CN107970194A - A kind of preserving moisture and protecting skin essence - Google Patents
A kind of preserving moisture and protecting skin essence Download PDFInfo
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- CN107970194A CN107970194A CN201711432034.8A CN201711432034A CN107970194A CN 107970194 A CN107970194 A CN 107970194A CN 201711432034 A CN201711432034 A CN 201711432034A CN 107970194 A CN107970194 A CN 107970194A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
The invention discloses a kind of preserving moisture and protecting skin essence, include the raw material of following components by weight percent：60 80 parts of water, 24 parts of caprylic/capric triglyceride, 1,238 parts of pentanediols, 26 parts of glycerine, 35 parts of ethanol, 24 parts of xanthans, 13 parts of pear oligose alcohol, 0.1 1 parts of carbomer, 0.02 0.04 parts of citric acid, 0.6 0.8 parts of Phenoxyethanol, 4 10 parts of moisturizer, 6 12 parts of antioxidant.Preserving moisture and protecting skin essence has significant moistening effect in the present invention, component formula is gently non-stimulated, mutually cooperateed between each component, it to the good penetrability of skin, can quickly go deep into skin epidermis, play the role of lasting moisturizing, it can effectively prevent that skin light decay is old at the same time, increase skin elasticity and improve the function of skin vigor, skin is full of elastic force and gloss, reduce wrinkle.
Description
Technical field
The present invention relates to cosmetic field, and in particular to a kind of preserving moisture and protecting skin essence.
Background technology
With the development of science and technology, oneself warp of cosmetics becomes a kind of essential articles for use of people.As skin care product,
Cosmetics are typically used for including cleaning, moisturizing, moisturizing, whitening etc., by using with the facial cleanser of some maintenance types, refreshing
Skin water, lotion, elite, the cosmetics such as skin whitener of eye cream or effect type carry out nursing skin, can keep the skin wet and seek to skin
Support, so that delay skin aging, reduces wrinkle, keep the younger state of skin.
Moisturizing is the key of skin care, and moisturizing refers to the moisturizing of skin.When air themperature reduces, keratoderma cannot
Adjust enough moisturizing factors in time, grease gland liveness declines, and grease, moisture decline on the face, skin occur tight phenomenon,
Even now and nose branch shows microgroove, by using the skin care with corresponding effect, foster skin product, skin care simultaneously prevents skin
Evaporation, improve microcirculation, strengthens the process of skin wettability, just cries moisturizing, best moisturizing is exactly skin and moisturizing product
Good interaction, because in order to cater to market, there is many Moisturizers at present, but moistening effect is poor, and use is not safe enough, and
Only there was only single moisture-keeping functions.Skin senescence refers to that skin surface is coarse and wrinkle occurs, and naturally-aged is mainly by body
Inherent cause causes, and is limited to systemic sites, hence it is evident that is characterized as wrinkle and relaxation, and phenomena such as pigmentation occurs；And light aging
Skin senescence mainly caused by ultraviolet damage accumulation, is that naturally-aged and ultraviolet irradiation are coefficient as a result, being limited to
Skin exposure portion, is mainly characterized by pachylosis tarnish, pigmentation intensification, elastosis, collagen and bullet
Phenomena such as property albumen synthesis capability and immunity degradation.Essence, as the superfine product in cosmetics, component is exquisite, effect is powerful,
Significant effect, it can build the effect of efficient moisture-retention, make flesh with moisturizing, anti-aging, crease-resistant, whitening, despeckle and other effects
Skin forms natural moisturizing water lock barrier, and absorption of the skin to promotion nutritional ingredient, constantly promotes skin metabolism, delaying skin
Aging.
In recent years, pursuit of the people to cosmetics is not limited solely to handy, is more the safety of cosmetics with being good for
Health, therefore tend to driven plant for the toxicity to chemical toilet and irritating doubt, more and more scientific researchers
Safe and efficient moisturising actives are found in thing, thus develop moistening effect obvious, action temperature and, it is nontoxic nonirritant
The Essence of natural component.Especially in autumn and winter, face skin can make the disease that peeling easily occurs in skin, cancer is itched after wind
Shape, and skin water shortage easily causes aging, needs to adjust the wettability of skin using the skin care item of moisturizing for this, maintains flesh
Skin.
The content of the invention
For above-mentioned the deficiencies in the prior art, the present invention provides a kind of preserving moisture and protecting skin essence.
A kind of preserving moisture and protecting skin essence, including following raw material：60-80 parts of water, caprylic/capric triglyceride 2-4
Part, 3-8 parts of 1,2- pentanediols, 2-6 parts of glycerine, 3-5 parts of ethanol, 2-4 parts of xanthans, 1-3 parts of pear oligose alcohol, carbomer 0.1-1
Part, 0.02-0.04 parts of citric acid, 0.6-0.8 parts of Phenoxyethanol, 4-10 parts of moisturizer, 6-12 parts of antioxidant.
The moisturizer is collagen, the one or more in fibroin, snail pituitary extract.
Preferably, the moisturizer is collagen, fibroin, the mixture of snail pituitary extract, wherein described
Collagen, fibroin, the mass ratio of snail pituitary extract are (1-5)：(1-5)：(1-5).
The antioxidant is Coriolus Versicolor P.E., the one or more in Cacumen Platycladi extract, erythrothioneine.
Preferably, the antioxidant is Coriolus Versicolor P.E., Cacumen Platycladi extract, the wherein mixture of erythrothioneine, institute
It is (1-5) to state Coriolus Versicolor P.E., Cacumen Platycladi extract, the mass ratio of erythrothioneine：(1-5)：(1-5).
The preparation method of the snail pituitary extract is：
I, chooses healthy snail, rests a period of time, it is excluded internal excrement and soil；
II, collects snail secretion, gained secretion is placed in quick-frozen 5-8h at 0-5 DEG C at a temperature of 20-30 DEG C,
Obtain snail mucus；
Above-mentioned snail mucus is placed in 20-30 DEG C, grinds 10-30min, low temperature mistake under the conditions of 1800-3200r/min by III,
Filter, obtains filtered fluid；
IV, centrifuges above-mentioned filtered fluid at a temperature of subzero 6 to subzero 2 DEG C, with 8000-10000r/min rotating speeds,
Centrifugation time 10-30min, obtains supernatant；
After the above-mentioned supernatant freeze-dryings of V, the snail pituitary extract is obtained.
Preferably, the preparation method of the snail pituitary extract is：
I, chooses healthy snail, rests a period of time, it is excluded internal excrement and soil；
II, collects snail secretion, gained secretion is placed in quick-frozen 5-8h at 0-5 DEG C at a temperature of 20-30 DEG C,
Obtain snail mucus；
Above-mentioned snail mucus is placed in 20-30 DEG C, grinds 10-30min, low temperature mistake under the conditions of 1800-3200r/min by III,
Filter, obtains filtrate；
IV, adds the enzyme of 0.8-1.2 times of quality into above-mentioned filtrate, is stirred under the conditions of 20-40 DEG C, 200-400r/min
0.5-1.5h, is ultrasonically treated under cryogenic conditions, obtains extracting solution；
V, centrifuges said extracted liquid at a temperature of subzero 6 to subzero 2 DEG C, with 8000-10000r/min rotating speeds,
Centrifugation time 10-30min, stands, obtains supernatant after liquid separation；
After the above-mentioned supernatant freeze-dryings of VI, the snail pituitary extract is obtained.
It is highly preferred that the preparation method of the snail pituitary extract is：
I, chooses healthy snail, rests a period of time, it is excluded internal excrement and soil；
II, collects snail secretion, gained secretion is placed in quick-frozen 5-8h at 0-5 DEG C at a temperature of 20-30 DEG C,
Obtain snail mucus；
Above-mentioned snail mucus is placed in 20-30 DEG C, grinds 10-30min, low temperature mistake under the conditions of 1800-3200r/min by III,
Filter, obtains filtered fluid A；
IV, adds the enzyme of 0.8-1.2 times of filtrate A weight into above-mentioned filtrate A, in 20-40 DEG C, 200-400r/min conditions
Lower stirring 0.5-1.5h, is ultrasonically treated under cryogenic conditions, obtains extracting solution；
V, centrifuges said extracted liquid at a temperature of subzero 6 to subzero 2 DEG C, with 8000-10000r/min rotating speeds,
Centrifugation time 10-30min, stands, obtains supernatant after liquid separation；
The above-mentioned supernatant liquid filterings of VI, 3 times, obtain filtered fluid B；
VII, is freeze-dried filtered fluid B, obtains the snail pituitary extract.
The preparation method of the Coriolus Versicolor P.E. is：Naturally dry after manyzoned polypore sporophore is cut into slices, is crushed to 30-60 mesh,
The extractant of 8-14 times of quality, slightly boiling extraction 1.5-3h are added into gained Yunzhi powder, filtrate is collected in filtering, and filter residue is equal
Condition is extracted again, is merged filtrate twice, is obtained rainbow conk extracting solution, the Coriolus Versicolor P.E. is obtained after dry extraction liquid；It is described
Extractant be concentration be 1-3wt% ethanol water, concentration be 1-3wt% ammonium hydroxide or water in one or more.
The preparation method of the Cacumen Platycladi extract is：Arbor-vitae leaf raw material is cleaned dry after be added to the water decoction 1-4 times, often
Secondary decocting time is 1-2.5h, decocts every time plus the quality of water is 9-10 times of cacumen biotae material quality, merge and decoct water, finally
Gained decoction liquor is by being concentrated under reduced pressure, being dried to obtain Cacumen Platycladi extract.
The production technology of the preserving moisture and protecting skin essence, comprises the following steps：
I, weighs each raw material components by weight；
II, by water, 1,2- pentanediols, glycerine, xanthans, pear oligose alcohol, carbomer mix, at a temperature of 70-90 DEG C with
The rotating speed stirring 5-15min of 600-1200r/min, obtains water and mutually expects after mixing；
Caprylic/capric triglyceride, ethanol are placed in 70-90 DEG C, stir 10- under conditions of 600-1200r/min by III,
25min, obtains oil phase material；
During IV, mutually expects oil phase material addition water, 5- is stirred with the rotating speed of 600-1200r/min at a temperature of 70-90 DEG C
15min, treats that material is cooled to 35-50 DEG C, Phenoxyethanol, citric acid, moisturizer, antioxidant is added, with 300-600r/min
Rotating speed continue stir 10-25min；
V, is cooled to 25-35 DEG C, stands 18-36h, and discharging, examine, filling and package, up to the preserving moisture and protecting skin essence of the present invention
Hua Su.
The application method of the present invention：After face cleaning, take and be gently massaged into absorption on the face in right amount, one day using twice.Also may be used
It is better Essence is instilled in the breast of cutin maintenance basis.
The suitable crowd of the present invention：Various skin, especially extreme dryness and the skin of aging.
By adopting the above-described technical solution, the present invention has the advantages that compared with prior art：The present invention carries
The preserving moisture and protecting skin essence of confession, containing active ingredients such as collagen, fibroin, snail pituitary extract, Coriolus Versicolor P.E.s,
Each component reasonable mixture ratio, synergy, have the function that lasting moisturizing, and it is old to can effectively prevent skin light decay, promote collagen
Deng the generation of U.S. sarcous element, reach replenishing water and preserving moisture, increase skin elasticity and improve skin vigor and other effects, can be widely used for various
Skin type, long-time service can make skin it is tender it is full, full of elastic force and gloss, reduce wrinkle.
Embodiment
The foregoing invention content of the present invention is described in further detail with reference to embodiment, but should not be incited somebody to action
This scope for being interpreted as the above-mentioned theme of the present invention is only limitted to following embodiments.
Each raw material in embodiment：
Caprylic/capric triglyceride, No. CAS：266-043-4, is provided using Guangzhou Nuo Xin bio tech ltd
3575/GTCC type caprylic/capric triglycerides.
1,2- pentanediol, No. CAS：5343-92-0, the cosmetics-stage 1,2- provided purchased from Guangzhou Yu Feng Chemical Co., Ltd.s
Pentanediol.
Glycerine, CAS：56-81-5, the cosmetics-stage glycerine provided using Anhui gracefulness Chemical Co., Ltd..
Ethanol, No. CAS：64-17-5, the cosmetics-stage ethanol provided using Shanghai Quan Ze Industrial Co., Ltd.s.
Xanthans, No. CAS：11138-66-2, the cosmetics-stage xanthan provided using Guangzhou Tao Sheng Chemical Co., Ltd.s
Glue.
Pear oligose alcohol, No. CAS：50-70-4, using the cosmetics-stage xanthan for providing Guangzhou Cheng Yue trade Co., Ltds
Glue.
Carbomer, No. CAS：9003-01-4, the U21 type carbomers provided using Guangzhou Sheng Xin Chemical Industry Science Co., Ltd.
Citric acid, No. CAS:77-92-9, the top grade product citric acid provided using hundred million rising sun Trade Co., Ltd. of Shanghai.
Phenoxyethanol, No. CAS：122-99-6, the cosmetics-stage benzene oxygen provided using upper sea blue handsome cosmetics Co., Ltd
Ethanol.
Collagen, No. CAS：9007-34-5, the W025 types provided using Tianjin Binhai victory into Chemical Co., Ltd. belonging to a category
Collagen.
Fibroin, the silk fibroin powder provided using Dalian U.S. logical sequence Technology Co., Ltd., article No. MB4792, point
Son amount is 250000,5 μm of average grain diameter.
Healthy snail, kind are white jade snail, are provided by Jiaxing City Hong Fu Food Co., Ltd.
Pepsin, No. CAS：9001-75-6, the P6322 types provided using Shanghai Mike's woods biochemical technology Co., Ltd
Pepsin, enzyme activity are more than 3000U/mg.
Rainbow conk, the Grade A rainbow conk provided using Shanghai Shi Sheng Industrial Co., Ltd.s.
Cacumen biotae, the dry side CedarLeaves provided using Hangzhou Mei Yan commerce and trade Co., Ltd.
Rubber mill, the JMF-80 type rubber mills provided using Guangzhou Heng Dong mechanical equipments Science and Technology Ltd..
High-speed centrifugal pump, the CR22GII type high speed freezing centrifuges provided using Japanese Hitachi companies.
Ultrasonic device, the JY96-IIN ultrasonic cell disruptors provided using Zhengzhou north and south experimental instruments and equipment limited
Instrument.
Sand core funnel：G4 types, aperture are 3-4 μm；G5 types, aperture are 1.5-2.5 μm；G6 types, aperture are 0.6-1.5 μm.
Purchased from Hangzhou Jia Chen Chemical Co., Ltd.s.
Vacuum freeze drier, the SCIENTZ-12N types provided using NingBo XinZhi Biology Science Co., Ltd are true
Vacuum freecing-dry machine.
Vacuum drying chamber, the DZF-6020 type vacuum drying chambers provided using Shanghai Ke Sheng Instrument Ltd..
The model RE-52C of Rotary Evaporators, purchased from Henan Yuhua Instrument Co., Ltd., Gongyi City.
Spray drying device, the ZOLLO-6000Y spray dryers provided using Shanghai Zuo Le Instrument Ltd..
Homogeneous emulsifying machine, the FJ200 type high speed dispersion homogenizers provided using Shanghai Da Ping Instrument Ltd..
Embodiment 1
A kind of preserving moisture and protecting skin essence, including following raw material：70 parts of water, 3 parts of caprylic/capric triglyceride, 1,
6 parts of 2- pentanediols, 4 parts of glycerine, 4 parts of ethanol, 3 parts of xanthans, 2 parts of pear oligose alcohol, 0.5 part of carbomer, 0.03 part of citric acid, benzene
0.6 part of oxyethanol, 3 parts of collagen, 3 parts of fibroin, 3 parts of snail pituitary extract, 9 parts of antioxidant.
The antioxidant is Coriolus Versicolor P.E., Cacumen Platycladi extract, the mixture of erythrothioneine, wherein described anti-oxidant
Agent is Coriolus Versicolor P.E., Cacumen Platycladi extract, the mass ratio of erythrothioneine are 1：1：1.
The preparation method of the snail pituitary extract is：
I, chooses 30-40 grams of weight, the healthy snail of 3 first quarter moons of monthly age to 4 months, be put into it is net in foster pond only support 3 days, often
It rinses foster pond only with clear water twice, it is excluded internal excrement and soil；
II, collects snail secretion, gained secretion is placed in quick-frozen 6h at 3 DEG C, obtains snail at a temperature of 25 DEG C
Mucus；
Above-mentioned snail mucus is placed in rubber mill by III, and 20min is ground under the conditions of 25 DEG C, 1800r/min, at 10 DEG C
The ground mucus of the lower filter screen filtration with 550 mesh, obtains filtered fluid A；
IV, adds the pepsin of filtered fluid A weight 90% into above-mentioned filtrate A, with 300r/min under the conditions of 35 DEG C
Rotating speed stirring 0.5h, be then ultrasonically treated 30min at 4 DEG C, the ultrasonic power of the supersound process is 400W, supersonic frequency
For 30kHz, extracting solution is obtained；
Said extracted liquid is placed in high-speed centrifugal pump by V, at a temperature of subzero 3 DEG C, with 8000r/min rotating speeds from
The heart separates 20min, stands 15min, supernatant is obtained after liquid separation；
VI, filters above-mentioned supernatant 3 times with sand core funnel, uses G4 type sand core funnels the 1st time, is using aperture for the 2nd time
G5 type sand core funnels, last time are all filtered using G6 types sand core funnel, finally obtain filtered fluid B；
Above-mentioned filtered fluid B is placed in vacuum freeze drier progress pre-freeze 40min by VII, cold-trap during vacuum freeze drying
Temperature is subzero 60 DEG C, vacuum 0.19Pa, and dry 5h, obtains the snail pituitary extract.
The preparation method of the Coriolus Versicolor P.E. is：Naturally dry after manyzoned polypore sporophore is cut into slices, is crushed to 50 mesh, to institute
The concentration for obtaining 8 times of addition Yunzhi powder weight in Yunzhi powder is 2wt% ammonium hydroxide, and slightly boiling extracts 1.5h, using 300 mesh filter cloth mistakes
Filter, filter residue equal conditions extract again, merge filtrate twice, by gained filtrate be placed in temperature 50 C, vacuum 0.09Pa it is true
Dry 3h, obtains Coriolus Versicolor P.E. in empty drying box.
The preparation method of the Cacumen Platycladi extract is：Arbor-vitae leaf raw material is cleaned dry after add distilled water in decoct 3 times,
3 decocting times are respectively 2h, 1.5h, 1h, decoct every time plus the weight of water is 10 times of cacumen biotae raw material weight, merge and decoct
Liquid, is placed in Rotary Evaporators, and 2h is concentrated in the case where temperature is 50 DEG C, vacuum is 0.05MPa, is then dried with spray drying process dense
Contracting liquid, inlet air temperature and leaving air temp are respectively 165 DEG C, 75 DEG C, and hot wind wind speed is 4m3/ min, feeding speed 50mL/min,
Cacumen Platycladi extract is obtained after drying.
The production technology of the preserving moisture and protecting skin essence, comprises the following steps：
I, weighs each raw material components by weight；
Water, 1,2- pentanediols, glycerine, xanthans, pear oligose alcohol, carbomer are added the water phase pot of homogeneous emulsifying machine by II,
In container, 10min is stirred with the rotating speed of 700r/min at a temperature of 80 DEG C, water is obtained after mixing and mutually expects；
III, adds caprylic/capric triglyceride, ethanol in the oil phase pot of homogeneous emulsifying machine in container, 80 DEG C,
15min is stirred under the conditions of 700r/min, obtains oil phase material；
IV, keeps temperature and rotating speed constant, during oil phase material addition water is mutually expected, continues to stir 10min, treats that material is cooled to
40 DEG C, Phenoxyethanol, citric acid, collagen, fibroin, snail pituitary extract, antioxidant are added, with 400r/min
Rotating speed stirring 15min；
V, is cooled to 30 DEG C, and after standing 24h, discharging, examine, filling and package, up to the preserving moisture and protecting skin elite of the present invention
Element.
Embodiment 2
A kind of preserving moisture and protecting skin essence, including following raw material：70 parts of water, 3 parts of caprylic/capric triglyceride, 1,
6 parts of 2- pentanediols, 4 parts of glycerine, 4 parts of ethanol, 3 parts of xanthans, 2 parts of pear oligose alcohol, 0.5 part of carbomer, 0.03 part of citric acid, benzene
0.6 part of oxyethanol, 4.5 parts of collagen, 4.5 parts of fibroin, 9 parts of antioxidant.
The antioxidant is Coriolus Versicolor P.E., Cacumen Platycladi extract, the mixture of erythrothioneine, wherein described anti-oxidant
Agent is Coriolus Versicolor P.E., Cacumen Platycladi extract, the mass ratio of erythrothioneine are 1：1：1.
The preparation method of the Coriolus Versicolor P.E. is：Naturally dry after manyzoned polypore sporophore is cut into slices, is crushed to 50 mesh, to institute
The concentration for obtaining 8 times of addition Yunzhi powder weight in Yunzhi powder is 2wt% ammonium hydroxide, and slightly boiling extracts 1.5h, using 300 mesh filter cloth mistakes
Filter, filter residue equal conditions extract again, merge filtrate twice, by gained filtrate be placed in temperature 50 C, vacuum 0.09Pa it is true
Dry 3h, obtains Coriolus Versicolor P.E. in empty drying box.
The preparation method of the Cacumen Platycladi extract is：Arbor-vitae leaf raw material is cleaned dry after add distilled water in decoct 3 times,
3 decocting times are respectively 2h, 1.5h, 1h, decoct every time plus the weight of water is 10 times of cacumen biotae raw material weight, merge and decoct
Liquid, is placed in Rotary Evaporators, and 2h is concentrated in the case where temperature is 50 DEG C, vacuum is 0.05MPa, is then dried with spray drying process dense
Contracting liquid, inlet air temperature and leaving air temp are respectively 165 DEG C, 75 DEG C, and hot wind wind speed is 4m3/ min, feeding speed 50mL/min,
Cacumen Platycladi extract is obtained after drying.
The production technology of the preserving moisture and protecting skin essence, comprises the following steps：
I, weighs each raw material components by weight；
Water, 1,2- pentanediols, glycerine, xanthans, pear oligose alcohol, carbomer are added the water phase pot of homogeneous emulsifying machine by II,
In container, 10min is stirred with the rotating speed of 700r/min at a temperature of 80 DEG C, water is obtained after mixing and mutually expects；
III, adds caprylic/capric triglyceride, ethanol in the oil phase pot of homogeneous emulsifying machine in container, 80 DEG C,
15min is stirred under the conditions of 700r/min, obtains oil phase material；
IV, keeps temperature and rotating speed constant, during oil phase material addition water is mutually expected, continues to stir 10min, treats that material is cooled to
40 DEG C, Phenoxyethanol, citric acid, collagen, fibroin, antioxidant are added, is stirred with the rotating speed of 400r/min
15min；
V, is cooled to 30 DEG C, and after standing 24h, discharging, examine, filling and package, up to the preserving moisture and protecting skin elite of the present invention
Element.
Embodiment 3
A kind of preserving moisture and protecting skin essence, including following raw material：70 parts of water, 3 parts of caprylic/capric triglyceride, 1,
6 parts of 2- pentanediols, 4 parts of glycerine, 4 parts of ethanol, 3 parts of xanthans, 2 parts of pear oligose alcohol, 0.5 part of carbomer, 0.03 part of citric acid, benzene
0.6 part of oxyethanol, 4.5 parts of fibroin, 4.5 parts of snail pituitary extract, 9 parts of antioxidant.
The antioxidant is Coriolus Versicolor P.E., Cacumen Platycladi extract, the mixture of erythrothioneine, wherein described anti-oxidant
Agent is Coriolus Versicolor P.E., Cacumen Platycladi extract, the mass ratio of erythrothioneine are 1：1：1.
The preparation method of the snail pituitary extract is：
I, chooses 30-40 grams of weight, the healthy snail of 3 first quarter moons of monthly age to 4 months, be put into it is net in foster pond only support 3 days, often
It rinses foster pond only with clear water twice, it is excluded internal excrement and soil；
II, collects snail secretion, gained secretion is placed in quick-frozen 6h at 3 DEG C, obtains snail at a temperature of 25 DEG C
Mucus；
Above-mentioned snail mucus is placed in rubber mill by III, and 20min is ground under the conditions of 25 DEG C, 1800r/min, at 10 DEG C
The ground mucus of the lower filter screen filtration with 550 mesh, obtains filtered fluid A；
IV, adds the pepsin of filtered fluid A weight 90% into above-mentioned filtrate A, with 300r/min under the conditions of 35 DEG C
Rotating speed stirring 0.5h, be then ultrasonically treated 30min at 4 DEG C, the ultrasonic power of the supersound process is 400W, supersonic frequency
For 30kHz, extracting solution is obtained；
Said extracted liquid is placed in high-speed centrifugal pump by V, at a temperature of subzero 3 DEG C, with 8000r/min rotating speeds from
The heart separates 20min, stands 15min, supernatant is obtained after liquid separation；
VI, filters above-mentioned supernatant 3 times with sand core funnel, uses G4 type sand core funnels the 1st time, is using aperture for the 2nd time
G5 type sand core funnels, last time are all filtered using G6 types sand core funnel, finally obtain filtered fluid B；
Above-mentioned filtered fluid B is placed in vacuum freeze drier progress pre-freeze 40min by VII, cold-trap during vacuum freeze drying
Temperature is subzero 60 DEG C, vacuum 0.19Pa, and dry 5h, obtains the snail pituitary extract.
The preparation method of the Coriolus Versicolor P.E. is：Naturally dry after manyzoned polypore sporophore is cut into slices, is crushed to 50 mesh, to institute
The concentration for obtaining 8 times of addition Yunzhi powder weight in Yunzhi powder is 2wt% ammonium hydroxide, and slightly boiling extracts 1.5h, using 300 mesh filter cloth mistakes
Filter, filter residue equal conditions extract again, merge filtrate twice, by gained filtrate be placed in temperature 50 C, vacuum 0.09Pa it is true
Dry 3h, obtains Coriolus Versicolor P.E. in empty drying box.
The preparation method of the Cacumen Platycladi extract is：Arbor-vitae leaf raw material is cleaned dry after add distilled water in decoct 3 times,
3 decocting times are respectively 2h, 1.5h, 1h, decoct every time plus the weight of water is 10 times of cacumen biotae raw material weight, merge and decoct
Liquid, is placed in Rotary Evaporators, and 2h is concentrated in the case where temperature is 50 DEG C, vacuum is 0.05MPa, is then dried with spray drying process dense
Contracting liquid, inlet air temperature and leaving air temp are respectively 165 DEG C, 75 DEG C, and hot wind wind speed is 4m3/ min, feeding speed 50mL/min,
Cacumen Platycladi extract is obtained after drying.
The production technology of the preserving moisture and protecting skin essence, comprises the following steps：
I, weighs each raw material components by weight；
Water, 1,2- pentanediols, glycerine, xanthans, pear oligose alcohol, carbomer are added the water phase pot of homogeneous emulsifying machine by II,
In container, 10min is stirred with the rotating speed of 700r/min at a temperature of 80 DEG C, water is obtained after mixing and mutually expects；
III, adds caprylic/capric triglyceride, ethanol in the oil phase pot of homogeneous emulsifying machine in container, 80 DEG C,
15min is stirred under the conditions of 700r/min, obtains oil phase material；
IV, keeps temperature and rotating speed constant, during oil phase material addition water is mutually expected, continues to stir 10min, treats that material is cooled to
40 DEG C, Phenoxyethanol, citric acid, fibroin, snail pituitary extract, antioxidant are added, is stirred with the rotating speed of 400r/min
Mix 15min；
V, is cooled to 30 DEG C, and after standing 24h, discharging, examine, filling and package, up to the preserving moisture and protecting skin elite of the present invention
Element.
Embodiment 4
A kind of preserving moisture and protecting skin essence, including following raw material：70 parts of water, 3 parts of caprylic/capric triglyceride, 1,
6 parts of 2- pentanediols, 4 parts of glycerine, 4 parts of ethanol, 3 parts of xanthans, 2 parts of pear oligose alcohol, 0.5 part of carbomer, 0.03 part of citric acid, benzene
0.6 part of oxyethanol, 4.5 parts of collagen, 4.5 parts of snail pituitary extract, 9 parts of antioxidant.
The antioxidant is Coriolus Versicolor P.E., Cacumen Platycladi extract, the mixture of erythrothioneine, wherein described anti-oxidant
Agent is Coriolus Versicolor P.E., Cacumen Platycladi extract, the mass ratio of erythrothioneine are 1：1：1.
The preparation method of the snail pituitary extract is：
I, chooses 30-40 grams of weight, the healthy snail of 3 first quarter moons of monthly age to 4 months, be put into it is net in foster pond only support 3 days, often
It rinses foster pond only with clear water twice, it is excluded internal excrement and soil；
II, collects snail secretion, gained secretion is placed in quick-frozen 6h at 3 DEG C, obtains snail at a temperature of 25 DEG C
Mucus；
Above-mentioned snail mucus is placed in rubber mill by III, and 20min is ground under the conditions of 25 DEG C, 1800r/min, at 10 DEG C
The ground mucus of the lower filter screen filtration with 550 mesh, obtains filtered fluid A；
IV, adds the pepsin of filtered fluid A weight 90% into above-mentioned filtrate A, with 300r/min under the conditions of 35 DEG C
Rotating speed stirring 0.5h, be then ultrasonically treated 30min at 4 DEG C, the ultrasonic power of the supersound process is 400W, supersonic frequency
For 30kHz, extracting solution is obtained；
Said extracted liquid is placed in high-speed centrifugal pump by V, at a temperature of subzero 3 DEG C, with 8000r/min rotating speeds from
The heart separates 20min, stands 15min, supernatant is obtained after liquid separation；
VI, filters above-mentioned supernatant 3 times with sand core funnel, uses G4 type sand core funnels the 1st time, is using aperture for the 2nd time
G5 type sand core funnels, last time are all filtered using G6 types sand core funnel, finally obtain filtered fluid B；
Above-mentioned filtered fluid B is placed in vacuum freeze drier progress pre-freeze 40min by VII, cold-trap during vacuum freeze drying
Temperature is subzero 60 DEG C, vacuum 0.19Pa, and dry 5h, obtains the snail pituitary extract.
The preparation method of the Coriolus Versicolor P.E. is：Naturally dry after manyzoned polypore sporophore is cut into slices, is crushed to 50 mesh, to institute
The concentration for obtaining 8 times of addition Yunzhi powder weight in Yunzhi powder is 2wt% ammonium hydroxide, and slightly boiling extracts 1.5h, using 300 mesh filter cloth mistakes
Filter, filter residue equal conditions extract again, merge filtrate twice, by gained filtrate be placed in temperature 50 C, vacuum 0.09Pa it is true
Dry 3h, obtains Coriolus Versicolor P.E. in empty drying box.
The preparation method of the Cacumen Platycladi extract is：Arbor-vitae leaf raw material is cleaned dry after add distilled water in decoct 3 times,
3 decocting times are respectively 2h, 1.5h, 1h, decoct every time plus the weight of water is 10 times of cacumen biotae raw material weight, merge and decoct
Liquid, is placed in Rotary Evaporators, and 2h is concentrated in the case where temperature is 50 DEG C, vacuum is 0.05MPa, is then dried with spray drying process dense
Contracting liquid, inlet air temperature and leaving air temp are respectively 165 DEG C, 75 DEG C, and hot wind wind speed is 4m3/ min, feeding speed 50mL/min,
Cacumen Platycladi extract is obtained after drying.
The production technology of the preserving moisture and protecting skin essence, comprises the following steps：
I, weighs each raw material components by weight；
Water, 1,2- pentanediols, glycerine, xanthans, pear oligose alcohol, carbomer are added the water phase pot of homogeneous emulsifying machine by II,
In container, 10min is stirred with the rotating speed of 700r/min at a temperature of 80 DEG C, water is obtained after mixing and mutually expects；
III, adds caprylic/capric triglyceride, ethanol in the oil phase pot of homogeneous emulsifying machine in container, 80 DEG C,
15min is stirred under the conditions of 700r/min, obtains oil phase material；
IV, keeps temperature and rotating speed constant, during oil phase material addition water is mutually expected, continues to stir 10min, treats that material is cooled to
40 DEG C, Phenoxyethanol, citric acid, collagen, snail pituitary extract, antioxidant are added, is stirred with the rotating speed of 400r/min
Mix 15min；
V, is cooled to 30 DEG C, and after standing 24h, discharging, examine, filling and package, up to the preserving moisture and protecting skin elite of the present invention
Element.
Comparative example 1
A kind of preserving moisture and protecting skin essence, including following raw material：70 parts of water, 3 parts of caprylic/capric triglyceride, 1,
6 parts of 2- pentanediols, 4 parts of glycerine, 4 parts of ethanol, 3 parts of xanthans, 2 parts of pear oligose alcohol, 0.5 part of carbomer, 0.03 part of citric acid, benzene
0.6 part of oxyethanol, 9 parts of antioxidant.
The antioxidant is Coriolus Versicolor P.E., Cacumen Platycladi extract, the mixture of erythrothioneine, wherein described anti-oxidant
Agent is Coriolus Versicolor P.E., Cacumen Platycladi extract, the mass ratio of erythrothioneine are 1：1：1.
The preparation method of the Coriolus Versicolor P.E. is：Naturally dry after manyzoned polypore sporophore is cut into slices, is crushed to 50 mesh, to institute
The concentration for obtaining 8 times of addition Yunzhi powder weight in Yunzhi powder is 2wt% ammonium hydroxide, and slightly boiling extracts 1.5h, using 300 mesh filter cloth mistakes
Filter, filter residue equal conditions extract again, merge filtrate twice, by gained filtrate be placed in temperature 50 C, vacuum 0.09Pa it is true
Dry 3h, obtains Coriolus Versicolor P.E. in empty drying box.
The preparation method of the Cacumen Platycladi extract is：Arbor-vitae leaf raw material is cleaned dry after add distilled water in decoct 3 times,
3 decocting times are respectively 2h, 1.5h, 1h, decoct every time plus the weight of water is 10 times of cacumen biotae raw material weight, merge and decoct
Liquid, is placed in Rotary Evaporators, and 2h is concentrated in the case where temperature is 50 DEG C, vacuum is 0.05MPa, is then dried with spray drying process dense
Contracting liquid, inlet air temperature and leaving air temp are respectively 165 DEG C, 75 DEG C, and hot wind wind speed is 4m3/ min, feeding speed 50mL/min,
Cacumen Platycladi extract is obtained after drying.
The production technology of the preserving moisture and protecting skin essence, comprises the following steps：
I, weighs each raw material components by weight；
Water, 1,2- pentanediols, glycerine, xanthans, pear oligose alcohol, carbomer are added the water phase pot of homogeneous emulsifying machine by II,
In container, 10min is stirred with the rotating speed of 700r/min at a temperature of 80 DEG C, water is obtained after mixing and mutually expects；
III, adds caprylic/capric triglyceride, ethanol in the oil phase pot of homogeneous emulsifying machine in container, 80 DEG C,
15min is stirred under the conditions of 700r/min, obtains oil phase material；
IV, keeps temperature and rotating speed constant, during oil phase material addition water is mutually expected, continues to stir 10min, treats that material is cooled to
40 DEG C, Phenoxyethanol, citric acid, antioxidant are added, 15min is stirred with the rotating speed of 400r/min；
V, is cooled to 30 DEG C, and after standing 24h, discharging, examine, filling and package, up to the preserving moisture and protecting skin elite of the present invention
Element.
Embodiment 5
It is substantially the same manner as Example 1, differ only in：The preparation method of the snail pituitary extract is：
I, chooses 30-40 grams of weight, and the healthy snail of 3 first quarter moons of monthly age to 4 months, it is quiet that the snail of selection is placed on intensive culture pond
Support 3 days, and rinse intensive culture pond with clear water twice daily, it is excluded internal excrement and soil；
II, collects snail secretion, gained secretion is placed in quick-frozen 6h at 3 DEG C, obtains snail at a temperature of 25 DEG C
Mucus；
Above-mentioned snail mucus is placed in rubber mill by III, and 20min is ground under the conditions of 25 DEG C, 1800r/min, at 10 DEG C
The ground mucus of the lower filter screen filtration with 550 mesh, obtains filtered fluid；
Said extracted liquid is placed in high-speed centrifugal pump by IV, at a temperature of subzero 3 DEG C, with 8000r/min rotating speeds from
The heart separates 20min, stands 15min, supernatant is obtained after liquid separation；
Supernatant is placed in vacuum freeze drier progress pre-freeze 40min by V, and condenser temperature is during vacuum freeze drying
Subzero 60 DEG C, vacuum 0.19Pa, dry 5h, obtains the snail pituitary extract.
Embodiment 6
It is substantially the same manner as Example 1, differ only in：The preparation method of the snail pituitary extract is：
I, chooses 30-40 grams of weight, the healthy snail of 3 first quarter moons of monthly age to 4 months, be put into it is net in foster pond only support 3 days, often
It rinses foster pond only with clear water twice, it is excluded internal excrement and soil；
II, collects snail secretion, gained secretion is placed in quick-frozen 6h at 3 DEG C, obtains snail at a temperature of 25 DEG C
Mucus；
Above-mentioned snail mucus is placed in rubber mill by III, and 20min is ground under the conditions of 25 DEG C, 1800r/min, at 10 DEG C
The ground mucus of the lower filter screen filtration with 550 mesh, obtains filtered fluid；
IV, adds the pepsin of filtered fluid A weight 90% into above-mentioned filtrate, with 300r/min's under the conditions of 35 DEG C
Rotating speed stirs 0.5h, is then ultrasonically treated 30min at 4 DEG C, and the ultrasonic power of the supersound process is 400W, supersonic frequency is
30kHz, obtains extracting solution；
Said extracted liquid is placed in high-speed centrifugal pump by V, at a temperature of subzero 3 DEG C, with 8000r/min rotating speeds from
The heart separates 20min, stands 15min, supernatant is obtained after liquid separation；
Above-mentioned supernatant is placed in vacuum freeze drier progress pre-freeze 40min by VI, cold-trap temperature during vacuum freeze drying
Spend for subzero 60 DEG C, vacuum 0.19Pa, dry 5h, obtains the snail pituitary extract.
Embodiment 7
It is substantially the same manner as Example 1, differ only in：The antioxidant is Coriolus Versicolor P.E. and Cacumen Platycladi extract
Mixture, wherein the mass ratio that the antioxidant is Coriolus Versicolor P.E. and Cacumen Platycladi extract is 1：1.
The Coriolus Versicolor P.E. is with as described in embodiment 1, and details are not described herein again.
The Cacumen Platycladi extract is with as described in embodiment 1, and details are not described herein again.
Embodiment 8
It is substantially the same manner as Example 1, differ only in：The antioxidant is Cacumen Platycladi extract and erythrothioneine
Mixture, wherein the mass ratio that the antioxidant is Cacumen Platycladi extract and erythrothioneine is 1：1.
The Cacumen Platycladi extract is with as described in embodiment 1, and details are not described herein again.
Embodiment 9
It is substantially the same manner as Example 1, differ only in：The antioxidant is the mixed of Coriolus Versicolor P.E. and erythrothioneine
Compound, wherein the mass ratio that the antioxidant is Coriolus Versicolor P.E. and erythrothioneine is 1：1.
The Coriolus Versicolor P.E. is with as described in embodiment 1, and details are not described herein again.
Comparative example 2
A kind of preserving moisture and protecting skin essence, including following raw material：70 parts of water, 3 parts of caprylic/capric triglyceride, 1,
6 parts of 2- pentanediols, 4 parts of glycerine, 4 parts of ethanol, 3 parts of xanthans, 2 parts of pear oligose alcohol, 0.5 part of carbomer, 0.03 part of citric acid, benzene
0.6 part of oxyethanol, 3 parts of collagen, 3 parts of fibroin, 3 parts of snail pituitary extract.
The preparation method of the snail pituitary extract is：
I, chooses 30-40 grams of weight, the healthy snail of 3 first quarter moons of monthly age to 4 months, be put into it is net in foster pond only support 3 days, often
It rinses foster pond only with clear water twice, it is excluded internal excrement and soil；
II, collects snail secretion, gained secretion is placed in quick-frozen 6h at 3 DEG C, obtains snail at a temperature of 25 DEG C
Mucus；
Above-mentioned snail mucus is placed in rubber mill by III, and 20min is ground under the conditions of 25 DEG C, 1800r/min, at 10 DEG C
The ground mucus of the lower filter screen filtration with 550 mesh, obtains filtered fluid A；
IV, adds the pepsin of filtered fluid A weight 90% into above-mentioned filtrate A, with 300r/min under the conditions of 35 DEG C
Rotating speed stirring 0.5h, be then ultrasonically treated 30min at 4 DEG C, the ultrasonic power of the supersound process is 400W, supersonic frequency
For 30kHz, extracting solution is obtained；
Said extracted liquid is placed in high-speed centrifugal pump by V, at a temperature of subzero 3 DEG C, with 8000r/min rotating speeds from
The heart separates 20min, stands 15min, supernatant is obtained after liquid separation；
VI, filters above-mentioned supernatant 3 times with sand core funnel, uses G4 type sand core funnels the 1st time, is using aperture for the 2nd time
G5 type sand core funnels, last time are all filtered using G6 types sand core funnel, finally obtain filtered fluid B；
Above-mentioned filtered fluid B is placed in vacuum freeze drier progress pre-freeze 40min by VII, cold-trap during vacuum freeze drying
Temperature is subzero 60 DEG C, vacuum 0.19Pa, and dry 5h, obtains the snail pituitary extract.
The production technology of the preserving moisture and protecting skin essence, comprises the following steps：
I, weighs each raw material components by weight；
Water, 1,2- pentanediols, glycerine, xanthans, pear oligose alcohol, carbomer are added the water phase pot of homogeneous emulsifying machine by II,
In container, 10min is stirred with the rotating speed of 700r/min at a temperature of 80 DEG C, water is obtained after mixing and mutually expects；
III, adds caprylic/capric triglyceride, ethanol in the oil phase pot of homogeneous emulsifying machine in container, 80 DEG C,
15min is stirred under the conditions of 700r/min, obtains oil phase material；
IV, keeps temperature and rotating speed constant, during oil phase material addition water is mutually expected, continues to stir 10min, treats that material is cooled to
40 DEG C, Phenoxyethanol, citric acid, collagen, fibroin, snail pituitary extract are added, is stirred with the rotating speed of 400r/min
Mix 15min；
V, is cooled to 30 DEG C, and after standing 24h, discharging, examine, filling and package, up to the preserving moisture and protecting skin elite of the present invention
Element.
Test case 1
Moistening effect is tested：20-55 Sui being selected, totally 200 people, men and women is fifty-fifty, health, rule of life, no skin disease,
10 groups are randomly divided into, every group of 20 people.After study subject cleaning facial skin, dry, smeared 3g preserving moisture and protecting skins essence with hand
It it is then 28 DEG C in test environment temperature, relative humidity is that the moisture that left face is measured in 60% environment contains on facial skin
Amount, while allow examinee to keep tranquil.The square Experimental Area of 2 2cm × 2cm is marked on the face on a left side, as preserving moisture and protecting skin
The test section of essence, using moisture of skin analyzer (German CK companies provide, model TM300), measure smears moisturizing respectively
The facial skin moisture content of 3h after facial treatment repair, records result.Concrete outcome is shown in Table 1.
Table 1：Moistening effect test result table
Embodiment 1-4 and 1 data of comparative example can be seen that embodiment and use by collagen, silk egg in comparison sheet
In vain, the moisturizer of snail pituitary extract combination, obtained preserving moisture and protecting skin essence, its moistening effect are better than embodiment 2-
In 4 preserving moisture and protecting skin essence (moisturizer is obtained by collagen, fibroin, any two kinds of combinations of snail pituitary extract) with
And the comparative example 1 of unused moisturizing.
Test case 2
Tolerance of skin is tested：Using the subject of lactic acid shouting pain 180 skin sensitivities of experiment screening, it is divided into 9 groups, every group
20 people, the easypro preserving moisture and protecting skin essence obtained respectively using embodiment 1-9, every group daily sooner or later twice by preserving moisture and protecting skin essence
Skin of face is applied to, and lactic acid shouting pain experiment is carried out to subject after product of the present invention is used 0 day, 14 days, 28 days.
Lactic acid shouting pain is tested：The 50 μ L of lactic acid solution of configuration 10wt% are dropped on the individual layer filter paper of a diameter of 0.8cm, are placed in
Subject's nasolabial groove position, inquires the tingling sensation of subject in 3min, 4min and 5min respectively and observes skin conditions, by 4 points
Method scores, and (0 point is no shouting pain, and 1 point is slight shouting pain, and 2 points are moderate shouting pain, and 3 points are severe shouting pain) shouting pain adds up
>=3 points are lactic acid shouting pain person, and test result is shown in Table 2.
Table 2：Lactic acid tingling sensation grade form
Embodiment 1, embodiment 5-6 data can be seen that embodiment 1 while carried using ultrasonic wave added enzyme and sand in comparison sheet
Snail pituitary extract obtained by the extracting method of core funnel filtering, is added in preserving moisture and protecting skin essence, its tolerance of skin
It is better than embodiment 5-6 to use the snail pituitary extract obtained by other extracting methods and be not added with snail pituitary extract
Embodiment 2, show that preserving moisture and protecting skin essence helps to form the protective barrier of one of skin in the present invention, improves the resistance to of skin
Stress.
Test case 3
Skin elasticity is tested：The anti-wrinkle performance of preserving moisture and protecting skin essence in embodiment 1-9 and comparative example 2 is commented
Valency, using skin elasticity as test index.The measure of skin elasticity uses suction method, and with constant negative pressure pattern, i.e. test probe exists
Skin surface applies negative pressure and skin is sucked probe aperture, and skin deformation is recovered after negative pressure disappears, and skin deformation is with negative pressure and time
Change can be measured by launching light in tester and receiving the device of light, which can reflect that skin is inhaled into depth, so may be used
Skin stretch length time history plot is obtained, represents skin maximum tension amount with Uf, Ue represents that constant negative pressure is added to
On skin at 0.1 second skin amount of tension, Ur indicates skin amount of recovery after no negative pressure 0.1S, Uv=Uf-Ue viscoelasticities part, Ua
Represent to cancel the amount of recovery that negative pressure adds negative pressure skin to next follow-on test again, R2=Ua/Uf, R2For a reflection skin elasticity
Parameter, R2The more big then skin elasticity of value is better, better closer to 1 elasticity.
Subjects：The subject at age 40-55 Sui is selected, men and women is fifty-fifty, is randomly divided into 10 groups, every group 30.It is tested
Person has the skin senescence phenomenons such as wrinkle, cutis laxa or dry skin.Subject is without serious systemic disease, no active mistake
Quick property disease, do not received yet skin treating, beauty and other may influence the test of result.Subject's experiment position is surveyed
Any cosmetics or topical drug cannot be used within 3 days before examination.
Test method：Before cosmetics are smeared, subject is using identical gentle detergent cleaning face, in subject's face
Symmetric position selects 5 × 5cm at left and right sides of portion2About 0.5g is smeared on the left of face as test area in the square areas of size
The preserving moisture and protecting skin essence of the present invention, smears the distilled water of equivalent on the right side of face, once in the morning and once at night, uses daily, avoids room
Outer exposure.
Before the cosmetics using the present invention, in test area, with skin elasticity tester, (German CK companies provide, type
Number it is MPA580) detection test area elasticity number；Detect test area elasticity number respectively again after smearing 30 days.Each experiment
5 hypoelasticity R of region detection2, and its average value is taken, specific test result is shown in Table 3.
Table 3：Skin elasticity test data table
| Sample | Elasticity number |
| Embodiment 1 | 0.81 |
| Embodiment 2 | 0.70 |
| Embodiment 3 | 0.72 |
| Embodiment 4 | 0.71 |
| Embodiment 5 | 0.73 |
| Embodiment 6 | 0.77 |
| Embodiment 7 | 0.66 |
| Embodiment 8 | 0.65 |
| Embodiment 9 | 0.67 |
| Comparative example 2 | 0.51 |
Observe table 3 to understand, the present invention strengthens preserving moisture and protecting skin essence anti-wrinkle effect by adding antioxidant.Compare reality
Apply example 1, embodiment 7-9 and comparative example 2 to understand, embodiment 1 is using by Coriolus Versicolor P.E., Cacumen Platycladi extract, erythrothioneine
The antioxidant of combination is applied to preserving moisture and protecting skin essence, its anti-wrinkle effect is better than preserving moisture and protecting skin essence in embodiment 7-9
(antioxidant is obtained by Coriolus Versicolor P.E., Cacumen Platycladi extract, any two kinds of combinations of erythrothioneine) and it is not used anti-oxidant
The comparative example 2 of agent.
The above described is only a preferred embodiment of the present invention, limitation in any form is not done to the present invention, therefore
The equivalent or simple change that all principles according to described in inventional idea of the present invention are done, is included in the protection domain of patent of the present invention
It is interior；Those skilled in the art can do various modifications or additions to described specific embodiment
Or substitute in a similar way, without departing from structure of the invention or surmount scope defined in the claims,
It is within the scope of protection of the invention.
Claims (10)
1. a kind of preserving moisture and protecting skin essence, it is characterised in that including following raw material：60-80 parts of water, caprylic/capric are sweet
Oily 2-4 parts of three ester, 3-8 parts of 1,2- pentanediols, 2-6 parts of glycerine, 3-5 parts of ethanol, 2-4 parts of xanthans, 1-3 parts of pear oligose alcohol, card
0.1-1 parts of ripple nurse, 0.02-0.04 parts of citric acid, 0.6-0.8 parts of Phenoxyethanol, 4-10 parts of moisturizer, 6-12 parts of antioxidant.
2. preserving moisture and protecting skin essence as claimed in claim 1, it is characterised in that the moisturizer is collagen, silk egg
In vain, the one or more in snail pituitary extract.
3. preserving moisture and protecting skin essence as claimed in claim 1, it is characterised in that the antioxidant is Coriolus Versicolor P.E., side
One or more in CedarLeaves extract, erythrothioneine.
4. preserving moisture and protecting skin essence as claimed in claim 2, it is characterised in that the preparation method of the snail pituitary extract
For：
I, chooses healthy snail, rests a period of time；
II, collects snail secretion, gained secretion is placed in quick-frozen 5-8h at 0-5 DEG C, is obtained at a temperature of 20-30 DEG C
Snail mucus；
Above-mentioned snail mucus is placed in 20-30 DEG C, grinds 10-30min under the conditions of 1800-3200r/min by III, and filter at low temperature, obtains
To filtered fluid；
IV, centrifuges above-mentioned filtered fluid, centrifugation at a temperature of subzero 6 to subzero 2 DEG C, with 8000-10000r/min rotating speeds
Time 10-30min, obtains supernatant；
After the above-mentioned supernatant freeze-dryings of V, the snail pituitary extract is obtained.
5. preserving moisture and protecting skin essence as claimed in claim 3, it is characterised in that the preparation method of the Coriolus Versicolor P.E. is：
Naturally dry after manyzoned polypore sporophore is cut into slices, is crushed to 30-60 mesh, and the extraction of 8-14 times of quality is added into gained Yunzhi powder
Agent, slightly boiling extraction 1.5-3h, filtering, collects filtrate, and filter residue equal conditions extract again, merges filtrate twice, obtains rainbow conk and carry
Liquid is taken, the Coriolus Versicolor P.E. is obtained after dry extraction liquid.
6. preserving moisture and protecting skin essence as claimed in claim 3, it is characterised in that the preparation method of the Cacumen Platycladi extract
For：Arbor-vitae leaf raw material is cleaned dry after be added to the water decoction 1-4 time, each decocting time be 1-2.5h, and decoction every time adds water
Quality is 9-10 times of arbor-vitae leaf raw material, merges and decocts water, and final gained decoction liquor is by being concentrated under reduced pressure, being dried to obtain cacumen biotae
Extract.
7. preserving moisture and protecting skin essence as claimed in claim 4, it is characterised in that the preparation method of the snail pituitary extract
For：
I, chooses healthy snail, rests a period of time；
II, collects snail secretion, gained secretion is placed in quick-frozen 5-8h at 0-5 DEG C, is obtained at a temperature of 20-30 DEG C
Snail mucus；
Above-mentioned snail mucus is placed in 20-30 DEG C, grinds 10-30min under the conditions of 1800-3200r/min by III, and filter at low temperature, obtains
To filtrate；
IV, adds the enzyme of 0.8-1.2 times of quality into above-mentioned filtrate, and 0.5- is stirred under the conditions of 20-40 DEG C, 200-400r/min
1.5h, is ultrasonically treated under cryogenic conditions, obtains extracting solution；
V, centrifuges said extracted liquid, centrifugation at a temperature of subzero 6 to subzero 2 DEG C, with 8000-10000r/min rotating speeds
Time 10-30min, stands, obtains supernatant after liquid separation；
After the above-mentioned supernatant freeze-dryings of VI, the snail pituitary extract is obtained.
8. preserving moisture and protecting skin essence as claimed in claim 5, it is characterised in that the extractant is that concentration is 1-3wt%'s
One or more in ethanol water, the ammonium hydroxide or water that concentration is 1-3wt%.
9. preserving moisture and protecting skin essence as claimed in claim 7, it is characterised in that the preparation method of the snail pituitary extract
For：
I, chooses healthy snail, rests a period of time；
II, collects snail secretion, gained secretion is placed in quick-frozen 5-8h at 0-5 DEG C, is obtained at a temperature of 20-30 DEG C
Snail mucus；
Above-mentioned snail mucus is placed in 20-30 DEG C, grinds 10-30min under the conditions of 1800-3200r/min by III, and filter at low temperature, obtains
To filtered fluid A；
IV, adds the enzyme of 0.8-1.2 times of filtrate A weight into above-mentioned filtrate A, is stirred under the conditions of 20-40 DEG C, 200-400r/min
0.5-1.5h is mixed, is ultrasonically treated under cryogenic conditions, obtains extracting solution；
V, centrifuges said extracted liquid, centrifugation at a temperature of subzero 6 to subzero 2 DEG C, with 8000-10000r/min rotating speeds
Time 10-30min, stands, obtains supernatant after liquid separation；
The above-mentioned supernatant liquid filterings of VI, 3 times, obtain filtered fluid B；
VII, is freeze-dried filtered fluid B, obtains the snail pituitary extract.
10. a kind of production technology of the essence of preserving moisture and protecting skin as described in the appended claim 1, it is characterised in that comprise the following steps：
I, weighs each raw material components by weight；
II, mixes water, 1,2- pentanediols, glycerine, xanthans, pear oligose alcohol, carbomer, with 600- at a temperature of 70-90 DEG C
The rotating speed stirring 5-15min of 1200r/min, obtains water and mutually expects after mixing；
Caprylic/capric triglyceride, ethanol are placed in 70-90 DEG C, stir 10-25min under conditions of 600-1200r/min by III,
Obtain oil phase material；
During IV, mutually expects oil phase material addition water, 5-15min is stirred with the rotating speed of 600-1200r/min at a temperature of 70-90 DEG C,
Treat that material is cooled to 35-50 DEG C, Phenoxyethanol, citric acid, moisturizer, antioxidant are added, with the rotating speed of 300-600r/min
Continue to stir 10-25min；
V, is cooled to 25-35 DEG C, stands 18-36h, and discharging, examine, filling and package, up to the preserving moisture and protecting skin elite of the present invention
Element.
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| CN201711432034.8A CN107970194A (en) | 2017-12-26 | 2017-12-26 | A kind of preserving moisture and protecting skin essence |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109846739A (en) * | 2019-03-18 | 2019-06-07 | 惠州市旭东实业有限公司 | A kind of moisturizing facial soap |
| CN110037964A (en) * | 2019-05-30 | 2019-07-23 | 谢鹏 | A kind of cleaning skin pore Essence |
| CN112535644A (en) * | 2020-12-23 | 2021-03-23 | 临沂大学 | Ergothioneine lipid complex gel and preparation method thereof |
-
2017
- 2017-12-26 CN CN201711432034.8A patent/CN107970194A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109846739A (en) * | 2019-03-18 | 2019-06-07 | 惠州市旭东实业有限公司 | A kind of moisturizing facial soap |
| CN110037964A (en) * | 2019-05-30 | 2019-07-23 | 谢鹏 | A kind of cleaning skin pore Essence |
| CN112535644A (en) * | 2020-12-23 | 2021-03-23 | 临沂大学 | Ergothioneine lipid complex gel and preparation method thereof |
| CN112535644B (en) * | 2020-12-23 | 2022-10-11 | 临沂大学 | Ergothioneine lipid complex gel and preparation method thereof |
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