CN107982439A - The extracting method of dendrobium candidum American ginseng capsule, its preparation method and dendrobium candidum - Google Patents
The extracting method of dendrobium candidum American ginseng capsule, its preparation method and dendrobium candidum Download PDFInfo
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- CN107982439A CN107982439A CN201711405898.0A CN201711405898A CN107982439A CN 107982439 A CN107982439 A CN 107982439A CN 201711405898 A CN201711405898 A CN 201711405898A CN 107982439 A CN107982439 A CN 107982439A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
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- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
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Abstract
The present invention provides the extracting method of a kind of dendrobium candidum American ginseng capsule, its preparation method and dendrobium candidum, belong to health product technology field, contain dendrobium candidum extract wherein in the capsule, the dendrobium candidum extract is aided in extraction process by bead, so that the active ingredient in dendrobium candidum fully discharges so that extract is more preferable for the health-care effect of human body.
Description
Technical field
The present invention relates to health product technology field, in particular to a kind of dendrobium candidum American ginseng capsule and its preparation
Method.
Background technology
Fatigue is a FAQs in daily life, be occur under modern efficient fast pace life mode one kind with slow
Property or recurrent exerbation the extremely tired state for outstanding behaviours, be often accompanied by it is absent minded, headache, sore-throat, arthralgia,
Low-heat, neuropsychic symptom and other nonspecific performances.Traditional Chinese medicine consumptive disease can be attributed to, is insomnia, is palpitaition, strongly fragrant disease, dirty dry
Deng category.Such as《Synopsis Golden Chamber》The consumptive disease that refers to, palpitaition, shortness of breath, the dirty performance such as dry.With the high speed development of society, Ren Mengong
The rhythm for make, learning and living substantially is accelerated, and the pressure of each side is increasing, more and more people is in immunity low
Under, the state of fatigue, so as to seriously affect the normal work and quality of life of people.
The health food using strengthen immunity, alleviation physical fatigue as major function can be divided mainly into currently on the market：Battalion
Support element replenishers class, pollen class, royal jelly and propolis class, Chinese medical extract etc..Wherein such as having dendrobium candidum extract, but
Mostly by being extracted after the leaf defibrination of dendrobium candidum, the extract obtained by this extracting mode has existing dendrobium candidum extract
Effect component is relatively low, and reason is that the active ingredient of dendrobium candidum more concentrates on stem, and since the tissue of stem more causes
Close, density is larger, and the mode such as putting forward using water is extracted, it is also difficult to extracts active ingredient from the stem of dendrobium candidum
Come.
The content of the invention
It is an object of the invention to provide a kind of extracting method of dendrobium candidum, it can be by the stem of dendrobium candidum
Active ingredient fully discharges, and greatly improves effective recovery rate of dendrobium candidum.
Another object of the present invention is to provide a kind of dendrobium candidum American ginseng capsule, it utilizes significantly more efficient iron sheet stone
The extracting method of dry measure used in former times is extracted to obtain dendrobium candidum extract, with other extract scientific compatibilities, can significantly improve the anti-tired of medicine
Labor effect.
It is still another object of the present invention to provide a kind of preparation method of dendrobium candidum American ginseng capsule, this is prepared
Dendrobium candidum American ginseng capsule.
What the embodiment of the present invention was realized in：
The present invention provides a kind of dendrobium candidum American ginseng capsule, including the dendrobium candidum extract of 4-6 parts by weight, 5-8 weight
Measure the American ginseng extract and the gadol extract of 18-22 parts by weight and the starch of 7-10 parts by weight of part, dendrobium candidum
Extract is prepared by the following manner：The drying stem of dendrobium candidum is cleaned rear water to carry, is concentrated and dried after merging Aqueous extracts
Arrive.
Wherein, water bag includes：Dry stem is mixed with water, bead, is warming up to 70-80 DEG C of holding 10-20min, cooling
To 20-30 DEG C, be collected by filtration to obtain Aqueous extracts, bead includes the first bead and the second bead, the first bead it is close
Degree is less than the density of water, density of the second bead density more than water.
The present invention provides the preparation method of above-mentioned dendrobium candidum American ginseng capsule, and dendrobium candidum extract, American Ginseng are carried
It is packaged in after taking thing, gadol extract and starch mixing in capsule.
The present invention provides a kind of extracting method of dendrobium candidum, and the drying stem of dendrobium candidum is cleaned rear water and is carried, and merges water
It is concentrated and dried after extract and obtains extract.
Wherein, water bag includes：Dry stem is mixed with water, bead, is warming up to 70-80 DEG C of holding 10-20min, cooling
To 20-30 DEG C, be collected by filtration to obtain Aqueous extracts, bead includes the first bead and the second bead, the first bead it is close
Degree is less than the density of water, density of the second bead density more than water.
The beneficial effect of present pre-ferred embodiments is：
The extracting method of dendrobium candidum provided by the invention, selects the drying stem of dendrobium candidum being extracted as raw material
During, extrusion wall-breaking is carried out to the stem of dendrobium candidum using movement of the bead of different densities in heating process, makes iron
The active ingredient of skin stem of noble dendrobium stem is fully released into solution, is extracted compared to using modes such as stirring, crushing, Bu Huizao
Fine tissue into stem enters solution system, influences the purity of extract finally obtained, and the mouthfeel after medicine is made.
And with the release of active ingredient, the density of solution system gradually increases, and bead is floated be subject to solution system
Power becomes larger, and rises with the temperature of solution system, and bead is increased by the amplitude of warm-up movement, to the stem of dendrobium candidum
Extrusion wall-breaking effect is stronger, while temperature increases, and stem's tissue of dendrobium candidum can also be subject to high temperature therewith, into one
Step discharges active ingredient, by the way that in dendrobium candidum extract made from the above method, active constituent content dramatically increases, at the same time
Dendrobium candidum utilization rate is significantly improved.
Due to the lifting of active ingredient in dendrobium candidum extract, its for human body health-care effect, antifatigue effect with
And the effect of strengthen immunity can also be been significantly enhanced.Science is carried out with American ginseng extract and gadol extract again to match somebody with somebody
5, obtained dendrobium candidum American ginseng capsule health care curative effect is splendid.
Embodiment
, below will be in the embodiment of the present invention to make the purpose, technical scheme and advantage of the embodiment of the present invention clearer
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, builds according to normal condition or manufacturer
The condition of view carries out.Reagents or instruments used without specified manufacturer, is the conventional production that can be obtained by commercially available purchase
Product.
Below to the extraction side of the dendrobium candidum American ginseng capsule of the embodiment of the present invention, its preparation method and dendrobium candidum
Method is specifically described.
As one aspect of the present invention, the present invention provides a kind of extracting method of dendrobium candidum, it comprises the following steps：
Carry out water after the drying stem of dendrobium candidum is cleaned to carry, the Aqueous extracts that each water raises merge, wherein water
Carry and at least carrying out once, can also carry out repeatedly.Concentrate drying obtains extract after being then combined with Aqueous extracts；
Wherein, water bag includes：Dry stem is cleaned, is mixed with water, bead, wherein, bead SiO2Material, according to
Its specific density needs that hollow bead can be made.In order to avoid bead introducing is unnecessary miscellaneous in extraction process
Matter, can carry out bead (HF acid) pickling before extraction and then deionized water is washed, prevent from introducing into extracting solution solvable
Solution forms extracting solution and pollutes in the impurity of water.
Bead includes the first bead and the second bead, and the density of first bead is less than the density of water, institute
State the density that the second bead density is more than water.Wherein the first bead preferably uses the bead of hollow-core construction, its averag density
Scope is with 0.8-0.9g/cm3It is advisable, wherein density range can be included between 0.8-0.9g/cm3Between all kinds glass
Pearl, smaller with the density difference of water, the buoyancy and its own gravitational difference that such first bead is subject to are relatively small, the first bead
Movement rate in solution system can be relatively slow.The averag density scope of second bead is with 1.01-1.05g/cm3For
Preferably, wherein density range can be included between 1.01-1.05g/cm3Between all kinds bead, the second same glass
The density contrast of pearl and aqueous systems is relatively small, and the movement rate of the second bead is opposite can be slow, beneficial to the first bead and
Stem of second bead more fully with dendrobium candidum in solution system is contacted, and dendrobium candidum is fully extruded brokenly
Broken, active ingredient fully discharges.Also, transported in the case of the movement rate relatively slow speed of the first bead and the second bead
It is dynamic, stem's surface texture of dendrobium candidum will not be caused to be broken into fine slag and enter solution system, cause solution system filtration difficulty, and
And fine slag enter subsequent concentration process after stay in extract, influence components compatibility and medicine mouthfeel, curative effect.
In addition, as the active principle in dendrobium candidum discharges, solution system starts gradually to become sticky, and solution system is close
Degree can rise accordingly, and after active constituent content gradually increases in solution system, the averag density of solution system is substantially
1.008-1.013g/cm3, at this time the density of the second bead still can relative solution system density differ greatly, the second glass at this time
Pearl can be in after the rising of solution system density and suspend or sink to the bottom state, further keep the extruding with dendrobium candidum stem to break
Wall.
In certain embodiments of the present invention, by controlling dry stem to clean, with water, bead order by merging, can reach
Effect is put forward to more preferable water.
Such as：Dry stem mixed with water, bead including：First bead is put into container and is laid in container
Bottom, the dry stem is layed on first bead, and second bead is placed on the dry stem, along appearance
Wall adds water.
Since the first bead is lighter, it is first placed in container bottom, and the drying stem of dendrobium candidum is placed in centre, the second glass
It is heavier that glass pearl compares water, and after water is added, the first bead has the movement tendency to floating, dry stem and the second bead tool
Dry stem is sandwiched in centre by the movement tendency of oriented sinking, the first bead and the second bead, both are mutually extruded to drying
The shell-broken effect of stem more preferably, meanwhile, in heating up process, the motion amplitude of the first bead is gradually violent, is subject to drying
The stop of stem, can slow down its movement rate.Especially after the density of solution system rises, the ascent rate of the first bead
Can further speed up, in mixing, just control the position relationship of the first bead and the second bead and dry stem for
Obtaining more preferable water, to put forward effect highly beneficial.
Likewise, for the second bead, the superiors are placed on, can also slow down its fall rate.Until solution system
Density gradually rises up to very few with its own density difference, and more second beades can be in suspended state, itself and dry stem
Contact, friction and shell-broken effect are more preferably.
It should be appreciated that the solution system refer to water carry during liquid phase and the material composition that is dissolved in liquid phase
System.
Added as water when adding along chamber wall, it can destroy the first glass to avoid causing to impact during Jia Shui
The position relationship of glass pearl and the second bead and dry stem.
As preference, the gross weight of the first bead, dendrobium candidum drying stem and the second bead is than preferred control
For 0.9-1.1：3-25：1, carry container bottom wherein the amount of the first bead can preferably be paved with water and be advisable.Also, extraction every time
When, amount of water is preferably 6-8 times of dendrobium candidum drying stem gross weight, and extraction time is preferred more than 3 times.
Effect is put forward in order to further improve the broken water of dry stem, dry stem can be cut into segment, example in advance in water
The segment that length is less than 3cm is such as cut into, for so dry stem in stacking process, its gap produced can be relatively small, and first
Bead cannot rapidly float, and the time of contact of the first bead of increase and dry stem, improves water and put forward effect.
70-80 DEG C of holding 10-20min is warming up to, heating rate is advisable with 2-3 DEG C/min, in the process, heating rate
It is unsuitable too fast, while temperature is no more than 80 DEG C, because the excessive active ingredient structure that can make dendrobium candidum of temperature is destroyed,
Its curative effect is caused to lose.
Then it is cooled to 20-30 DEG C, in temperature-fall period, rate of temperature fall is advisable with 2-3 DEG C/min, same temperature change speed
Rate is too fast, is unfavorable for the lasting spilling of active ingredient in dendrobium candidum.It is collected by filtration to obtain the Aqueous extracts.It is multiple when carrying out
When water proposes operation, every time after the completion of filtering, the drying stem slag of dendrobium candidum repeated to add carry out, operating procedure with it is above-mentioned
Method is identical.
After merging the Aqueous extracts that each water raises, in certain embodiments of the present invention, the water of dendrobium candidum is carried
Carry out 3 times, carry out water using 8 times, 8 times, 6 times of water respectively and carry, the time that each water carries substantially continues 1h.
The Aqueous extracts obtained to merging are concentrated under reduced pressure, and it is substantially 1.02 to be concentrated into relative density, is concentrated under reduced pressure for example
Carried out under the conditions of vacuum 0.08MPa, temperature 60 C.Concentrate is spray-dried, wherein, can in spray-drying process
To carry out in the following manner, 140-160 DEG C of intake air temperature, 60-70 DEG C of air outlet temperature, crosses 80 mesh sieves up to iron sheet after dry
Herba Dendrobii extract.
As another aspect of the present invention, the present invention provides a kind of dendrobium candidum American ginseng capsule, it includes：4-6 weights
Measure part dendrobium candidum extract, the American ginseng extract of 5-8 parts by weight and the gadol extract of 18-22 parts by weight and
The starch of 7-10 parts by weight.
Wherein, starch can be the starch made of cereal, potato, beans etc. are Raw material processing ".
Wherein, dendrobium candidum extract is extracted to obtain by the extracting method of above-mentioned dendrobium candidum.
American ginseng extract can extract to obtain in the following manner：American Ginseng dry root is crushed to below 20 mesh, uses second
Alcohol reflux extracts to obtain ethanol extract, and the American ginseng extract is obtained with extracting n-butyl alcohol after concentration.
Specifically, such as：
1. take American Ginseng dry root；
2. crush, sieving：American Ginseng dry root is crushed, crosses 20 mesh sieves, obtains coarse powder；
3. extraction：80% alcohol reflux extracts 3 times, measures for 8 times every time, refluxing extraction 2h, filtering, merges 3 filtrates, obtain second
Alcohol extract.
4. concentration：Be concentrated under reduced pressure recycling ethanol, obtains concentrate；
5. extraction：With equivalent extracting n-butyl alcohol 4 times, merge 4 extracts, obtain extract；
6. concentration：N-butanol is recovered under reduced pressure, obtains residue；
7. drying：It is dried under reduced pressure (0.08Mpa, 80 DEG C), crushes, crosses 80 mesh sieves, obtain American ginseng extract.
8. packaging, is examined, storage.
Gadol extract can extract to obtain in the following manner：Rhodiola root is crushed, ethanol extraction is extracted to obtain with ethanol
Liquid, dries and obtains after being concentrated under reduced pressure.
In certain embodiments of the present invention, for example,
Rhodiola root is crushed, obtains coarse powder：
By rhodiola root coarse powder add 6 times amount 80% ethanol extract 3 times, every time 1.5 it is small when, filtering, merge 3 filtrates,
Obtain ethanol extract.
By ethanol extract be recovered under reduced pressure ethanol, be concentrated into (60 DEG C) of relative density 1.05 concentrate.
Concentrate is spray-dried, (intake air temperature：140 DEG C -160 DEG C, 60 DEG C -70 DEG C of air outlet temperature) it must dry and carry
Take thing
Dried extract crushes, crosses 80 mesh sieves, warehousing finished products.
As another aspect of the present invention, the present invention also provides the preparation method of above-mentioned dendrobium candidum American ginseng capsule：
It is packaged in after dendrobium candidum extract, American ginseng extract, gadol extract and starch are mixed in capsule.
Wherein, in the preparation, it is preferable that can in the following manner carry out, prepare the mistake of dendrobium candidum extract first
Cheng Zhong, mixes after Aqueous extracts are concentrated with starch, both are dried together.This have the advantage that after Aqueous extracts concentration
In more sticky state, adding starch at this time can preferably contact starch with dendrobium candidum extract, dendrobium candidum
Extract can be preferably carried on starch, and gadol extract and American ginseng extract mixing, such people are after dry
After taking, the absorption more conducively to dendrobium candidum extract.
The feature and performance of the present invention are described in further detail with reference to embodiments.
Embodiment 1
A kind of extracting method of dendrobium candidum, carries out according to the following steps：
Carry out 3 water after the drying stem of dendrobium candidum is cleaned to carry, water bag includes：Will dry stem and water, the first bead
Mixed with the second bead, wherein, the averag density substantially 0.85g/cm of the first bead3, the second bead it is average close
Spend substantially 1.03g/cm3.The total mass ratio of first bead and the second bead is 0.9:1, dendrobium candidum dries the total of stem
Quality is 3 times of the second bead gross mass, and water consumption dries 8 times of the gross mass of stem for dendrobium candidum.
70 DEG C of holding 30min are warming up to, 20 DEG C is cooled to, is collected by filtration to obtain the Aqueous extracts, each water is carried by upper
The mode of stating carries out, and putting forward water used difference lies in water three times is followed successively by 8 times of amounts, 8 times of amounts, 6 times of amounts.
After merging Aqueous extracts, it is 1.02g/cm that density is concentrated under the conditions of vacuum 0.08MPa, temperature 60 C3, it is dry
Obtain dendrobium candidum extract.
Embodiment 2
A kind of extracting method of dendrobium candidum, carries out according to the following steps：
Carry out 3 water after the drying stem of dendrobium candidum is cleaned to carry, water bag includes：Will dry stem and water, the first bead
Mixed with the second bead, wherein, the averag density substantially 0.87g/cm of the first bead3, the second bead it is average close
Spend substantially 1.04g/cm3.The total mass ratio of first bead and the second bead is 1:1, dendrobium candidum dries total matter of stem
Measure as 25 times of the second bead gross mass, water consumption dries 8 times of the gross mass of stem for dendrobium candidum.
80 DEG C of holding 20min are warming up to, 20 DEG C is cooled to, is collected by filtration to obtain the Aqueous extracts, each water is carried by upper
The mode of stating carries out, and putting forward water used difference lies in water three times is followed successively by 8 times of amounts, 8 times of amounts, 6 times of amounts.
After merging Aqueous extracts, it is 1.02g/cm that density is concentrated under the conditions of vacuum 0.08MPa, temperature 60 C3, it is dry
Obtain dendrobium candidum extract.
Embodiment 3
A kind of extracting method of dendrobium candidum, carries out according to the following steps：
Carry out 3 water after the drying stem of dendrobium candidum is cleaned to carry, water bag includes：Will dry stem and water, the first bead
Mixed with the second bead, wherein, the averag density substantially 0.88g/cm of the first bead3, the second bead it is average close
Spend substantially 1.04g/cm3.The total mass ratio of first bead and the second bead is 0.9:1, dendrobium candidum dries the total of stem
Quality is 3 times of the second bead gross mass, and water consumption dries 8 times of the gross mass of stem for dendrobium candidum.
Order by merging is as follows：The first bead is first laid in water and carries container bottom, dry stem is layed in described first
On bead, the second bead is placed on the dry stem, water is added along chamber wall.
75 DEG C of holding 15min are warming up to, 25 DEG C is cooled to, is collected by filtration to obtain the Aqueous extracts, each water is carried by upper
The mode of stating carries out, and putting forward water used difference lies in water three times is followed successively by 8 times of amounts, 8 times of amounts, 6 times of amounts.
After merging Aqueous extracts, it is 1.02g/cm that density is concentrated under the conditions of vacuum 0.08MPa, temperature 60 C3, it is dry
Obtain dendrobium candidum extract.
Embodiment 4
A kind of extracting method of dendrobium candidum, carries out according to the following steps：
Carry out 3 water after the drying stem of dendrobium candidum is cleaned to carry, water bag includes：Will dry stem and water, the first bead
Mixed with the second bead, wherein, the averag density substantially 0.85g/cm of the first bead3, the second bead it is average close
Spend substantially 1.03g/cm3.The total mass ratio of first bead and the second bead is 0.9:1, dendrobium candidum dries the total of stem
Quality is 10 times of the second bead gross mass, and water consumption dries 8 times of the gross mass of stem for dendrobium candidum.
Order by merging is as follows：The first bead is first laid in water and carries container bottom, dry stem is layed in described first
On bead, the second bead is placed on the dry stem, water is added along chamber wall.
70 DEG C of holding 15min are warming up to, 20 DEG C is cooled to, is collected by filtration to obtain the Aqueous extracts, each water is carried by upper
The mode of stating carries out, and putting forward water used difference lies in water three times is followed successively by 8 times of amounts, 8 times of amounts, 6 times of amounts.
After merging Aqueous extracts, it is 1.02g/cm that density is concentrated under the conditions of vacuum 0.08MPa, temperature 60 C3, it is dry
Obtain dendrobium candidum extract.
Embodiment 5
A kind of extracting method of dendrobium candidum, carries out according to the following steps：
Carry out 3 water after the drying stem of dendrobium candidum is cleaned to carry, water bag includes：Will dry stem and water, the first bead
Mixed with the second bead, wherein, the averag density substantially 0.85g/cm of the first bead3, the second bead it is average close
Spend substantially 1.03g/cm3.The total mass ratio of first bead and the second bead is 1:1, dendrobium candidum dries total matter of stem
Measure as 18 times of the second bead gross mass, water consumption dries 8 times of the gross mass of stem for dendrobium candidum.
Order by merging is as follows：The first bead is first laid in water and carries container bottom, dry stem is layed in described first
On bead, the second bead is placed on the dry stem, water is added along chamber wall.
70 DEG C of holding 15min are warming up to, 20 DEG C is cooled to, is collected by filtration to obtain the Aqueous extracts, each water is carried by upper
The mode of stating carries out, and putting forward water used difference lies in water three times is followed successively by 8 times of amounts, 8 times of amounts, 6 times of amounts.
After merging Aqueous extracts, it is 1.02g/cm that density is concentrated under the conditions of vacuum 0.08MPa, temperature 60 C3, it is dry
Obtain dendrobium candidum extract.
Embodiment 6
A kind of extracting method of dendrobium candidum, carries out according to the following steps：
Carry out 3 water after the drying stem of dendrobium candidum is cleaned to carry, water bag includes：Will dry stem and water, the first bead
Mixed with the second bead, wherein, the averag density substantially 0.85g/cm of the first bead3, the second bead it is average close
Spend substantially 1.03g/cm3.The total mass ratio of first bead and the second bead is 1.1:1, dendrobium candidum dries the total of stem
Quality is 20 times of the second bead gross mass, and water consumption dries 8 times of the gross mass of stem for dendrobium candidum.
Order by merging is as follows：The first bead is first laid in water and carries container bottom, dry stem is layed in described first
On bead, the second bead is placed on the dry stem, water is added along chamber wall.
70 DEG C of holding 15min are warming up to, 20 DEG C is cooled to, is collected by filtration to obtain the Aqueous extracts, each water is carried by upper
The mode of stating carries out, and putting forward water used difference lies in water three times is followed successively by 8 times of amounts, 8 times of amounts, 6 times of amounts.
After merging Aqueous extracts, it is 1.02g/cm that density is concentrated under the conditions of vacuum 0.08MPa, temperature 60 C3, it is dry
Obtain dendrobium candidum extract.
Embodiment 7
The present embodiment provides a kind of dendrobium candidum American ginseng capsule, it includes the dendrobium candidum extract of 5 parts by weight, 6.7
The starch of the gadol extract and 8.3 parts by weight of the American ginseng extract of parts by weight and 20 parts by weight, above-mentioned each component
It is packaged in capsule.
Wherein, dendrobium candidum extract is extracted to obtain by the extracting method of embodiment 1 respectively.American ginseng extract is by following
Mode obtains：American Ginseng dry root is crushed, crosses 20 mesh sieves, obtains coarse powder；80% alcohol reflux extracts 3 times, and 8 times of amounts, are returned every time
Stream extraction 2h, filtering, merges 3 filtrates, obtains ethanol extract.Be concentrated under reduced pressure recycling ethanol, obtains concentrate；With equivalent n-butanol
Extract concentrate 4 times, merge 4 extracts, obtain extract；N-butanol is recovered under reduced pressure, obtains residue, 80 mesh are crossed after being dried under reduced pressure
Sieve, to obtain the final product.
Gadol extract obtains in the following manner：By rhodiola root coarse powder add 6 times amount 80% ethanol extract 3 times, often
It is secondary 1.5 it is small when, filtering, merge 3 filtrates, obtain ethanol extract.By ethanol extract be recovered under reduced pressure ethanol, be concentrated into it is relatively close
1.05 (60 DEG C) of degree obtains concentrate.Concentrate is spray-dried, (intake air temperature：140 DEG C -160 DEG C, 60 DEG C of air outlet temperature -
70 DEG C) dried extract is obtained, dried extract crushes, crosses 80 mesh sieves to obtain the final product.
Embodiment 8
The present embodiment provides a kind of dendrobium candidum American ginseng capsule, it includes the dendrobium candidum extract of 4 parts by weight, 6.5
The starch of the gadol extract and 8.5 parts by weight of the American ginseng extract of parts by weight and 18 parts by weight, above-mentioned each component
It is packaged in capsule.
Wherein, dendrobium candidum extract is extracted to obtain by the extracting method of embodiment 6 respectively.American ginseng extract is by following
Mode obtains：American Ginseng dry root is crushed, crosses 20 mesh sieves, obtains coarse powder；80% alcohol reflux extracts 3 times, and 8 times of amounts, are returned every time
Stream extraction 2h, filtering, merges 3 filtrates, obtains ethanol extract.Be concentrated under reduced pressure recycling ethanol, obtains concentrate；With equivalent n-butanol
Extract concentrate 4 times, merge 4 extracts, obtain extract；N-butanol is recovered under reduced pressure, obtains residue, 80 mesh are crossed after being dried under reduced pressure
Sieve, to obtain the final product.
Gadol extract obtains in the following manner：By rhodiola root coarse powder add 6 times amount 80% ethanol extract 3 times, often
It is secondary 1.5 it is small when, filtering, merge 3 filtrates, obtain ethanol extract.By ethanol extract be recovered under reduced pressure ethanol, be concentrated into it is relatively close
1.05 (60 DEG C) of degree obtains concentrate.Concentrate is spray-dried, (intake air temperature：140 DEG C -160 DEG C, 60 DEG C of air outlet temperature -
70 DEG C) dried extract is obtained, dried extract crushes, crosses 80 mesh sieves to obtain the final product.
Embodiment 9
The present embodiment provides a kind of dendrobium candidum American ginseng capsule, it includes the dendrobium candidum extract of 6 parts by weight, 5 weights
The American ginseng extract and the gadol extract of 19 parts by weight and the starch of 8 parts by weight of part are measured, it is above-mentioned each component packaged
In capsule.
Wherein, dendrobium candidum extract is extracted to obtain by the extracting method of embodiment 2 respectively.American ginseng extract is by following
Mode obtains：American Ginseng dry root is crushed, crosses 20 mesh sieves, obtains coarse powder；80% alcohol reflux extracts 3 times, and 8 times of amounts, are returned every time
Stream extraction 2h, filtering, merges 3 filtrates, obtains ethanol extract.Be concentrated under reduced pressure recycling ethanol, obtains concentrate；With equivalent n-butanol
Extract concentrate 4 times, merge 4 extracts, obtain extract；N-butanol is recovered under reduced pressure, obtains residue, 80 mesh are crossed after being dried under reduced pressure
Sieve, to obtain the final product.
Gadol extract obtains in the following manner：By rhodiola root coarse powder add 6 times amount 80% ethanol extract 3 times, often
It is secondary 1.5 it is small when, filtering, merge 3 filtrates, obtain ethanol extract.By ethanol extract be recovered under reduced pressure ethanol, be concentrated into it is relatively close
1.05 (60 DEG C) of degree obtains concentrate.Concentrate is spray-dried, (intake air temperature：140 DEG C -160 DEG C, 60 DEG C of air outlet temperature -
70 DEG C) dried extract is obtained, dried extract crushes, crosses 80 mesh sieves to obtain the final product.
Embodiment 10
The present embodiment provides a kind of dendrobium candidum American ginseng capsule, it includes the dendrobium candidum extract of 5 parts by weight, 6 weights
The American ginseng extract and the gadol extract of 22 parts by weight and the starch of 9 parts by weight of part are measured, it is above-mentioned each component packaged
In capsule.
Wherein, dendrobium candidum extract is extracted to obtain by the extracting method of embodiment 3 respectively.American ginseng extract is by following
Mode obtains：American Ginseng dry root is crushed, crosses 20 mesh sieves, obtains coarse powder；80% alcohol reflux extracts 3 times, and 8 times of amounts, are returned every time
Stream extraction 2h, filtering, merges 3 filtrates, obtains ethanol extract.Be concentrated under reduced pressure recycling ethanol, obtains concentrate；With equivalent n-butanol
Extract concentrate 4 times, merge 4 extracts, obtain extract；N-butanol is recovered under reduced pressure, obtains residue, 80 mesh are crossed after being dried under reduced pressure
Sieve, to obtain the final product.
Gadol extract obtains in the following manner：By rhodiola root coarse powder add 6 times amount 80% ethanol extract 3 times, often
It is secondary 1.5 it is small when, filtering, merge 3 filtrates, obtain ethanol extract.By ethanol extract be recovered under reduced pressure ethanol, be concentrated into it is relatively close
1.05 (60 DEG C) of degree obtains concentrate.Concentrate is spray-dried, (intake air temperature：140 DEG C -160 DEG C, 60 DEG C of air outlet temperature -
70 DEG C) dried extract is obtained, dried extract crushes, crosses 80 mesh sieves to obtain the final product.
Embodiment 11
The present embodiment provides a kind of dendrobium candidum American ginseng capsule, it includes the dendrobium candidum extract of 4.5 parts by weight, 8
The starch of the gadol extract and 7 parts by weight of the American ginseng extract of parts by weight and 20 parts by weight, it is above-mentioned respectively into subpackage
Loaded in capsule.
Wherein, dendrobium candidum extract is extracted to obtain by the extracting method of embodiment 4 respectively.American ginseng extract is by following
Mode obtains：American Ginseng dry root is crushed, crosses 20 mesh sieves, obtains coarse powder；80% alcohol reflux extracts 3 times, and 8 times of amounts, are returned every time
Stream extraction 2h, filtering, merges 3 filtrates, obtains ethanol extract.Be concentrated under reduced pressure recycling ethanol, obtains concentrate；With equivalent n-butanol
Extract concentrate 4 times, merge 4 extracts, obtain extract；N-butanol is recovered under reduced pressure, obtains residue, 80 mesh are crossed after being dried under reduced pressure
Sieve, to obtain the final product.
Gadol extract obtains in the following manner：By rhodiola root coarse powder add 6 times amount 80% ethanol extract 3 times, often
It is secondary 1.5 it is small when, filtering, merge 3 filtrates, obtain ethanol extract.By ethanol extract be recovered under reduced pressure ethanol, be concentrated into it is relatively close
1.05 (60 DEG C) of degree obtains concentrate.Concentrate is spray-dried, (intake air temperature：140 DEG C -160 DEG C, 60 DEG C of air outlet temperature -
70 DEG C) dried extract is obtained, dried extract crushes, crosses 80 mesh sieves to obtain the final product.
Embodiment 12
The present embodiment provides a kind of dendrobium candidum American ginseng capsule, it includes the dendrobium candidum extract of 5.5 parts by weight, 7
The starch of the gadol extract and 10 parts by weight of the American ginseng extract of parts by weight and 21 parts by weight, it is above-mentioned respectively into subpackage
Loaded in capsule.
Wherein, dendrobium candidum extract is extracted to obtain by the extracting method of embodiment 5 respectively.American ginseng extract is by following
Mode obtains：American Ginseng dry root is crushed, crosses 20 mesh sieves, obtains coarse powder；80% alcohol reflux extracts 3 times, and 8 times of amounts, are returned every time
Stream extraction 2h, filtering, merges 3 filtrates, obtains ethanol extract.Be concentrated under reduced pressure recycling ethanol, obtains concentrate；With equivalent n-butanol
Extract concentrate 4 times, merge 4 extracts, obtain extract；N-butanol is recovered under reduced pressure, obtains residue, 80 mesh are crossed after being dried under reduced pressure
Sieve, to obtain the final product.
Gadol extract obtains in the following manner：By rhodiola root coarse powder add 6 times amount 80% ethanol extract 3 times, often
It is secondary 1.5 it is small when, filtering, merge 3 filtrates, obtain ethanol extract.By ethanol extract be recovered under reduced pressure ethanol, be concentrated into it is relatively close
1.05 (60 DEG C) of degree obtains concentrate.Concentrate is spray-dried, (intake air temperature：140 DEG C -160 DEG C, 60 DEG C of air outlet temperature -
70 DEG C) dried extract is obtained, dried extract crushes, crosses 80 mesh sieves to obtain the final product.
Comparative example 1
Carry out 3 water after the drying stem of dendrobium candidum is cleaned to carry, water proposes routinely operation and carries out, specifically, by iron sheet
The stem of noble dendrobium is dried stem and is mixed with 8 times of amount water, is warming up to 80 ° of extraction 1h, extracting solution is collected by filtration, filter residue is carried for the second time again
Take, amount of water dries 8 times of stem for dendrobium candidum, is warming up to 80 ° of extraction 1h, extracting solution is collected by filtration, filter residue is carried out again
Third time is extracted, and amount of water dries 6 times of stem for dendrobium candidum, and extracting solution is collected by filtration, and merges the extracting solution extracted three times.
Vacuum 0.08MPa, is concentrated under reduced pressure under the conditions of temperature 60 C, is spray-dried after concentration, and 80 mesh sieves are crossed after dry up to iron
Skin Herba Dendrobii extract.
Polyoses content detection, detection method ginseng are carried out to embodiment 1-6 and comparative example 1 the dendrobium candidum extract obtained
See《Pharmacopeia》Shown in method carry out, testing result is as follows：
| Polyoses content (%) | |
| Embodiment 1 | 77.6 |
| Embodiment 2 | 78.34 |
| Embodiment 3 | 81.3 |
| Embodiment 4 | 82.12 |
| Embodiment 5 | 83.28 |
| Embodiment 6 | 83.16 |
| Comparative example 1 | 70.25 |
Test example
Sample：The dendrobium candidum American ginseng capsule that embodiment 7-12 is obtained
Experimental animal and raising
SPF grades of male ICR mouses, weight 18g~22g, (animal qualification is provided by Chengdu up to large bio tech ltd
Card number：SCXK (river) 2008-24).Rearing conditions：Barrier level animal house (the management of laboratory animal committee of Sichuan Province licensing
Number：SYXK CJ rivers) 2008-011).
Key instrument and reagent
SBA- bio-sensings analyzer, UNIC0-7200 types spectrophotometer, refiner, centrifuge, electronic balance.
Experimental method
Experimental animal is randomly divided into blank control group and three dendrobium candidum American ginseng capsule experimental groups, wherein, will be real
Apply the dendrobium candidum American ginseng capsule mixing that a 7-12 is obtained, the tested agent as experimental group.Tested material dosage is respectively
133.3mg/kg.bw, 266.7mg/kg.bw, 400.0mg/kg.bw (are respectively equivalent to 10,20 and of human body recommended intake
30 times).Gavage liquid is prepared：Dendrobium candidum American ginseng capsule content 0.67g, 1.3g, 2.0g are weighed respectively, are diluted with shop water is steamed
To l00ml.Blank control group animal is to steam shop water gavage, and each test group of animals is with the dendrobium candidum American ginseng capsule of corresponding dosage
Aqueous solution presses 20ml/kg.bw gavages, and once a day, continuous gavage carries out following experiment respectively after 30 days：
1 swimming with a load attached to the body is tested：After last gives tested material 30min, the mouse of 5% weight sheet lead of root of the tail portion load is placed in
Swimming trunk went swimming.The depth of water is no less than 30cm in case, l DEG C of water temperature 2sc scholar, record mouse from swimming to death when
Between.
2 blood lactase acids measure：After last gives tested material 30min, animal is put into not swimming with a load attached to the body in the water that temperature is 30 DEG C
L0min, and rest 20min respectively adopts 20 μ L of eyeball blood measure lactic acid contents immediately, after swimming before swimming, after swimming.And by with
Lower formula calculates blood lactase acid area under the curve, to judge blood lactase acid situation of change after moving.
Blood lactase acid area under the curve=5 × (before swimming after blood lactase acid value+3 × swimming after Omin blood lactase acids value+2 × swimming
Rest 20min blood lactase acids value)
3 serum urea nitrogen determinations：After last gives tested material 30min, mouse is put in the water that temperature is 30 DEG C and is not born a heavy burden
Swim 90min, and eyeball blood 0.5mL is adopted after rest 60min, and serum diacetyl-oxime method measure serum urea nitrogen is taken after blood clotting
Content.
4 hepatic glycogen measure：30min puts to death animal after last gives tested material, takes liver to be used after physiological saline rinses
Filter paper blots, and weighs liver l00mg, measure hepatic glycogen content (anthrone method) rapidly.
Test result is shown in Table 1-table 8
Influence (swimming with a load attached to the body experiment) of the 1 dendrobium candidum American ginseng capsule of table to mouse weight
Influence (blood lactase acid determination experiment) of the 2 dendrobium candidum American ginseng capsule of table to mouse weight
Influence (determination of urea nitrogen experiment) of the 3 dendrobium candidum American ginseng capsule of table to mouse weight
Influence (hepatic glycogen determination experiment) of the 4 dendrobium candidum American ginseng capsule of table to mouse weight
Table l~table 4 shows, three dosage groups of dendrobium candidum American ginseng capsule and blank control group that embodiment 7-12 is obtained
Between weight there was no significant difference (P at the end of mouse original body mass, experiment mid-term weight and experiment>0.05).
Influence of the dendrobium candidum American ginseng capsule to the mice burden swimming time：It the results are shown in Table 5.
Influence of the 5 dendrobium candidum American ginseng capsule of table to the mice burden swimming time
* compared with the control group of space, P<0.05.
As shown in table 5, during three dosage group mice burden swimmings of dendrobium candidum American ginseng capsule that embodiment 7-12 is obtained
Between be longer than control group, and the low dose group mice burden swimming time has significant difference compared with the control group.(P<0.05).
Influence of the dendrobium candidum American ginseng capsule to mouse Serum lactic acid content：It is shown in Table 6.
Influence of the 6 dendrobium candidum American ginseng capsule of table to mouse Serum lactic acid content
* compared with the control group of space, P<0.05.
As shown in table 6, three dosage groups of dendrobium candidum American ginseng capsule that embodiment 7-12 is obtained are 20 minutes after swimming
The Serum lactic acid content at time point is substantially less than blank control group (P<0.05), three dosage group blood lactase acid area under the curve have
Reduced, but with control group there was no significant difference (P>0.05).
Influence of the dendrobium candidum American ginseng capsule to mouse hepatic glycogen content：It is shown in Table 7
Influence of the 7 dendrobium candidum American ginseng capsule of table to mouse hepatic glycogen content
* compared with the control group of space, P<0.05.
As shown in table 7, the liver mansion original content of three dosage groups of dendrobium candidum American ginseng capsule that embodiment 7-12 is obtained is equal
There is increase, wherein middle high dose group hepatic glycogen content is write higher than blank control group (P<0.05).
Influence of the dendrobium candidum American ginseng capsule to mice serum urea nitrogen content：It is shown in Table 8.
Influence of the 8 dendrobium candidum American ginseng capsule of table to mice serum urea nitrogen content
As shown in table 8, the middle and high dosage group serum urea nitrogen content of dendrobium candidum American ginseng capsule that embodiment 7-12 is obtained
There is reduction, and high dose group serum urea nitrogen content is substantially less than control group (P<0.05).
Result above shows that the mice burden swimming time of dendrobium candidum American ginseng capsule low dose group, middle high dose group are small
The hepatic glycogen content of mouse is all remarkably higher than blank control group (P<0.05)；High dose group serum urea nitrogen content is substantially less than blank
Control group (P<0.05).The Serum lactic acid content of 20 minutes points is substantially less than blank control group after the swimming of three dosage group animals
(P<0.05).Therefore it can be determined that the dendrobium candidum American ginseng capsule that embodiment 7-12 is obtained has the work(for alleviating physical fatigue
Energy.
Embodiments described above is part of the embodiment of the present invention, instead of all the embodiments.The reality of the present invention
The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiments of the present invention, those of ordinary skill in the art are obtained without creative efforts
Every other embodiment, belongs to the scope of protection of the invention.
Claims (10)
1. a kind of dendrobium candidum American ginseng capsule, it is characterised in that dendrobium candidum extract, 5-8 weight including 4-6 parts by weight
The American ginseng extract and the gadol extract of 18-22 parts by weight and the starch of 7-10 parts by weight of part,
The dendrobium candidum extract is prepared by the following manner：The drying stem of dendrobium candidum is cleaned rear water to carry, merges water
It is concentrated and dried and obtains after extract；
Wherein, water bag includes：Dry stem is mixed with water, bead, 70-80 DEG C of holding 10-20min is warming up to, is cooled to 20-
30 DEG C, it is collected by filtration to obtain the Aqueous extracts, the bead includes the first bead and the second bead, first glass
The density of pearl is less than the density of water, and the second bead density is more than the density of water.
2. dendrobium candidum American ginseng capsule according to claim 1, it is characterised in that dry stem is mixed with water, bead
Including：First bead is put into container and is laid in container bottom, the dry stem is layed in first glass
On glass pearl, second bead is placed on the dry stem, water is added along chamber wall.
3. dendrobium candidum American ginseng capsule according to claim 2, it is characterised in that first bead is hollow micro-
The total mass ratio of pearl, the gross mass of first bead and second bead is 0.9-1.1:1.
4. dendrobium candidum American ginseng capsule according to claim 3, it is characterised in that the dry stem is cut in advance in water
It is less than the segment of 3cm into length.
5. dendrobium candidum American ginseng capsule according to claim 3, it is characterised in that after Aqueous extracts concentration with it is described
Starch mixes, dry.
6. according to claim 1-5 any one of them dendrobium candidum American ginseng capsules, it is characterised in that the American Ginseng extraction
Thing is obtained by the following manner：American Ginseng dry root is crushed to below 20 mesh, ethanol extract is extracted to obtain with alcohol reflux, is concentrated
Afterwards the American ginseng extract is obtained with extracting n-butyl alcohol.
7. according to claim 1-5 any one of them dendrobium candidum American ginseng capsules, it is characterised in that the rhodiola root extraction
Thing is made by the following method：Rhodiola root is crushed, ethanol extract is extracted to obtain with ethanol, dries and obtains after being concentrated under reduced pressure.
8. such as the preparation method of claim 1-7 any one of them dendrobium candidum American ginseng capsules, it is characterised in that by described in
Capsule is packaged in after dendrobium candidum extract, the American ginseng extract, the gadol extract and starch mixing
In.
9. a kind of extracting method of dendrobium candidum, it is characterised in that the drying stem of dendrobium candidum is cleaned into rear water and is carried, merges water and carries
It is concentrated and dried after liquid and obtains extract；
Wherein, water bag includes：Dry stem is mixed with water, bead, 70-80 DEG C of holding 10-20min is warming up to, is cooled to 20-
30 DEG C, it is collected by filtration to obtain the Aqueous extracts, the bead includes the first bead and the second bead, first glass
The density of pearl is less than the density of water, and the second bead density is more than the density of water.
10. the preparation method of dendrobium candidum American ginseng capsule according to claim 9, it is characterised in that dry stem and water,
Bead mixing includes：First bead is put into container and is laid in container bottom, the dry stem is layed in
On first bead, second bead is placed on the dry stem, water is added along chamber wall.
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| CN115669835A (en) * | 2022-11-11 | 2023-02-03 | 广州市东鹏食品饮料有限公司 | Lucid ganoderma and dendrobium officinale anti-fatigue beverage |
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