CN107929685A - 一种治疗羔羊痢疾的组合物及其制备方法 - Google Patents
一种治疗羔羊痢疾的组合物及其制备方法 Download PDFInfo
- Publication number
- CN107929685A CN107929685A CN201711135496.3A CN201711135496A CN107929685A CN 107929685 A CN107929685 A CN 107929685A CN 201711135496 A CN201711135496 A CN 201711135496A CN 107929685 A CN107929685 A CN 107929685A
- Authority
- CN
- China
- Prior art keywords
- parts
- composition
- treatment
- lamb dysentery
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000019687 Lamb Nutrition 0.000 title claims abstract description 33
- 208000001848 dysentery Diseases 0.000 title claims abstract description 25
- 239000000203 mixture Substances 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000003814 drug Substances 0.000 claims abstract description 44
- 239000002994 raw material Substances 0.000 claims abstract description 15
- BITDLWAQPKSXTF-UHFFFAOYSA-M 1-[(3-nitrophenyl)methoxymethyl]pyridin-1-ium;chloride Chemical compound [Cl-].[O-][N+](=O)C1=CC=CC(COC[N+]=2C=CC=CC=2)=C1 BITDLWAQPKSXTF-UHFFFAOYSA-M 0.000 claims abstract description 13
- 229960002581 moroxydine hydrochloride Drugs 0.000 claims abstract description 13
- HOBWAPHTEJGALG-JKCMADFCSA-N [(1r,5s)-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate;sulfate Chemical compound [O-]S([O-])(=O)=O.C([C@H]1CC[C@@H](C2)[NH+]1C)C2OC(=O)C(CO)C1=CC=CC=C1.C([C@H]1CC[C@@H](C2)[NH+]1C)C2OC(=O)C(CO)C1=CC=CC=C1 HOBWAPHTEJGALG-JKCMADFCSA-N 0.000 claims abstract description 12
- 229960002028 atropine sulfate Drugs 0.000 claims abstract description 12
- 235000001405 Artemisia annua Nutrition 0.000 claims abstract description 9
- 240000000011 Artemisia annua Species 0.000 claims abstract description 9
- 241001504477 Pycnonotidae Species 0.000 claims abstract description 9
- 238000001914 filtration Methods 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 241000218202 Coptis Species 0.000 claims 1
- 235000002991 Coptis groenlandica Nutrition 0.000 claims 1
- VWPYEPBQDNXCDS-UHFFFAOYSA-N guanidine;quinoline Chemical compound NC(N)=N.N1=CC=CC2=CC=CC=C21 VWPYEPBQDNXCDS-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 4
- 208000024891 symptom Diseases 0.000 abstract description 4
- 241000283707 Capra Species 0.000 abstract description 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract description 2
- 229940126680 traditional chinese medicines Drugs 0.000 abstract description 2
- 206010012735 Diarrhoea Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 241001494479 Pecora Species 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000006651 lactation Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010010071 Coma Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 208000034347 Faecal incontinence Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 241000283903 Ovis aries Species 0.000 description 1
- 206010039424 Salivary hypersecretion Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- 244000273928 Zingiber officinale Species 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000003143 atherosclerotic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 206010030306 omphalitis Diseases 0.000 description 1
- 206010030899 opisthotonus Diseases 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000001902 propagating effect Effects 0.000 description 1
- 208000026451 salivation Diseases 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000003954 umbilical cord Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明属于中药技术领域,尤其是一种治疗羔羊痢疾的组合物及其制备方法,采用胡黄连6~10份、石榴皮8~12份、干姜8~12份、青蒿8~12份、黄柏7~10份、秦皮8~12份、白头翁14~17份、陈皮7~10份为原料,将其进行粉碎后进行煎煮,过滤后制得药剂;该药剂能够有效的治疗山羊痢疾的症状,治疗周期短、治愈率高、安全可靠;尤其是通过加入硫酸阿托品和盐酸吗啉胍片,采用中西结合的方式,使得药物之间形成协同的功效,进而实现短期内治愈率达到100%,不复发,是一种理想的药物制剂。
Description
技术领域
本发明属于中药技术领域,尤其是一种治疗羔羊痢疾的组合物及其制备方法。
背景技术
羊痢疾是由魏氏梭菌B型引起的初生羔羊的一种急性毒血性传染病;以剧烈腹泻和小肠发生溃疡为特征,此病主要危害7日龄内的羔羊,可造成大批死亡,是影响羔羊成活率的一种常见疾病;1.本病的发生和流行,与怀孕母羊营养不良、护理不当、产羔季节气候突变、羊舍阴暗潮湿等有密切关系;此外,哺乳不当、饥饱不匀、接羔、育羔时清洁卫生条件差等也可诱发本病;传播源为病羔羊粪便,经消化道、脐带和创伤感染,潜伏期一般为1~2天,有的出生几小时,因病原菌不同而异;2.临床症状病初羔羊精神沉郁,食欲减退或停止哺乳,随后1~2天,病羔腹泻粥状或水样物,颜色有绿、黄绿、灰白等,并有恶臭味,体温升高至39.5℃;病羔萎靡呆立、低头弓背、腹部下凹,后期粪内带血、肛门失禁;由于持续性腹泻,体温偏低,经1~2天死亡,个别病例出现神经症状,流涎、牙关紧闭、角弓反张、四肢抽搐或神志昏迷,以死亡告终。
目前,针对治疗羔羊痢疾的药物大多采用西药治疗,而西药的价格较为昂贵,治疗效果不佳,容易出现复发,毒副作用也较大;采用中药治疗,大多治疗周期较长,起效慢,容易延误病情。
发明内容
为解决上述技术问题,本发明提供一种治疗羔羊痢疾的组合物及其制备方法。
具体是通过以下技术方案得以实现的:
一种治疗羔羊痢疾的组合物,包括以下重量份的原料:胡黄连6~10份、石榴皮8~12份、干姜8~12份、青蒿8~12份、黄柏7~10份、秦皮8~12份、白头翁14~17份、陈皮7~10份。
所述原料以重量份计为:胡黄连8份、石榴皮10份、干姜10份、青蒿10份、黄柏8份、秦皮10份、白头翁15份、陈皮8份。
所述原料中含有硫酸阿托品。
所述原料中含有盐酸吗啉胍片。
所述原料中含有硫酸阿托品和盐酸吗啉胍片。
将上述中药材进行混合后,加水淹没药材后进行煎煮,将煎煮液进行过滤,得药剂。
按照配方量取各中药,采用清水冲洗干净后混合,放入粉碎机中粉碎至60~80目,再加入其重量4~6倍水煎煮2~3h,过滤后滤渣加入1~2倍水煎煮1~1.5h,过滤;将两次过滤后的滤液进行合并,得药剂。
所述药剂按照100ml:1~3mg的比例添加硫酸阿托品。
所述药剂按照100ml:4~6mg的比例添加盐酸吗啉胍片。
所述药剂按照100ml:1~3mg的比例添加硫酸阿托品,按照100ml:4~6mg的比例添加盐酸吗啉胍片。
有益效果
本发明采用胡黄连6~10份、石榴皮8~12份、干姜8~12份、青蒿8~12份、黄柏7~10份、秦皮8~12份、白头翁14~17份、陈皮7~10份为原料,将其进行粉碎后进行煎煮,过滤后制得药剂;该药剂能够有效的治疗山羊痢疾的症状,治疗周期短、治愈率高、安全可靠;尤其是通过加入硫酸阿托品和盐酸吗啉胍片,采用中西结合的方式,使得药物之间形成协同的功效,进而实现短期内治愈率达到100%,不复发,是一种理想的药物制剂。
具体实施方式
下面结核具体的实施方式来对本发明的技术方案做进一步的限定,但要求保护的范围不仅局限于所作的描述。
实施例1
一种治疗羔羊痢疾的组合物,包括以下重量份的原料:胡黄连6g、石榴皮8g、干姜8g、青蒿8g、黄柏7g、秦皮8g、白头翁14g、陈皮7g。
将上述中药材进行混合后,加水淹没药材后进行煎煮,将煎煮液进行过滤,得药剂。
实施例2,采用同实施例1相同的配方,区别在于制备方法不同,实施例2按照上述配方量取各中药,采用清水冲洗干净后混合,放入粉碎机中粉碎至60~80目,再加入其重量4~6倍水煎煮2~3h,过滤后滤渣加入1~2倍水煎煮1~1.5h,过滤;将两次过滤后的滤液进行合并,得药剂。
实施例3,采用同实施例1相同的技术方案,区别在于,将上述药剂与硫酸阿托品按照按照100ml:1~3mg的比例混合。
实施例4,采用同实施例1相同的技术方案,区别在于,将上述药剂按照100ml:4~6mg的比例添加盐酸吗啉胍片。
实施例5,采用同实施例1相同的技术方案,区别在于,将上述药剂按照100ml:1~3mg的比例添加硫酸阿托品,按照100ml:4~6mg的比例添加盐酸吗啉胍片。
供试羔羊:选用饲养管理条件相同患有痢疾的山羊羔羊中随机挑选168头,随机分为5组,每组分别按照实施例1~实施例5方案制备的药物,每日灌服三次,连续3d,用药后,每日观察病记录羔羊的病况,3d后,分别对各组的治疗效果进行分析,结果如下表:
治愈:用药后下痢停止,精神、食欲粪便均转为正常;
组别 | 治疗数/只 | 治愈数/只 | 治愈率/% |
实施例1 | 30 | 24 | 80% |
实施例2 | 34 | 29 | 85% |
实施例3 | 29 | 26 | 90% |
实施例4 | 37 | 34 | 92% |
实施例5 | 38 | 38 | 100% |
由试验结果可知,采用实施例1方案制备的药物能够有效的治疗羔羊痢疾,实施例2在实施例1的方案上对制备方法进行优化,进而增强了药效,其治愈率达到了85%;实施例3将硫酸阿托品加入的实施例1方案制备的药物中进行配伍使用,使得治愈率达到了90%;实施例4将盐酸吗啉胍片加入的实施例1方案制备的药物中进行配伍使用,使得治愈率达到了92%;同时将硫酸阿托品和盐酸吗啉胍片加入到实施例1方案制备的药物中进行配伍使用,使得药物之间形成协同的功效,使得治疗效果得到显著的提升,治愈率达到100%。
实施例2
一种治疗羔羊痢疾的组合物,包括以下重量份的原料:胡黄连10g、石榴皮12g、干姜12g、青蒿12g、黄柏10g、秦皮12g、白头翁17g、陈皮10g。
将上述中药材进行混合后,加水淹没药材后进行煎煮,将煎煮液进行过滤,得药剂,将药剂每日灌服下痢羔羊3次,连续使用3天,治愈率达到82%。
实施例3
一种治疗羔羊痢疾的组合物,包括以下重量份的原料:胡黄连8g、石榴皮10g、干姜10g、青蒿10g、黄柏8g、秦皮10g、白头翁15g、陈皮8g。
将上述中药材进行混合后,加水淹没药材后进行煎煮,将煎煮液进行过滤,得药剂,将药剂每日灌服下痢羔羊3次,连续使用3天,治愈率达到86%。
在此有必要指出的是,以上实施例和试验例仅限于对本发明的技术方案做进一步的阐述和理解,不能理解为对本发明的技术方案做进一步的限定,本领域技术人员作出的非突出实质性特征和显著进步的发明创造,仍然属于本发明的保护范畴。
Claims (10)
1.一种治疗羔羊痢疾的组合物,其特征在于,包括以下重量份的原料:胡黄连6~10份、石榴皮8~12份、干姜8~12份、青蒿8~12份、黄柏7~10份、秦皮8~12份、白头翁14~17份、陈皮7~10份。
2.如权利要求1所述治疗羔羊痢疾的组合物,其特征在于,所述原料以重量份计为:胡黄连8份、石榴皮10份、干姜10份、青蒿10份、黄柏8份、秦皮10份、白头翁15份、陈皮8份。
3.如权利要求1或2所述治疗羔羊痢疾的组合物,其特征在于,所述原料中含有硫酸阿托品。
4.如权利要求1或2所述治疗羔羊痢疾的组合物,其特征在于,所述原料中含有盐酸吗啉胍片。
5.如权利要求1或2所述治疗羔羊痢疾的组合物,其特征在于,所述原料中含有硫酸阿托品和盐酸吗啉胍片。
6.如权利要求1或2所述治疗羔羊痢疾的组合物的制备方法,其特征在于,将所述的中药材进行混合后,加水淹没药材后进行煎煮,将煎煮液进行过滤,得药剂。
7.如权利要求6所述治疗羔羊痢疾的组合物的制备方法,其特征在于,按照配方量取各中药,采用清水冲洗干净后混合,放入粉碎机中粉碎至60~80目,再加入其重量4~6倍水煎煮2~3h,过滤后滤渣加入1~2倍水煎煮1~1.5h,过滤;将两次过滤后的滤液进行合并,得药剂。
8.如权利要求7所述治疗羔羊痢疾的组合物的制备方法,其特征在于,所述药剂按照100ml:1~3mg的比例添加硫酸阿托品。
9.如权利要求7所述治疗羔羊痢疾的组合物的制备方法,其特征在于,所述药剂按照100ml:4~6mg的比例添加盐酸吗啉胍片。
10.如权利要求7所述治疗羔羊痢疾的组合物的制备方法,其特征在于,所述药剂按照100ml:1~3mg的比例添加硫酸阿托品,按照100ml:4~6mg的比例添加盐酸吗啉胍片。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711135496.3A CN107929685A (zh) | 2017-11-16 | 2017-11-16 | 一种治疗羔羊痢疾的组合物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711135496.3A CN107929685A (zh) | 2017-11-16 | 2017-11-16 | 一种治疗羔羊痢疾的组合物及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN107929685A true CN107929685A (zh) | 2018-04-20 |
Family
ID=61931391
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201711135496.3A Pending CN107929685A (zh) | 2017-11-16 | 2017-11-16 | 一种治疗羔羊痢疾的组合物及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN107929685A (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108743898A (zh) * | 2018-08-09 | 2018-11-06 | 思南县绿诚牧业科技发展有限公司 | 一种治疗羔羊痢疾的中药组合物及其制剂制备方法 |
CN108904769A (zh) * | 2018-08-09 | 2018-11-30 | 紫云自治县翔锋种养殖农民专业合作社 | 一种治疗黑山羊痢疾的药物组合及其制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1939466A (zh) * | 2006-09-28 | 2007-04-04 | 天津生机集团有限公司 | 治疗畜禽肠炎的中药组合物 |
CN107335047A (zh) * | 2017-09-05 | 2017-11-10 | 佛山市秸和科技有限公司 | 一种治疗热痢疾的中药组合物 |
-
2017
- 2017-11-16 CN CN201711135496.3A patent/CN107929685A/zh active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1939466A (zh) * | 2006-09-28 | 2007-04-04 | 天津生机集团有限公司 | 治疗畜禽肠炎的中药组合物 |
CN107335047A (zh) * | 2017-09-05 | 2017-11-10 | 佛山市秸和科技有限公司 | 一种治疗热痢疾的中药组合物 |
Non-Patent Citations (1)
Title |
---|
张克家: "《中兽医方剂大全》", 31 December 1994, 中国农业出版社 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108743898A (zh) * | 2018-08-09 | 2018-11-06 | 思南县绿诚牧业科技发展有限公司 | 一种治疗羔羊痢疾的中药组合物及其制剂制备方法 |
CN108904769A (zh) * | 2018-08-09 | 2018-11-30 | 紫云自治县翔锋种养殖农民专业合作社 | 一种治疗黑山羊痢疾的药物组合及其制备方法 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2236149A1 (en) | Medicinal composition | |
CN102028795B (zh) | 用于畜禽细菌性疾病的白头翁颗粒剂、制备方法和预混料 | |
CN102038100A (zh) | 用于预防和治疗猪瘟的饲料添加剂 | |
CN101732517A (zh) | 一种治疗犬瘟热的中药组合物及其制备方法 | |
CN107929685A (zh) | 一种治疗羔羊痢疾的组合物及其制备方法 | |
CN102671011A (zh) | 一种用于预防和治疗仔猪黄白痢的中药复方粉剂及其制备方法 | |
CN101468057A (zh) | 一种用于治疗仔猪黄白痢的复方中药制剂 | |
CN102579622B (zh) | 一种治疗副猪嗜血杆菌病的中草药制剂及其制备方法 | |
CN108904769A (zh) | 一种治疗黑山羊痢疾的药物组合及其制备方法 | |
CN101317879B (zh) | 治疗牛、羊、猪附红细胞体疾病的药物 | |
CN101390965A (zh) | 一种治疗畜禽细菌性和病毒性传染病的中兽药及其制备方法 | |
CN101249097B (zh) | 灰树花多糖在制备防治猪病毒性疾病药物中的应用 | |
CN102048830A (zh) | 一种具有治疗风湿骨痛功效的药酒 | |
CN101879238A (zh) | 一种预防和治疗鸡大肠杆菌病的药物组合物及其制备方法 | |
CN105616808A (zh) | 一种具有健胃驱虫功能的中兽药及其制备方法 | |
CN102406740B (zh) | 一种治疗家禽组织滴虫病的纯中药组合物及其制备方法 | |
CN102973577B (zh) | 治疗幼兔球虫病的复方磺胺喹恶啉钠组合物及其制备方法 | |
CN102302575A (zh) | 一种用于治疗仔猪白痢的口服药物及其制备方法 | |
CN108175793A (zh) | 一种兽药组合物及其制备方法和应用 | |
CN116036188B (zh) | 防治鸡球虫病的中药组合物及其制备方法与应用 | |
CN107789343A (zh) | 一种治疗偏头痛的药物及其制备方法 | |
CN104606627B (zh) | 一种治疗仔猪腹泻的药物组合物及其制备方法 | |
CN1261156C (zh) | 一种治疗慢性胃肠炎、结肠炎的药物 | |
CN108186750A (zh) | 一种防治仔猪腹泻的中药组合物及其制备方法和应用 | |
CN110772627B (zh) | 一种藏药消痹膏及其制备方法和应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180420 |
|
RJ01 | Rejection of invention patent application after publication |