CN107952544A - Biological tissue's mill - Google Patents
Biological tissue's mill Download PDFInfo
- Publication number
- CN107952544A CN107952544A CN201711311603.3A CN201711311603A CN107952544A CN 107952544 A CN107952544 A CN 107952544A CN 201711311603 A CN201711311603 A CN 201711311603A CN 107952544 A CN107952544 A CN 107952544A
- Authority
- CN
- China
- Prior art keywords
- biological tissue
- closed shell
- mill
- gear
- grinding rod
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
- B02C18/06—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives
- B02C18/08—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives within vertical containers
- B02C18/10—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives within vertical containers with drive arranged above container
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
- B02C18/06—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives
- B02C18/16—Details
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
- B02C18/06—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives
- B02C18/16—Details
- B02C18/24—Drives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C23/00—Auxiliary methods or auxiliary devices or accessories specially adapted for crushing or disintegrating not provided for in preceding groups or not specially adapted to apparatus covered by a single preceding group
- B02C23/06—Selection or use of additives to aid disintegrating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C25/00—Control arrangements specially adapted for crushing or disintegrating
Landscapes
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Centrifugal Separators (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses a kind of biological tissue's mill, including closed shell, whole process of lapping is in confined space, avoids biological tissue from being contaminated, power unit, gear unit, the execution unit being arranged in closed shell, the power unit, including motor；Gear unit, including main drive gear, main drive gear are connected on motor, are engaged with main drive gear and are surrounded symmetrically arranged at least two driven gear of main drive gear；Execution unit, including sample cell, grinding rod for the biological tissue in ground sample pipe, sample cell is detachably connected on closed shell, grinding rod is detachably connected on the driven gear, can be made multiple grinding rod simultaneous grinding biological organization samples using gear drive, be improved grinding efficiency, grinding rod is detachably connected on driven gear, installation, dismounting easy to grinding rod.
Description
Technical field
The present invention relates to a kind of biomedicine technical field, especially a kind of biological tissue's mill.
Background technology
Biological tissue's mill be in terms of nucleic acid and protein preparation it is essential, it is common in medical experiment at present
It is the mill of mortar formula, using the mill of mortar formula, there are problems with：1) mortar formula mill is sudden and violent in operation
It is exposed in air, process of lapping easily pollutes；2) due to being hand lapping, grinding dynamics is difficult to control, and milling time is long will
The nucleic acid decomposition in sample is caused to go bad, and milling time is too short insufficient in the presence of grinding, grinding effect is bad, and extraction is difficult
The problems such as；3) not only labor intensive hand-manipulated, can only once grind a sample, grinding efficiency is low, and once testing often needs
Want several to more than ten a mortars, the big quantity space of operation console need to be occupied；4) also need to transfer samples in centrifuge tube after the completion of grinding
Separation and Extraction is carried out, sample loss and pollution are easily led in transfer process；5) in order to make to keep low temperature in mortar, in process of lapping
It need to repeatedly add liquid nitrogen, it is time-consuming and laborious and easily cause danger；6) mortar is recycling, and disinfecting process needs to use medicining liquid dipping
24 it is small when after high-temperature sterilization again, disinfection cycle is longer, influences experiment progress, and if cleaning and sterilizing is not thorough, will pollute next
Secondary experimental specimen.Therefore, it is badly in need of a kind of biological tissue's mill easy to operate, grinding effect is good, grinding efficiency is high.
The content of the invention
The technical problems to be solved by the invention are to provide biological tissue's grinding that a kind of grinding efficiency is high, grinding effect is good
Device.
The technical solution adopted in the present invention is：Biological tissue's mill, including closed shell, make at whole process of lapping
In confined space, biological tissue is avoided to be contaminated, power unit, gear unit, the execution unit being arranged in closed shell, institute
State power unit, including motor；Gear unit, including main drive gear, main drive gear are connected on motor, motor band moving teeth
Wheel, sample cell grinding, grinding dynamics is balanced, can be fully ground biological tissue, and grinding effect is good, and saves manpower, with main biography
Moving gear engages and surrounds symmetrically arranged at least two driven gear of main drive gear；Execution unit, including sample cell, are used for
The grinding rod of biological tissue in ground sample pipe, sample cell are detachably connected on closed shell, and grinding rod is removably
It is connected on the driven gear, multiple grinding rod simultaneous grinding biological organization samples can be made using gear drive, raising is ground
Efficiency is ground, grinding rod is detachably connected on driven gear, installation, dismounting easy to grinding rod.
Further, sample cell includes the sample tube body of supporting connection, sample tube cover, and sample tube cover is run through in grinding rod lower end
Stretch into sample cell body, the protrusion for being connected with closed shell is provided with sample tube cover, be provided with and be used among the protrusion
The opening of grinding rod is installed, sample cell is detachably connected with closed shell, is easily installed and dismantles sample cell, while ensures to grind
Sample cell does not turn when frotton rotates.
Further, centrifuge, extract sample tube body using centrifuge tube centrifugation, the extraction that can be used for centrifuging, extracting, easy to straight
Connect and the sample for grinding completion is installed in the tube cover of centrifuge tube, avoid sample loss and pollution
Further, the lower part of grinding rod is provided with set of blades, can fully grind biological tissue.
Further, it is provided with driven gear and the raised matched groove in sample tube cover.
Further, closed shell lower end is detachably connected with cryogenic box, fills liquid nitrogen in cryogenic box, ensures at liquid nitrogen
In low temperature environment, it is easy to grind, while confined space can prevent liquid nitrogen from volatilizing.
Further, power supply is provided with closed shell, closed shell outer surface is provided with timer, power supply is opened
Close, motor, power switch, power supply series connection, timer are connected in parallel on power supply, and power supply provides power for motor and timer, passes through
The milling time of different specimens in timer control process of lapping.
The beneficial effects of the invention are as follows：
(1) grinding rod is driven to grind biological tissue, and multiple grinding rod simultaneous grinding samples using motor, travelling gear
This, improves grinding efficiency, ensure that grinding effect, save manpower.
(2) it is ground on grinding rod using blade, makes grinding more abundant, further ensure grinding effect.
(3) grinding rod is disposable detachable structure, is conveniently replaceable grinding rod, reduces the process and intersection of cleaning and sterilizing
The possibility of infection.
(4) timer is set, can be according to different types of sample milling time different with amount setting.
(5) sample cell uses centrifuge tube, both saves cost, need not shift sample when centrifuging, extracting after the completion of grinding, grasp
Make simply, to reduce sample loss.
(6) liquid nitrogen is filled in cryogenic box, is easy to grind, ensures that liquid nitrogen is in low temperature environment, can prevent liquid nitrogen from volatilizing, save
The trouble of multiple liquid feeding nitrogen has been gone, liquid nitrogen can have been recycled after operation.
Brief description of the drawings
Fig. 1 is the structure diagram of mill of the present invention.
Fig. 2 is the internal structure scheme of installation of mill of the present invention.
Fig. 3 is the structure diagram of driven gear of the present invention.
Fig. 4 is grinding rod of the present invention and the scheme of installation of sample tube cover.
Fig. 5 is grinding rod of the present invention and sample cell, the scheme of installation of driven gear.
Fig. 6 is scheme of installation of the sample tube body with the original-pack lid of centrifuge tube of the present invention.
Fig. 7 is the scheme of installation of inventive samples pipe and grinding rod.
In figure mark for：1- power supplys, 2- timers, 3- motors, 4- power switches, 5- main drive gears, 6- driven gears,
7- grinding rods, 8- sample tube bodies, 9- cryogenic boxes, 10- cylindrical recesses, 11- rotation axis, 12- grinding rods upper end, 13- sample tube covers,
The original-pack lid of 14- centrifuge tubes, 15- " ten " font is raised, 16- " ten " font groove, 17- closed shells, 18- set of blades.
Embodiment
The present invention is further described with reference to the accompanying drawings and examples.
As shown in Figures 1 to 7, biological tissue's mill of the invention, including closed shell 17, are arranged on closed shell 17
Interior power unit, gear unit, execution unit, the power unit, including motor 3, motor 3 use micromachine 3, ensure
While 7 power of grinding rod, reduce the weight of whole mill；Gear unit, including main drive gear 5, main drive gear 5
It is connected on motor 3, is engaged with main drive gear 5 and surround symmetrically arranged at least two driven gear 6 of main drive gear 5,
The specific can be six driven gears 6；Execution unit, including sample cell, for grinding for the biological tissue in ground sample pipe
Frotton 7, sample cell are detachably connected on closed shell 17, and grinding rod 7 is detachably connected on the driven gear 6.
As shown in fig. 7, sample cell includes the sample tube body 8 of supporting connection, sample tube cover 13, sample is run through in 7 lower end of grinding rod
Quality control lid 13 is stretched into sample tube body 8, and the lower part of grinding rod 7 is provided with set of blades 18, can specifically be placed equidistant with three groups of knives
Piece, the protrusion for being connected with closed shell 17 is provided with sample tube cover 13, should the specific can be " ten " font protrusion 15
The opening for installing grinding rod 7 is provided among raised, is provided with 17 bottom of closed shell 15 raised with " ten " font
" ten " font groove 16 as shown in Figure 2 matched somebody with somebody, as shown in figure 3,6 upper end of driven gear is connected with rotation axis 11, the rotation axis
11 are fixed on closed shell 17, and lower end is provided with the cylindrical recesses 10 with 12 form fit of grinding rod upper end, are ground for connecting
The upper end of frotton 7, when specifically making, can be made integrative-structure, sample tube cover 13 by sample tube cover 13, " ten " font protrusion 15
Specification lid 14 original-pack with centrifuge tube specification it is identical, drive grinding rod 7 to rotate and sample cell does not rotate when motor 3 rotates,
As shown in Figure 1,17 lower end of closed shell is detachably connected with cryogenic box 9, it can specifically use and be threadedly coupled, cryogenic box 9
Interior filling liquid nitrogen, ensures that liquid nitrogen is in low temperature environment, is easy to grind, while confined space can prevent liquid nitrogen from volatilizing.
As shown in Figure 1 and Figure 2, power supply 1 is provided with closed shell 17, power supply 1 uses rechargeable battery, repeatable to make
With, timer 2, power switch 4 are provided with 17 outer surface of closed shell, motor 3, power supply 1 are fixed on closed shell 17, electricity
Machine 3, power switch 4, power supply 1 are connected, and power supply 1 is used for the power for providing motor 3 and timer 2, and power switch 4 controls motor 3
Startup, timer 2 is connected in parallel on power supply 1.
The mill application method of the present invention is as follows：The biological tissue samples amount and quantity ground as needed, select one
Secondary property centrifuge tube is as sample cell and the grinding rod of respective numbers 7, as shown in figure 4, grinding rod upper end 12 is inserted into sample tube cover
Opening on 13, the biological tissue for needing to grind is added into centrifuge tube, as shown in fig. 7, centrifuge tube is screwed to sample tube cover 13
On, the grinding rod 7 for connecting centrifuge tube is symmetrically inserted into the cylindrical recesses 10 on corresponding driven gear 6, while such as Fig. 5 institutes
Show, " ten " font protrusion 15 in sample tube cover 13 is embedded in " ten " font groove 16 of closed shell 17, then in cryogenic box 9
Middle addition liquid nitrogen, the closed shell 17 for assembling sample cell is screwed on cryogenic box 9, makes entirely to grind using cryogenic box 9 as base
Grinder is positioned over operation console, turns on the power switch 4 at this time, according to the species and amount of required ground sample, is set on timer 2
Corresponding milling time, drives grinding rod 7 to rotate and starts to grind sample and sample cell will not rotate when motor 3 rotates.Grind
Cheng Hou, as shown in fig. 6, covering the original-pack lid 14 of centrifuge tube is directly used in the operation of the subsequent experimentals such as centrifugation, extraction.The present invention's grinds
Grinder is not limited to the grinding of biological tissue, it can also be used to the grinding of unclassified stores.
Claims (7)
1. biological tissue's mill, it is characterised in that：Including closed shell (17), the power list being arranged in closed shell (17)
Member, gear unit, execution unit, it is described
Power unit, including motor (3)；
Gear unit, including main drive gear (5), main drive gear (5) are connected on motor (3), are nibbled with main drive gear (5)
Close and surround symmetrically arranged at least two driven gear (6) of main drive gear (5)；
Execution unit, including sample cell, for the grinding rod (7) of the biological tissue in ground sample pipe, sample cell is removably
It is connected on closed shell (17), grinding rod (7) is detachably connected on the driven gear (6).
2. biological tissue's mill as claimed in claim 1, it is characterised in that：Sample cell includes the sample tube body of supporting connection
(8), sample tube cover (13), grinding rod (7) lower end are stretched into sample tube body (8) through sample tube cover (13), sample tube cover (13)
On be provided with for the protrusion that be connected with closed shell (17), be provided with the opening for being used for installing grinding rod (7) among the protrusion.
3. biological tissue's mill as claimed in claim 2, it is characterised in that：Centrifugation, extraction sample tube body (8) are using available
In the centrifuge tube of centrifugation, extraction.
4. biological tissue's mill as claimed in claim 3, it is characterised in that：The lower part of grinding rod (7) is provided with set of blades
(18)。
5. biological tissue's mill as claimed in claim 4, it is characterised in that：It is provided with driven gear (6) and sample cell
Cover the raised matched groove on (13).
6. biological tissue's mill as claimed in claim 5, it is characterised in that：Closed shell (17) lower end is detachably connected
There is cryogenic box (9), liquid nitrogen is filled in cryogenic box (9).
7. biological tissue's mill as described in claim 1 to 6, it is characterised in that：Electricity is provided with closed shell (17)
Source (1), timer (2), power switch (4), motor (3), power switch (4), electricity are provided with closed shell (17) outer surface
Source (1) is connected, and timer (2) is connected in parallel on power supply (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711311603.3A CN107952544A (en) | 2017-12-11 | 2017-12-11 | Biological tissue's mill |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711311603.3A CN107952544A (en) | 2017-12-11 | 2017-12-11 | Biological tissue's mill |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107952544A true CN107952544A (en) | 2018-04-24 |
Family
ID=61958448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711311603.3A Pending CN107952544A (en) | 2017-12-11 | 2017-12-11 | Biological tissue's mill |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107952544A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110317713A (en) * | 2019-08-09 | 2019-10-11 | 象山冰川智能装备有限公司 | A kind of animal tissue's homogenate milling apparatus |
| CN110567768A (en) * | 2018-06-05 | 2019-12-13 | 安徽省农业科学院蚕桑研究所 | Single moth grinder for detecting silkworm corpuscle disease mother moth |
| CN113789255A (en) * | 2021-08-05 | 2021-12-14 | 南通大学 | Liquid nitrogen freezing type multi-sample biological tissue grinding device |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160143480A1 (en) * | 2014-11-24 | 2016-05-26 | Jim Watts | Manually Operable Herb Grinder |
| WO2016095458A1 (en) * | 2014-12-16 | 2016-06-23 | 南通市肿瘤医院 | Homogenizer for separating subcellular fractions |
| CN205462524U (en) * | 2016-03-18 | 2016-08-17 | 广州拓普基因科技有限公司 | Grinding device |
| CN205981832U (en) * | 2016-08-24 | 2017-02-22 | 南昌乐悠生物科技有限公司 | Electronic tissue homogenate devices of turning round more |
| CN207805736U (en) * | 2017-12-11 | 2018-09-04 | 中国人民解放军成都军区总医院 | Biological tissue's mill |
-
2017
- 2017-12-11 CN CN201711311603.3A patent/CN107952544A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160143480A1 (en) * | 2014-11-24 | 2016-05-26 | Jim Watts | Manually Operable Herb Grinder |
| WO2016095458A1 (en) * | 2014-12-16 | 2016-06-23 | 南通市肿瘤医院 | Homogenizer for separating subcellular fractions |
| CN205462524U (en) * | 2016-03-18 | 2016-08-17 | 广州拓普基因科技有限公司 | Grinding device |
| CN205981832U (en) * | 2016-08-24 | 2017-02-22 | 南昌乐悠生物科技有限公司 | Electronic tissue homogenate devices of turning round more |
| CN207805736U (en) * | 2017-12-11 | 2018-09-04 | 中国人民解放军成都军区总医院 | Biological tissue's mill |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110567768A (en) * | 2018-06-05 | 2019-12-13 | 安徽省农业科学院蚕桑研究所 | Single moth grinder for detecting silkworm corpuscle disease mother moth |
| CN110317713A (en) * | 2019-08-09 | 2019-10-11 | 象山冰川智能装备有限公司 | A kind of animal tissue's homogenate milling apparatus |
| CN110317713B (en) * | 2019-08-09 | 2020-10-23 | 信阳农林学院 | Animal tissue homogenate grinding device |
| CN113789255A (en) * | 2021-08-05 | 2021-12-14 | 南通大学 | Liquid nitrogen freezing type multi-sample biological tissue grinding device |
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