CN107998286A - A kind of Chinese medicine koro gel and preparation method thereof - Google Patents
A kind of Chinese medicine koro gel and preparation method thereof Download PDFInfo
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- CN107998286A CN107998286A CN201711266915.7A CN201711266915A CN107998286A CN 107998286 A CN107998286 A CN 107998286A CN 201711266915 A CN201711266915 A CN 201711266915A CN 107998286 A CN107998286 A CN 107998286A
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- chinese medicine
- gel
- koro
- triethanolamine
- collagen
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- 239000003814 drug Substances 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 238000001879 gelation Methods 0.000 title abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 31
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 26
- 102000008186 Collagen Human genes 0.000 claims abstract description 21
- 108010035532 Collagen Proteins 0.000 claims abstract description 21
- 229920001436 collagen Polymers 0.000 claims abstract description 21
- 241000005787 Cistanche Species 0.000 claims abstract description 20
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 20
- ZSBXGIUJOOQZMP-UHFFFAOYSA-N Isomatrine Natural products C1CCC2CN3C(=O)CCCC3C3C2N1CCC3 ZSBXGIUJOOQZMP-UHFFFAOYSA-N 0.000 claims abstract description 19
- ZSBXGIUJOOQZMP-JLNYLFASSA-N Matrine Chemical compound C1CC[C@H]2CN3C(=O)CCC[C@@H]3[C@@H]3[C@H]2N1CCC3 ZSBXGIUJOOQZMP-JLNYLFASSA-N 0.000 claims abstract description 19
- 241001145025 Saussurea involucrata Species 0.000 claims abstract description 19
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 19
- 229930014456 matrine Natural products 0.000 claims abstract description 19
- 210000000582 semen Anatomy 0.000 claims abstract description 19
- 239000011780 sodium chloride Substances 0.000 claims abstract description 19
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 18
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 18
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 18
- 241001313857 Bletilla striata Species 0.000 claims abstract description 18
- 241000167550 Centella Species 0.000 claims abstract description 18
- 229940116229 borneol Drugs 0.000 claims abstract description 18
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 18
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 18
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 18
- 239000008213 purified water Substances 0.000 claims abstract description 18
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 12
- 229960001631 carbomer Drugs 0.000 claims abstract description 12
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- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 4
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Classifications
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- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A61K36/64—Orobanchaceae (Broom-rape family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
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- A61K2236/50—Methods involving additional extraction steps
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Abstract
The present invention relates to a kind of Chinese medicine koro gel and preparation method thereof, it is made of following raw material：Matrine, centella, the bletilla striata, saline cistanche, Herba Lycopi, Semen Leonuri, saussurea involucrata, collagen, hyaluronic acid, borneol, carbomer, triethanolamine, purified water；According to the characteristics of human body, a kind of matrix developed using bionics principle, either pH value and component are similar to women love liquid, carrier is done as matrix using this bionical liquid, Chinese medicine is passed through into water body, alcohol precipitation, heated by a certain percentage with the matrix emulsified after secondary inclusion, the product obtained after condensation, this technology can not only fully ensure that the activity of Chinese medicine, sustained release can also be played, controlled release, absorb sufficiently effect, make impaired collagenous fibres, elastomer etc. is shunk, restructuring, so that secret wall thickening, tightening, make secret degree of compacting, susceptibility, lubricity significantly increases, secret is compacted as before.
Description
Technical field
The present invention relates to medical technical field, especially a kind of Chinese medicine koro gel and preparation method thereof.
Background technology
According to statistics, 90% women and 80% postpartum women can have different degrees of privates relaxation, and privates is dry and astringent, roomy
Relaxation, under mode pain, desire, the moon blow, leakage of urine etc., bring many worries to female friend, at heart long-term personal integrity constrain, feelings
Thread anxiety, cause insomnia, irritability, easy wan and sallow, anxiety, endocrine wadding random etc., occur senile symptom too early.With the epoch
Progress, the increasingly attention that female friend maintains oneself, privates secret care product starts to popularize.
The drawbacks of traditional koro product：
Turunda:In short-term, side effect is big, there is dependence, and long-time service can make privates inner wall thinning, autogenous shrinkage functional deterioration and forever
Relaxation long.
Operation:Effectively, certain risk and pain are born, it is impossible to row production again.
Injection:In short-term, there is the possibility for inducing complication, effect duration is limited.
Basic reproduction health nursing:Low effort, course for the treatment of length, effect unobvious.
Instrument:Effectively, there is foreign matter to enter internal, have the danger of mucous membrane in privates of burning, can not solve the problems, such as elastic force and wettability.
The content of the invention
The present invention provides a kind of Chinese medicine koro gel and preparation method thereof, and the technical problem to be solved is that existing koro is produced
The technical problem that timeliness present in product and technology is not long, ineffective and therapeutic process is uncomfortable etc..
The technical solution that the present invention solves above-mentioned technical problem is as follows：
A kind of Chinese medicine koro gel, is made of the raw material of following weight proportion：It is matrine 50-100g, centella 0-130g, white
It is splendid achnatherum 0-215g, saline cistanche 0-215g, Herba Lycopi 0-215g, Semen Leonuri 100-200g, saussurea involucrata 0-150g, collagen 0-20g, transparent
Matter acid 0-30g, borneol 4-5g, carbomer 4-5g, triethanolamine 5-6g, purified water 10-490g.
Based on the above technical solutions, the present invention can also be improved as follows.
Further, matrine 50g, centella 100g, bletilla striata 200g, saline cistanche 200g, Herba Lycopi 200g, Semen Leonuri 100g,
Saussurea involucrata 50g, collagen 10g, hyaluronic acid 5g, borneol 5g, carbomer 4g, triethanolamine 6g, purified water 70g.
Further, matrine 100g, centella 0g, bletilla striata 0g, saline cistanche 0g, Herba Lycopi 0g, Semen Leonuri 200g, saussurea involucrata
150g, collagen 20g, hyaluronic acid 30g, borneol 5g, carbomer 5g, triethanolamine 6g, purified water 490g.
Further, matrine 50g, centella 130g, bletilla striata 210g, saline cistanche 210g, Herba Lycopi 210g, Semen Leonuri 130g,
Saussurea involucrata 0g, collagen 0g, hyaluronic acid 0g, borneol 5g, carbomer 4g, triethanolamine 6g, purified water 50g.
Further, matrine 55g, centella 100g, bletilla striata 215g, saline cistanche 215g, Herba Lycopi 215g, Semen Leonuri 100g,
Saussurea involucrata 55g, collagen 12g, hyaluronic acid 6g, borneol 4g, carbomer 5g, triethanolamine 5g, purified water 13g.
The present invention also provides a kind of preparation method of Chinese medicine koro gel, comprise the following steps：
S1：Each raw material are weighed according to weight proportion；
S2：Ethanol is added in matrine and borneol to dissolve to obtain solution A；
S3：Centella, the bletilla striata, saline cistanche, Herba Lycopi, Semen Leonuri and saussurea involucrata are added water to cook twice, every time plus 8 times of water amount, every time 1
Hour, cooked rear filtering, the filtrate being obtained by filtration twice is merged, the filtrate after merging is concentrated into relative density 1.10- every time
1.20 obtain 60 DEG C of extractum A, and adding 95% ethanol makes extractum A alcohol content reach 60%, is filtered after placing 24h, and recycling ethanol is extremely
Without alcohol taste, then it is concentrated to give medicinal extract B；
S4：Collagen, hyaluronic acid and carbomer are soaked in 24h in water, treats that it is expanded completely, slowly instills triethanolamine
PH value is tested while stirring to obtaining gel-type vehicle after 7；
S5：The solution A, medicinal extract B and gel-type vehicle are mixed, purified water is added and stirs and evenly mixs, instills triethanolamine
Gel is made in stirring, test pH value to 6.5-7, stirring.
The beneficial effects of the invention are as follows：A kind of base of the invention according to the characteristics of human body, developed using bionics principle
Matter, either pH value and component are similar to women and like liquid, do carrier as matrix using this bionical liquid, Chinese medicine is passed through water
Heated by a certain percentage with the matrix emulsified after body, alcohol precipitation, secondary inclusion, condense after obtained product, this technology not only may be used
To fully ensure that the activity of Chinese medicine, slow-release controlled-release can also be played the role of, absorbed sufficiently, make impaired collagenous fibres, elasticity
Fiber etc. is shunk, restructuring, so that secret wall thickening, tightening, significantly increase secret degree of compacting, susceptibility, lubricity, secret
Compact as before, be a kind of new gynaecology's product, for the dry and astringent vaginal relaxation of women and daily nursing.With compacting, conserve, clearly
The effects such as clean, lubrication, keep normal pH value.
Embodiment
Further to technical scheme below to be specifically described, the given examples are served only to explain the present invention, and
It is non-to be used to limit the scope of the present invention.
Embodiment 1
A kind of Chinese medicine koro gel, is made of the raw material of following weight proportion：Matrine 50g, centella 100g, the bletilla striata
200g, saline cistanche 200g, Herba Lycopi 200g, Semen Leonuri 100g, saussurea involucrata 50g, collagen 10g, hyaluronic acid 5g, borneol 5g, card
Ripple nurse 4g, triethanolamine 6g, purified water 70g.
Embodiment 2
A kind of Chinese medicine koro gel, is made of the raw material of following weight proportion：Matrine 100g, centella 0g, bletilla striata 0g, meat
Desert cistanche 0g, Herba Lycopi 0g, Semen Leonuri 200g, saussurea involucrata 150g, collagen 20g, hyaluronic acid 30g, borneol 5g, carbomer 5g, three
Monoethanolamine 6g, purified water 490g.
Embodiment 3
A kind of Chinese medicine koro gel, is made of the raw material of following weight proportion：Matrine 50g, centella 130g, the bletilla striata
210g, saline cistanche 210g, Herba Lycopi 210g, Semen Leonuri 130g, saussurea involucrata 0g, collagen 0g, hyaluronic acid 0g, borneol 5g, card ripple
Nurse 4g, triethanolamine 6g, purified water 50g.
Embodiment 4
A kind of Chinese medicine koro gel, is made of the raw material of following weight proportion：Matrine 55g, centella 100g, the bletilla striata
215g, saline cistanche 215g, Herba Lycopi 215g, Semen Leonuri 100g, saussurea involucrata 55g, collagen 12g, hyaluronic acid 6g, borneol 4g, card
Ripple nurse 5g, triethanolamine 5g, purified water 13g.
Gel is fabricated to using following preparation method by the raw material of above-described embodiment weight proportion.
A kind of preparation method of Chinese medicine koro gel, comprises the following steps：
S1：Each raw material are weighed according to weight proportion；
S2：Ethanol is added in matrine and borneol to dissolve to obtain solution A；
S3：Centella, the bletilla striata, saline cistanche, Herba Lycopi, Semen Leonuri and saussurea involucrata are added water to cook twice, every time plus 8 times of water amount, every time 1
Hour, cooked rear filtering, the filtrate being obtained by filtration twice is merged, the filtrate after merging is concentrated into relative density 1.10- every time
1.20 obtain 60 DEG C of extractum A, and adding 95% ethanol makes extractum A alcohol content reach 60%, is filtered after placing 24h, and recycling ethanol is extremely
Without alcohol taste, then it is concentrated to give medicinal extract B；
S4：Collagen, hyaluronic acid and carbomer are soaked in 24h in water, treats that it is expanded completely, slowly instills triethanolamine
PH value is tested while stirring to obtaining gel-type vehicle after 7；
S5：The solution A, medicinal extract B and gel-type vehicle are mixed, purified water is added and stirs and evenly mixs, instills triethanolamine
Gel is made in stirring, test pH value to 6.5-7, stirring.
The important component that the present invention adds has the advantages that：
Matrine：For antibacterial anti-inflammatory, heat-clearing and damp-drying drug, wind dispelling insecticide, pruritus vulvae is widely used in multiple humidifier fever under treatment zone.
Centella：Plant collagen is commonly called as, promotes skin collagen regeneration, strengthens cell basal layer cell vigor,
Keep elasticity of skin and consolidation;It is anti-oxidant, suppress free radical activity, adjust skin immunity;Desalinate melanin pigmentation, update flesh
Skin cytothesis;Increase skin water conservation degree, activation renewal skin cell;Antiallergic protective action, protects skin from external injury.
The bletilla striata：It is mainly used for astringing to arrest bleeding, detumescence and promoting granulation is effective to yin exhaustion, leukorrhea.
Saline cistanche：Slow down aging most effective component.Saline cistanche under human body the position such as pituitary, sexual gland, thymus gland it is old
Change has obvious retarding action.
Semen Leonuri：Promoting blood circulation for regulating menstruation, for irregular menstruation, closed dysmenorrhea.
Herba Lycopi：For irregular menstruation, Amenorrhea, dysmenorrhoea, postpartum blood stasis abdominal pain, sore and toxic, oedema ascites.
Saussurea involucrata：With clearing and activating the channels and collaterals, dispelling cold and removing dampness, hemostasia and detumescence, isostere endotoxin and other effects.
Collagen：Strengthen gonad cell substrate vigor, vaginal wall elasticity and consolidation, anti-oxidant, desalination private parts can be recovered
Melanin is heavy, can stimulate the replacement of deep skin cell, promotes cortex growth ovary maintenance.
Hyaluronic acid：Improve skin-nourishing metabolism, make skin it is tender, it is smooth, go to wrinkle, increase elasticity, replenishing water and preserving moisture, prevent
Aging, then be good skin penetration enhancer again while moisturizing.
For the embodiment of the present invention 1- embodiments 4,200 volunteers are randomly selected, every group 50 are tested, knot
Fruit is as follows：
| Verification Project | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 |
| Fungistatic effect is obvious | 48 | 45 | 47 | 47 |
| Fungistatic effect unobvious | 2 | 5 | 3 | 3 |
| Tightening effect is obvious | 47 | 5 | 43 | 46 |
| Tightening effect unobvious | 3 | 45 | 7 | 4 |
| Lubricant effect is obvious | 50 | 46 | 2 | 49 |
| Lubricant effect unobvious | 0 | 4 | 48 | 1 |
As can be seen from the above table, corresponding functional component content directly affects the effect of product, the embodiment comprising all the components
It is better.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent replacement, improvement and so on, should all be included in the protection scope of the present invention.
Claims (6)
1. a kind of Chinese medicine koro gel, it is characterised in that be made of the raw material of following weight proportion：Matrine 50-100g, product
Avenge grass 0-130g, bletilla striata 0-215g, saline cistanche 0-215g, Herba Lycopi 0-215g, Semen Leonuri 100-200g, saussurea involucrata 0-150g, collagen
Albumen 0-20g, hyaluronic acid 0-30g, borneol 4-5g, carbomer 4-5g, triethanolamine 5-6g, purified water 10-490g.
2. a kind of Chinese medicine koro gel according to claim 1, it is characterised in that matrine 50g, centella 100g, the bletilla striata
200g, saline cistanche 200g, Herba Lycopi 200g, Semen Leonuri 100g, saussurea involucrata 50g, collagen 10g, hyaluronic acid 5g, borneol 5g, card
Ripple nurse 4g, triethanolamine 6g, purified water 70g.
3. a kind of Chinese medicine koro gel according to claim 1, it is characterised in that matrine 100g, centella 0g, the bletilla striata
0g, saline cistanche 0g, Herba Lycopi 0g, Semen Leonuri 200g, saussurea involucrata 150g, collagen 20g, hyaluronic acid 30g, borneol 5g, carbomer
5g, triethanolamine 6g, purified water 490g.
4. a kind of Chinese medicine koro gel according to claim 1, it is characterised in that matrine 50g, centella 130g, the bletilla striata
210g, saline cistanche 210g, Herba Lycopi 210g, Semen Leonuri 130g, saussurea involucrata 0g, collagen 0g, hyaluronic acid 0g, borneol 5g, card ripple
Nurse 4g, triethanolamine 6g, purified water 50g.
5. a kind of Chinese medicine koro gel according to claim 1, it is characterised in that matrine 55g, centella 100g, the bletilla striata
215g, saline cistanche 215g, Herba Lycopi 215g, Semen Leonuri 100g, saussurea involucrata 55g, collagen 12g, hyaluronic acid 6g, borneol 4g, card
Ripple nurse 5g, triethanolamine 5g, purified water 13g.
6. the preparation method of a kind of Chinese medicine koro gel as described in claim 1-5, it is characterised in that comprise the following steps：
S1：Each raw material are weighed according to weight proportion；
S2：Ethanol is added in matrine and borneol to dissolve to obtain solution A；
S3：Centella, the bletilla striata, saline cistanche, Herba Lycopi, Semen Leonuri and saussurea involucrata are added water to cook twice, every time plus 8 times of water amount, every time 1
Hour, cooked rear filtering, the filtrate being obtained by filtration twice is merged, the filtrate after merging is concentrated into relative density 1.10- every time
1.20 obtain 60 DEG C of extractum A, and adding 95% ethanol makes extractum A alcohol content reach 60%, is filtered after placing 24h, and recycling ethanol is extremely
Without alcohol taste, then it is concentrated to give medicinal extract B；
S4：Collagen, hyaluronic acid and carbomer are soaked in 24h in water, treats that it is expanded completely, slowly instills triethanolamine
PH value is tested while stirring to obtaining gel-type vehicle after 7；
S5：The solution A, medicinal extract B and gel-type vehicle are mixed, purified water is added and stirs and evenly mixs, instills triethanolamine
Gel is made in stirring, test pH value to 6.5-7, stirring.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110680877A (en) * | 2018-07-04 | 2020-01-14 | 西安萱御紫金药业有限公司 | Traditional Chinese medicine composition for repairing vaginal injury and preparation method thereof |
| CN111053827A (en) * | 2020-01-13 | 2020-04-24 | 李荣忠 | External traditional Chinese medicine for contracting vagina and treating gynecological inflammation and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110680877A (en) * | 2018-07-04 | 2020-01-14 | 西安萱御紫金药业有限公司 | Traditional Chinese medicine composition for repairing vaginal injury and preparation method thereof |
| CN111053827A (en) * | 2020-01-13 | 2020-04-24 | 李荣忠 | External traditional Chinese medicine for contracting vagina and treating gynecological inflammation and preparation method thereof |
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