CN107961364B - 一种治疗慢性肾衰竭的中药组合物 - Google Patents

一种治疗慢性肾衰竭的中药组合物 Download PDF

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CN107961364B
CN107961364B CN201711279546.5A CN201711279546A CN107961364B CN 107961364 B CN107961364 B CN 107961364B CN 201711279546 A CN201711279546 A CN 201711279546A CN 107961364 B CN107961364 B CN 107961364B
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魏连波
汪东涛
伍晓辉
邹小虎
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Abstract

本发明公开了一种中药组合物，该中药组合物由党参，白术，丹参，川芎，陈皮，姜半夏，干姜，黄连，杜仲，牛膝，大黄，春砂仁组成；其中，按质量份计，党参10～50份，白术5～20份，丹参10～50份，川芎5～20份，陈皮5～20份，姜半夏5～20份，干姜5～20份，黄连5～20份，杜仲5～40份，牛膝5～20份，大黄5～20份，春砂仁5～20份。采用本发明公开的中药组合物，对慢性肾衰竭有比较显著的疗效，显著降低了传统治疗方法成本，有望大规模应用。

Description

一种治疗慢性肾衰竭的中药组合物
技术领域
本发明涉及中药领域，特别涉及一种治疗慢性肾衰竭的中药组合物。
背景技术
慢性肾衰竭(CRF)是指各种原因造成慢性进行性肾实质损害，致使肾脏明显萎缩，不能维持基本功能，临床出现以代谢产物潴留，水、电解质、酸碱平衡失调，全身各系统受累为主要表现的临床综合征。其主要病因有原发性肾小球肾炎、慢性肾盂肾炎、高血压肾小动脉硬化、糖尿病肾病、继发性肾小球肾炎、肾小管间质病变、遗传性肾脏疾病以及长期服用解热镇痛剂及接触重金属等。
各种肾病都有发展为肾功能衰竭的可能，所以对肾功能衰竭--尿毒症的早期治疗是很重要的。目前西医治疗尿毒症主要采用血液透析、腹膜透析和肾脏移植进行治疗。对尿毒症患者的症状采用对症治疗。如：尿毒症患者轻度恶心、呕吐可通过饮食疗法减轻，严重者可用胃复安5～10mg口服，每日3次或肌肉注射；或氯丙嗪12.5～25mg，每日3次，口服或肌肉注射。采取肾移植治疗尿毒症，成功率还不是太高，以及排异现象一时还难以彻底解决，再加上费用的昂贵，往往使患者望而却步。如果一味地被动等待单纯性的透析，会造成患者丧失治疗信心，血透就会越来越频繁，进而终生依赖的后果。因此，可以采用中药治疗，或可取得理想的疗效。
发明内容
本发明的目的在于公开一种治疗慢性肾衰竭的中药组合物。
本发明所采取的技术方案是：一种中药组合物，该中药组合物由党参，白术，丹参，川芎，陈皮，姜半夏，干姜，黄连，杜仲，牛膝，大黄，春砂仁组成。
优选的，按质量份计，该中药组合物由党参10～50份，白术5～20份，丹参10～50份，川芎5～20份，陈皮5～20份，姜半夏5～20份，干姜5～20份，黄连5～20份，杜仲5～40份，牛膝5～20份，大黄5～20份，春砂仁5～20份组成。
优选的，按质量份计，该中药组合物由党参25份，白术10份，丹参25份，川芎10份，陈皮10份，姜半夏10份，干姜10份，黄连10份，杜仲20份，牛膝10份，大黄10份，春砂仁10份组成。
中药组合物在制备治疗慢性肾衰竭药物中的应用。
中药组合物在在制备辅助治疗慢性肾衰竭药物中的应用。
本发明的有益效果是：采用本发明公开的中药组合物，对慢性肾衰竭有比较显著的疗效，显著降低了传统治疗方法成本，有望大规模应用。
具体实施方式
实施例1
配制中药组合物，配方如下：党参25克，白术10克，丹参25克，川芎10克，陈皮10克，姜半夏10克，干姜10克，黄连10克，杜仲20克，牛膝10克，大黄10克，春砂仁10克。
实施例2
配制中药组合物，配方如下：党参50克，白术5克，丹参25克，川芎10克，陈皮10克，姜半夏10克，干姜5克，黄连20克，杜仲20克，牛膝10克，大黄5克，春砂仁5克。
实施例3
配制中药组合物，配方如下：党参25克，白术10克，丹参10克，川芎20克，陈皮20克，姜半夏5克，干姜10克，黄连10克，杜仲40克，牛膝5克，大黄20克，春砂仁10克。
实施例4
配制中药组合物，配方如下：党参10克，白术20克，丹参50克，川芎5克，陈皮5克，姜半夏20克，干姜20克，黄连5克，杜仲5克，牛膝20克，大黄10克，春砂仁20克。
实验例
132例均为南方医科大学深圳医院门诊病人，男78例，女54例，年龄26～77岁，病程最短6个月，最长12年，都为慢性病程。其中肾炎51例，DN(糖尿病肾病)26例，NS(肾病综合征)38例，高血压肾损害17例。随机分为治疗组67例，对照组65例，两组在年龄、性别、病情等方面均无明显差异(P>0.05)，具有可比性。所有病例均符合《内科学》慢性肾衰竭的诊断标准。
对照组给予低盐低磷优质低蛋白饮食，对高血压患者给予培哚普利4mg，每日1次口服，水肿者应用利尿剂，并纠正酸中毒、贫血、水电解质紊乱。同时用中药大黄合剂(大黄30g，槐花30g，地榆炭30g，甘草30g)100mL保留灌肠，每日1次。
治疗组在对照组治疗基础上给予本发明实施例1的处方。每日1剂，水煎服，分2次服用。两组均1个月为1个疗程，2疗程后比较疗效。
疗效标准与结果
疗效标准参考2011年中华中医药学会制定的《CRF诊疗指南》。显效：症状明显减轻或消失，BUN及Cr较治疗前下降>30％；有效：症状减轻，BUN及Cr较治疗前下降20％；无效：治疗后达不到以上标准或加重。
治疗结果：见下表：
表治疗组与对照组治疗前后主要实验室指标对比
Figure BDA0001497267170000031
治疗组67例，显效37例(55.2％)，有效22例(32.8％)，无效8例(12.0％)，总有效率88.0％；对照组65例，显效21例(32.3％)，有效20例(30.8％)，无效24例(36.9％)，总有效率63.1％。两组比较差异有统计学意义(P<0.05)。在改善肾功能、纠正贫血及酸中毒等方面治疗组明显优于对照组。

Claims (1)

1.一种治疗慢性肾衰竭的中药组合物，其特征在于，按质量份计，所述中药组合物由党参25份、白术10份、丹参25份、川芎10份、陈皮10份、姜半夏10份、干姜10份、黄连10份、杜仲20份、牛膝10份、大黄10份、春砂仁10份组成。
CN201711279546.5A 2017-12-06 2017-12-06 一种治疗慢性肾衰竭的中药组合物 Expired - Fee Related CN107961364B (zh)

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CN102648976A (zh) * 2012-04-24 2012-08-29 赵丽 延缓慢性肾衰的药物
CN103071006A (zh) * 2013-02-07 2013-05-01 云南理想药业有限公司 一种治疗肾功能衰竭中药的制备方法及质量检测方法

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