CN108022822A - The in-out apparatus of MALDI TOF MS instrument sample target - Google Patents
The in-out apparatus of MALDI TOF MS instrument sample target Download PDFInfo
- Publication number
- CN108022822A CN108022822A CN201711277024.1A CN201711277024A CN108022822A CN 108022822 A CN108022822 A CN 108022822A CN 201711277024 A CN201711277024 A CN 201711277024A CN 108022822 A CN108022822 A CN 108022822A
- Authority
- CN
- China
- Prior art keywords
- sample target
- connecting rod
- moving mechanism
- dimensional surface
- jacking mechanism
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/40—Time-of-flight spectrometers
Abstract
The in-out apparatus of MALDI TOF MS instrument sample target, is related to time of-flight mass spectrometer.Equipped with main cavity, main cavity cover board and molecular pump, main chamber body, main cavity cover board and molecular pump composition vacuum system, two dimensional surface moving mechanism and connecting rod jacking mechanism are equipped with the vacuum system, the connecting rod jacking mechanism is located in two dimensional surface moving mechanism；The mobile drive connecting rod jacking mechanism of the two dimensional surface moving mechanism realize put with taking sample target and vacuum sealing, and realize the position that test will be moved to mounted in the sample target of sample target groove；Accurate lead screw rotation is driven by shaft coupling by vacuum stepper motor, so as to drive Y-direction movable block to be moved back and forth in Y-direction, with the encoder of position-sensing switch and record position control sample target groove shift position；Movement in same X-direction also uses similar mechanism.
Description
Technical field
The present invention relates to time of-flight mass spectrometer, more particularly, to MALDI TOF MS instrument sample
The in-out apparatus of target.
Background technology
The ionization process of MALDI TOF MS sample and the Mass Spectrometer Method process of sample are all
Carried out in the environment of high vacuum.Sample under normal temperature and pressure environment is transferred to vacuum system and realizes more throughput samples
Test is required to a reliable transmission mechanism and accurate positioning moving mechanism to ensure.Also in the transmittance process of sample
Ensure that vacuum system cannot be destroyed, be even more important so the disengaging structure of sample target seems in the quasi-instrument.
To realize the transmission and test of MALDI TOF MS instrument sample, have many types at present
Sample target disengaging structure, it is most of all to be realized using the target groove equipped with sample target through multistage linkage transmission.This is more
Connecting rod transmission mechanism, complicated, linkage all uses riveting method substantially the reason for because of space, and assembling is difficult, to personnel
It is required that it is high, and the failures such as quality is inconsistent, bite easily occurs, riveting comes off；Involve great expense；Also because of the target groove for filling sample target
It is in the state not being fixedly connected in the inside of instrument, target groove may occurs in the transport, handling process in instrument and come off,
So as to cause failure.
The content of the invention
The purpose of the present invention is to provide the disengaging of achievable sample target and the movement of test position, simple in structure, can
By the in-out apparatus with durable MALDI TOF MS instrument sample target.
The present invention is equipped with main cavity, main cavity cover board and molecular pump, main chamber body, main cavity cover board and molecular pump composition
Vacuum system, is equipped with two dimensional surface moving mechanism and connecting rod jacking mechanism, the connecting rod jacking mechanism in the vacuum system
It is located in two dimensional surface moving mechanism；
The mobile drive connecting rod jacking mechanism realization of the two dimensional surface moving mechanism is put close with taking sample target and vacuum
Envelope, and realize and the position of test will be moved to mounted in the sample target of sample target groove；
By vacuum stepper motor by shaft coupling drive accurate lead screw rotation so that drive Y-direction movable block in Y-direction back and forth
Movement, with the encoder of position-sensing switch and record position control sample target groove shift position；Movement in same X-direction also uses
Similar mechanism.
When the position that two dimensional surface moving mechanism moves to left Y-direction movable block, connecting rod jacking mechanism is driven to the left side
Movement, when the bearing on connecting rod jacking mechanism encounters the inner wall of main cavity, Y-direction movable block continues to left movement, in connecting rod
Drive lower bearing to be moved upwards along main cavity inner wall, so as to drive sample target groove to move upwards, main cavity is would be pressed against when moving to
During cover board, sealing is realized by compressing O circles, so as to fulfill sample target to be sent to the position putting and take, at this moment connecting rod just at
Plumbness, when taking or during setting-out product target, the pressure of air directly can be transmitted to line slideway by connecting rod, so as to protect screw
Nut；When needing test sample target, vacuum stepper motor is reversely rotated so as to drive Y-direction to move in two dimensional surface moving mechanism
Block moves right, and drives connecting rod jacking mechanism above moving mechanism also to be moved to the right, since connecting rod jacking mechanism is equipped with return
Spring, under the pulling force effect of return spring, so that drive sample target groove to fall back on adjustment positioning column, it is fixed by adjusting adjustment
The height of position column, so as to fulfill size of the sample range from extraction pole.
The present invention includes following action：Transport the orientable planar motion of sample target；Raise sample target
With the connecting rod top target drone structure for compressing O circles.
The advantage of the invention is that during the disengaging of sample target, the mechanism of rise sample target and compression O circles is using simple
Linkage；Sample target groove is connected in entirely disengaging instrument and detection process with moving mechanism, will not transport sample cell
Or phenomena such as dropping in instrument transport handling process；Structure is reliable at the same time, and assembling is simple.
Brief description of the drawings
Fig. 1 is the floor map of the embodiment of the present invention；
Fig. 2 is the schematic three dimensional views of the embodiment of the present invention；
Fig. 3 is the connecting rod jacking mechanism initial position schematic diagram of the embodiment of the present invention；
Fig. 4 is the connecting rod jacking mechanism elevation process schematic diagram of the embodiment of the present invention；
Fig. 5 is that the connecting rod jacking mechanism of the embodiment of the present invention is raised to top schematic diagram.
Embodiment
The present invention is further described below in conjunction with the accompanying drawings.
As illustrated in fig. 1 and 2, the environment for the high vacuum that the present invention is made of main cavity 1, main cavity cover board 4 and molecular pump 5
It is interior, the two dimensional surface moving mechanism 3 in the vacuum system, and the connecting rod jacking mechanism 2 in two dimensional surface moving mechanism.
Molecular pump 5 is connected with main cavity 1 using the interior hexagonal double-ended bolt of c-type clamp and M10；Main cavity cover board 4 is using hexagonal spiral shell in 4 M6
Column is fixedly connected with main cavity 1；Two dimensional surface moving mechanism 3 is fixedly connected using hexagonal double-ended bolt in 6 M4 with main cavity 1；Even
Bar jacking mechanism 2 is fixedly connected using hexagonal double-ended bolt in 4 M5 with two dimensional surface moving mechanism 3.
During work, connected by high vacuum stepper motor 19 by shaft coupling 16 and drive accurate lead screw 12 to rotate, so that band
Dynamic Y-direction movable block 11 moves back and forth in the Y direction, which is controlled using the encoder 17 of position-sensing switch 14 and record position
22 shift position of sample target groove；Movement in same X-direction also uses similar mechanism；The movement of two dimensional surface moving mechanism 3
Drive the connecting rod jacking mechanism 2 on top realize put with taking sample target and vacuum sealing in terms of required action request, and
Realize and be moved to each position for needing to test with the sample target mounted in sample target groove 22.High vacuum stepper motor 19 uses 4
Together with hexagonal double-ended bolt is fixed with Y-motor fixed plate 18 through hexagonal double-ended bolt in 4 M4 with platform base 15 in a M3；Position-sensing switch 14
Fixed using the pan head screw and locating piece 13 of two M2.5, locating piece 13 is using hexagonal double-ended bolt in two M3 and platform base 15
It is fixedly connected；Encoder 17 is fixedly connected using hexagonal double-ended bolt in two M2.5 with Y-motor fixed plate 18.
The connecting rod jacking mechanism 2 of the present invention works as seen in figures 3-5, when two dimensional surface moving mechanism 3 is by Y-direction movable block
11 positions to move to left, drive connecting rod jacking mechanism 2 above moving mechanism also to be moved to the left side, when on jacking mechanism 2
When bearing 21 encounters the inner wall of main cavity 1, Y-direction movable block 11 continues to left movement, connecting rod 26 drive lower bearing 21 along master
1 inner wall of cavity moves upwards, so as to drive sample target groove 22 to move upwards；When move to be pressed onto main cavity cover board 4 soon when, pass through
Compress O circles and realize sealing, so as to fulfill sample target to be sent to the position of taking and placing, at this moment connecting rod 26 is just at plumbness, this
During sample taking and placing sample target, the pressure of air directly can be transmitted to X line slideways group 8 and Y line slideways group 20 by connecting rod 26, from
And the feed screw nut protected.When needing test sample target, high vacuum stepper motor 19 reversely revolves in two dimensional surface moving mechanism 3
Turn so as to be moved right with Y-direction movable block 11, drive connecting rod jacking mechanism 2 above moving mechanism also to be moved to the right, due to even
Bar jacking mechanism 2 is equipped with return spring 24, under the pulling force effect of return spring 24, so as to drive sample target groove to fall back to adjustment
On positioning column 25, by adjusting the height of adjustment positioning column 25, so as to fulfill size of the sample range from extraction pole.Wherein Y-direction
Movable block 11 is fixedly connected using hexagonal double-ended bolt in 16 M3 with the sliding block of X line slideways group 8, and the guide rail of X line slideways group 8 is adopted
It is fixedly connected with hexagonal double-ended bolt in M3 with Y-direction movable block 11；Y-direction movable block 11 is connected with platform base 15 uses Y line slideways
Group 20.Sample target groove 22 is fixedly connected using 4 PEEK screws with isolation board 23；Isolation board 23 uses 4 PEEK screws and company
The bar seat of honour 28 connects；Bearing 21 is connected through shaft 27 with the connecting rod seat of honour 28；The both ends of return spring 24 are sleeved on two shafts 27, should
Shaft be through respectively the connecting rod seat of honour 28, connecting rod base 29 hole in；Adjust screw thread and connecting rod base of the positioning column 25 by itself
29 link together；Together with hexagonal double-ended bolt is fixed with X movable plates 6 in 3 M5 of the use of connecting rod base 29.
Claims (3)
1. the in-out apparatus of MALDI TOF MS instrument sample target, it is characterised in that equipped with main cavity, master
Cavity cover board and molecular pump, main chamber body, main cavity cover board and molecular pump form vacuum system, are equipped with the vacuum system
Two dimensional surface moving mechanism and connecting rod jacking mechanism, the connecting rod jacking mechanism are located in two dimensional surface moving mechanism；
The mobile drive connecting rod jacking mechanism of the two dimensional surface moving mechanism realize put with taking sample target and vacuum sealing, and
The position of test will be moved to mounted in the sample target of sample target groove by realizing；
Vacuum stepper motor drives accurate lead screw rotation by shaft coupling, so as to drive Y-direction movable block to be moved back and forth in Y-direction, uses
The encoder of position-sensing switch and record position control sample target groove shift position.
2. the in-out apparatus of MALDI TOF MS instrument sample target as claimed in claim 1, its feature exist
In the position that the two dimensional surface moving mechanism moves to left Y-direction movable block, connecting rod jacking mechanism is driven to be moved to the left side,
When the bearing on connecting rod jacking mechanism encounters the inner wall of main cavity, Y-direction movable block continues to left movement, under the drive of connecting rod
Bearing moves upwards along main cavity inner wall, so as to drive sample target groove to move upwards；When move to would be pressed against main cavity cover board when,
Realize sealing by compressing O circles, so as to fulfill sample target to be sent to the position putting and take, connecting rod is in plumbness, when taking or
During setting-out product target, the pressure of air is directly transmitted to line slideway by connecting rod, so as to protect feed screw nut.
3. the in-out apparatus of MALDI TOF MS instrument sample target as claimed in claim 1, its feature exist
When test sample target, vacuum stepper motor is reversely rotated so as to drive Y-direction movable block to transport to the right in two dimensional surface moving mechanism
It is dynamic, drive connecting rod jacking mechanism above moving mechanism also to be moved to the right, connecting rod jacking mechanism is equipped with return spring, in return bullet
Under the pulling force effect of spring, so that drive sample target groove to fall back on adjustment positioning column, by adjusting the height of adjustment positioning column, from
And realize size of the sample range from extraction pole.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711277024.1A CN108022822B (en) | 2017-12-06 | 2017-12-06 | The in-out apparatus of MALDI TOF MS instrument sample target |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711277024.1A CN108022822B (en) | 2017-12-06 | 2017-12-06 | The in-out apparatus of MALDI TOF MS instrument sample target |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108022822A true CN108022822A (en) | 2018-05-11 |
| CN108022822B CN108022822B (en) | 2019-08-06 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711277024.1A Active CN108022822B (en) | 2017-12-06 | 2017-12-06 | The in-out apparatus of MALDI TOF MS instrument sample target |
Country Status (1)
| Country | Link |
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| CN (1) | CN108022822B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109270285A (en) * | 2018-11-19 | 2019-01-25 | 厦门元谱生物科技有限公司 | A kind of vacuum sampling device |
| CN109712863A (en) * | 2019-02-26 | 2019-05-03 | 安图实验仪器(郑州)有限公司 | Vacuum interactive system suitable for laser desorption ionization time of flight mass spectrometry instrument |
| CN109900780A (en) * | 2019-04-02 | 2019-06-18 | 厦门历思科技服务有限公司 | The online pretreating device of hair sample sample introduction |
| CN114388336A (en) * | 2022-01-18 | 2022-04-22 | 生物岛实验室 | Small portable time-of-flight mass spectrometer |
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| CN102306603A (en) * | 2011-08-19 | 2012-01-04 | 北京大学 | Mass spectrum multichannel rotary electrospray ion source |
| KR101491996B1 (en) * | 2007-06-27 | 2015-02-10 | 고쿠리츠다이가쿠호우진 도쿄다이가쿠 | Sample holder for MALDI mass spectrometric analysis, and mass spectrometric analysis method |
| CN205246600U (en) * | 2015-12-11 | 2016-05-18 | 安图实验仪器(郑州)有限公司 | Analytic ion source business turn over appearance device of matrix auxiliary laser |
| CN105891318A (en) * | 2016-06-12 | 2016-08-24 | 江苏天瑞仪器股份有限公司 | Matrix-assisted laser desorption ion source sampling device |
| WO2017035229A1 (en) * | 2015-08-24 | 2017-03-02 | Zeteo Tech, Llc | Coating of aerosol particles using an acoustic coater |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR101491996B1 (en) * | 2007-06-27 | 2015-02-10 | 고쿠리츠다이가쿠호우진 도쿄다이가쿠 | Sample holder for MALDI mass spectrometric analysis, and mass spectrometric analysis method |
| CN102306603A (en) * | 2011-08-19 | 2012-01-04 | 北京大学 | Mass spectrum multichannel rotary electrospray ion source |
| WO2017035229A1 (en) * | 2015-08-24 | 2017-03-02 | Zeteo Tech, Llc | Coating of aerosol particles using an acoustic coater |
| CN205246600U (en) * | 2015-12-11 | 2016-05-18 | 安图实验仪器(郑州)有限公司 | Analytic ion source business turn over appearance device of matrix auxiliary laser |
| CN105891318A (en) * | 2016-06-12 | 2016-08-24 | 江苏天瑞仪器股份有限公司 | Matrix-assisted laser desorption ion source sampling device |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109270285A (en) * | 2018-11-19 | 2019-01-25 | 厦门元谱生物科技有限公司 | A kind of vacuum sampling device |
| CN109712863A (en) * | 2019-02-26 | 2019-05-03 | 安图实验仪器(郑州)有限公司 | Vacuum interactive system suitable for laser desorption ionization time of flight mass spectrometry instrument |
| CN109900780A (en) * | 2019-04-02 | 2019-06-18 | 厦门历思科技服务有限公司 | The online pretreating device of hair sample sample introduction |
| CN114388336A (en) * | 2022-01-18 | 2022-04-22 | 生物岛实验室 | Small portable time-of-flight mass spectrometer |
| CN114388336B (en) * | 2022-01-18 | 2023-09-01 | 生物岛实验室 | Portable small-sized time-of-flight mass spectrometer |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108022822B (en) | 2019-08-06 |
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Effective date of registration: 20200617 Address after: No.5, Taikang Road, building 38, Jianqiao Industrial Park, Dadukou District, Chongqing Patentee after: Chongqing topu Bioengineering Co., Ltd Address before: 361028 01-03 unit, tenth floor, building 1, Xiamen bio Pharmaceutical Industrial Park, 2050 West Weng Road West, Haicang District, Xiamen, Fujian Patentee before: FUJIAN BRANCH OF JIANGSU SKYRAY INSTRUMENT Co.,Ltd. |
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Effective date of registration: 20210728 Address after: 6 / F, no.1-400000, industrial park, Taikang District, Chongqing Patentee after: CHONGQING ZHONGYUAN HUIJI BIOTECHNOLOGY Co.,Ltd. Address before: No.5, Taikang Road, No.38 standard workshop, Zone C, Jianqiao Industrial Park, Dadukou District, Chongqing 400084 Patentee before: Chongqing topu Bioengineering Co., Ltd |
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Address after: Floor 1-4, building 30, No. 6, Taikang Road, Zone C, Jianqiao Industrial Park, Dadukou District, Chongqing 404100 Patentee after: Zhongyuan Huiji Biotechnology Co.,Ltd. Address before: 6 / F, no.1-400000, industrial park, Taikang District, Chongqing Patentee before: CHONGQING ZHONGYUAN HUIJI BIOTECHNOLOGY Co.,Ltd. |