CN108003175A - A kind of extraction process of cantharidin - Google Patents
A kind of extraction process of cantharidin Download PDFInfo
- Publication number
- CN108003175A CN108003175A CN201810016834.XA CN201810016834A CN108003175A CN 108003175 A CN108003175 A CN 108003175A CN 201810016834 A CN201810016834 A CN 201810016834A CN 108003175 A CN108003175 A CN 108003175A
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- CN
- China
- Prior art keywords
- blister beetle
- chinese blister
- cantharidin
- extraction process
- electromagnetization
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/18—Bridged systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Saccharide Compounds (AREA)
Abstract
The present invention relates to a kind of extraction process of cantharidin, it includes material selection, process, cell and broken, ultrasonic wave extraction, electromagnetization is stood, electromagnetization separates and dissociates quiet heavy layering, the material selection carries out decaptitating for the Chinese blister beetle of in the market and goes sufficient processing, described process is to go sufficient Chinese blister beetle to carry out rice stir-fry at 40 DEG C~85 DEG C decaptitating, when middle moisture is 2%~15% in Chinese blister beetle body, stop processing, Chinese blister beetle after the processing is rapidly cooled to 30 DEG C~20 DEG C of temperature, then Chinese blister beetle after cooling is put into cell grade crusher and is crushed, the temperature setting range of cell grade crusher is 10 DEG C~35 DEG C, Chinese blister beetle is crushed to granular size as the mesh of 24 mesh~80 in temperature setting range；Therefore, the present invention has the advantages that safe and efficient, no pollution, zero agriculture be residual, energy conservation and environmental protection.
Description
Technical field
The invention belongs to the technical field of cantharidin extraction, and in particular to a kind of extraction process of cantharidin.
Background technology
Health, ecology, nonreactive, cultivation are aquaculture development main trend, and the important channel that food security ensures；Subtract
Few medication reduce medicine it is residual be it is basic, Chinese medicine Dietotherapy health is gradually recognized；Traditional Chinese medicine natural component is played to be more preferable
Proportionality, does not purify, not deep processing, simply processing liquid processed, powder processed；Chinese blister beetle product is as no silkworm raiser's medicine, organic plantation, tree
The articles for use supplementary materials such as seedling maintenance, the cultivation health care of animal class, such as：Cultivated according to environmental health, it is exactly former that original birds, which eat worm health care,
The dietotherapy of beginning ecological birds, while Chinese blister beetle also has the effect of strong chicken body, enhancing is immune as a kind of Chinese medicine；With intensive
Change, large-scale cultivation development, it is unrealistic by searching for food naturally, for more preferable, more convenient aquaculture health care dietotherapy；Therefore, open
It is safe and efficient to send out a kind of, the extraction process of no pollution, residual, the energy-saving and environment-friendly cantharidin of zero agriculture tool is of great significance.
The content of the invention
The purpose of the invention is to overcome the shortcomings of without silkworm raiser's medicine and health care dietotherapy in animal husbandry, and provide a kind of safety
Efficiently, no pollution, zero agriculture be residual, a kind of energy-saving and environment-friendly extraction process of cantharidin.
The object of the present invention is achieved like this：A kind of extraction process of cantharidin, it include material selection, processings, carefully
Born of the same parents and broken, ultrasonic wave extraction, electromagnetization standing, the electromagnetization separation and quiet heavy layering that dissociates.
The material selection carries out decaptitating for the Chinese blister beetle of in the market and goes sufficient processing.
Described process is to go sufficient Chinese blister beetle to carry out rice stir-fry at 40 DEG C~85 DEG C decaptitating, when middle moisture in Chinese blister beetle body
For 2%~15% when, stop process.
Chinese blister beetle after the processing is rapidly cooled to -30 DEG C~-20 DEG C of temperature, is then put into Chinese blister beetle after cooling carefully
Crushed in born of the same parents' level crusher, the temperature setting range of cell grade crusher is -10 DEG C~35 DEG C, in temperature setting range
Chinese blister beetle is crushed to granular size as the mesh of 24 mesh~80.
It is described will it is broken after Chinese blister beetle be put into ultrosonic extractor and extracted, the temperature control of ultrasonic wave is 10
DEG C~80 DEG C, obtain Chinese blister beetle mixed liquor.
It is described to carry out electromagnetization stratification, electromagnetization stratification by the Chinese blister beetle mixed liquor after ultrasonic wave extraction
Temperature setting range be -5 DEG C~65 DEG C, take supernatant.
For the supernatant by the quiet heavy layering that dissociates, the quiet heavy separation time that dissociates is 12h~72h, and temperature range is -5 DEG C
~10 DEG C, supernatant is then taken again.
The supernatant is Chinese blister beetle stoste finished product.
Beneficial effects of the present invention：In the present invention using microbial fermentation technology produce person poultry harmless, no pollution it is micro-
Biological medicine fertilizer, effectively kills root nematode, solves the problems, such as soil bacteria pest and disease damage, by the extraction process of the present invention, can accomplish
Effect does not drop in toxicity reduction, while solves the problem of drug safety and high residue, realizes the residual ecology guarantee of no pollution, zero agriculture, safety is again
Reliably；Therefore, the present invention has the advantages that safe and efficient, no pollution, zero agriculture be residual, energy conservation and environmental protection.
Embodiment
Embodiment 1
A kind of extraction process of cantharidin, it is quiet including material selection, processing, cell and broken, ultrasonic wave extraction, electromagnetization
Put, electromagnetization separation and the quiet heavy layering that dissociates, the material selection carry out decaptitating for the Chinese blister beetle of in the market and remove sufficient processing, the big gun
It is made as going sufficient Chinese blister beetle to carry out rice stir-fry at 40 DEG C~85 DEG C decaptitating, when middle moisture is 2%~15% in Chinese blister beetle body,
Stop processing, the Chinese blister beetle after the processing is rapidly cooled to -30 DEG C~-20 DEG C of temperature, is then put into Chinese blister beetle after cooling
Crushed in cell grade crusher, the temperature setting range of cell grade crusher is -10 DEG C~35 DEG C, in temperature setting range
It is interior that Chinese blister beetle is crushed to granular size as the mesh of 24 mesh~80.
In the present invention Chinese blister beetle decaptitating go it is sufficient be advantageous in that the impurity for avoiding head and foot as far as possible is entered in extract,
Play the role of purifying medicinal material；The method fried during processing using rice, is advantageous in that stable pharmacological property, reduces toxicity, stablizes Chinese blister beetle thorn
Swash property, be also improved the advantages of pharmacological property is by yield；Cell grade, which crushes, is advantageous in that convenient extraction and increase are impregnated with rate；Therefore,
The present invention has the advantages that safe and efficient, no pollution, zero agriculture be residual, energy conservation and environmental protection.
Embodiment 2
A kind of extraction process of cantharidin, it is quiet including material selection, processing, cell and broken, ultrasonic wave extraction, electromagnetization
Put, electromagnetization separates and the quiet heavy layering that dissociates.It is described will it is broken after Chinese blister beetle be put into ultrosonic extractor and extracted,
The temperature control of ultrasonic wave obtains Chinese blister beetle mixed liquor at 10 DEG C~80 DEG C, described to be mixed by the Chinese blister beetle after ultrasonic wave extraction
Close liquid and carry out electromagnetization stratification, the temperature setting range of electromagnetization stratification is -5 DEG C~65 DEG C, takes supernatant, described
For supernatant by the quiet heavy layering that dissociates, the quiet heavy separation time that dissociates is 12h~72h, and temperature range is -5 DEG C~10 DEG C, Ran Houzai
Supernatant is taken, the supernatant is Chinese blister beetle stoste finished product.
Ultrasonic wave extraction is advantageous in that medicine stability strengthens in the present invention, improves dissolution rate；Therefore, the present invention has
The advantages of safe and efficient, no pollution, zero agriculture are residual, energy conservation and environmental protection.
Embodiment is unrestricted to further explanation of the invention, is existed for those of ordinary skills
Further conversion is done in the case of not departing from substantive content of the present invention to structure, and all these conversion should all belong to institute of the present invention
Attached scope of the claims.
Claims (8)
1. a kind of extraction process of cantharidin, it is quiet including material selection, processing, cell and broken, ultrasonic wave extraction, electromagnetization
Put, electromagnetization separates and the quiet heavy layering that dissociates.
A kind of 2. extraction process of cantharidin according to claim 1, it is characterised in that：The material selection is in the market
Chinese blister beetle carry out decaptitating go sufficient processing.
A kind of 3. extraction process of cantharidin according to claim 1 and 2, it is characterised in that：Described process is by decaptitating
Go sufficient Chinese blister beetle to carry out rice stir-fry at 40 DEG C~85 DEG C, when middle moisture is 2%~15% in Chinese blister beetle body, stop processing.
A kind of 4. extraction process of cantharidin according to claim 1 and 3, it is characterised in that：Chinese blister beetle after the processing
- 30 DEG C~-20 DEG C of temperature is rapidly cooled to, then Chinese blister beetle after cooling is put into cell grade crusher and is crushed, carefully
The temperature setting range of born of the same parents' level crusher is -10 DEG C~35 DEG C, and Chinese blister beetle is crushed to granular size in temperature setting range is
The mesh of 24 mesh~80.
A kind of 5. extraction process of cantharidin according to claim 1 and 4, it is characterised in that：It is described will it is broken after
Chinese blister beetle is put into ultrosonic extractor and is extracted, and the temperature control of ultrasonic wave obtains Chinese blister beetle mixed liquor at 10 DEG C~80 DEG C.
A kind of 6. extraction process of cantharidin according to claim 1 and 5, it is characterised in that：It is described to pass through ultrasonic wave
Chinese blister beetle mixed liquor after extraction carries out electromagnetization stratification, and the temperature setting range of electromagnetization stratification is -5 DEG C~65
DEG C, take supernatant.
A kind of 7. extraction process of cantharidin according to claim 1 and 6, it is characterised in that：The supernatant is by trip
From quiet heavy layering, the quiet heavy separation time that dissociates is 12h~72h, and temperature range is -5 DEG C~10 DEG C, then takes supernatant again.
A kind of 8. extraction process of cantharidin according to claim 1 and 7, it is characterised in that：The supernatant is spot
Chinese blister beetle stoste finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810016834.XA CN108003175A (en) | 2018-01-09 | 2018-01-09 | A kind of extraction process of cantharidin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810016834.XA CN108003175A (en) | 2018-01-09 | 2018-01-09 | A kind of extraction process of cantharidin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108003175A true CN108003175A (en) | 2018-05-08 |
Family
ID=62050278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810016834.XA Pending CN108003175A (en) | 2018-01-09 | 2018-01-09 | A kind of extraction process of cantharidin |
Country Status (1)
| Country | Link |
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| CN (1) | CN108003175A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113519742A (en) * | 2021-08-02 | 2021-10-22 | 曌靓生物科技开发(上海)有限公司 | Ginseng and medlar beverage |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1634152A (en) * | 2004-10-28 | 2005-07-06 | 俞锋 | Raw material medicine of methylcantharidinimide and its preparation process |
| CN102146086A (en) * | 2011-04-12 | 2011-08-10 | 贵州金桥药业有限公司 | Preparation method of sodium cantharidate |
| CN107085045A (en) * | 2017-04-06 | 2017-08-22 | 广西壮族自治区药用植物园 | The assay method of cantharidin in green side blister beetle |
-
2018
- 2018-01-09 CN CN201810016834.XA patent/CN108003175A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1634152A (en) * | 2004-10-28 | 2005-07-06 | 俞锋 | Raw material medicine of methylcantharidinimide and its preparation process |
| CN102146086A (en) * | 2011-04-12 | 2011-08-10 | 贵州金桥药业有限公司 | Preparation method of sodium cantharidate |
| CN107085045A (en) * | 2017-04-06 | 2017-08-22 | 广西壮族自治区药用植物园 | The assay method of cantharidin in green side blister beetle |
Non-Patent Citations (2)
| Title |
|---|
| 刘亚楠: "中药斑蝥研究进展", 《中药与临床》 * |
| 董磊等: "斑蝥不同米制方法及其质量评价", 《科技导报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113519742A (en) * | 2021-08-02 | 2021-10-22 | 曌靓生物科技开发(上海)有限公司 | Ginseng and medlar beverage |
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| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180508 |
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| RJ01 | Rejection of invention patent application after publication |