CN107929685A - 一种治疗羔羊痢疾的组合物及其制备方法 - Google Patents
一种治疗羔羊痢疾的组合物及其制备方法 Download PDFInfo
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Abstract
本发明属于中药技术领域，尤其是一种治疗羔羊痢疾的组合物及其制备方法，采用胡黄连6～10份、石榴皮8～12份、干姜8～12份、青蒿8～12份、黄柏7～10份、秦皮8～12份、白头翁14～17份、陈皮7～10份为原料，将其进行粉碎后进行煎煮，过滤后制得药剂；该药剂能够有效的治疗山羊痢疾的症状，治疗周期短、治愈率高、安全可靠；尤其是通过加入硫酸阿托品和盐酸吗啉胍片，采用中西结合的方式，使得药物之间形成协同的功效，进而实现短期内治愈率达到100％，不复发，是一种理想的药物制剂。
Description
技术领域
本发明属于中药技术领域，尤其是一种治疗羔羊痢疾的组合物及其制备方法。
背景技术
羊痢疾是由魏氏梭菌B型引起的初生羔羊的一种急性毒血性传染病；以剧烈腹泻和小肠发生溃疡为特征，此病主要危害7日龄内的羔羊，可造成大批死亡，是影响羔羊成活率的一种常见疾病；1.本病的发生和流行，与怀孕母羊营养不良、护理不当、产羔季节气候突变、羊舍阴暗潮湿等有密切关系；此外，哺乳不当、饥饱不匀、接羔、育羔时清洁卫生条件差等也可诱发本病；传播源为病羔羊粪便，经消化道、脐带和创伤感染，潜伏期一般为1～2天，有的出生几小时，因病原菌不同而异；2.临床症状病初羔羊精神沉郁，食欲减退或停止哺乳，随后1～2天，病羔腹泻粥状或水样物，颜色有绿、黄绿、灰白等，并有恶臭味，体温升高至39.5℃；病羔萎靡呆立、低头弓背、腹部下凹，后期粪内带血、肛门失禁；由于持续性腹泻，体温偏低，经1～2天死亡，个别病例出现神经症状，流涎、牙关紧闭、角弓反张、四肢抽搐或神志昏迷，以死亡告终。
目前，针对治疗羔羊痢疾的药物大多采用西药治疗，而西药的价格较为昂贵，治疗效果不佳，容易出现复发，毒副作用也较大；采用中药治疗，大多治疗周期较长，起效慢，容易延误病情。
发明内容
为解决上述技术问题，本发明提供一种治疗羔羊痢疾的组合物及其制备方法。
具体是通过以下技术方案得以实现的：
一种治疗羔羊痢疾的组合物，包括以下重量份的原料：胡黄连6～10份、石榴皮8～12份、干姜8～12份、青蒿8～12份、黄柏7～10份、秦皮8～12份、白头翁14～17份、陈皮7～10份。
所述原料以重量份计为：胡黄连8份、石榴皮10份、干姜10份、青蒿10份、黄柏8份、秦皮10份、白头翁15份、陈皮8份。
所述原料中含有硫酸阿托品。
所述原料中含有盐酸吗啉胍片。
所述原料中含有硫酸阿托品和盐酸吗啉胍片。
将上述中药材进行混合后，加水淹没药材后进行煎煮，将煎煮液进行过滤，得药剂。
按照配方量取各中药，采用清水冲洗干净后混合，放入粉碎机中粉碎至60～80目，再加入其重量4～6倍水煎煮2～3h，过滤后滤渣加入1～2倍水煎煮1～1.5h，过滤；将两次过滤后的滤液进行合并，得药剂。
所述药剂按照100ml：1～3mg的比例添加硫酸阿托品。
所述药剂按照100ml：4～6mg的比例添加盐酸吗啉胍片。
所述药剂按照100ml：1～3mg的比例添加硫酸阿托品，按照100ml：4～6mg的比例添加盐酸吗啉胍片。
有益效果
本发明采用胡黄连6～10份、石榴皮8～12份、干姜8～12份、青蒿8～12份、黄柏7～10份、秦皮8～12份、白头翁14～17份、陈皮7～10份为原料，将其进行粉碎后进行煎煮，过滤后制得药剂；该药剂能够有效的治疗山羊痢疾的症状，治疗周期短、治愈率高、安全可靠；尤其是通过加入硫酸阿托品和盐酸吗啉胍片，采用中西结合的方式，使得药物之间形成协同的功效，进而实现短期内治愈率达到100％，不复发，是一种理想的药物制剂。
具体实施方式
下面结核具体的实施方式来对本发明的技术方案做进一步的限定，但要求保护的范围不仅局限于所作的描述。
实施例1
一种治疗羔羊痢疾的组合物，包括以下重量份的原料：胡黄连6g、石榴皮8g、干姜8g、青蒿8g、黄柏7g、秦皮8g、白头翁14g、陈皮7g。
将上述中药材进行混合后，加水淹没药材后进行煎煮，将煎煮液进行过滤，得药剂。
实施例2，采用同实施例1相同的配方，区别在于制备方法不同，实施例2按照上述配方量取各中药，采用清水冲洗干净后混合，放入粉碎机中粉碎至60～80目，再加入其重量4～6倍水煎煮2～3h，过滤后滤渣加入1～2倍水煎煮1～1.5h，过滤；将两次过滤后的滤液进行合并，得药剂。
实施例3，采用同实施例1相同的技术方案，区别在于，将上述药剂与硫酸阿托品按照按照100ml：1～3mg的比例混合。
实施例4，采用同实施例1相同的技术方案，区别在于，将上述药剂按照100ml：4～6mg的比例添加盐酸吗啉胍片。
实施例5，采用同实施例1相同的技术方案，区别在于，将上述药剂按照100ml：1～3mg的比例添加硫酸阿托品，按照100ml：4～6mg的比例添加盐酸吗啉胍片。
供试羔羊：选用饲养管理条件相同患有痢疾的山羊羔羊中随机挑选168头，随机分为5组，每组分别按照实施例1～实施例5方案制备的药物，每日灌服三次，连续3d，用药后，每日观察病记录羔羊的病况，3d后，分别对各组的治疗效果进行分析，结果如下表：
治愈：用药后下痢停止，精神、食欲粪便均转为正常；
| 组别 | 治疗数/只 | 治愈数/只 | 治愈率/％ |
| 实施例1 | 30 | 24 | 80％ |
| 实施例2 | 34 | 29 | 85％ |
| 实施例3 | 29 | 26 | 90％ |
| 实施例4 | 37 | 34 | 92％ |
| 实施例5 | 38 | 38 | 100％ |
由试验结果可知，采用实施例1方案制备的药物能够有效的治疗羔羊痢疾，实施例2在实施例1的方案上对制备方法进行优化，进而增强了药效，其治愈率达到了85％；实施例3将硫酸阿托品加入的实施例1方案制备的药物中进行配伍使用，使得治愈率达到了90％；实施例4将盐酸吗啉胍片加入的实施例1方案制备的药物中进行配伍使用，使得治愈率达到了92％；同时将硫酸阿托品和盐酸吗啉胍片加入到实施例1方案制备的药物中进行配伍使用，使得药物之间形成协同的功效，使得治疗效果得到显著的提升，治愈率达到100％。
实施例2
一种治疗羔羊痢疾的组合物，包括以下重量份的原料：胡黄连10g、石榴皮12g、干姜12g、青蒿12g、黄柏10g、秦皮12g、白头翁17g、陈皮10g。
将上述中药材进行混合后，加水淹没药材后进行煎煮，将煎煮液进行过滤，得药剂，将药剂每日灌服下痢羔羊3次，连续使用3天，治愈率达到82％。
实施例3
一种治疗羔羊痢疾的组合物，包括以下重量份的原料：胡黄连8g、石榴皮10g、干姜10g、青蒿10g、黄柏8g、秦皮10g、白头翁15g、陈皮8g。
将上述中药材进行混合后，加水淹没药材后进行煎煮，将煎煮液进行过滤，得药剂，将药剂每日灌服下痢羔羊3次，连续使用3天，治愈率达到86％。
在此有必要指出的是，以上实施例和试验例仅限于对本发明的技术方案做进一步的阐述和理解，不能理解为对本发明的技术方案做进一步的限定，本领域技术人员作出的非突出实质性特征和显著进步的发明创造，仍然属于本发明的保护范畴。
Claims (10)
1.一种治疗羔羊痢疾的组合物，其特征在于，包括以下重量份的原料：胡黄连6～10份、石榴皮8～12份、干姜8～12份、青蒿8～12份、黄柏7～10份、秦皮8～12份、白头翁14～17份、陈皮7～10份。
2.如权利要求1所述治疗羔羊痢疾的组合物，其特征在于，所述原料以重量份计为：胡黄连8份、石榴皮10份、干姜10份、青蒿10份、黄柏8份、秦皮10份、白头翁15份、陈皮8份。
3.如权利要求1或2所述治疗羔羊痢疾的组合物，其特征在于，所述原料中含有硫酸阿托品。
4.如权利要求1或2所述治疗羔羊痢疾的组合物，其特征在于，所述原料中含有盐酸吗啉胍片。
5.如权利要求1或2所述治疗羔羊痢疾的组合物，其特征在于，所述原料中含有硫酸阿托品和盐酸吗啉胍片。
6.如权利要求1或2所述治疗羔羊痢疾的组合物的制备方法，其特征在于，将所述的中药材进行混合后，加水淹没药材后进行煎煮，将煎煮液进行过滤，得药剂。
7.如权利要求6所述治疗羔羊痢疾的组合物的制备方法，其特征在于，按照配方量取各中药，采用清水冲洗干净后混合，放入粉碎机中粉碎至60～80目，再加入其重量4～6倍水煎煮2～3h，过滤后滤渣加入1～2倍水煎煮1～1.5h，过滤；将两次过滤后的滤液进行合并，得药剂。
8.如权利要求7所述治疗羔羊痢疾的组合物的制备方法，其特征在于，所述药剂按照100ml：1～3mg的比例添加硫酸阿托品。
9.如权利要求7所述治疗羔羊痢疾的组合物的制备方法，其特征在于，所述药剂按照100ml：4～6mg的比例添加盐酸吗啉胍片。
10.如权利要求7所述治疗羔羊痢疾的组合物的制备方法，其特征在于，所述药剂按照100ml：1～3mg的比例添加硫酸阿托品，按照100ml：4～6mg的比例添加盐酸吗啉胍片。
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