2016248366B2 (en) 2019-06-13

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Granted publication date: 20190903