CN107951950A - A kind of pharmaceutical composition for treating amenorrhoea and preparation method thereof - Google Patents
A kind of pharmaceutical composition for treating amenorrhoea and preparation method thereof Download PDFInfo
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- CN107951950A CN107951950A CN201810055339.XA CN201810055339A CN107951950A CN 107951950 A CN107951950 A CN 107951950A CN 201810055339 A CN201810055339 A CN 201810055339A CN 107951950 A CN107951950 A CN 107951950A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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Abstract
The present invention relates to a kind of pharmaceutical composition for treating amenorrhoea, it is prepared by the raw material of following parts by weight：15 25 parts of RADIX ANGELICAE SINEINSIS, 15 25 parts of Ligusticum wallichii, 15 25 parts of Radix Paeoniae Alba, 15 25 parts of prepared rhizome of rehmannia, 15 25 parts of Herba Lycopi, 10 20 parts of Radix Salviae Miltiorrhizae, 8 12 parts of reticulate millettia, 8 12 parts of radix cyathulae, 10 20 parts of radix astragali, 8 12 parts of Rhizoma Atractylodis Macrocephalae, 8 12 parts of motherwort, 0.2 0.4 parts of antisterone.Compared with prior art, therapeutic effect of the invention is good, and (multiple) comes short through the time, and convenient to take, inexpensive, curative effect is good, through row process and more normal through measuring, without side-effects, without repeatedly, can effectively release the misgivings of patient in time.
Description
Technical field
The invention belongs to pharmaceutical technology field, more particularly to a kind of pharmaceutical composition for treating amenorrhoea and preparation method thereof.
Background technology
Women over 18 years through not yet rising, or or after the menstrual cycle establishes, and more than 3 months persons of menopause are known as closing
Through.(the former is primary amenorrhea, and the latter is secondary amenorrhea).The gestational period, nursing period, postclimacteric menopause belong to physiology and show
As being not belonging to amenorrhoea category.《Synopsis Golden Chamber》Record：The disease of married woman, Yin Sai, heat are cold, knot gas, and the amenorrhoea broken off for Zhu Jingshui is former
Cause.For plug person, more because the sea of blood is hollow, no blood can under, or both liver and kidney deficiency, asthenia of essence and blood.Real person is more because of qi and blood stasis, in extravasated blood
Resistance, insufficiency of vital energy and blood, Chong and Ren channel disorder, thus amenorrhoea.
The treatment of amenorrhoea, always uses traditional Chinese medicine dialectical treatmert, and needs for a long time, up to more than 1 year, short then half a year
As long as, even if sometimes by above-mentioned treatment come (multiple) warp, but, few through measuring, easily amenorrhoea repeatedly, is difficult in a short time through row irregularly
Prove effective.According to western medicine, although curative effect is fast, Western medicine expensive and intake should not be not excessive.
The content of the invention
It is an object of the invention to：A kind of pharmaceutical composition of collaborative treatment of Chinese and western medicines amenorrhoea and preparation method thereof is provided.
To achieve the above object, the present invention provides following technical solution：
A kind of pharmaceutical composition for treating amenorrhoea, is prepared by the raw material of following parts by weight：
15-25 parts of RADIX ANGELICAE SINEINSIS, 15-25 parts of Ligusticum wallichii, 15-25 parts of Radix Paeoniae Alba, 15-25 parts of prepared rhizome of rehmannia, 15-25 parts of Herba Lycopi, Radix Salviae Miltiorrhizae
10-20 parts, 8-12 parts of reticulate millettia, 8-12 parts of radix cyathulae, 10-20 parts of radix astragali, 8-12 parts of Rhizoma Atractylodis Macrocephalae, 8-12 parts of motherwort, chloroxoquinoline
It is 0.2-0.4 parts logical.
Preferably, a kind of pharmaceutical composition for treating amenorrhoea, is prepared by the raw material of following parts by weight：
20 parts of RADIX ANGELICAE SINEINSIS, 20 parts of Ligusticum wallichii, 20 parts of Radix Paeoniae Alba, 20 parts of prepared rhizome of rehmannia, 20 parts of Herba Lycopi, 15 parts of Radix Salviae Miltiorrhizae, 10 parts of reticulate millettia,
10 parts of radix cyathulae, 15 parts of radix astragali, 10 parts of Rhizoma Atractylodis Macrocephalae, 10 parts of motherwort, 0.3 part of antisterone.
Preferably, a kind of preparation method for the pharmaceutical composition for treating amenorrhoea, comprises the following steps that：
By RADIX ANGELICAE SINEINSIS, Ligusticum wallichii, Radix Paeoniae Alba, prepared rhizome of rehmannia, Herba Lycopi, Radix Salviae Miltiorrhizae, reticulate millettia, radix cyathulae, radix astragali, Rhizoma Atractylodis Macrocephalae, motherwort, peace
Body relaxes after logical mixing, grind into powder.
The beneficial effects of the present invention are：
Compared with prior art, therapeutic effect of the invention is good, and (multiple) carrys out, convenient to take, inexpensive, curative effect short through the time
It is good, it is through row process and more normal through measuring, it is without side-effects, without repeatedly, the misgivings of patient can be effectively released in time.
Specific embodiment
Embodiment 1
A kind of pharmaceutical composition for treating amenorrhoea, is prepared by the raw material of following parts by weight：
RADIX ANGELICAE SINEINSIS 15g, Ligusticum wallichii 15g, Radix Paeoniae Alba 15g, prepared rhizome of rehmannia 15g, Herba Lycopi 15g, Radix Salviae Miltiorrhizae 10g, reticulate millettia 8g, radix cyathulae
8g, radix astragali 10g, Rhizoma Atractylodis Macrocephalae 8g, motherwort 8g, antisterone 0.2g.
Its preparation method is as follows：By RADIX ANGELICAE SINEINSIS, Ligusticum wallichii, Radix Paeoniae Alba, prepared rhizome of rehmannia, Herba Lycopi, Radix Salviae Miltiorrhizae, reticulate millettia, radix cyathulae, Huang
After stilbene, Rhizoma Atractylodis Macrocephalae, motherwort, antisterone mixing, grind into powder.
Embodiment 2
A kind of pharmaceutical composition for treating amenorrhoea, is prepared by the raw material of following parts by weight：
RADIX ANGELICAE SINEINSIS 20g, Ligusticum wallichii 20g, Radix Paeoniae Alba 20g, prepared rhizome of rehmannia 20g, Herba Lycopi 20g, Radix Salviae Miltiorrhizae 15g, reticulate millettia 10g, radix cyathulae
10g, radix astragali 15g, Rhizoma Atractylodis Macrocephalae 10g, motherwort 10g, antisterone 0.3g.
Its preparation method is as follows：By RADIX ANGELICAE SINEINSIS, Ligusticum wallichii, Radix Paeoniae Alba, prepared rhizome of rehmannia, Herba Lycopi, Radix Salviae Miltiorrhizae, reticulate millettia, radix cyathulae, Huang
After stilbene, Rhizoma Atractylodis Macrocephalae, motherwort, antisterone mixing, grind into powder.
Embodiment 3
A kind of pharmaceutical composition for treating amenorrhoea, is prepared by the raw material of following parts by weight：
RADIX ANGELICAE SINEINSIS 25g, Ligusticum wallichii 25g, Radix Paeoniae Alba 25g, prepared rhizome of rehmannia 25g, Herba Lycopi 25g, Radix Salviae Miltiorrhizae 20g, reticulate millettia 12g, radix cyathulae
12g, radix astragali 20g, Rhizoma Atractylodis Macrocephalae 12g, motherwort 12g, antisterone 0.4g.
Its preparation method is as follows：By RADIX ANGELICAE SINEINSIS, Ligusticum wallichii, Radix Paeoniae Alba, prepared rhizome of rehmannia, Herba Lycopi, Radix Salviae Miltiorrhizae, reticulate millettia, radix cyathulae, Huang
After stilbene, Rhizoma Atractylodis Macrocephalae, motherwort, antisterone mixing, grind into powder.
Embodiment 4
To show Chinese and Western medicine of the present invention to treating the effect of amenorrhoea, inventor to patient'ss (being women) of 67 amenorrhoeas,
Age 18-45 Sui, each 5g, 3 times a day, warm water (about 150ml) take, using the pharmaceutical composition of embodiment 2.3 days are 1
A course for the treatment of, a general course for the treatment of i.e. come it is (multiple) warp, it is most 2 days short, most long 5-6 days and pass through process and through amount more normal, no pair
Effect, without repeatedly.Fat and cool drink carrys out (multiple) pass through by the wet excessive person of water, in two courses for the treatment of.
In addition, detecting prolactin(PRL (normal reference value 4.61-30.75 μ g/L) before going to a doctor to amenorrhea patients, pass through detection
It was found that：Prolactin(PRL is all more than 30.75 μ g/L.After taking medicine of the present invention, detection is found：All amenorrhoeas for taking medicine of the present invention
Patient checks prolactin(PRL below 30.75 μ g/L.
The pharmacology analysis of the Chinese and Western medicine of the present invention：Hyperprolactinemia can cause menstrual function disorder-amenorrhoea etc..Original bromine
Hidden booth confrontation, but the medicine is expensive, and side effect is larger, easily repeatedly.Therefore, the present inventor expects treating using Chinese and Western medicine
Amenorrhoea, is treated by multiple clinical practice, it has unexpectedly been found that, prolactin blood trouble can be also resisted, has reached healing amenorrhoea, and the course for the treatment of
Short, menstruation process and more normal through measuring is without side-effects, without repeatedly.
Pharmic function：
RADIX ANGELICAE SINEINSIS：Promoting blood circulation for regulating menstruation relieves pain, for irregular menstruation；
Ligusticum wallichii：Invigorate blood circulation promoting the circulation of qi, for irregular menstruation, dysmenorrhoea, amenorrhoea；
Radix Paeoniae Alba：Nourishing blood and liver, analgesic in delaying, holds back cloudy receipts sweat；
Prepared rhizome of rehmannia：Blood-nourishing qi-restoratives；
Herba Lycopi：Invigorate blood circulation promoting the circulation of qi, for amenorrhoea, postpartum stasis of blood；
Radix Salviae Miltiorrhizae：Promoting blood circulation for regulating menstruation stagnation resolvation, for amenorrhoea；
Reticulate millettia：Clearing and activating the channels and collaterals, promoting circulation of blood are enriched blood, for amenorrhoea；
Radix cyathulae：Clearing and activating the channels and collaterals, for blood stasis amenorrhoea, inducing diuresis for treating strangurtia；
Radix astragali：Sun is helped in invigorating qi for strengthening superficies, tonifying Qi；
Rhizoma Atractylodis Macrocephalae：Strengthening QI of middle-JIAO；
Motherwort：Promoting blood circulation for regulating menstruation, for irregular menstruation, promoting circulation of blood dissolving stasis；
Western medicine：Antisterone：There is aldosterone antagonist and antiandrogen；
It is active that all medicines share reaches promoting blood circulation for regulating menstruation, through saying：Also there is " gas promoting circulation of blood is also gone " logical (multiple) warp.
Explanation:The composition of the present invention can also be taken as follows：Chinese and Western separates takes that (Chinese medicine, is decocted in water for oral dose at the same time；
Western medicine, oral) effect same can be reached.
Claims (3)
1. a kind of pharmaceutical composition for treating amenorrhoea, it is characterised in that be prepared by the raw material of following parts by weight：
15-25 parts of RADIX ANGELICAE SINEINSIS, 15-25 parts of Ligusticum wallichii, 15-25 parts of Radix Paeoniae Alba, 15-25 parts of prepared rhizome of rehmannia, 15-25 parts of Herba Lycopi, Radix Salviae Miltiorrhizae 10-20
Part, 8-12 parts of reticulate millettia, 8-12 parts of radix cyathulae, 10-20 parts of radix astragali, 8-12 parts of Rhizoma Atractylodis Macrocephalae, 8-12 parts of motherwort, antisterone 0.2-
0.4 part.
2. the pharmaceutical composition for the treatment of amenorrhoea according to claim 1, it is characterised in that by the raw material system of following parts by weight
It is standby to form：
20 parts of RADIX ANGELICAE SINEINSIS, 20 parts of Ligusticum wallichii, 20 parts of Radix Paeoniae Alba, 20 parts of prepared rhizome of rehmannia, 20 parts of Herba Lycopi, 15 parts of Radix Salviae Miltiorrhizae, 10 parts of reticulate millettia, river ox
10 parts of knee, 15 parts of radix astragali, 10 parts of Rhizoma Atractylodis Macrocephalae, 10 parts of motherwort, 0.3 part of antisterone.
3. the preparation method of the pharmaceutical composition of the treatment amenorrhoea according to claim 1-2 any one, it is characterised in that
Comprise the following steps that：
By RADIX ANGELICAE SINEINSIS, Ligusticum wallichii, Radix Paeoniae Alba, prepared rhizome of rehmannia, Herba Lycopi, Radix Salviae Miltiorrhizae, reticulate millettia, radix cyathulae, radix astragali, Rhizoma Atractylodis Macrocephalae, motherwort, chloroxoquinoline
After logical mixing, grind into powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810055339.XA CN107951950A (en) | 2018-01-19 | 2018-01-19 | A kind of pharmaceutical composition for treating amenorrhoea and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810055339.XA CN107951950A (en) | 2018-01-19 | 2018-01-19 | A kind of pharmaceutical composition for treating amenorrhoea and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
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| CN107951950A true CN107951950A (en) | 2018-04-24 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201810055339.XA Pending CN107951950A (en) | 2018-01-19 | 2018-01-19 | A kind of pharmaceutical composition for treating amenorrhoea and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103356961A (en) * | 2013-07-22 | 2013-10-23 | 黄淑娟 | Traditional Chinese medicinal composition for treating amenorrhoea |
| CN106620531A (en) * | 2017-01-03 | 2017-05-10 | 张先军 | Traditional Chinese medicine composition for treating amenorrhea |
-
2018
- 2018-01-19 CN CN201810055339.XA patent/CN107951950A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103356961A (en) * | 2013-07-22 | 2013-10-23 | 黄淑娟 | Traditional Chinese medicinal composition for treating amenorrhoea |
| CN106620531A (en) * | 2017-01-03 | 2017-05-10 | 张先军 | Traditional Chinese medicine composition for treating amenorrhea |
Non-Patent Citations (3)
| Title |
|---|
| 刘思达等: "《准妈妈教室》", 31 December 1999, 新疆人民出版社 * |
| 大理白族自治州卫生局: "《白族民间单方验方精粹》", 31 December 2015, 云南科技出版社 * |
| 陈凯佳等: "近现代名老中医治疗"闭经"用药规律初探", 《中医药学刊》 * |
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Application publication date: 20180424 |