CN107970356A - A kind of benzoic pharmaceutical composition - Google Patents
A kind of benzoic pharmaceutical composition Download PDFInfo
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- CN107970356A CN107970356A CN201711414062.7A CN201711414062A CN107970356A CN 107970356 A CN107970356 A CN 107970356A CN 201711414062 A CN201711414062 A CN 201711414062A CN 107970356 A CN107970356 A CN 107970356A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The present invention provides a kind of benzoic pharmaceutical composition, it is characterised in that the pharmaceutical composition prescription parts by weight are calculated as 50 300 parts of styrax, 50 300 parts of camphor, 50 280 parts of garlic, 50 260 parts of Chinese prickly ash, 30 200 parts of Chinese Fevervine Herb, 30 180 parts of radix astragali, 10 100 parts of radix glycyrrhizae.The drug combination preparation is made of pharmaceutically acceptable carrier, and formulation includes water decoction, pill, tablet, capsule, granule, electuary and oral liquid.The present composition is evident in efficacy for roundworm disease, enterobiasis, has no toxic side effect.
Description
Technical field
The invention belongs to field of traditional Chinese, and in particular to a kind of benzoic pharmaceutical composition.
Background technology
Roundworm, hookworm and whipworm are most common several intestinal nematodes, can cause the intestinal nematode infection or enteron aisle of human body
Nematodiasis.Roundworm is to parasitize the most parasitic nematode of mankind's internal organ, can grow to 15 to 35 centimeter lengths.Roundworm is passed by ingesting
Broadcast.The splanchnopleure of people is pierced through after roundworm egg hatching quickly, into blood.Lung is entered by blood flow, then by expectoration and is swallowed,
Turn again to internal organ.Parasitizing in human body, taste mechanism of qi can be upset, roundworm happiness temperature, To Be Protected from Heat for aversion to cold, and property, which is moved, alters, and is good at drilling,
Therefore work as human body dysfunction of spleen and stomach, or have whole body generate heat illness when, roundworm i.e. easily run helter-skelter in abdomen and cause a variety of diseases.Because of ascarid
Insect infection and the illness for causing acute abdominalgia and peripheral coldness, symptoms include cramp, cold limbs, pain very then sweating, or ptysis
Foam, or vomiting of ascaris worm, when stop when sending out, or with syndromes such as fever and chills, gastrointestinal dysfunctions.Enterobiasis is to cause anus, perineum
A kind of intestinal parasitical diseases with the characteristics of itch.It is popular extremely wide all over the world, whole world infection population 300~500,000,000, China
South, the north are generally popular, and childhood infection rate is higher than adult.Especially collective's institution child infection rate is high.National survey data sheet
Child's infection rate will be up to 40%~70% tomorrow.In family's often most members illness at the same time of sanitary condition difference.Therefore enterobiasis is value
The disease that must pay attention to.
At present, what Chinese medicine the inside expelling parasite prescription was famous is Black Plum Pill, but it is ineffective for abdominal pain；And Western medicine is mainly
Albendazole and mebendazole, effect is preferable, but long-time service, often occur such as dry, dizziness, headache, abdominal distension, abdominal pain,
The side effects such as fash.And the present invention has found by clinical practice for many years, tool has a better effect, safe.
The content of the invention
A kind of the present invention is intended to provide benzoic pharmaceutical composition.
For achieving the above object, a kind of benzoic pharmaceutical composition of the present invention, its concrete scheme are：
A kind of benzoic pharmaceutical composition of the present invention, its prescription parts by weight are calculated as：
50-300 parts of styrax, 50-300 parts of camphor, 50-280 parts of garlic, 50-260 parts of Chinese prickly ash, 30-200 parts of Chinese Fevervine Herb, radix astragali
30-180 parts, 10-100 parts of radix glycyrrhizae.
A kind of benzoic pharmaceutical composition of the present invention, its prescription parts by weight are calculated as：
80-280 parts of styrax, 80-240 parts of camphor, 50-230 parts of garlic, 50-240 parts of Chinese prickly ash, 30-150 parts of Chinese Fevervine Herb, radix astragali
30-140 parts, 10-60 parts of radix glycyrrhizae.
Composite preparation of the present invention is oral formulations.
Composite preparation of the present invention is made of Chinese medicine composition and pharmaceutically acceptable carrier, and formulation includes water
Decoction, pill, tablet, capsule, granule, electuary and oral liquid.
Preparation of the present invention is tablet.
Preparation of the present invention, its preparation method are：Add the ethanol of 5-10 times of volume into crude drug, soak 12-36
Hour, flow back 1-2h, filtering；Repetitive operation 1 time, filtering, merging filtrate；Relative density 1.20~1.40 is concentrated under reduced pressure into, is obtained
Thick paste.40-80 mesh sieves are crossed after thick paste drying, add the auxiliary material of proper proportion, softwood processed.24 mesh sieves are crossed, obtain wet granular.It is dry
It is dry, dry particl cooling after respectively cross 60 mesh sieve whole grains, additional superfine silica gel powder, tabletting, to obtain the final product.
Auxiliary material of the present invention is sucrose, lactose or mannitol, pre-paying starch, sodium carboxymethylcellulose, low substitution
One or more combinations in hydroxypropylcellulose；The concentration of the ethanol is 40-90%；The drying temperature is 40-60 DEG C.
Further, pharmaceutical composition purposes of the present invention：Treatment available for roundworm disease, enterobiasis.
Prescription each component pharmacology analysis of the present invention：
Styrax：Its acrid flavour, hardship, it is warm-natured, enter heart spleen and lung stomach, there is inducing resuscitation of having one's ideas straightened out, blood-activating and qi-promoting, analgesic, be used for
Treat the diseases such as apoplexy coma due to blocking of the respiratory system, bstruction of the circulation of vital energy is fainted cruelly, apoplectic coma, trusted subordinate's pain, postpartum anemic fainting, child convulsion.
Camphor：Its acrid flavour, heat.The thoughts of returning home, liver, the spleen channel.With orifice opening, qi stagnation removing, ward off foul, desinsection is antipruritic, detumescence stop
The effect of pain, cure mainly the symptoms such as mange itch, injuries from falls as well, toothache.
Garlic：It is warm-natured, acrid flavour；Enter spleen, stomach, lung channel.Middle benefit gas row is stagnant；Removing toxic substances, desinsection.Main coldness and pain in the epigastrium；Dysentery；Diarrhea；
Tuberculosis；Pertussis；Flu；Carbuncle furuncle poison；Acute appendicitis；Tinea sore；Snakebite and bugbite；Hookworm disease；Enterobiasis；With lower pruritus vulvae；Malaria；Larynx
Numbness；Oedema.
Chinese prickly ash：It is pungent, heat.Returns spleen, stomach, kidney channel.Warm in pain, desinsection are antipruritic.
Chinese Fevervine Herb：Its sweet in flavor, slight bitter, it is mild-natured.With expelling wind and removing dampness, analgesic antidotal, promoting digestion and removing indigestion, the work(of activating blood circulation and reducing swelling
Effect.For rheumatalgia, traumatic injury, traumatic pain, liver and gall and stomach and intestine angina, indigestion, infantile malnutrition, bronchus
It is scorching；It is used for dermatitis, eczema and sore swollen toxin outside.
Radix astragali：Return lung, spleen, liver and kidney channel.The effect of invigorating qi for strengthening superficies, inducing diuresis for removing edema, detoxification myogenic.
Radix glycyrrhizae：Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.
Prescription styrax blood-activating and qi-promoting of the present invention, analgesic；Camphor desinsection is antipruritic, swelling and pain relieving is monarch drug in a prescription；Garlic sterilization solution
Poison, desinsection, Chinese prickly ash warm in pain, desinsection is ministerial drug；Chinese Fevervine Herb expelling wind and removing dampness, promoting digestion and removing indigestion, radix astragali invigorating qi for strengthening superficies are adjutant；It is sweet
Grass is invigorated the spleen and benefited qi, clearing heat and detoxicating, to make medicine.We complement each other, to being caused by roundworm, pinworm through dialectical compatibility using
Abdominal pain therapeutic effect it is notable.
Embodiment
Example below is only of the invention to further illustrate, scope that the invention is not limited in any way.
Embodiment 1
Present composition tablet formulation and preparation method：280 parts of styrax, 220 parts of camphor, 160 parts of garlic, 175 parts of Chinese prickly ash,
105 parts of Chinese Fevervine Herb, 120 parts of radix astragali, 55 parts of radix glycyrrhizae.Above-mentioned medicinal material is mixed, 55% ethanol of 6 times of volumes, leaching are added into crude drug
Steep 15 it is small when, flow back 2h, filtering；Repetitive operation 1 time, filtering, merging filtrate；Relative density 1.20~1.40 is concentrated under reduced pressure into,
Obtain thick paste.60 sieves are crossed after thick paste drying, add the auxiliary material of proper proportion, softwood processed.24 mesh sieves are crossed, obtain wet granular.50 DEG C dry
It is dry, dry particl cooling after respectively cross 60 mesh sieve whole grains, additional superfine silica gel powder, tabletting, to obtain the final product.
Embodiment 2
Present composition tablet formulation and preparation method：240 parts of styrax, 230 parts of camphor, 175 parts of garlic, 155 parts of Chinese prickly ash,
90 parts of Chinese Fevervine Herb, 130 parts of radix astragali, 35 parts of radix glycyrrhizae.Above-mentioned medicinal material is mixed, 55% ethanol of 5 times of volumes, leaching are added into crude drug
Steep 15 it is small when, flow back 1.5h, filtering；Repetitive operation 1 time, filtering, merging filtrate；Be concentrated under reduced pressure into relative density 1.20~
1.40, obtain thick paste.60 sieves are crossed after thick paste drying, add the auxiliary material of proper proportion, softwood processed.24 mesh sieves are crossed, obtain wet granular.
45 DEG C of dryings, dry particl cooling after respectively cross 60 mesh sieve whole grains, additional superfine silica gel powder, tabletting, to obtain the final product.
Embodiment 3
Present composition capsule prescription and preparation method：270 parts of styrax, 245 parts of camphor, 165 parts of garlic, Chinese prickly ash 160
Part, 125 parts of Chinese Fevervine Herb, 96 parts of radix astragali, 45 parts of radix glycyrrhizae.Above-mentioned medicinal material is mixed, 70% ethanol of 5 times of volumes is added into crude drug,
Soak 12 it is small when, flow back 2h, filtering；Repetitive operation 1 time, filtering, merging filtrate；Be concentrated under reduced pressure into relative density 1.20~
1.40, obtain thick paste.60 sieves are crossed after thick paste drying, add the auxiliary material of proper proportion, softwood processed.24 mesh sieves are crossed, obtain wet granular.
50 DEG C of dryings, cross 60 mesh sieve whole grains respectively after dry particl cooling, encapsulated, to obtain the final product.
Embodiment 4
Present composition granule prescription and preparation method：268 parts of styrax, 226 parts of camphor, 150 parts of garlic, Chinese prickly ash 165
Part, 100 parts of Chinese Fevervine Herb, 120 parts of radix astragali, 50 parts of radix glycyrrhizae.Above-mentioned medicinal material is mixed, 70% second of 5 times of volumes is added into crude drug
Alcohol, when immersion 12 is small, flow back 2h, filtering；Repetitive operation 1 time, filtering, merging filtrate；Be concentrated under reduced pressure into relative density 1.20~
1.40, obtain thick paste.60 sieves are crossed after thick paste drying, add the auxiliary material of proper proportion, softwood processed.24 mesh sieves are crossed, obtain wet granular.
55 DEG C of dryings, cross 60 mesh sieve whole grains, respectively after dry particl cooling to obtain the final product.
Embodiment 5
Clinical observation：The present inventor is in January, 2012 in December, 2016, respectively to 265 roundworm patients and 248
Pinworm patient carries out clinical observation treatment.
Data：
(1) roundworm disease
Patient：Totally 265, wherein man 142, female 123, the age is between 3~14 years old.
(2) enterobiasis
Patient：Totally 248, wherein man 134, female 114, the age is between 3~14 years old.
(3) usage and dosage
The tablet prepared by embodiment 1, takes orally, three times per day, 1 to 2 tablets once, one after each meal.7 days as one therapeutic course.
(4) curative effect determinate standard
Cure：Symptom all disappears；Main Physico-chemical tests index is normal；
It is effective：Symptomatology eliminates or cardinal symptom eliminates；Physico-chemical tests index is normal；
Effectively：Cardinal symptom disappears substantially；Main Physico-chemical tests index makes moderate progress；
It is invalid：Main Physico-chemical tests index has no difference to that before treatment.
(5) result after a course for the treatment of is treated：
| Indication | Cure rate % | Obvious effective rate % | Efficient % | Inefficiency % | Adverse reaction rate % |
| Roundworm disease | 98.11 | 1.51 | 0.38 | 0 | 0 |
| Enterobiasis | 97.18 | 2.02 | 0.81 | 0 | 0 |
(6) result after being treated 10 days for serious symptom patient：
| Indication | Cure rate % |
| Roundworm disease | 100 |
| Enterobiasis | 100 |
There is result to see, the present invention is notable for roundworm disease and enterobiasis therapeutic effect, has no toxic side effect, safe.
Preferred embodiment of the invention described in detail above.It should be appreciated that those of ordinary skill in the art are without wound
The property made work can conceive according to the present invention makes many modifications and variations.Therefore, all technician in the art
Pass through the available technology of logical analysis, reasoning, or a limited experiment on the basis of existing technology under this invention's idea
Scheme, all should be in the protection domain being defined in the patent claims.
Claims (8)
1. a kind of benzoic pharmaceutical composition, it is characterised in that the pharmaceutical composition prescription parts by weight are calculated as：Styrax 50-
300 parts, 50-300 parts of camphor, 50-280 parts of garlic, 50-260 parts of Chinese prickly ash, 30-200 parts of Chinese Fevervine Herb, 30-180 parts of radix astragali, radix glycyrrhizae
10-100 parts.
A kind of 2. benzoic pharmaceutical composition according to claim 1, it is characterised in that the pharmaceutical composition prescription weight
Number is calculated as：80-280 parts of styrax, 80-240 parts of camphor, 50-230 parts of garlic, 50-240 parts of Chinese prickly ash, Chinese Fevervine Herb 30-150
Part, 30-140 parts of radix astragali, 10-60 parts of radix glycyrrhizae.
3. according to claim 1-2 any one of them composite preparations, it is characterised in that the preparation is oral formulations.
4. preparation according to claim 3, it is characterised in that the preparation by Chinese medicine composition with it is pharmaceutically acceptable
Carrier forms, and formulation includes water decoction, pill, tablet, capsule, granule, electuary and oral liquid.
5. preparation according to claim 4, it is characterised in that the preparation is tablet.
6. preparation according to claim 5, it is characterised in that the preparation method of the tablet is：Add 5- into crude drug
The ethanol of 10 times of volumes, when immersion 12-36 is small, flow back 1-2h, filtering；Repetitive operation 1 time, filtering, merging filtrate；It is concentrated under reduced pressure
To relative density 1.20~1.40, thick paste is obtained；40-80 mesh sieves are crossed after thick paste drying, add the auxiliary material of proper proportion, system is soft
Material；24 mesh sieves are crossed, obtain wet granular；It is dry, cross 60 mesh sieve whole grains after dry particl cooling respectively, additional superfine silica gel powder, tabletting, i.e.,
.
7. preparation method according to claim 6, it is characterised in that the auxiliary material is sucrose, lactose or mannitol, pre-pays
Change one or more combinations in starch, sodium carboxymethylcellulose, low-substituted hydroxypropyl cellulose；The concentration of the ethanol is 40-
90%；The drying temperature is 40-60 DEG C.
8. claim 1-2 any one of them pharmaceutical composition purposes, it is characterised in that can be used for roundworm disease, enterobiasis
Treatment.
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| CN201711414062.7A CN107970356A (en) | 2017-12-25 | 2017-12-25 | A kind of benzoic pharmaceutical composition |
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| CN201711414062.7A CN107970356A (en) | 2017-12-25 | 2017-12-25 | A kind of benzoic pharmaceutical composition |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103505669A (en) * | 2012-06-17 | 2014-01-15 | 陈绍爱 | Medicament for treating enterobiasis |
| CN105169321A (en) * | 2015-09-19 | 2015-12-23 | 淄博齐鼎立专利信息咨询有限公司 | Pharmaceutic preparation for treating biliary tract ascariasis |
| CN105726746A (en) * | 2016-04-13 | 2016-07-06 | 合肥慧而美生物科技有限公司 | Traditional Chinese medicine decoction for treating infantile ascariasis |
-
2017
- 2017-12-25 CN CN201711414062.7A patent/CN107970356A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103505669A (en) * | 2012-06-17 | 2014-01-15 | 陈绍爱 | Medicament for treating enterobiasis |
| CN105169321A (en) * | 2015-09-19 | 2015-12-23 | 淄博齐鼎立专利信息咨询有限公司 | Pharmaceutic preparation for treating biliary tract ascariasis |
| CN105726746A (en) * | 2016-04-13 | 2016-07-06 | 合肥慧而美生物科技有限公司 | Traditional Chinese medicine decoction for treating infantile ascariasis |
Non-Patent Citations (1)
| Title |
|---|
| 李时珍等: "《增补本草纲目》", 31 August 2016, 中国医药科技出版社 * |
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