CN107997854A - 一种人工鼻 - Google Patents

一种人工鼻 Download PDF

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Publication number
CN107997854A
CN107997854A CN201711222531.5A CN201711222531A CN107997854A CN 107997854 A CN107997854 A CN 107997854A CN 201711222531 A CN201711222531 A CN 201711222531A CN 107997854 A CN107997854 A CN 107997854A
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China
Prior art keywords
artificial nose
parts
polymer
makrolon
coating
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CN201711222531.5A
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English (en)
Inventor
卢晔
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Chengdu Chuangkezhijia Technology Co Ltd
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Chengdu Chuangkezhijia Technology Co Ltd
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Priority to CN201711222531.5A priority Critical patent/CN107997854A/zh
Publication of CN107997854A publication Critical patent/CN107997854A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/18—Internal ear or nose parts, e.g. ear-drums
    • A61F2/186—Nose parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Graft Or Block Polymers (AREA)
  • Materials For Medical Uses (AREA)

Abstract

本发明公开了一种人工鼻，属于整形领域，所述的人工鼻的表面设有一层聚合物抗菌涂层，所述的抗菌涂层的厚度为0.01mm‑1mm，所述的聚合物涂层是一种聚碳酸酯多单体接枝聚合物,所述的接枝单体包括二甲基(2‑吡啶基)乙烯基硅烷和丙烯腈单体。

Description

一种人工鼻
技术领域
本发明涉及医疗器材领域，具体来说是一种人工鼻。
背景技术
人工鼻(artificial nose )，用医用高分子材料制成的外形、颜色和柔软性与人体真鼻一般的医用制品。用于那些因外伤或其他病变形成鼻缺损患者的整形美容，还有一类则是鞍鼻整形植入物。人工鼻尚不具有嗅觉、加热空气并起到肺部首道防线的作用
现有的人工鼻的抗菌性是一个问题，人工鼻表面会附着有大量的细菌，对人体有巨大的安全隐患。
发明内容
本发明的目的在于为了解决上述问题，公开了一种人工鼻，所述的人工鼻的表面设有一层聚合物抗菌涂层，所述的抗菌涂层的厚度为0.01mm-1mm，所述的的聚合物涂层是一种聚碳酸酯多单体接枝聚合物,所述的接枝单体包括二甲基(2-吡啶基)乙烯基硅烷和丙烯腈单体。
作为改进，所述的聚合物及接枝单体原料重量份如下：聚碳酸酯100份，二甲基(2-吡啶基)乙烯基硅烷5-20份，丙烯腈单体5-20份。
作为改进，所述的聚合物涂层的制备方法如下：
步骤A：将不饱和硅烷、丙烯腈均匀混合；
步骤B: 将聚碳酸酯在流变仪中熔融；
步骤C：步骤A后的混合物以及引发剂加入到流变仪中，反应5 min -10min。
作为改进，所述的引发剂选自过氧化苯甲酰、过氧化月桂酰、异丙苯过氧化氢、叔丁基过氧化氢、过氧化二异丙苯。
作为改进，所述的引发剂为过氧化苯甲酰和过氧化二异丙苯的混合物，摩尔比为1:（0.7-1.5）。
作为改进，所述步骤B的熔融时间为1-5min。。
在对比实验中，发明人将可引发感染和炎症、耐药性较强的绿脓杆菌和金黄色葡萄球菌分别移植到这种具有抗菌涂层的人工鼻和普通的人工鼻。经过10周后进行的测试显示，新型聚合物涂层表面的病原菌残留量仅相当于普通人工鼻表面细菌数量的数千至数百万分之一。
具体实施方式
下面对本发明作详细的说明。
为了使本发明的目的、技术方案及优点更加清楚明白，以下结合实施例，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限定本发明。
具体实施例1：一种人工鼻，所述的人工鼻的表面设有一层聚合物抗菌涂层，所述的抗菌涂层的厚度为0.05，所述的的聚合物涂层是一种聚碳酸酯多单体接枝聚合物,所述的接枝单体包括二甲基(2-吡啶基)乙烯基硅烷和丙烯腈单体。
所述的聚合物及接枝单体原料重量份如下：聚碳酸酯100份，二甲基(2-吡啶基)乙烯基硅烷10份，丙烯腈单体10份。
所述的聚合物涂层的制备方法如下：
步骤A：将不饱和硅烷、丙烯腈均匀混合；
步骤B: 将聚碳酸酯在流变仪中熔融；
步骤C：步骤A后的混合物以及引发剂加入到流变仪中，反应5 min -10min。
所述的引发剂为过氧化苯甲酰和过氧化二异丙苯的混合物，摩尔比为1:0.7，所述步骤B的熔融时间为1-5min。

Claims (6)

1.一种人工鼻，其特征在于，所述的人工鼻的表面设有一层聚合物抗菌涂层，所述的抗菌涂层的厚度为0.01mm-1mm，所述的的聚合物涂层是一种聚碳酸酯多单体接枝聚合物,所述的接枝单体包括二甲基(2-吡啶基)乙烯基硅烷和丙烯腈单体。
2.根据权利要求1所述的人工鼻，其特征在于，所述的聚合物及接枝单体原料重量份如下：聚碳酸酯100份，二甲基(2-吡啶基)乙烯基硅烷5-20份，丙烯腈单体5-20份。
3.根据权利要求2所述的人工鼻，其特征在于，所述的聚合物涂层的制备方法如下：
步骤A：将不饱和硅烷、丙烯腈均匀混合；
步骤B: 将聚碳酸酯在流变仪中熔融；
步骤C：步骤A后的混合物以及引发剂加入到流变仪中，反应5 min -10min。
4.根据权利要求3所述的人工鼻，其特征在于，所述的引发剂选自过氧化苯甲酰、过氧化月桂酰、异丙苯过氧化氢、叔丁基过氧化氢、过氧化二异丙苯。
5.根据权利要求4所述的人工鼻，其特征在于，所述的引发剂为过氧化苯甲酰和过氧化二异丙苯的混合物，摩尔比为1:（0.7-1.5）。
6.根据权利要求5所述的人工鼻，其特征在于，所述步骤B的熔融时间为1-5min。
CN201711222531.5A 2017-11-29 2017-11-29 一种人工鼻 Withdrawn CN107997854A (zh)

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Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4937285A (en) * 1987-11-10 1990-06-26 Bayer Aktiengesellschaft Use of redox graft polymers to improve the petroleum-resistance of thermoplastic, aromatic polycarbonate and/or polyester carbonate moulding compositions
EP0628601A1 (en) * 1993-06-03 1994-12-14 General Electric Company Reduced gloss blends of ABS graft copolymers and polycarbonates
CN1349831A (zh) * 2001-11-28 2002-05-22 周星 记忆合金鼻腔管支撑模
CN101230540A (zh) * 2008-02-22 2008-07-30 东南大学 一种抗菌聚合物纳米纤维及其制备方法
CN103108895A (zh) * 2010-09-17 2013-05-15 沙伯基础创新塑料知识产权有限公司 聚碳酸酯接枝共聚物
CN103551055A (zh) * 2013-11-01 2014-02-05 中国海诚工程科技股份有限公司 一种醋酸纤维素滤膜的改性方法
CN104193950A (zh) * 2014-07-30 2014-12-10 东莞市吉鑫高分子科技有限公司 一种纳米抗菌聚氨酯组合物及其制备方法
CN106632864A (zh) * 2016-12-05 2017-05-10 彭州市运达知识产权服务有限公司 一种hdpe多单体接枝聚合物及其制备方法
CN107148432A (zh) * 2014-11-18 2017-09-08 日油株式会社 乙烯‑乙酸乙烯酯共聚物树脂组合物、接枝共聚物、热塑性树脂组合物及树脂成型品

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4937285A (en) * 1987-11-10 1990-06-26 Bayer Aktiengesellschaft Use of redox graft polymers to improve the petroleum-resistance of thermoplastic, aromatic polycarbonate and/or polyester carbonate moulding compositions
EP0628601A1 (en) * 1993-06-03 1994-12-14 General Electric Company Reduced gloss blends of ABS graft copolymers and polycarbonates
CN1349831A (zh) * 2001-11-28 2002-05-22 周星 记忆合金鼻腔管支撑模
CN101230540A (zh) * 2008-02-22 2008-07-30 东南大学 一种抗菌聚合物纳米纤维及其制备方法
CN103108895A (zh) * 2010-09-17 2013-05-15 沙伯基础创新塑料知识产权有限公司 聚碳酸酯接枝共聚物
CN103551055A (zh) * 2013-11-01 2014-02-05 中国海诚工程科技股份有限公司 一种醋酸纤维素滤膜的改性方法
CN104193950A (zh) * 2014-07-30 2014-12-10 东莞市吉鑫高分子科技有限公司 一种纳米抗菌聚氨酯组合物及其制备方法
CN107148432A (zh) * 2014-11-18 2017-09-08 日油株式会社 乙烯‑乙酸乙烯酯共聚物树脂组合物、接枝共聚物、热塑性树脂组合物及树脂成型品
CN106632864A (zh) * 2016-12-05 2017-05-10 彭州市运达知识产权服务有限公司 一种hdpe多单体接枝聚合物及其制备方法

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Application publication date: 20180508