CN107982321A - One kind nasal obstruction ventilation oil and its preparation method and application - Google Patents
One kind nasal obstruction ventilation oil and its preparation method and application Download PDFInfo
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- CN107982321A CN107982321A CN201711286332.0A CN201711286332A CN107982321A CN 107982321 A CN107982321 A CN 107982321A CN 201711286332 A CN201711286332 A CN 201711286332A CN 107982321 A CN107982321 A CN 107982321A
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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Abstract
Have a stuffy nose the invention discloses one kind and use ventilation oil and its preparation method and application, belong to the technical field of the medicine for the treatment of nasal obstruction.The present invention includes the raw material of following weight percentage：Eucalyptus oil 15 35%, dragon spruce essential oil 65 85%；The present invention gives the preparation method of above-mentioned ventilation oil, and eucalyptus oil and dragon spruce essential oil are uniformly mixed and obtained；The nasal cavity malaise symptoms such as the nasal obstruction when ventilation oil of the present invention is suitable for acute rhinitis, rhinitis chronic, allergic rhinitis and nasal obstruction caused by flu and has a running nose.The ventilation oil of the present invention has wetting, anti-inflammatory and antibacterial action, by soaking nasal cavity, dissolving nasal mucus and dredging respiratory system, has achieveed the purpose that ventilation, anti-inflammatory and cleaning nasal cavity, so as to thoroughly treat the nasal cavity malaise symptoms such as nasal obstruction and rhinorrhea, the pain of patient, smell delicate fragrance are alleviated, calm nerves, using simple, ventilatory effect is good, has no toxic side effect, cost is low, it is easy to carry, low, easily production is required production equipment.
Description
Technical field
The invention belongs to the technical field of nasal cavity applied medicine thing, particularly relate to a kind of nasal obstruction ventilate oil and preparation method thereof with
Using.
Background technology
Nasal obstruction and rhinorrhea are the cardinal symptoms of acute rhinitis, rhinitis chronic, allergic rhinitis and flu etc., and nasal obstruction is led
Cause patient respiratory difficult, can particularly aggravate during sleep at night, some unilateral nasal obstructions, some alternating nasal obstructions, some bilaterals are all
Nasal obstruction, serious patient mouth breathing when feeling bad of having a stuffy nose, running into cold air can also continuously sneeze, flow clear nasal mucus, very
Itch to rhiocnesmus and eye, can also cough gather, abundant expectoration or asthma, the time, which has been grown, can cause providing brain with oxygen insufficient, lessen one's memory and shadow
Ring IQ.
Occur the medicine of some treatment nasal obstructions in the prior art, such as：Chinese patent CN105412247A discloses one
The logical nose essential oil of kind, includes magnolia essential oil, root of Dahurain angelica essential oil and base oil, its weight proportion is 10-25 parts of magnolia essential oil, root of Dahurain angelica essence
Oily 10-20 parts and 10-20 parts of base oil；The essential oil is using rhinitis such as pure Chinese medicine essential oil treatment cold stuffy nasal obstruction, sneezing, rhinorrheas
Symptom, safe to use effectively to have no toxic side effect, not only adult can use, and infant is equally applicable；But this essential oil
Application method complexity is, it is necessary to lead to fragrant cave, nose cave, ophryon point, point Hegu, Danzhong, fei shu cave etc. is smeared and massaged, general
Logical people is difficult these acupuncture points of distinguishing one from the other, so that it is difficult to find these acupuncture points, causes its weak curative effect, it is impossible to meets the need of nasal obstruction patient
Ask.
The content of the invention
Have a stuffy nose the object of the present invention is to provide one kind and use ventilation oil and its preparation method and application, solve in the prior art
The problem of leading to nose essential oil application method complexity and causing its weak curative effect.
A kind of nasal obstruction ventilation oil of the present invention, what it was mainly realized by the following technical programs：Including following
The raw material of weight percentage：Eucalyptus oil 15-35%, dragon spruce essential oil 65-85%.
The ventilation oil of the present invention has wetting, anti-inflammatory and antibacterial action, is breathed by soaking nasal cavity, dissolving nasal mucus and dredging
System, has achieveed the purpose that ventilation, anti-inflammatory and cleaning nasal cavity, so as to thoroughly treat acute rhinitis, rhinitis chronic, allergic rhinitis
With flu caused by nasal obstruction and the nasal cavity malaise symptoms such as nasal obstruction when having a running nose, alleviate the pain of patient, its smell delicate fragrance can
With calm nerves, the mood of smooth fluctuation, alleviates the state of mind for being on wires and being easy to irascible, ventilatory effect is good, nontoxic pair
Effect, cost is low, easy to carry；It need to be only sprayed at during use on clothes or be sprayed at during sleep on pillow cover, patient can
The taste of ventilation oil is smelt, application method is very simple, very popular.
As a kind of preferred embodiment, include the raw material of following weight percentage：Eucalyptus oil 20-30%, dragon spruce
Essential oil 70-80%.Eucalyptus oil is to asthma, influenza, the infection of the upper respiratory tract (bronchitis, cough in the ventilation oil of the present invention
Cough) etc. there is good therapeutic efficiency, have effectively alleviate sinus infection, influenza, bronchitis, cold nasal obstruction and other breathing
The effect of systemic disease；Dragon spruce essential oil can effectively be alleviated and eliminate nasal obstruction and effect snotty, after both mix, its
Effect mutually collaboration, complements each other, in nasal obstruction and stream caused by treatment acute rhinitis, rhinitis chronic, allergic rhinitis and flu
There is the effect of notable in terms of the nasal cavity such as nasal obstruction during nasal mucus malaise symptoms.
As a kind of preferred embodiment, include the raw material of following weight percentage：Eucalyptus oil 25-30%, dragon spruce
Essential oil 70-75%.The eucalyptus oil of the present invention also has certain bactericidal effect, can clean nasal cavity, promote the damage of nasal membrane
Wound is repaired, and keeps cleaning and maintaining in nasal cavity the activity of nasal membrane；The dragon spruce essential oil of the present invention, which also has, alleviates body pole
Tired, antifatigue and strength anti-inflammatory effect is spent, can releive patient mood, the nerve of gentle patient, make patient heart pleasant；
The ventilation oil ventilatory effect is notable, also with antibacterial action, is loved by consumers.
As a kind of preferred embodiment, the eucalyptus oil include Cineole, terpinol, firpene, terpinyl acetate and
Aromadendrene, the content of Cineole are more than 85%.Eucalyptus oil, to weak yellow liquid, has the smell like camphor and borneol, master to be colourless
Contain the components such as cineole (65-75%), terpenes, isoamyl leaf oil, Eucarvone, pulegone and piperitone, be dissolved in ethanol, it is several
It is not soluble in water；Eucalyptus oil is since with biocidal efficacies, a kind of simple and effective disinfectant can be become by being mixed with water, be usually used in
Treat bruise and skin disease；Eucalyptus oil rate of oxygen is high, is extraordinary respiratory system physical therapy oil, sexy to asthma, prevalence
Emit with the great effect such as the infection of the upper respiratory tract (bronchitis, cough), can effectively alleviate sinus infection, influenza, bronchitis,
Cold nasal obstruction and other respiratory diseases.Eucalyptus oil is also used as fragrance component, is good culicifuge, meanwhile, eucalyptus oil
The state of mind for being on wires and being easy to irascible can be alleviated with the mood of smooth fluctuation, or treat wound and abscess it is best
One of essential oil.Eucalyptus oil purposes is very extensive, available for preparing cosmetics, toothpaste, perfumed soap, detergent, cleaning agent for mouth cavity, interior
Detergent, chewing gum etc., can also be used as the medicinal raw materials such as oral cavity, rhinitis use, eliminating the phlegm use, cooling ointment, wind dispelling cream.
As a kind of preferred embodiment, the dragon spruce essential oil includes terpinenes, amphene, firpene, camphor, borneol and dragon
Brain ethyl ester, the content of terpinenes are more than 22.5%.Oxygenatedchemicals occupies sizable ratio in dragon spruce essential oil, and main component is
Borneol, camphor and borneol ethyl ester etc., dragon spruce essential oil naturally have effects that to eliminate mucous hyperemia, effectively can alleviate and eliminate
Nasal obstruction and have a running nose, also have certain effect of releiving, the caused nerve of balance overwork for symptoms such as the headaches that is brought by flu
System disorders, meanwhile, there is antimycotic and anti-infectious effect.
A kind of nasal obstruction of present invention preparation method of ventilation oil, it is mainly realized by the following technical programs
's：Comprise the following steps：1) eucalyptus oil and dragon spruce essential oil are taken respectively, it is spare；2) eucalyptus oil and dragon spruce essential oil are uniformly mixed, obtained
To ventilation oil.
The preparation method technique of present invention ventilation oil is simple, and mild condition, production equipment requirement is low, and raw material sources are wide, raw
It is low to produce cost, it is with short production cycle, it is easy to accomplish large-scale production；Moreover, it is easy to carry, have a wide range of application, available for acute nose
Inflammation, rhinitis chronic, allergic rhinitis and nasal obstruction caused by flu and the nasal cavity malaise symptoms such as nasal obstruction when having a running nose, during use only
It need to be sprayed on clothes or be sprayed at during sleep on pillow cover, patient can smell the taste of ventilation oil, user
Method is very simple, and short treating period, dosage is few, deep to be welcome by patient.
The molecular structure of eucalyptus oil and dragon spruce essential oil is very small in the ventilation oil of the present invention, is the 1/ of Skin Cell gap
10, there are very strong permeability and volatility, the two works human body by two paths.First, eucalyptus oil and dragon spruce essence
Oil by schneiderian membrane enters human body, can penetrate within general 4 seconds schneiderian membrane cell, Cineole, alcohol, alkene and fat in eucalyptus oil
Class material, and terpinenes, camphor, various alkenes lipid materials contained by dragon spruce essential oil, can stimulate the work of schneiderian membrane cell
Property, strengthen schneiderian membrane cell metabolism, keep vibrissa uprightly and promote epithelial cilia swing, preferably stop air in compared with
Big grit suction, will stick together have grit, the mucus of bacterium is arranged to pharyngeal；Meanwhile eucalyptus oil and the excellent antibacterial of dragon spruce essential oil
And bactericidal property, the inflammation of schneiderian membrane can be eliminated, further reduces stimulation of the external environment condition to schneiderian membrane, alleviates and eliminates
The congested phenomenon of schneiderian membrane；Also, stimulate and reduce the reduction of glandular secretion thing, the nasal mucus that schneiderian membrane irritability produces is reduced, and nose glues
Film recovers normal physiological activity, has lasting heating and humidification to the air of suction, so that improve and eliminate mycteroxerosis,
The symptoms such as nasal obstruction, stream nose tears.Secondly, eucalyptus oil and dragon spruce essential oil can penetrate into for general 0.5 second after breathing and entering lung
Alveolar, can enter blood circulation and Lymphatic Circulation for 1 minute, Cineole, alcohol, alkene and lipid material and dragon spruce in eucalyptus oil
Terpinenes, camphor, various alkenes lipid materials, can stimulate respiratory system contained by essential oil, and control machine somatic nerves and muscle are put
Pine, makes breathing lengthen and deepen, makes breathing smooth.
As a kind of preferred embodiment, in the step 2), eucalyptus oil and dragon spruce essential oil mix at room temperature.Eucalyptus
Oil and dragon spruce essential oil can be achieved it and be mutually dissolved at room temperature, and eucalyptus oil is dissolved into dragon spruce essential oil, both mutually promote, phase
Mutually collaboration, plays a role jointly；Room temperature will not damage eucalyptus oil and the dragon spruce essential oil component of itself, its active ingredient is most
Limits play a role, so as to reach the effect of more preferable.
A kind of application of nasal obstruction of present invention ventilation oil, what it was mainly realized by the following technical programs：Institute
State ventilation oil and be used for acute rhinitis, rhinitis chronic, allergic rhinitis and nasal obstruction symptom caused by flu.The ventilation oil of the present invention is logical
Wetting nasal cavity, dissolving nasal mucus and dredging respiratory system are crossed, has achieveed the purpose that ventilation, anti-inflammatory and cleaning nasal cavity, has effectively alleviated
Acute rhinitis, rhinitis chronic, allergic rhinitis and nasal obstruction symptom caused by flu, have that ventilatory effect is good, the easy to use, course for the treatment of
The advantages of short and usage amount is few.
Compared with prior art, the beneficial effects of the invention are as follows：There is the ventilation oil of the present invention wetting, anti-inflammatory and antibacterial to make
With, by soak nasal cavity, dissolving nasal mucus and dredging respiratory system, achieveed the purpose that ventilation, anti-inflammatory and cleaning nasal cavity so that thorough
The nasal cavities such as nasal obstruction when bottom treatment acute rhinitis, rhinitis chronic, allergic rhinitis and nasal obstruction caused by flu and rhinorrhea are uncomfortable
Symptom, alleviates the pain of patient；Its smell delicate fragrance, can be with calm nerves, and ventilatory effect is good, and short treating period, usage amount is few, nontoxic
Side effect, cost is low, easy to carry, easy to use；Its preparation method technique is simple, mild condition, and production equipment requires low, original
Expect that source is wide, it is with short production cycle, it is easy to accomplish large-scale production.
Embodiment
Technical scheme is clearly and completely described below in conjunction with the specific embodiment of the present invention, is shown
So, described embodiment is only the part of the embodiment of the present invention, instead of all the embodiments.Based in the present invention
Embodiment, those of ordinary skill in the art's all other embodiments obtained without creative efforts, all
Belong to the scope of protection of the invention.
Embodiment one
A kind of nasal obstruction of present invention preparation method of ventilation oil, comprises the following steps：
1) taken respectively according to following parts by weight and weigh raw material：Eucalyptus oil 15g, dragon spruce essential oil 85g, it is spare；
2) eucalyptus oil and dragon spruce essential oil are uniformly mixed, obtain ventilation oil.
Embodiment two
A kind of nasal obstruction of present invention preparation method of ventilation oil, comprises the following steps：
1) taken respectively according to following parts by weight and weigh raw material：Eucalyptus oil 35g, dragon spruce essential oil 65g, it is spare；
2) eucalyptus oil and dragon spruce essential oil are uniformly mixed at room temperature, obtain ventilation oil.
Embodiment three
A kind of nasal obstruction of present invention preparation method of ventilation oil, comprises the following steps：
1) taken respectively according to following parts by weight and weigh raw material：Eucalyptus oil 28.5g, dragon spruce essential oil 71.5g, it is spare；
2) eucalyptus oil and dragon spruce essential oil are uniformly mixed at room temperature, obtain ventilation oil.
Experiment 1
By using the embodiment of the present invention one to embodiment three method prepare ventilation oil i.e. experiment sample with it is existing commercially available
Naphazoline, that is, control sample one is respectively used to cause the patient of nasal obstruction to carry out daily nursing rhinitis and flu etc., and records clinical treatment
Imitate observation experiment result.
1.1 case scenario
Outpatient service and inpatient are counted, is observed altogether because rhinitis and flu etc. cause the patient 160 of nasal obstruction, average age 35
Year, patient have different degrees of nasal obstruction symptom；Patient is randomly divided into four groups, respectively using the embodiment of the present invention one to implementation
The obtained oily and commercially available Naphazoline, that is, control sample one of ventilation of example three.Every four hours using once, 4 spray every time, and effect is observed after 4 times
Fruit；Wherein, the embodiment of the present invention one to the obtained ventilation oil of embodiment three is to be sprayed on clothes or be sprayed at during sleep
On pillow cover, control sample one is to be sprayed directly on nasal cavity by spraying nose application.
1.2 efficacy assessment standard
It is effective：Symptom of having a stuffy nose disappears, smooth breathing；
Effectively：Nasal obstruction symptom disappears substantially, phenomenon of occasionally feeling suffocated；
It is invalid：Nasal obstruction symptom does not improve, or even has exacerbation trend, has difficulty in breathing；
Calculation formula：[(total number of persons-invalid number) ÷ total numbers of persons] × 100%.
1.3 clinical observation result
Table 1 ventilate oil and Naphazoline to nasal obstruction treatment clinical efficacy comparing result table
| Name of product | Effective (example) | Effectively (example) | Invalid (example) | Total effective rate (%) |
| Embodiment one | 26 | 12 | 2 | 95.0 |
| Embodiment two | 25 | 13 | 2 | 95.0 |
| Embodiment three | 26 | 11 | 3 | 92.5 |
| Control sample one | 10 | 26 | 4 | 90.0 |
As can be seen from Table 1, compared with existing commercially available Naphazoline, that is, control sample one, the ventilation of method of the invention preparation
When oil is used for nasal obstruction patient caused by rhinitis and flu, obvious effective rate improves with having obtained conspicuousness, and effective number is improved more than two times,
Obvious effective rate is up to 65%, and invalid number is decreased obviously, and inefficiency reduces 50%, and total effective rate is improved；Total effective rate is pressed
Calculated according to above-mentioned formula.Therefore, the effect of ventilation oil of the invention is when treating nasal obstruction symptom caused by rhinitis and flu is notable
Better than commercially available Naphazoline.
Experiment 2
By using the embodiment of the present invention one to embodiment three method prepare ventilation oil i.e. experiment sample with it is existing commercially available
Naphazoline, that is, control sample one is respectively used to cause rhinitis and flu etc. rhiocnesmus, nose inflammation and patient snotty progress daily
Nursing, and record clinical observation on the therapeutic effect experimental result.
1.1 case scenario
Outpatient service and inpatient are counted, is observed altogether because rhinitis and flu etc. cause rhiocnesmus, nose inflammation and trouble snotty
Person 160, average age 33 years old, patient have the symptoms such as different degrees of rhiocnesmus, nose inflammation and rhinorrhea；Patient is random
It is divided into four groups, is respectively the oily and commercially available Naphazoline, that is, control sample one of ventilation made from the embodiment of the present invention one to embodiment three.Often
Every four hours using once, 4 spray every time, observing effect after 4 times；Wherein, lead to made from the embodiment of the present invention one to embodiment three
Gas and oil is to be sprayed on clothes or be sprayed at during sleep on pillow cover, and control sample one is to be sprayed directly on nasal cavity to pass through spray
Nose application.
1.2 efficacy assessment standard
It is effective：Rhiocnesmus, nose inflammation and rhinorrhea symptom are obviously improved；
Effectively：Rhiocnesmus, nose inflammation and rhinorrhea symptom take a favorable turn；
It is invalid：Rhiocnesmus, nose inflammation and rhinorrhea symptom are not improved or aggravate；
Calculation formula：[(total number of persons-invalid number) ÷ total numbers of persons] × 100%.
1.3 clinical observation result
Table 2 ventilates oil and Naphazoline to rhiocnesmus, nose inflammation and the clinical efficacy comparing result table for flowing nose tears symptom treatment
| Name of product | Effective (example) | Effectively (example) | Invalid (example) | Total effective rate (%) |
| Embodiment one | 23 | 14 | 3 | 92.5 |
| Embodiment two | 21 | 15 | 4 | 90.0 |
| Embodiment three | 25 | 12 | 3 | 92.5 |
| Control sample one | 11 | 23 | 6 | 85.0 |
As can be seen from Table 2, compared with existing commercially available Naphazoline, that is, control sample one, the ventilation of method of the invention preparation
When oil is used for rhiocnesmus, nose inflammation and rhinorrhea patient caused by rhinitis and flu, obvious effective rate improves with having obtained conspicuousness, shows
Effect number improves nearly two times, and invalid number is decreased obviously, and inefficiency reduces 50%, and total effective rate is improved, total effective
Rate is calculated according to above-mentioned formula；Therefore, ventilation oil of the invention is in rhiocnesmus, nose inflammation and stream caused by treatment rhinitis and flu
The effect of during nasal mucus symptom, is significantly better than commercially available Naphazoline.
The ventilation oil effect of the present invention is good and without any side effects, and children and adult can be used, eucalyptus oil and dragon spruce
Essential oil molecule is very small, after use 12 it is small when within can excrete, be not detained in vivo, as long as application method and dosage are just
Really, any side effect is not had.And product such as Naphazoline, that is, control sample first-class ephedrine class product of presently commercially available treatment nasal obstruction,
It is a kind of adrenergic, long-time service, can cause rhinitis medicamentosa, atrophic rhinitis, ephedrine is to heart and maincenter god
It is more through system side effect, such as long-time service, vascular wall anoxic can be produced, Secondary cases blood vessel dilatation can be caused, easily produce according to
Rely, with the passing of time can form rhinitis medicamentosa；This product also result in infant occur it is drowsiness, vomiting etc. symptom, such product be
Disable and the report of poisoning is played with the efficacy-enhancing ingredient in infant patient, existing more infants domestic at present.
Compared with prior art, the beneficial effects of the invention are as follows：There is the ventilation oil of the present invention wetting, anti-inflammatory and antibacterial to make
With, by soak nasal cavity, dissolving nasal mucus and dredging respiratory system, achieveed the purpose that ventilation, anti-inflammatory and cleaning nasal cavity so that thorough
The nasal cavities such as nasal obstruction when bottom treatment acute rhinitis, rhinitis chronic, allergic rhinitis and nasal obstruction caused by flu and rhinorrhea are uncomfortable
Symptom, alleviates the pain of patient；Its smell delicate fragrance, can be with calm nerves, and ventilatory effect is good, and short treating period, usage amount is few, nontoxic
Side effect, cost is low, easy to carry, easy to use；Its preparation method technique is simple, mild condition, and production equipment requires low, original
Expect that source is wide, it is with short production cycle, it is easy to accomplish large-scale production.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
With within principle, any modification, equivalent replacement, improvement and so on, should all be included in the protection scope of the present invention god.
Claims (8)
1. one kind nasal obstruction ventilation oil, it is characterised in that：Include the raw material of following weight percentage：
Eucalyptus oil 15-35%, dragon spruce essential oil 65-85%.
2. nasal obstruction according to claim 1 ventilation oil, it is characterised in that：Include the raw material of following weight percentage：
Eucalyptus oil 20-30%, dragon spruce essential oil 70-80%.
3. nasal obstruction according to claim 2 ventilation oil, it is characterised in that：Include the raw material of following weight percentage：
Eucalyptus oil 25-30%, dragon spruce essential oil 70-75%.
4. nasal obstruction according to claim 1 ventilation oil, it is characterised in that：
The eucalyptus oil includes Cineole, terpinol, firpene, terpinyl acetate and aromadendrene, and the content of Cineole is more than 85%.
5. nasal obstruction according to claim 1 ventilation oil, it is characterised in that：
The dragon spruce essential oil includes terpinenes, amphene, firpene, camphor, borneol and borneol ethyl ester, and the content of terpinenes is more than
22.5%.
6. the preparation method of the nasal obstruction ventilation oil according to any one in claim 1-5, it is characterised in that：Including with
Lower step：
1) eucalyptus oil and dragon spruce essential oil are taken respectively, it is spare；
2) eucalyptus oil and dragon spruce essential oil are uniformly mixed, obtain ventilation oil.
7. the preparation method of nasal obstruction ventilation oil according to claim 6, it is characterised in that：
In the step 2), eucalyptus oil and dragon spruce essential oil mix at room temperature.
8. the application of the nasal obstruction ventilation oil according to any one in claim 1-5, it is characterised in that：
The ventilation oil is used for acute rhinitis, rhinitis chronic, allergic rhinitis and nasal obstruction symptom caused by flu.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711286332.0A CN107982321A (en) | 2017-12-07 | 2017-12-07 | One kind nasal obstruction ventilation oil and its preparation method and application |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711286332.0A CN107982321A (en) | 2017-12-07 | 2017-12-07 | One kind nasal obstruction ventilation oil and its preparation method and application |
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| Publication Number | Publication Date |
|---|---|
| CN107982321A true CN107982321A (en) | 2018-05-04 |
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ID=62036796
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711286332.0A Pending CN107982321A (en) | 2017-12-07 | 2017-12-07 | One kind nasal obstruction ventilation oil and its preparation method and application |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111317756A (en) * | 2020-04-22 | 2020-06-23 | 洛阳采方医药科技有限公司 | A Chinese medicinal composition liquid blasting bead for mask and its preparation method |
-
2017
- 2017-12-07 CN CN201711286332.0A patent/CN107982321A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111317756A (en) * | 2020-04-22 | 2020-06-23 | 洛阳采方医药科技有限公司 | A Chinese medicinal composition liquid blasting bead for mask and its preparation method |
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Application publication date: 20180504 |
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