CN107983437A - Test tube fixing device for sonicator - Google Patents

Test tube fixing device for sonicator Download PDF

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Publication number
CN107983437A
CN107983437A CN201711387374.3A CN201711387374A CN107983437A CN 107983437 A CN107983437 A CN 107983437A CN 201711387374 A CN201711387374 A CN 201711387374A CN 107983437 A CN107983437 A CN 107983437A
Authority
CN
China
Prior art keywords
test tube
fixture block
fixing device
fixed cylinder
turntable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201711387374.3A
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Chinese (zh)
Inventor
黄泽浩
张升校
马金艺
葛同
李书亭
李仲珉
韩天奇
徐旖旎
张静
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Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201711387374.3A priority Critical patent/CN107983437A/en
Publication of CN107983437A publication Critical patent/CN107983437A/en
Pending legal-status Critical Current

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00Supporting devices; Holding devices
    • B01L9/06Test-tube stands; Test-tube holders
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B02CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02CCRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C19/00Other disintegrating devices or methods
    • B02C19/18Use of auxiliary physical effects, e.g. ultrasonics, irradiation, for disintegrating
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/023Adapting objects or devices to another adapted for different sizes of tubes, tips or container

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  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

The present invention relates to the test tube fixing device for sonicator, belong to cell breaking plant technical field, test tube is difficult to the fixed, technical problem of rack for test tube interchangeability difference during solving the cell breaking plant use such as Ultrasonic Cell Disruptor in the prior art, and solution is:It includes test tube fixing device, test tube pallet and test tube fixed cylinder, the side wall of test tube fixed cylinder is provided with interlayer, thermal insulation material is filled with interlayer, one group of rotary disk limitation groove is symmetrically arranged with the outside of test tube fixed cylinder, the upper end of the test tube fixed cylinder is arranged to open end, the outer wall of open end is provided with screw thread, and fixing device is threadedly coupled with the open end of test tube fixed cylinder, and test tube pallet is installed on the inside of test tube fixed cylinder.Perseverance cryogenic property of the invention is good, and test tube fixing device interchangeability is strong, and test tube fixing device coordinates support action good with test tube pallet, and test tube position in test tube fixing device is stablized.

Description

Test tube fixing device for sonicator
Technical field
The invention belongs to cell breaking plant technical field, and in particular to the test tube for sonicator fixes dress Put.
Background technology
Electric energy is exactly converted to acoustic energy by sonication instrument by transducer, and the cavitation based on ultrasonic wave in a liquid is made With electric flux is produced high intensity shearing force by transducer by ultrasonic transformer in tool heads overhead-liquid, forms the alternation of high frequency Hydraulic pressure is strong, expandable cavity, explosion is smashed cell.Sonication instrument be used for a variety of animal and plant cells, virocyte it is broken, Prepare liposome or nanoparticle etc., be widely used in biochemistry, microbiology, pharmaceutical chemistry, pharmacy, surface chemistry, The experiment and research work such as extraction of zoology and production of vaccine, surface antigen.
But there are following defect for the cell breaking plant such as Ultrasonic Cell Disruptor used in the prior art:
1., using during Ultrasonic Cell Disruptor without heat sink.When being ultrasonically treated, the molecular motion in formulation samples can generally cause Temperature rises, and temperature rises faster particularly in the case of volume is less, this will influence the stability of formulation samples.Tradition side Method will cause drug substance stable for test tube is put into ice-water bath beaker again after supersound process in a large amount of thermal energy caused by supersound process Property is destroyed, and using effect is undesirable.
2., using during Ultrasonic Cell Disruptor without test tube fixing device.Generally require ultrasonic probe placed in the middle when being ultrasonically treated, no It is adherent, and fixed into liquid depth, therefore it is more demanding to the degree of stability of test tube.Conventional method is to hold or be placed on test tube On frame, hand-held be easy to cause is rocked, and ultrasonic probe is encountered tube wall or Level Change, is influenced crushing efficiency.
3., traditional rack for test tube specification it is consistent, specification test tube of the same race, therefore the need when test tube specification changes can only be placed per hole Other specification rack for test tubes are changed to fix test tube, conventional efficient will be influenced.
The content of the invention
In order to overcome the shortcomings of the prior art, solve the cell breaking plant such as Ultrasonic Cell Disruptor in the prior art and use During test tube be difficult to the fixed, technical problem of rack for test tube interchangeability difference, the present invention is provided to the test tube of sonicator Fixing device.
The present invention is achieved by the following technical programs:
For the test tube fixing device of sonicator, it includes test tube fixing device, test tube pallet and test tube fixed cylinder, its In:
The side wall of test tube fixed cylinder is provided with interlayer, and thermal insulation material is filled with interlayer, along test tube fixed cylinder diametric(al) to One group of rotary disk limitation groove is symmetrically arranged with the outside of test tube fixed cylinder, the lower surface of the rotary disk limitation groove is arranged to be bent upwards Cambered surface;The upper end of the test tube fixed cylinder is arranged to open end, and the outer wall of open end is provided with screw thread, fixing device and examination The open end of pipe fixed cylinder is threadedly coupled, and test tube pallet is installed on the inside of test tube fixed cylinder;
The fixing device includes turntable, fixture block and the fixture block base from top to bottom set gradually, and turntable and fixture block base are all provided with Annular shape is set to, some axis pins are along the circumferential direction evenly arranged with the upper surface of fixture block base;The lower face of fixture block one end with Boss is provided between fixture block base, boss and fixture block are provided with pin shaft hole, the other end of fixture block is arranged to arc wedge angle End, is provided with arc kidney slot in the middle part of fixture block, and the pin shaft hole on some pieces of fixture blocks, which corresponds to, to be installed on axis pin, every piece of fixture block point Do not rotate around axis pin;The turntable rotates relative to fixture block base, lower face and the fixture block base of turntable Arc waist hole position corresponding position is provided with some limit shafts between upper surface, limit shaft is respectively in corresponding arc kidney slot Middle slip;
Saddle is provided with the middle part of the test tube pallet lower surface, pallet bullet is provided between saddle and the bottom surface of test tube fixed cylinder Spring, is provided with pyramidal pits in the middle part of test tube tray upper surface, symmetrical along the diametric(al) of test tube pallet in pyramidal pits both sides Sliding slot is provided with, sliding block is provided with sliding slot, the lower surface of sliding block is arranged to and the matched arc in the lower surface of rotary disk limitation groove Connected between the center portion of face, sliding block and test tube pallet by sliding block spring, the sliding block spring is in compressive state, sliding block spring Driving sliding block is slid into from sliding slot in rotary disk limitation groove.
Further, when the turntable driving limit shaft slides into arc kidney slot close to axis pin side, some pieces of fixture blocks Arc closed angle end closure, the diameter of the polygon of the intrados composition of some pieces of fixture blocks is equal to the diameter of test tube;The turntable When driving limit shaft slides into arc kidney slot away from axis pin side, the arc closed angle end of some pieces of fixture blocks opens, some pieces of cards The diameter of the polygon of the intrados composition of block is not less than ring-type turntable and the diameter of fixture block base inner headed face.
Further, some groups are disposed with from top to bottom along the axis direction of test tube fixed cylinder according to the model of test tube Rotary disk limitation groove.
Further, the fixture block is along the circumferential direction evenly arranged with six pieces along fixture block base upper surface.
Further, when fixture block closure state, on the medial surface of fixture block arc closed angle end with the contact of test tube outer wall Cushion block is provided between face.
Compared with prior art the invention has the advantages that:
1st, permanent cryogenic property is good.Since molecular motion causes temperature to raise in ultrasonication, easily make the decomposition products such as nucleic acid, this Device maintains permanent low temperature by thermal insulation material, and the fixture block in the test tube fixing device of upper end is in close contact with test tube effectively prevent ice Water is contacted with the external world, keeps permanent low temperature.
2nd, fixed supporting function.The fixture block of upper end effectively secures test tube, and the pallet of lower end plays supporting function, back taper Base effectively prevent the swing of test tube.
3rd, suitable for Multiple Type.With multiple gears, the test tube of different model is adapted to, the back taper of pallet, which is recessed, to be set Meter, which can change little height, to be adapted to, and has universal usability.
Brief description of the drawings
Fig. 1 is the overall main view schematic cross-sectional view of the present invention.
Test tube fixing device removes present invention looks up structural representation after fixture block base when Fig. 2 is in closure state for fixture block.
Test tube fixing device removes present invention looks up structural representation after fixture block base when Fig. 3 is in open configuration for fixture block.
Fig. 4 is the main structure diagram of fixture block in Fig. 2 or Fig. 3.
Fig. 5 is the right side structural representation of fixture block in Fig. 4.
Fig. 6 is the main structure diagram of turntable.
Fig. 7 is the present invention looks up structural representation of Fig. 6 turntables.
In figure, 1 is turntable, and 11 be limit shaft, and 21 be boss, and 22 be fixture block, and 23 be arc kidney slot, and 24 be fixture block bottom Seat, 25 be axis pin, and 3 be test tube fixed cylinder, and 31 be rotary disk limitation groove, and 41 be test tube pallet, and 42 be sliding block, and 43 be saddle, and 44 are Tray spring, 45 be sliding slot, and 46 be sliding block spring.
Embodiment
The present invention is described in further detail with reference to the accompanying drawings and examples.
The test tube fixing device for sonicator as shown in Figures 1 to 7, it includes test tube fixing device, examination Conduit saddle disk 41 and test tube fixed cylinder 3, wherein:
The side wall of test tube fixed cylinder 3 is provided with interlayer, thermal insulation material is filled with interlayer, along the diametric(al) of test tube fixed cylinder 3 One group of rotary disk limitation groove 31 is symmetrically arranged with to the outside of test tube fixed cylinder 3, the lower surface of the rotary disk limitation groove 31 is arranged to The cambered surface being bent upwards;The upper end of the test tube fixed cylinder 3 is arranged to open end, and the outer wall of open end is provided with screw thread, Gu The open end for determining device with test tube fixed cylinder 3 is threadedly coupled, and test tube pallet 41 is installed on the inside of test tube fixed cylinder 3;
The fixing device includes the turntable 1, fixture block 22 and fixture block base 24, turntable 1 and fixture block bottom from top to bottom set gradually Seat 24 is disposed as annular shape, and some axis pins 25 are along the circumferential direction evenly arranged with the upper surface of fixture block base 24;Fixture block 22 Boss 21 is provided between the lower face of one end and fixture block base 24, boss 21 and fixture block 22 are provided with pin shaft hole, fixture block 22 other end is arranged to arc closed angle end, and the middle part of fixture block 22 is provided with arc kidney slot 23, the pin on some pieces of fixture blocks 22 Axis hole is corresponded to and is installed on axis pin 25, and every piece of fixture block 22 rotates rotating around axis pin 25;The turntable 1 is relative to fixture block bottom Seat 24 rotates, between the lower face of turntable 1 and the upper surface of fixture block base 24 with 23 position correspondence of arc kidney slot Some limit shafts 11 are provided with, limit shaft 11 slides in corresponding arc kidney slot 23 respectively;
Saddle 43 is provided with the middle part of 41 lower surface of test tube pallet, is set between saddle 43 and the bottom surface of test tube fixed cylinder 3 There is tray spring 44, test tube pallet is provided with pyramidal pits in the middle part of 41 upper surface, in pyramidal pits both sides along test tube pallet 41 Diametric(al) be symmetrically arranged with sliding slot 45, be provided with sliding block 42 in sliding slot 45, the lower surface of sliding block 42 is arranged to and turntable limits The matched cambered surface in lower surface of position groove 31, is connected, institute between sliding block 42 and the center portion of test tube pallet 41 by sliding block spring 46 State sliding block spring 46 and be in compressive state, sliding block spring 46 drives sliding block 42 to be slid into from sliding slot 45 in rotary disk limitation groove 31.
Further, it is some when the driving of turntable 1 limit shaft 11 slides into arc kidney slot 23 close to 25 side of axis pin The arc closed angle end closure of block fixture block 22, the diameter of the polygon of the intrados composition of some pieces of fixture blocks 22 are equal to the straight of test tube Footpath;When the driving of turntable 1 limit shaft 11 slides into arc kidney slot 23 away from 25 side of axis pin, the arc of some pieces of fixture blocks 22 Closed angle end opens, and the diameter of the polygon of the intrados composition of some pieces of fixture blocks 22 is not less than ring-type turntable 22 and fixture block base 24 The diameter of inner headed face.
Further, it is disposed with from top to bottom according to the axis direction of the model of test tube along test tube fixed cylinder 3 some Group rotary disk limitation groove 31.
Further, the fixture block 22 is along the circumferential direction evenly arranged with six pieces along 24 upper surface of fixture block base.
Further, when 22 closure state of fixture block, on the medial surface of 22 arc closed angle end of fixture block with test tube outer wall Cushion block is provided between contact surface.
The use process of the present invention is as follows:
In figure, 1 is turntable, and 11 be limit shaft, and 21 be boss, and 22 be fixture block, and 23 be arc kidney slot, and 24 be fixture block base, 25 It is test tube fixed cylinder for axis pin, 3,31 be rotary disk limitation groove, and 41 be test tube pallet, and 42 be sliding block, and 43 be saddle, and 44 be pallet bullet Spring, 45 be sliding slot, and 46 be sliding block spring.
Rotary turnplate 1, limit shaft 11 make 22 outward turning of fixture block, and the arc closed angle end of fixture block 22 is in open configuration, model compared with Small test tube is put into test tube fixed cylinder 3 from cricoid turntable 1 and fixture block base 24, and the bottom of test tube can touch test tube pallet In 41 pyramidal pits, pyramidal pits can fix test tube bottom, prevent test tube from tilting.After test tube bottom touching test tube pallet 41 Press at first group of 31 position of rotary disk limitation groove, sliding block 42 is ejected by sliding block spring 46, and sliding block 42 is sprung into first group of turntable In limiting slot 31, the height of test tube is fixed.
Turntable 1 is reversely rotated, fixture block 22 inwardly rotates, and the arc closed angle end of fixture block 22 is in closure state to clamp examination Pipe.
It is essentially identical with above-mentioned steps when using the larger test tube of type instead.Test tube is firmly pushed, test tube bottom pushes examination Conduit saddle disk 41, sliding block 42 continue to push test tube pallet 41, due to 31 bottom of rotary disk limitation groove in first group of rotary disk limitation groove 31 For the cambered surface being bent upwards, 42 bottom surface of sliding block is similarly cambered surface, therefore sliding block 42 can continue directly to press to second group of turntable limit Position groove 31, then, reversely rotates turntable 1, fixture block 22 is inwardly rotated to fix test tube.
After test tube takes out, slight left-right rotation test tube pallet 41, sliding block 42 is revolved from second group of rotary disk limitation groove 31 Go out, sliding block 42 is pressed into sliding slot 45.Tray spring 44, which affranchises, state and to be recovered test tube pallet 41 to initial position.
Turntable 1 is finally reversely rotated, the rotation of fixture block 22 reduces open circles to closure.Freely it can place and incline inside the present apparatus Frozen water, shell are thermal insulation material mineral wool, and isoperibol and ice-water bath are provided for test tube.
The above description is merely a specific embodiment, but protection scope of the present invention is not limited thereto, any Be familiar with those skilled in the art the invention discloses technical scope in, the change or replacement that can readily occur in should all be contained Cover within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.

Claims (5)

1. for the test tube fixing device of sonicator, it includes test tube fixing device, test tube pallet(41)Consolidate with test tube Safety barrel(3), it is characterised in that:
Test tube fixed cylinder(3)Side wall be provided with interlayer, thermal insulation material is filled with interlayer, along test tube fixed cylinder(3)Diameter Direction is to test tube fixed cylinder(3)Outside be symmetrically arranged with one group of rotary disk limitation groove(31), the rotary disk limitation groove(31)Under Surface is arranged to the cambered surface being bent upwards;The test tube fixed cylinder(3)Upper end be arranged to open end, the outer wall of open end is set It is equipped with screw thread, fixing device and test tube fixed cylinder(3)Open end be threadedly coupled, test tube pallet(41)It is installed on test tube fixed cylinder (3)Inside;
The fixing device includes the turntable from top to bottom set gradually(1), fixture block(22)With fixture block base(24), turntable(1) With fixture block base(24)Annular shape is disposed as, in fixture block base(24)Upper surface be along the circumferential direction evenly arranged with some pins Axis(25);Fixture block(22)The lower face of one end and fixture block base(24)Between be provided with boss(21), through boss(21)With card Block(22)It is provided with pin shaft hole, fixture block(22)The other end be arranged to arc closed angle end, fixture block(22)Middle part be provided with arc Kidney slot(23), some pieces of fixture blocks(22)On pin shaft hole correspond to be installed on axis pin(25)On, every piece of fixture block(22)Rotating around pin Axis(25)Rotate;The turntable(1)Relative to fixture block base(24)Rotate, turntable(1)Lower face and card Block base(24)Upper surface between with arc kidney slot(23)Some limit shafts are provided with position correspondence(11), limit shaft (11)Respectively in corresponding arc kidney slot(23)Middle slip;
The test tube pallet(41)Saddle is provided with the middle part of lower surface(43), saddle(43)With test tube fixed cylinder(3)Bottom surface Between be provided with tray spring(44), test tube pallet(41)Pyramidal pits are provided with the middle part of upper surface, in pyramidal pits both sides Along test tube pallet(41)Diametric(al) be symmetrically arranged with sliding slot(45), sliding slot(45)Inside it is provided with sliding block(42), sliding block(42) Lower surface be arranged to and rotary disk limitation groove(31)The matched cambered surface in lower surface, sliding block(42)With test tube pallet(41)The heart Pass through sliding block spring between portion(46)Connection, the sliding block spring(46)In compressive state, sliding block spring(46)Drive sliding block (42)From sliding slot(45)In slide into rotary disk limitation groove(31)In.
2. the test tube fixing device according to claim 1 for sonicator, it is characterised in that:The turntable (1)Drive limit shaft(11)Slide into arc kidney slot(23)Close to axis pin(25)During side, some pieces of fixture blocks(22)Arc Closed angle end closes, some pieces of fixture blocks(22)Intrados composition polygon diameter be equal to test tube diameter;The turntable(1) Drive limit shaft(11)Slide into arc kidney slot(23)Away from axis pin(25)During side, some pieces of fixture blocks(22)Arc wedge angle End is opened, some pieces of fixture blocks(22)The diameter of polygon of intrados composition be not less than ring-type turntable(22)With fixture block base (24)The diameter of inner headed face.
3. the test tube fixing device according to claim 1 for sonicator, it is characterised in that:According to test tube Model is along test tube fixed cylinder(3)Axis direction be disposed with some groups of rotary disk limitation grooves from top to bottom(31).
4. the test tube fixing device according to claim 1 for sonicator, it is characterised in that:The fixture block (22)Along fixture block base(24)Upper surface is along the circumferential direction evenly arranged with six pieces.
5. the test tube fixing device according to claim 1 for sonicator, it is characterised in that:Work as fixture block(22) During closure state, in fixture block(22)On the medial surface of arc closed angle end cushion block is provided between the contact surface of test tube outer wall.
CN201711387374.3A 2017-12-20 2017-12-20 Test tube fixing device for sonicator Pending CN107983437A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201711387374.3A CN107983437A (en) 2017-12-20 2017-12-20 Test tube fixing device for sonicator

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201711387374.3A CN107983437A (en) 2017-12-20 2017-12-20 Test tube fixing device for sonicator

Publications (1)

Publication Number Publication Date
CN107983437A true CN107983437A (en) 2018-05-04

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201711387374.3A Pending CN107983437A (en) 2017-12-20 2017-12-20 Test tube fixing device for sonicator

Country Status (1)

Country Link
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108836360A (en) * 2018-07-24 2018-11-20 烟台毓璜顶医院 The hand-held anti-interference fixator of blood sampling

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5993745A (en) * 1998-03-04 1999-11-30 Roche Diagnostics Corporation Archival storage tray for multiple test tubes
CN202367740U (en) * 2011-12-30 2012-08-08 重庆机床(集团)有限责任公司 Loading mechanism capable of loading work pieces with different diameters
CN103420070A (en) * 2013-07-30 2013-12-04 济南大学 Cylinder like material conveying device
CN204973986U (en) * 2015-09-15 2016-01-20 南京市第二医院 Medical test -tube rack
CN205672962U (en) * 2016-06-23 2016-11-09 张海艳 Socket unit for test tube rack
CN107081768A (en) * 2017-06-02 2017-08-22 山东英才学院 A kind of children education robot for being easy to child resistant
CN206746630U (en) * 2017-05-24 2017-12-15 绥化学院 A kind of rack for test tube for supersonic cleaning machine
CN207694868U (en) * 2017-12-20 2018-08-07 黄泽浩 A kind of test tube fixing device for sonicator

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5993745A (en) * 1998-03-04 1999-11-30 Roche Diagnostics Corporation Archival storage tray for multiple test tubes
CN202367740U (en) * 2011-12-30 2012-08-08 重庆机床(集团)有限责任公司 Loading mechanism capable of loading work pieces with different diameters
CN103420070A (en) * 2013-07-30 2013-12-04 济南大学 Cylinder like material conveying device
CN204973986U (en) * 2015-09-15 2016-01-20 南京市第二医院 Medical test -tube rack
CN205672962U (en) * 2016-06-23 2016-11-09 张海艳 Socket unit for test tube rack
CN206746630U (en) * 2017-05-24 2017-12-15 绥化学院 A kind of rack for test tube for supersonic cleaning machine
CN107081768A (en) * 2017-06-02 2017-08-22 山东英才学院 A kind of children education robot for being easy to child resistant
CN207694868U (en) * 2017-12-20 2018-08-07 黄泽浩 A kind of test tube fixing device for sonicator

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108836360A (en) * 2018-07-24 2018-11-20 烟台毓璜顶医院 The hand-held anti-interference fixator of blood sampling
CN108836360B (en) * 2018-07-24 2024-03-29 烟台毓璜顶医院 Handheld blood sampling anti-interference fixer

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Application publication date: 20180504