CN107970396A - A kind of herbal composite for improving rainbow trout Performance and immune function - Google Patents

A kind of herbal composite for improving rainbow trout Performance and immune function Download PDF

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Publication number
CN107970396A
CN107970396A CN201610918347.3A CN201610918347A CN107970396A CN 107970396 A CN107970396 A CN 107970396A CN 201610918347 A CN201610918347 A CN 201610918347A CN 107970396 A CN107970396 A CN 107970396A
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parts
radix
rainbow trout
malt
bark
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刘鼎阔
赵晶晶
王立红
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Dingzheng Animal Pharmaceutical Tianjin Co Ltd
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Dingzheng Animal Pharmaceutical Tianjin Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13Coniferophyta (gymnosperms)
    • A61K36/15Pinaceae (Pine family), e.g. pine or cedar
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/344Codonopsis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/46Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/894Dioscoreaceae (Yam family)
    • A61K36/8945Dioscorea, e.g. yam, Chinese yam or water yam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8998Hordeum (barley)

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
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Abstract

The present invention relates to a kind of herbal composite for improving rainbow trout Performance and immune function, it is characterised in that:Include the following components of the proportioning of fraction by weight:20~30 parts of radix glycyrrhizae, 25~35 parts of pine needle, 25~40 parts of malt, 25~35 parts of radix astragali, 10~20 parts of the bark of eucommia, 15~25 parts of hawthorn, 15~25 parts of Radix Codonopsis, 5~10 parts of the tuber of multiflower knotweed, 8~15 parts of Chinese yam, 5~8 parts of sea-buckthorn, 35~45 parts of honeysuckle.The present invention is according to tcm theory, scientific compatibility.Each taste Chinese herbal medicine contains multiple nutritional components and bioactive substance in side.Such as bark of eucommia contains chlorogenic acid, loose ester alcohol diglucoside, amino acid, trace element, can promote the metabolism of cholesterol and lipid, improve meat;Pine needle contains 18 kinds of amino acid, and vitamin A, B1, B2, E, K, C and trace element etc., Radix Codonopsis cauline leaf contains 18 kinds of amino acid, 12 kinds of inorganic elements and active material;The main component of radix glycyrrhizae is glycyrrhizic acid, liquiritin etc., has strengthen immunity, maintains the function of water-electrolyte metabolism balance;Malt is rich in nutritional ingredients such as vitamin B1, nicotinic acid, phosphorus, potassium, iron, zinc, protein.These above-mentioned components can play the role of extra-nutrition.The invention has extra-nutrition, deposits into growth, build up health, improve the effect of premunition as additive of bait.

Description

A kind of herbal composite for improving rainbow trout Performance and immune function
Technical field
The invention belongs to Medicines in Aquaculture technical field, especially a kind of Chinese herbal medicine combination for improving rainbow trout growth performance index Thing.
Background technology
Rainbow trout category Osteichthyes, salmonidae, dog salmon category, be it is a kind of it is precious it is worldwide be cold water culture fish.Should Meat quality of fish is fresh and tender, full of nutrition, and edible value is high, growth is rapid, easily fishing, artificial propagation is simple and easy to do, it has also become the United Nations One of food and agricultural organization's four freshwater fish class breed variety high and best in quality to the yield of world-wide deployment.Since rainbow trout is supported The continuous expansion of scale is grown, breeding environment deteriorates, and various diseases are increasing, and economic loss is huge.
Chinese herbal medicine is natural drug, the active material rich in enhancing human body immune function, has that toxic side effect is small, resource is rich Richness, be not likely to produce the advantages that drug resistance, and favor is searched in aquaculture.The species of Chinese herbal medicine is enriched, for different effects Object and purpose have a variety of compatibilities, multiple choices are provided for disease preventing and treating, enhancing body's immunity, by as " green Medicine " is increasingly extensive to be applied to aquaculture of aquatic animal, also provides wide sky to promote fish body to grow and improve its immunity Between.
The content of the invention
It is an object of the invention in place of overcome the deficiencies in the prior art, there is provided safe to use, environmentally protective one kind can Improve the herbal composite of rainbow trout growth performance index and immune function.
The technical solution adopted by the present invention is:
A kind of herbal composite for improving rainbow trout growth performance index and immune function, it is characterised in that:Including The following components of fraction proportioning by weight:20~30 parts of radix glycyrrhizae, 25~35 parts of pine needle, 25~40 parts of malt, 25~35 parts of radix astragali, 10~20 parts of the bark of eucommia, 15~25 parts of hawthorn, 15~25 parts of Radix Codonopsis, 5~10 parts of the tuber of multiflower knotweed, 8~15 parts of Chinese yam, 5~8 parts of sea-buckthorn, gold 35~45 parts of of honeysuckle flower
Moreover, the component is 25 parts of radix glycyrrhizae, and 30 parts of pine needle, 35 parts of malt, 25 parts of radix astragali, 15 parts of the bark of eucommia, 20 parts of hawthorn, 25 parts of Radix Codonopsis, 8 parts of the tuber of multiflower knotweed, 10 parts of Chinese yam, 6 parts of sea-buckthorn, 40 parts of of honeysuckle
The advantages and positive effects of the present invention are:
The present invention is according to tcm theory, scientific compatibility.Each taste Chinese herbal medicine is lived containing multiple nutritional components and biology in side Property material.Such as bark of eucommia contains chlorogenic acid, loose ester alcohol diglucoside, amino acid, trace element, can promote cholesterol and lipid Metabolism, improve meat;Pine needle contains 18 kinds of amino acid, vitamin A, B1, B2, E, K, C and trace element etc., Radix Codonopsis cauline leaf Containing 18 kinds of amino acid, 12 kinds of inorganic elements and active material;The main component of radix glycyrrhizae is glycyrrhizic acid, liquiritin etc., is had Strengthen immunity, maintains the function of water-electrolyte metabolism balance;Malt is rich in vitamin B1, nicotinic acid, phosphorus, potassium, iron, zinc, protein etc. Nutritional ingredient.These above-mentioned components can play the role of extra-nutrition.The invention as additive of bait, have extra-nutrition, Growth is deposited into, is built up health, improves the effect of premunition.
Embodiment
With reference to embodiment, the present invention is further described, and following embodiments are illustrative, be not it is limited, Protection scope of the present invention cannot be limited with following embodiments.
A kind of herbal composite for improving rainbow trout growth performance index and immune function, it is characterised in that:Including The following components of fraction proportioning by weight:20~30 parts of radix glycyrrhizae, 25~35 parts of pine needle, 25~40 parts of malt, 25~35 parts of radix astragali, 10~20 parts of the bark of eucommia, 15~25 parts of hawthorn, 15~25 parts of Radix Codonopsis, 5~10 parts of the tuber of multiflower knotweed, 8~15 parts of Chinese yam, 5~8 parts of sea-buckthorn, gold 35~45 parts of of honeysuckle flower
Most preferred group is divided into 25 parts of radix glycyrrhizae, 30 parts of pine needle, 35 parts of malt, 25 parts of radix astragali, 15 parts of the bark of eucommia, 20 parts of hawthorn, party 25 parts of ginseng, 8 parts of the tuber of multiflower knotweed, 10 parts of Chinese yam, 6 parts of sea-buckthorn, 40 parts of of honeysuckle
The preparation method of the medicine is:
1. each component is each crushed, the granularity of crushing can all pass through 80 mesh sieve nets.
2. each component after crushing is weighed successively, is checked.
3. each component is added in V-type high efficient mixer, mixing 25 minutes, to obtain the final product.
Experiment process is:
1. comparative formula
Compound 1:20 kilograms of garlic;50 kilograms of honeysuckle, 30 kilograms of Divine Comedy, 20 kilograms of cloves, 30 kilograms of earthworm,;Dried orange peel 20 kilograms, 30 kilograms of radix scutellariae, 40 kilograms of the coptis, 20 kilograms of gynostemma pentaphylla, 20 kilograms of the dried immature fruit of citron orange.
Compound 2:30 kilograms of hawthorn, 30 kilograms of folium artemisiae argyi, 30 kilograms of fennel seeds, 30 kilograms of the fleece-flower root, 20 kilograms of rhizoma zingiberis, pine needle 30 kilograms, 30 kilograms of capsicum, 20 kilograms of sea-buckthorn, 15 kilograms of the banksia rose, 15 kilograms of monkshood.
Most preferably component:25 parts of radix glycyrrhizae, 30 parts of pine needle, 35 parts of malt, 25 parts of radix astragali, 15 parts of the bark of eucommia, 20 parts of hawthorn, Radix Codonopsis 25 parts, 8 parts of the tuber of multiflower knotweed, 10 parts of Chinese yam, 6 parts of sea-buckthorn, 40 parts of of honeysuckle
2. the component of feed
Above-mentioned three kinds of Chinese herb compounds, are added in basal feed with mass fraction 0.3%, add the feed of medicine respectively The grit of 3.5 millimeters of diameter is made through feed processor, it is spare after dry.Basal feed formula is shown in Table 1.
1. basal feed formula of table
3. experimental condition and management
The rainbow trout for choosing health is experiment fingerling, and totally 360 tail, is randomly divided into four groups, is 1 group of compound, compound 2 respectively Group, optimal set packet and control group, every group of 3 repetitions, divide and support in 12 aquariums (130cm × 100cm × 80cm), often 30 tails of group.
Test group and feed corresponding feed, control group feeds basal feed, and feeding rate is 2%, raises 60 days.
The water temperature of during the experiment has circulation filter pump and inflator pump, refreshes the water periodically and clean filter pulp at 20.4~27.3 DEG C, ties up Dissolved oxygen is held in 4.6~7.2mg/L, for pH value 6.2~8.0, the concentration of control ammonia (NH3) is less than 0.02mg/L, control nitrous The content of hydrochlorate (NO2-) is less than 0.20mg/L.
4. Testing index
4.1 growth performances (terminate to stop within first 1 day feeding) on the day of on-test and on the day of terminating, and claim fish with electronic balance Weight (is accurate to 0.01g), calculates feed coefficient, feed conversion rate, rate of body weight gain and specific growth rate.Result of the test is shown in Table 2.
After the test, each group randomly selects 15 tail fishes to 4.2 liver function indexs, tail vein blood, separates serum, measure with The related biochemical indicator of liver function.With spectrophotometric determination Serum Adenosine Deaminase (ADA) activity, gamma glutamyl transpeptidase (γ-GT) activity, cholinesterase (CHE) activity and total bilirubin (TBIL) concentration.Used kit is purchased from Nanjing and builds up life Thing Graduate School of Engineering.Result of the test is shown in Table 3
After the test, each group randomly selects 15 tail fishes to 4.3 liver index, after gathering liver, weighs wet quality immediately, calculates liver Index.Liver index=liver quality (g)/weight (g).Result of the test is shown in Table 3
5. result of the test
Table 2:Influence of the herbal composite to rainbow trout growth performance
Influence of 3 herbal composite of table to rainbow trout liver function
From above-mentioned every result, the effect of most preferred component is best, can effectively facilitate the growth of rainbow trout, improve it Immunity of organisms.
In conclusion the present invention is according to tcm theory, scientific compatibility, obtained finished product have to rainbow trout good growth promotion and Improve the effect of immunity, multi-medicament cooperates, and can strengthen its drug effect and reconcile bias, makes its toxicity, eliminate or Mitigate the harmful effect to body, can preferably adapt to complicated illness than simple, improve therapeutic effect.The present invention is a kind of Good effect, nuisanceless, noresidue, Chinese medicine easy to use, especially suitable for extensive fish culture.

Claims (2)

  1. A kind of 1. herbal composite for improving rainbow trout growth indexes and immune function, it is characterised in that:Including by weight The following components of fraction proportioning:20~30 parts of radix glycyrrhizae, 25~35 parts of pine needle, 25~40 parts of malt, 25~35 parts of radix astragali, the bark of eucommia 10 ~20 parts, 15~25 parts of hawthorn, 15~25 parts of Radix Codonopsis, 5~10 parts of the tuber of multiflower knotweed, 8~15 parts of Chinese yam, 5~8 parts of sea-buckthorn, honeysuckle 35 ~45 parts.
  2. 2. a kind of herbal composite for improving rainbow trout Performance and immune function according to claim 1, its It is characterized in that:The component is 25 parts of radix glycyrrhizae, 30 parts of pine needle, 35 parts of malt, 25 parts of radix astragali, 15 parts of the bark of eucommia, 20 parts of hawthorn, Radix Codonopsis 25 parts, 8 parts of the tuber of multiflower knotweed, 10 parts of Chinese yam, 6 parts of sea-buckthorn, 40 parts of honeysuckle.
CN201610918347.3A 2016-10-21 2016-10-21 A kind of herbal composite for improving rainbow trout Performance and immune function Pending CN107970396A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110839784A (en) * 2019-10-31 2020-02-28 洛阳师范学院 Rainbow trout fingerling compound Chinese herbal medicine compound feed capable of enhancing immune function and preparation method thereof
CN113287687A (en) * 2021-05-14 2021-08-24 四川大农佳品农业科技有限公司 Medicinal and edible Chinese herbal medicine live pig feed additive and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110839784A (en) * 2019-10-31 2020-02-28 洛阳师范学院 Rainbow trout fingerling compound Chinese herbal medicine compound feed capable of enhancing immune function and preparation method thereof
CN113287687A (en) * 2021-05-14 2021-08-24 四川大农佳品农业科技有限公司 Medicinal and edible Chinese herbal medicine live pig feed additive and preparation method thereof

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