CN107937179A - A kind of efficiently anti-inflammatory anti-acne handmade soap - Google Patents
A kind of efficiently anti-inflammatory anti-acne handmade soap Download PDFInfo
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- CN107937179A CN107937179A CN201711251545.XA CN201711251545A CN107937179A CN 107937179 A CN107937179 A CN 107937179A CN 201711251545 A CN201711251545 A CN 201711251545A CN 107937179 A CN107937179 A CN 107937179A
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/38—Products in which the composition is not well defined
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D10/00—Compositions of detergents, not provided for by one single preceding group
- C11D10/04—Compositions of detergents, not provided for by one single preceding group based on mixtures of surface-active non-soap compounds and soap
- C11D10/045—Compositions of detergents, not provided for by one single preceding group based on mixtures of surface-active non-soap compounds and soap based on non-ionic surface-active compounds and soap
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/26—Organic compounds, e.g. vitamins containing oxygen
- C11D9/262—Organic compounds, e.g. vitamins containing oxygen containing carbohydrates
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/30—Organic compounds, e.g. vitamins containing nitrogen
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Abstract
The present invention relates to a kind of efficiently anti-inflammatory anti-acne handmade soap and preparation method thereof, it is characterised in that：Being calculated according to weight fraction includes following component：10 15 parts of marine active component, 0.5 2 parts of recombinant antimicrobial peptide, 0.01 part of epidermal growth factor, 0.01 part of fibroblast growth factor, 0.01 part of transforming growth factor, 35 parts of texifolin, 58 parts of perilla leaf extract, 6 10 parts of niacinamide, 0.3 1 parts of Tea Saponin, 80 100 parts of Seabuckthorm Seed Oil, natural 270 320 parts of soap base.Efficiently anti-inflammatory anti-acne handmade soap of the invention combines full marine active component composite extract and a variety of antibacterial peptides and growth factor first, edible is prepared, it is non-stimulated without preservative, efficient anti-inflammatory is antibacterial, anti-acne, anti-oxidant, reparation pockmark, the pure natural handmade soap for preventing acne scar from being formed.Because biological transdermal enhancer derives from animal and plant extracts, there is good biocompatibility, and skin will not be caused to damage, there is security.
Description
Technical field
Shield skin care item preparing technical field is washed the invention belongs to daily, it is manual more particularly to a kind of efficiently anti-inflammatory anti-acne
Soap.
Background technology
Handmade soap is also known as " natural interfacial agent ", and main component is the advanced fat that natural oil is manufactured with highly basic
Fat acid sodium, various surfactants of the handmade soap without synthesis, after contact with water, can be bacterially decomposed into water and titanium dioxide
Carbon, it is environmental.Handmade soap is divided into cold process soap, hot soapmaking and regeneration soap.Cold process soap be relative to industrial soap used by thermosol
For method, after grease, sodium hydroxide solution mixing, saponification occurs, it is except being needed before mixing that the grease heating of solid is molten
Forming liquid is external, need not be heated at high temperature during into soap, and after the completion of reaction, soap lye, which enters mould, makes its natural drying,
Demould after three to five weeks and just can be used directly.Hot soapmaking is the soap made using hot preparation method, is carried out in grease and sodium hydroxide
During saponification to the thick shape stage, then in a manner of intermittent heat, make its quick saponification, being placed after the demoulding one week steams moisture
Hair, you can use.Regeneration soap is processing again, the optimization to cold process soap and hot soapmaking, publicizes various effects on the market at present,
The essential oil soap that with the addition of essential oil and extract belongs to regeneration soap.
Whelk also known as acne, the generation of acne is mainly blocked with hypersteatosis, pilosebaceous duct, bacterium sense
Dye and the factor such as inflammatory reaction are closely related.Adolesce the rapid rise of level of the particularly emerald green ketone of androgen in descendant's body,
Sebaceous glands is promoted to develop and produce a large amount of sebums.The dyskeratosis of pilosebaceous duct causes catheter blockage, sebum row at the same time
Go out obstacle, form horn plug, that is, micro mist thorn.Multiple-microorganism especially propionibacterium acnes amount reproduction, acne propionic acid in hair follicle
The lipase that bacillus produces decomposes sebum generation free fatty, while chemotactic inflammatory cell and medium, finally induces and aggravates inflammation
Disease is reacted.
With the lifting of people's consumption consciousness, consumer increasingly focuses on product when cleaning product and skin care item are selected
Security, the security of product is much than therapeutic and esthetics itself is important more.Natural plants and the extraction of animal
Thing sensitization rate itself is very low, and security is very high, and the product that production is prepared using this kind of active component extract is also increasingly subject to
The attention of consumer and like.
And the most effect unobvious of handmade soap that use at present mainly due to production handmade soap for playing drug effect
The extraction efficiency of active substance of plant is not high, and destruction is easily produced to active components of plants.Meanwhile for containing active material
Contain a certain amount of preservative ingredient, the addition of the preservative of such skin care item, for long-time service person's in handmade soap
Skin can cause a degree of influence, and the damage for skin surface is larger, once skin is subject to permanent injury not
Easily transfer the original activity of skin to go to repair damage automatically, so as to leave permanent scar.And in the cosmetics of anti-acne class
More options salicylic acid plays the role of antiphlogistic antibacterial.Adding salicylic while be required for adding a certain amount of alcohol as molten
Liquid, can all cause skin a degree of stimulation.But such product do not have usually it is antibacterial and dispel long lasting for property
The ability that the effect of acne, no acne print and color spot are dispelled.
The content of the invention
For overcome the deficiencies in the prior art, it is an object of the present invention to provide a kind of efficiently anti-inflammatory anti-acne handmade soap and its preparation
Method, can effectively solve the handmade soap that produces at present for the extraction efficiency that plays the active substance of plant of drug effect it is not high,
Skin, the weak formation that not can effectively prevent pockmark and acne scar of oxidation resistance are injured containing preservative and while anti-inflammatory
The problem of containing irritant solvent.
The present invention is achieved by the following technical solution：
A kind of efficiently anti-inflammatory anti-acne handmade soap, it is characterised in that being calculated according to weight fraction includes following component：
10-15 parts of marine active component,
0.5-2 parts of recombinant antimicrobial peptide,
0.01 part of epidermal growth factor,
0.01 part of fibroblast growth factor,
0.01 part of transforming growth factor,
3-5 parts of texifolin,
5-8 parts of perilla leaf extract,
6-10 parts of niacinamide,
0.3-1 parts of Tea Saponin,
80-100 parts of Seabuckthorm Seed Oil,
Natural 270-320 parts of soap base；
The recombinant antimicrobial peptide is by 3 parts of mud snail antibacterial peptide, 2 parts of mussel antibacterial peptide, 1 part of bank crab antibacterial peptide and Ch-penaedin 1
The composition of part composition；
Its component according to weight fraction meter of the marine active component is：10 parts of oyster extract, 3 parts of moray, clam carries
Take 3 parts of thing, 5 parts of marine red alga extract, 5 parts of marine green algae extract.
Further, the preparation method of the oyster extract is as follows：After fresh oyster meat is drained, is homogenized, according to male
Oyster is homogenized and the mass ratio of 95% ethanol is 1:2 ratio adds ethanol, stirs 1.5h at normal temperatures, stands 30min, 4900r/
After centrifuging 15min under the conditions of min, sediment fraction is taken, the mass ratio according to oyster homogenate and deionized water is 1:3 ratio adds
After deionized water extracts 2h in 90 DEG C of water-baths, it is cooled to room temperature, stands after 30min under conditions of 4900r/min at centrifugation
15min is managed, is collected supernatant, and the method that sediment fraction is precipitated according to above-mentioned processing repeats extraction once, merging filtrate；Adjust
PH value is saved to 4.6,15min is then centrifuged under conditions of 4900r/min and is collected supernatant, adding alcohol to alcohol concentration is
70%, 15min is then centrifuged under the conditions of 4900r/min, after taking precipitation, oyster extract is obtained after vacuum freeze drying.
Further, the preparation method of the clam extract is as follows：Take Clam Meat to clean, smash, be homogenized, according to Clam Meat
It is 1 to be homogenized quality and deionized water quality ratio:20 ratio adds deionized water, under the conditions of ultrasonic power 200W, ultrasonic extraction
30 min, stand 30min, pour out supernatant, add same amount water and extract again once, discard the meat slag after standing, merge supernatant,
And be concentrated into and add 1/10th being advisable for deionized water volume first, that is, obtain clam extract.
Further, the preparation method of the marine red alga and marine green algae extract is as follows：By the seaweed of fresh collection
The seawater that product is crossed with purified treatment cleans three times, to remove surface deposits, zooplankter and other organic matters, is subsequently placed in
Refrigerator-freezer freezes, spare；After taking freezing seaweed sample room temperature 24h, smash, weigh powder and be placed in mortar, add 85% methanol
It is transferred to completely after solution grinding in tool plug container, under the conditions of 40 DEG C of water temperature, ultrasonic power 200W, 30 min of ultrasonic extraction,
Room temperature cools down, and extracting solution is centrifuged 10 min under 4000 rpm/min rotating speeds；Centrifugation gained supernatant liquor is concentrated into semi-fluid
After dynamic slurry, by slurry with 1：10 volume ratios are dissolved in deionized water, agitated, shake up, and obtain marine algae extract.
Further, the preparation method of the perilla leaf extract specifically includes following steps：By raw material perilla leaf through dry
It is dry, beat and 100 mesh sieves crossed after powder, obtain the powder of raw material, then add 95% ethanol solution, in 44 DEG C of water temperature, ultrasonic power
Under the conditions of 200W, ultrasonic extraction 35min, obtains extracting solution；Extracting solution filtering is concentrated under reduced pressure, obtains slurry；By slurry with 1：
10 volume ratios are dissolved in deionized water, agitated, shake up, and obtain perilla leaf extract.
A kind of preparation method of efficiently anti-inflammatory anti-acne handmade soap, it is characterised in that include the following steps：
（1）By Seabuckthorm Seed Oil, heating water bath is at the uniform velocity stirred to 62 DEG C, and A is made；
（2）Deionized water, niacinamide, Tea Saponin and natural soap base are added in A, is stirred evenly, mixture B is made；
（3）By marine active component, texifolin, perilla leaf extract is uniformly mixed by number and together added in mixture B, is stirred
Mix 15min to be uniformly mixed, mixture C is made；
（4）Recombinant antimicrobial peptide, epidermal growth factor, fibroblast growth factor, transforming growth factor is equal by number mixing
It is even together to add in mixture C, it is stirred for 30min and fully mixes, then grinding tool is poured into, then cure 25h in 45 DEG C of constant temperature, make
Obtain semi-finished product；
（5）Semi-finished product are demoulded, are placed in shady and cool, dry place 15 days, after finishing packaging i.e. obtained efficient anti-inflammatory anti-acne handmade soap into
Product.
Oyster is a kind of high protein, easily low fat, digestion and food full of nutrition, contains abundant glycine and one
The glucide of the entitled hepatic glycogen of kind, the basis of their oyster delicious food.Dry oyster meat is up to 45%-57%, fat containing protein
7%-11%, hepatic glycogen 19%-38%.In addition, also contain multivitamin and the nutritional ingredient such as taurine and calcium, phosphorus, iron, zinc.Its
For middle calcium content close to milk, iron content is 21 times of milk.Because containing iron and copper, for the distinctive sideropenic anemia of women
Treatment be most fairly effective.In addition, oyster contains the sub- lead all lacked in a large amount of, most people body.Therefore edible oyster
It can prevent from having dry skin, promote the metabolism of skin, decompose subcutaneous melanin, produce tender and lovely skin white touched with red.It is male
Oyster is referred to as ' in the sea milk ', rich in very excellent protein, liver glycogen, vitamin and mineral matter, containing 18 kinds with
On amino acid, in these amino acid rich in can synthesize anti-acid material glutathione amino acid (paddy amino acid, sugar
Glue).After edible oyster, the synthesizing glutathion in human body, removes internal active acid element, improves immunity, suppress aging.It is male
Oyster extract is directed to the nutritional agents of skin as a kind of specialty, in the present invention can be after other compositions antibacterial anti-inflammatory anti-acne
It is effective to help skin to return to original health status, prevent the formation of the deposition and acne print acne scar of melanin.
Moray, Chinese medicine name.Blood, entirety for moray section animal Gymnothorax undulatus (Lacepede), Gymnothorax reticularis (Bloch) etc..Moray is Chinese herbal medicine
One kind of the inside, can treat many diseases using moray, also have good health maintenance effect, itself have removing toxic substances, detumescence,
The effect of analgesic, hemostasis, anti-corrosion, anti-inflammatory.
Meretrix Veneridae animal, also known as flower clam, yellow clam, circle clam etc., China coast is distributed.Clam Meat is clam
Software part, taste saltiness are put down, and clam shell taste is salty, cold nature, tool clearing lung and eliminating phlegm, softening and resolving hard mass, inducing diuresis for removing edema, the work(of anti-inflammatory analgesic
Effect.Contain substantial amounts of polysaccharide and a certain amount of nucleic acid, protein, amino acid, mineral matter and trace element in clam extract, its
Middle polysaccharide and nucleic acid are the components for having in clam extract important biomolecule activity, it, which has, adjusts body's immunity, resists prominent
Change, antibacterial, anti-inflammatory, detumescence, antiviral, reduction tissue secretion, analgesic, antipruritic, promotion tissue resorption, control the work of lesion scope
With.It can be seen from the above that clam extract is the component that a kind of effective anti-acne rises flesh in itself.
Seaweed is submarine algae, is the cryptogam of plant kingdom, and algae includes several inhomogeneities with photosynthetic work
With the biology for producing energy.They are generally considered to be simple plant, are mainly characterized by：Without vascular tissue, without real
Root, stem, the differentiating phenomenon of leaf；Do not bloom, no fruit and seed；Protective tissue of the reproductive organs without specialization, often directly by single
Cell produces spore or gamete；And the formation without embryo.Seaweed contains a kind of special protein and is known as close glycoprotein, it is right
Certain sugars have compatibility and therewith Non-covalent binding.Close glycoprotein and cell membrane glycan molecule can cause cell settlement after combining
Phenomenon, therefore be a kind of agglutinin.Agglutinin is the glycoprotein purified from various plants, invertebrate and higher mammal,
In the defence of cell recognition and organism, growth, nutrition plays an important role in storing.Research is found, solidifying in marine organisms
Collection element, some also have anti-inflammatory effect.The seaweed agglutinin extracted from marine green algae has well fixed defence, anti-inflammatory and town
Pain acts on.Seaweed accounts for more than the 50% of seaweed dry mass rich in food fiber, these fiber category sulfated polysaccharides or acidic polysaccharose it
The material of class, in addition to the function of having foregoing food fiber, some also have, and anti-inflammatory is antibacterial, anti-oxidant and active anticancer.Marine red alga
In polysaccharide component can improve the oedema of carragheen induction, reduce histamine tryptamines and ease up the inflammation of sharp skin induction, suppression can be passed through
The expression of proinflammatory factor plays anti-inflammatory effect.Sulfated polysaccharide tool in marine green algae also has anti-inflammatory, analgesia and moisture-keeping function.
Also containing the multivitamin such as Aneurine, B2, D, A and K in marine red alga and marine green algae, while also contain more than 45 kinds
Inorganic microelement, these components can be skin injury region nutrition is provided in time and repaired.China's Traditional Chinese Medicine
Think that seaweed has the effect of inducing diuresis for removing edema, clearing heat and detoxicating.Therefore marine red alga and marine green algae have been selected at the same time in the present invention
Extract be exactly to be effectively combined wherein various active ingredients, synergy plays more preferable antiphlogistic effects, while again can
Enough the skin being damaged by small pox, acne repair and the formation of antioxidation prevention pockmark can be had concurrently.
The combination of the active ingredient of above-mentioned five Large Marine Ecosystems biology, can both comprehensively utilize between each component for skin
Anti-inflammatory, antibacterial, the effect of removing toxicity for detumescence, antioxidation can effectively be repaired and be had concurrently for the skin being damaged by having
Prevent the formation of pockmark.
Texifolin is hidden in larchen tree root deeply, and " top grade of medicine " is described as by medicine sage's Li Shizhen (1518-1593 A.D.), is a kind of high-end rare
Healthy treasure, be even more medicine, health food, daily necessities, the raw materials for production of cosmetics, texifolin belongs to citrin race, its
Name is from a kind of most precious pine tree pesudotsuga taxifolia (also known as yellow cloth) in the U.S..The scientific name of texifolin " dihydroquercetin ", it
Mysterious effect be special molecular structure, possess active phenolic hydroxyl group can effectively remove free radical, maintenance repair cell, net blood
Toxin expelling, strengthen immunity, delaying cell aging, have the function that excellent anti-oxidant, antibacterial removing toxic substances, anti-inflammatory.
Antibacterial peptide is the defensive bioactive peptide material of one kind that animal immune system of defense is produced through induction, can resist external source
The pathogenic effects of pathogen, are an important components of animal body fluid system of defense.Extracted in marine organisms body
Peptide matters with antibacterial activity.They have the characteristics that some are common:Majority is the cationic point rich in cysteine
Son;Molecular weight is generally in below 10kDa;With broad spectrum antibiotic activity, and bacterium is not easy to produce drug resistance to it.And antibacterial
Peptide can play the role of preservative as natural anti-corrosion composition in skin care item and cleaning kind in itself, it is not necessary to extra addition
Any preservative, natural preservative ingredient will not produce skin any stimulation, safe and non-toxic, cause the several of skin allergy
Rate is very low.Antibacterial peptide can not only kill propionibacterium acnes, and have significant its caused inflammation inflammation of reduction of energy
Effect and potentiality.The composition tool of mud snail antibacterial peptide, mussel antibacterial peptide, bank crab antibacterial peptide and Ch-penaedin that the present invention uses
There is synthetic marine biologic antibiotic peptide, antibacterial effect is more preferable, is not likely to produce drug resistance, noresidue, and natural anticorrosion is safer.
Growth factor (Growth factor, GF) is presence in vivo and the growth and development to body difference cell has tune
Section (promotes or suppresses) type cytokines of effect, also referred to as peptide growth factor, and content is atomic in vivo for they, but biology is living
Property it is high, play various kinds of cell physiological function and metabolic activity biological regulation effect, really connect or affect indirectly polytype
Growth, division, differentiation, propagation and the migration of cell.
Epidermal growth factor（Epidermal growth factor, EGF）It is the growth factor found earliest, to adjusting
Cell growth, propagation and differentiation play an important role, it is former as the stimulation of chrotoplast division growth, by transmitting signal,
EGF is combined with the EGF receptor on cell membrane, then passes through a systems such as the autophosphorylation of acceptor, activator protein G and lecithinase C
Row biochemical reaction, changes intracellular calcium ion concentration, promotes glycolysis and protein, RNA and DNA synthesis, startup and cell
Divide related gene, akinete is entered cell division phase, thus be effectively facilitated and adjust epidermal cell growth and
Propagation, removes various spots.In the generation for promoting Skin Cell at the same time, it can also increase and take the photograph containing for other Endogenous Growth Factors,
Promote cell secretion hyaluronic acid and glycoprotein, rationally adjust skin texture, make skin become to moisten, is smooth, soft, preventing skin
Skin dries coarse, delaying skin aging, is described as " the beautiful factor " by numerous scientists.
Fibroblast growth factor (Fibroblast growth factors, FGFs) is a kind of multi-functional non-spy
A variety of mesoderms such as specific activities material, Human Umbilical Vein Endothelial Cells, fibroblast and the cell in the outer embryo source of nerve, which have, promotes DNA to close
Into with promote fissional effect.FGFs also plays fibroblastic collage synthesis double regulation control effect:By to collagen
Continuous synthesis, secretion, reconstruction and renewal, and constantly improve and rehabilitate the structure and intensity of tissue, while clostridiopetidase A can be stimulated
Expression, therefore can effectively suppress the pathologic scar produced by a large amount of synthesis of collagen and excessive deposition, so as to improve
The quality of wound healing.
Transforming growth factor (transforming growth factor- β, TGF-β) is that one kind has various biological
The cell factor of activity, its family is the relevant polypeptide modulin of a class formation, is produced by various kinds of cell.TGF-β is to it
He can play collaboration or inhibitory action at cell factor.Research shows that TGF-β is fibroblastic major chemokine, can be pierced
Swash fibroblast division growth.Since fibroblast is main tissue repair cell, induction of the TGF-β to it, chemotactic
Be conducive to the progress of process of tissue reparation.In addition, TGF-β can induce macrophages secrete angiogenesis factor, this factor can be pierced
Swash vascular endothelial cell proliferation, accelerate vascularization, TGF-β can also promote extracellular matrix to synthesize in wound healing, bag
Include collagenous fibres connection albumen, glycoprotein, ammonia polyose of candy and hyaluronic acid etc..Skin can be repaired well, same to time-varying
Must be smooth ruddy, show the beauty of natural health.In addition, TGF-β is also to the protein degradation enzyme such as metal of various kinds of cell epimatrix
Stromatin enzyme has inhibitory action, suppresses the generation of extracellular matrix degrading enzyme, strengthens the combination of matrix and cell, slows down the aging of skin
Process, the flexible beautiful skin of lasting holding.
The antibacterial peptide targetedly acted on and growth factor are used in combination, the acne for resolving skin that can be more efficient
The problem of acne are brought, while greatly improve the antibacterial anti-inflammatory of product, performance that is anti-oxidant, promoting healing and reparation.
Niacinamide belongs to one kind of B family vitamin, alias nicotinic acid etc., it has very as a kind of medical components
A kind of basic vitamins replenishers in high security, and the treatment of clinic skin section.Niacinamide can prevent black
Element is deposited to horn cell, can desalinate spot, be effectively improved skin.Niacinamide can lift skin acne-removal function,
Because niacinamide has anti-inflammatory attribute, inflammatory reaction can be participated in, skin anti-acne is helped by anti-inflammatory, reaches effect.Nicotinoyl
Amine is also prevented from skin crumple and promotes to moisten.
Tea Saponin is a series of similar pentacyclic triterpene saponin compound of the structures extracted from plant of theaceae.
Emulsify, disperse, blister and wettability with good, be a kind of excellent natural nonionic surface active agent.Modern medicine
Reason research finds that Tea Saponin has good analgesia, anti-inflammatory, antiallergic and other effects.Triterpene saponins have extensive bioactivity,
Some researches show that Triterpene saponins also have effects that the activity for suppressing tyrosinase at the same time.
Seabuckthorm Seed Oil is saturating to brownish red by the brown color that seabuckthorn seeds are obtained by supercritical extract or subcritical low-temperature extraction
Bright oily liquids, integrates the highly concentrated thing of Effective Compositions of Seabuckthorn.Include flavones, organic acid, alkaloid, sterols, three
The 140 multiple biological activities component such as terpenes and various vitamins.Seabuckthorm Seed Oil as medicinal raw material there is obvious biology to make
With its is anti-infective by force, promotion healing is fast, there have to tonsillitis, stomatitis, skin inflammation, Gynecological cervical inflammation etc. to be good and steady
The effect of determining.Seabuckthorm Seed Oil is the complex of multivitamin and bioactive substance.It can nourishes rough skin, promotion new old generation
Thank, antiallergy, bactericidal antiphlogistic, promote re-epithelilization, have repair to skin, the sour environment of skin can be kept, have
There is stronger permeability, thus be also the important source material of beauty and skin care.Total seabuckthorn flavone in sea-buckthorn can Direct Acquisition super oxygen from
By base and hydroxy radical, Ve, Vc superoxide dismutase（SOD）Have the function that anti-oxidant and eliminate free radical on cell membrane,
Effective delaying human body caducity.The VC contents of sea-buckthorn occupy one and cut fruit, first of vegetables, are known as " king of VC ".And VC is exactly one kind
Natural internal whitening agent, can effectively suppress the deposition of abnormal pigment and the activity of tyrosinase on skin, and help DOPA
The reduction of pigment (tyrosine transforms into the intermediate of melanin), forms so as to reduce melanin, effectively net white muscle skin.Sea-buckthorn
In rich in VE, carrotene, carotenoid, cupreol, unrighted acid etc., can inhibit subcutaneous tissue inflammation, enhancing is scorching
The anti-inflammatory effect at disease center, hence it is evident that promote ulcer healing.
Contain a variety of important active ingredients, perilla alcohol, menthones, eugenol and other furanones therein in perilla leaf
Red pigments anthocyanidin -3- (6- is to coumaric acyl-β-D-Glucose) -5- β-D-Glucose glucoside in derivative and leaf can rise
To natural anti-corrosion, the effect of anti-oxidant anti-inflammatory.So perilla leaf can form natural anti-corrosion with reference to composite antibacterial peptide components
Agent system, without especially adding, naturally, and efficiently, safety.
Efficiently anti-inflammatory anti-acne handmade soap and preparation method thereof of the invention has the advantages that：
1st, efficiently anti-inflammatory anti-acne handmade soap combines full marine active component composite extract and a variety of antibacterials to the present invention first
Peptide and growth factor, prepare edible, non-stimulated without preservative, and efficient anti-inflammatory is antibacterial, anti-acne, anti-oxidant, reparation acne
Trace, the pure natural handmade soap for preventing pockmark and acne scar from being formed.The present invention is added without any industrial goods preservative, has day in component
Right preservative is safe and non-toxic, good water solubility, heat endurance is good, sphere of action is wide.
2nd, extract most in efficient anti-inflammatory anti-acne handmade soap of the present invention and preparation method thereof uses ultrasonic extraction
Carry, the technique extraction efficiency is high, and for plant, the active ingredient utilization rate in fruit medicine is high, not waste of resource.The present invention
Extract is prepared using ultrasonic extraction, is imitated using the judder of ultrasonic wave generation, higher acceleration, strong cavitation
The special effects such as should, stirring, can destroy plant cell, solvent is penetrated into Materials Cell, promote in raw material to be extracted
Chemical composition is dissolved in solvent, then required chemical composition is drawn by separating-purifying.Using ultrasonic wave extraction 30min than conventional
The recovery rate of decocting method extraction 3h will be higher by 9%.
3rd, antibacterial peptide and perilla leaf effectively make use of to form naturally effectively in the efficient anti-inflammatory anti-acne handmade soap of the present invention
Preservative system, without especially adding, pro-skin is non-stimulated, also reduces cost.
4th, cleverly by the amino acid in marine organisms, vitamin, micro member in the efficient anti-inflammatory anti-acne handmade soap of the present invention
The nutritional ingredient and potent anti-inflammatory anti-acne component of the promotions such as element healing, the effective suppression in perilla leaf, Seabuckthorm Seed Oil and antibacterial peptide
Bacterium anti-inflammatory component, Tea Saponin, the synergistic function of niacinamide, extremely good Seabuckthorm Seed Oil matrix, and a variety of growths because
Subconstiuent is combined togather, and has more efficiently given play to the anti-oxidant of overall handmade soap, anti-acne, has prevented pockmark, acne scar from being formed
The effect of, it is prepared for a kind of pure natural, nontoxic non-stimulated and efficient product for resolving poxes.
5th, the efficient anti-inflammatory anti-acne handmade soap of the present invention, because biological transdermal enhancer derives from animals and plants extract, has
There is good biocompatibility, and skin will not be caused to damage, there is security.
Embodiment
The invention discloses a kind of efficiently anti-inflammatory anti-acne handmade soap and preparation method thereof with reference to specific embodiments right
The present invention is described further：
Embodiment 1：
Efficient anti-inflammatory anti-acne handmade soap, being calculated according to weight fraction includes following component：10 parts of marine active component, composite antibacterial
0.5 part of peptide, 0.01 part of epidermal growth factor, 0.01 part of fibroblast growth factor, 0.01 part of transforming growth factor, pesudotsuga taxifolia
3 parts of element, 5 parts of perilla leaf extract, 6 parts of niacinamide, 0.3 part of Tea Saponin, 80 parts of Seabuckthorm Seed Oil, natural 270 parts of soap base；It is compound anti-
Bacterium peptide is by 1 part of 3 parts of mud snail antibacterial peptide, 2 parts of mussel antibacterial peptide, 1 part of bank crab antibacterial peptide and Ch-penaedin composition formed；
Its component according to weight fraction meter of marine active component is：10 parts of oyster extract, 3 parts of moray, 3 parts of clam extract, sea
5 parts of fuchsin algae extract, 5 parts of marine green algae extract.
Embodiment 2：
Efficient anti-inflammatory anti-acne handmade soap, being calculated according to weight fraction includes following component：12 parts of marine active component, composite antibacterial
1.2 parts of peptide, 0.01 part of epidermal growth factor, 0.01 part of fibroblast growth factor, 0.01 part of transforming growth factor, pesudotsuga taxifolia
4 parts of element, 6 parts of perilla leaf extract, 8 parts of niacinamide, 0.7 part of Tea Saponin, 90 parts of Seabuckthorm Seed Oil, natural 300 parts of soap base；It is compound anti-
Bacterium peptide is by 1 part of 3 parts of mud snail antibacterial peptide, 2 parts of mussel antibacterial peptide, 1 part of bank crab antibacterial peptide and Ch-penaedin composition formed；
Its component according to weight fraction meter of marine active component is：10 parts of oyster extract, 3 parts of moray, 3 parts of clam extract, sea
5 parts of fuchsin algae extract, 5 parts of marine green algae extract.
Embodiment 3：
Efficient anti-inflammatory anti-acne handmade soap, being calculated according to weight fraction includes following component：15 parts of marine active component, composite antibacterial
2 parts of peptide, 0.01 part of epidermal growth factor, 0.01 part of fibroblast growth factor, 0.01 part of transforming growth factor, texifolin
5 parts, 8 parts of perilla leaf extract, 10 parts of niacinamide, 1 part of Tea Saponin, 100 parts of Seabuckthorm Seed Oil, natural 320 parts of soap base；Composite antibacterial
Peptide is by 1 part of 3 parts of mud snail antibacterial peptide, 2 parts of mussel antibacterial peptide, 1 part of bank crab antibacterial peptide and Ch-penaedin composition formed；Sea
Its component according to weight fraction meter of foreign active ingredient is：10 parts of oyster extract, 3 parts of moray, 3 parts of clam extract, ocean
5 parts of red algae extract, 5 parts of marine green algae extract.
Raw material extracting method in each embodiment is as follows：
The preparation method of oyster extract is as follows：After fresh oyster meat is drained, is homogenized, according to oyster homogenate and 95% ethanol
Mass ratio be 1:2 ratio adds ethanol, stirs 1.5h at normal temperatures, is centrifuged under the conditions of standing 30min, 4900r/min
After 15min, sediment fraction is taken, the mass ratio according to oyster homogenate and deionized water is 1:3 ratio adds deionized water in 90
After extracting 2h in DEG C water-bath, it is cooled to room temperature, stands centrifugal treating 15min, collection under conditions of 4900r/min after 30min
Supernatant, and the method that sediment fraction is precipitated according to above-mentioned processing repeats extraction once, merging filtrate；PH value is adjusted to 4.6,
Then centrifuge 15min under conditions of 4900r/min to collect supernatant, it is 70%, Ran Hou to add alcohol to alcohol concentration
15min is centrifuged under the conditions of 4900r/min, after taking precipitation, oyster extract is obtained after vacuum freeze drying.
The preparation method of clam extract is as follows：Take Clam Meat to clean, smash, be homogenized, according to Clam Meat homogenate quality and
Deionized water quality ratio is 1:20 ratio adds deionized water, and under the conditions of ultrasonic power 200W, 30 min of ultrasonic extraction, stands
30min, pours out supernatant, adds same amount water and extracts again once, discard the meat slag after standing, merges supernatant, and be concentrated into head
/ 10th of secondary addition deionized water volume are advisable, that is, obtain clam extract.
The preparation method of marine red alga and marine green algae extract is as follows：By the seaweed products purified treatment of fresh collection
The seawater crossed cleans three times, to remove surface deposits, zooplankter and other organic matters, is subsequently placed in refrigerator-freezer freezing, spare；
After taking freezing seaweed sample room temperature 24h, smash, weigh powder and be placed in mortar, add after the grinding of 85% methanol solution completely
It is transferred in tool plug container, under the conditions of 40 DEG C of water temperature, ultrasonic power 200W, 30 min of ultrasonic extraction, room temperature cooling, will extract
Liquid centrifuges 10 min under 4000 rpm/min rotating speeds；After centrifugation gained supernatant liquor is concentrated into half flowing slurry, it will starch
Shape thing is with 1：10 volume ratios are dissolved in deionized water, agitated, shake up, and obtain marine algae extract.
The preparation method of perilla leaf extract specifically includes following steps：By raw material perilla leaf through drying, beat powder after cross 100
Mesh sieve, obtains the powder of raw material, then adds 95% ethanol solution, under the conditions of 44 DEG C of water temperature, ultrasonic power 200W, ultrasound
35min is extracted, obtains extracting solution；Extracting solution filtering is concentrated under reduced pressure, obtains slurry；By slurry with 1：10 volume ratios be dissolved in from
It is agitated, shake up in sub- water, obtain perilla leaf extract.
On mud snail antibacterial peptide, mussel antibacterial peptide, bank crab antibacterial peptide and prawn in the composite antibacterial peptide components in the present invention
The Feedstock treating of antibacterial peptide and extraction are general with the following method：
After 4 kinds of marine organisms such as mud snail are cleaned, it is placed in high-speed tissue mashing machine and is homogenized 3 min, add 100 mL distilled water, soaks
70 DEG C or so extraction 1h of ultrasonic extractor are used after steeping 2h, is filtered while hot with 4 layers of gauze of high-temperature sterilization, filtrate is heated and is concentrated
To 100 mL, then concentrate is centrifuged to 5 min under conditions of 5000r/min.Supernatant is taken, medicinal material ratio is adjusted to distilled water
Measure as 1g/mL, be poured into sterile test tube, bacteriostatic experiment use can be done after autoclaving.Generally extract is placed in 4 DEG C of refrigerators
Save backup.
The preparation method of efficient anti-inflammatory anti-acne handmade soap in embodiment includes the following steps：
（1）By Seabuckthorm Seed Oil, heating water bath is at the uniform velocity stirred to 62 DEG C, and A is made；
（2）Deionized water, niacinamide, Tea Saponin and natural soap base are added in A, is stirred evenly, mixture B is made；
（3）By marine active component, texifolin, perilla leaf extract is uniformly mixed by number and together added in mixture B, is stirred
Mix 15min to be uniformly mixed, mixture C is made；
（4）Recombinant antimicrobial peptide, epidermal growth factor, fibroblast growth factor, transforming growth factor is equal by number mixing
It is even together to add in mixture C, it is stirred for 30min and fully mixes, then grinding tool is poured into, then cure 25h in 45 DEG C of constant temperature, make
Obtain semi-finished product；
（5）Semi-finished product are demoulded, are placed in shady and cool, dry place 15 days, after finishing packaging i.e. obtained efficient anti-inflammatory anti-acne handmade soap into
Product.
Evaluation on efficiently anti-inflammatory anti-acne handmade soap effect of the invention：
The application method of handmade soap of the present invention：Facial skin is soaked with warm water so that the abundant diastole of pore is opened, and takes production of the present invention
Product play foam in the palm of the hand in right amount, are then uniformly applied to face, with finger face gently loop massage 3 minutes, then
Cleaned up with warm water.
Human skin irritation is tested
Select male, women each 200 of the age at 18-28 Sui, after continuous use 10 days, observation skin whether red and swollen, oedema, 10
The test result fed back after it occurs for 400 study subjects without red and swollen, oedema phenomenon, shows the handmade soap of the present invention to skin
Without any stimulation, the people that may adapt to various skins uses skin.
Anti-acne effect detects
Selecting the face of 300 18-28 one full year of life has acne patient continuously after 30 days on probation, be divided into three groups of every group of 100 people feedbacks go acne,
Anti-acne effect.
Wherein, it is effective oneself to think that three groups of the number that acne, small pox substantially mitigate is respectively 76 people, 80 people and 78 people；
It is respectively 24 people, 20 people and 22 people effectively oneself to think that acne, small pox have mitigated three groups of the number to make moderate progress；It is invalid to be
Oneself think that three groups of the number that acne, small pox mitigate unobvious or do not take a favourable turn is 0 people.From the point of view of testing result, three groups
Significant effect rate, that is, obvious effective rate be respectively 76%, 80% and 78%, three groups of average obvious effective rate is 78%.Prove that the present invention's is efficient
Anti-inflammatory anti-acne handmade soap has very excellent anti-acne using effect.If the long-term handmade soap adhered to using the present invention at the same time,
The extraneous and oxidative factors of itself can also be effectively resisted, resist the formation of pigment deposition and pockmark and acne scar.
Efficiently anti-inflammatory anti-acne handmade soap of the invention combines full marine active component composite extract and a variety of anti-first
Bacterium peptide and growth factor, prepare edible, non-stimulated without preservative, and efficient anti-inflammatory is antibacterial, anti-acne, anti-oxidant, reparation acne
Trace, the pure natural handmade soap for preventing pockmark and acne scar from being formed.The present invention is added without any industrial goods preservative, has day in component
Right preservative is safe and non-toxic, good water solubility, heat endurance is good, sphere of action is wide.Because biological transdermal enhancer is planted from dynamic
Thing extract, has good biocompatibility, and skin will not be caused to damage, and has security.
Most extracts is carried using ultrasonic extraction in efficiently anti-inflammatory anti-acne handmade soap and preparation method thereof of the invention,
The technique extraction efficiency is high, and for plant, the active ingredient utilization rate in fruit medicine is high, not waste of resource.The present invention adopts
Extract is prepared with ultrasonic extraction, is imitated using the judder of ultrasonic wave generation, higher acceleration, strong cavitation
The special effects such as should, stirring, can destroy plant cell, solvent is penetrated into Materials Cell, promote in raw material to be extracted
Chemical composition is dissolved in solvent, then required chemical composition is drawn by separating-purifying.Using ultrasonic wave extraction 30min than conventional
The recovery rate of decocting method extraction 3h will be higher by 9%.
Antibacterial peptide and perilla leaf effectively make use of to form naturally effectively in efficiently anti-inflammatory anti-acne handmade soap of the invention
Preservative system, without especially adding, pro-skin is non-stimulated, also reduces cost.
Cleverly by the amino acid in marine organisms, vitamin, trace element in efficiently anti-inflammatory anti-acne handmade soap of the invention
It is effective antibacterial in perilla leaf, Seabuckthorm Seed Oil and antibacterial peptide Deng the nutritional ingredient and potent anti-inflammatory anti-acne component of promotion healing
Anti-inflammatory component, Tea Saponin, the synergistic function of niacinamide, extremely good Seabuckthorm Seed Oil matrix, and a variety of growth factors
Component is combined togather, and has more efficiently given play to the anti-oxidant of overall handmade soap, anti-acne, has prevented pockmark, acne scar from being formed
Effect, is prepared for a kind of pure natural, nontoxic non-stimulated and efficient product for resolving poxes.
Exemplary description is carried out to the present invention above in conjunction with specific embodiment, it is clear that realization of the invention and from upper
The limitation of mode is stated, if the various improvement of inventive concept and technical scheme of the present invention progress are employed, or not improved general
The design and technical solution of the present invention directly applies to other occasions, within the scope of the present invention.
Claims (5)
1. a kind of efficiently anti-inflammatory anti-acne handmade soap, it is characterised in that being calculated according to weight fraction includes following component：
10-15 parts of marine active component,
0.5-2 parts of recombinant antimicrobial peptide,
0.01 part of epidermal growth factor,
0.01 part of fibroblast growth factor,
0.01 part of transforming growth factor,
3-5 parts of texifolin,
5-8 parts of perilla leaf extract,
6-10 parts of niacinamide,
0.3-1 parts of Tea Saponin,
80-100 parts of Seabuckthorm Seed Oil,
Natural 270-320 parts of soap base；
The recombinant antimicrobial peptide is by 3 parts of mud snail antibacterial peptide, 2 parts of mussel antibacterial peptide, 1 part of bank crab antibacterial peptide and Ch-penaedin 1
The composition of part composition；
Its component according to weight fraction meter of the marine active component is：10 parts of oyster extract, 3 parts of moray, clam carries
Take 3 parts of thing, 5 parts of marine red alga extract, 5 parts of marine green algae extract.
2. efficiently anti-inflammatory anti-acne handmade soap according to claim 1, it is characterised in that：The preparation side of the oyster extract
Method is as follows：After fresh oyster meat is drained, is homogenized, the mass ratio according to oyster homogenate and 95% ethanol is 1:2 ratio adds
Ethanol, stirs 1.5h, after centrifuging 15min under the conditions of standing 30min, 4900r/min, sediment fraction is taken, according to male at normal temperatures
Oyster is homogenized and the mass ratio of deionized water is 1:After 3 ratio addition deionized water extracts 2h in 90 DEG C of water-baths, room is cooled to
Temperature, stand after 30min the centrifugal treating 15min under conditions of 4900r/min, collects supernatant, and by sediment fraction according to upper
The method for stating processing precipitation repeats extraction once, merging filtrate；PH value is adjusted to 4.6, then under conditions of 4900r/min from
Heart 15min is collected supernatant, and it is 70% to add alcohol to alcohol concentration, 15min is then centrifuged under the conditions of 4900r/min, it is heavy to take
Behind shallow lake, oyster extract is obtained after vacuum freeze drying.
3. efficiently anti-inflammatory anti-acne handmade soap according to claim 1 or 2, it is characterised in that：The system of the clam extract
Preparation Method is as follows：Take Clam Meat to clean, smash, be homogenized, it is 1 to be homogenized quality and deionized water quality ratio according to Clam Meat:20
Ratio adds deionized water, and under the conditions of ultrasonic power 200W, 30 min of ultrasonic extraction, stands 30min, pour out supernatant, adds
Same amount water extracts once again, discards the meat slag after standing, and merges supernatant, and is concentrated into and adds the ten of deionized water volume first
/ mono- is advisable, that is, obtains clam extract.
4. efficiently anti-inflammatory anti-acne handmade soap according to claim 3, it is characterised in that：The marine red alga and ocean green
The preparation method of algae extract is as follows：The seawater that the seaweed products of fresh collection are crossed with purified treatment is cleaned three times, to remove
Surface deposits, zooplankter and other organic matters, are subsequently placed in refrigerator-freezer freezing, spare；Take freezing seaweed sample room temperature
After 24h, smash, weigh powder and be placed in mortar, be transferred to completely in tool plug container after adding the grinding of 85% methanol solution, in water
It is 40 DEG C warm, under the conditions of ultrasonic power 200W, 30 min of ultrasonic extraction, room temperature cooling, by extracting solution in 4000 rpm/min rotating speeds
10 min of lower centrifugation；After centrifugation gained supernatant liquor is concentrated into half flowing slurry, by slurry with 1：10 volume ratios are dissolved in
It is agitated, shake up in deionized water, obtain marine algae extract.
5. the efficient anti-inflammatory anti-acne handmade soap according to claim 1,2,3 and 4, it is characterised in that：The perilla leaf carries
The preparation method of thing is taken to specifically include following steps：By raw material perilla leaf through drying, beat powder after cross 100 mesh sieves, obtain raw material
Powder, then adds 95% ethanol solution, and under the conditions of 44 DEG C of water temperature, ultrasonic power 200W, ultrasonic extraction 35min, must extract
Liquid；Extracting solution filtering is concentrated under reduced pressure, obtains slurry；By slurry with 1：10 volume ratios are dissolved in deionized water, agitated, shake
It is even, obtain perilla leaf extract.
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Cited By (1)
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