CN107929616A - 一种治疗痛风的外敷药贴组合物 - Google Patents
一种治疗痛风的外敷药贴组合物 Download PDFInfo
- Publication number
- CN107929616A CN107929616A CN201711361078.6A CN201711361078A CN107929616A CN 107929616 A CN107929616 A CN 107929616A CN 201711361078 A CN201711361078 A CN 201711361078A CN 107929616 A CN107929616 A CN 107929616A
- Authority
- CN
- China
- Prior art keywords
- external application
- drug paste
- urine
- medicine
- point
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/487—Psoralea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/69—Polygalaceae (Milkwort family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/716—Clematis (leather flower)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明属于中药技术领域,涉及一种以中草药为原料的治疗痛风的外敷药贴;其原料包括苍术、黄柏、薏米、川牛膝、怀牛膝、土茯苓、萆薢、车前草、威灵仙、丹参、鸡血藤、忍冬藤、海风藤、络石藤、桃仁、红花、猪苓、汉防己等;将选用的各味中药加工后先精制成80~100目的药粉后与发热体混合制成外敷药贴,贴敷于相应的经络穴位,其中发热体包含氯化铁、铁粉和盐酸;使用时,外敷贴中的组合物遇空气发热,所含挥发性成份不断从药贴中透出,在主穴及配穴中形成具有45~60℃温湿度的“药雾”,在热力的作用下,直达穴位,迅速渗入经络,促进药物吸收;其药物配伍合理严谨,无毒副作用,具有健脾培本、祛风除湿、通络止痛的作用和功效,应用环境友好。
Description
技术领域:
本发明属于中药技术领域,涉及一种以中草药为原料的治疗痛风的外敷药贴,特别是一种以中草药为原料的治疗痛风的药物组合外敷药贴组合物及其制备工艺和使用方法。
背景技术:
近年来随着人民生活水平的提高,饮食结构中嘌呤等成分增加,痛风病人的患病率也逐年增高,尤其是东南沿海一带,喜吃海鲜啤酒等高嘌呤食物。流行病学调查患病率已超过0.3%,是仅次于糖尿病的人类第二大代谢类疾病,痛风在男性中较为多见,拇趾是最常见的受累区域,50%~70%初次发病发生于此,90%的痛风患者在其一生中的某个时期会发生第一跖趾关节受累。由于体内尿酸增高致使尿酸盐沉积在关节囊、滑膜、软骨等处,从而引起组织病损及炎性反应。急性痛风性关节炎以男性为主,多在半夜起病,发作没有预兆,首发症状常出现在一个关节并持续数天,症状逐渐消失,关节功能恢复,如不预防,会出现慢性症状,导致症状反复的发作并可波及多个关节,致使病变关节产生永久性损害,严重影响人们的正常工作和生活。微小的损伤、手术、过量饮酒、过多食用富含蛋白质的食物、疲劳、情绪紧张及各种疾病均可诱发,西医对于急性痛风性关节炎患者多采用秋水仙碱、消炎痛、强的松等,不良反应多,副作用大,病人往往不能耐受,容易复发。
中医古代医家对痛风的认识可追朔到《内经》,“热痹”范畴,乃风、寒、湿、热等泄气杂至,或兼痰瘀,痹阻经络影响气血运行所致肢体关节疼痛,痛风属于中医痹证范畴,由于脾肾功能失调,脾失健运,致使湿浊内生;中医辩证痛风多属湿热浊瘀搏结者,症见关节急慢性疼痛,受累关节与周围组织红肿发热及活动受限,或者关节变形,或肢体肿胀,或酸软无力,或见皮下痛风石,或小便色黄等;对于痛风,在临床中发现浊,瘀,痰內邪互为因果,导致化毒致痹,在临床主要采取清热利湿,泄化瘀浊,通利关节,祛风止痛,兼顾脾肾之法。因此,寻求一种治疗痛风的外敷药贴组合物,结合现代中医药防治痛风的临床与实验研究,减小毒副作用,有非常好的的应用前景。
发明内容:
本发明的目的在于克服现有技术存在的缺点,寻求设计提供一种健脾扶阳、祛风止痛、除湿浊、通利关节的中药外敷药贴,通过贴于不同的穴位达到不同治疗疾病的功效,调节痛风体质以期使其达到平和质,防止复发。
为了实现上述目的,本发明所述外敷药贴组合物中的原料按重量组分为:苍术10g、黄柏10g、薏米30g、川牛膝15g、怀牛膝15g、土茯苓90g、萆薢45g、车前草30g、威灵仙45g、丹参15g、鸡血藤30g、忍冬藤30g、海风藤30g、络石藤30g、桃仁g10、红花10g、猪苓30g、汉防己10g、希俭草15g、老鹳草15g、穿山龙10g、炒地龙15g、远志10g、川断20g、桑寄生15g、补骨脂30g、知母15g、黑顺片45g、独活15g、白术15g、王不留行15g、黄芪30g、官桂6g、细辛9g。
本发明所述忍冬藤、海风藤、络石藤三味药物均采用以下方式炮制而成:选取上等新品,清水洗净,去除杂质,控水晾干,不得发霉,然后切段成5厘米长,将晾干后的干品放入5~8倍重量的童便中浸泡三日,置于通风处阴干后,再置于3~5倍重量的童便中浸泡三日后,放于空气干燥流通处阴干,而后再置于2~4倍重量的童便浸泡三日,干燥通风处予以阴干,检查无霉坏变质品后备用;通过三次童便浸泡,三次阴干后能增强药物的清热解毒、凉血消肿、止痛活血之功效;所述的童便为2~8岁儿童的小便尿液,以晨尿为佳。
本发明所述桃仁、红花、炒地龙均在控温150~200℃条件下,陶瓷锅中炒制20~40分钟使用。
本发明选用各味中药,先精制成80~100目的药粉后与发热体混合制成外敷药贴,贴敷于相应的经络穴位,用于治疗痛风;所述发热体包括氯化铁、铁粉和盐酸;其外敷药贴的具体制备过程为:将铁粉用20目的网筛过筛,除去大于20目的部分,将20目以下的铁粉和药粉按比例搅拌混合均匀后加入重量比为50~60的氯化铁水溶液继续搅拌均匀后放置冷却分装到包装袋备用;其中铁粉:氯化铁水溶液:药粉的重量比为30:9:10,所采用的发热体温度能持续6~8h;使用时将外敷药贴贴于人体的主穴,即关元穴和腰阳关穴,另根据人体不同的体质,贴于不同的配穴。
本发明所述包装袋分内、外两层,其中内袋直接用于包装药粉与发热体制成的外敷药贴,内袋的表面开有小孔,用于控制空气进入的速度从而实现控制发热温度和恒温时间,小孔的大小和数量根据所需发热温度和恒温时间确定;外袋采用密封性好的塑料袋隔绝空气。
本发明所述外敷药贴使用时,外敷药贴遇空气自行发热,所含挥发性成份不断从药贴中透出,在主穴及配穴中形成具有45~60℃温湿度的“药雾”,在热力的作用下,直达穴位,迅速渗入经络,促进药物吸收;外敷药贴使用时的平均温度在53℃,具有与人体辐射吸收相应波长的远红外辐射率,与人体接触后,辐射出远红外线作用于人体,产生共振吸收及穿透皮层组织,起到改善人体微循环等作用,有助于生物酶的生长,加强人体组织的再生功能,促进新陈代谢,增强免疫功能,促进血液循环,同时使血管扩张、加快血流,改善人体血液循环、促进药物透皮吸收。
本发明与现有技术相比,药物配伍合理严谨,使用方法简单,价格低廉,能长期使用,无毒副作用,疗效高,经过临床使用表明,具有健脾培本、祛风除湿、通络止痛的作用和功效,适应于脾失健运,致使湿浊内生之痛风症。
具体实施方式:
下面通过实施例对本发明作进一步详述。
实施例1:
本实施例所述外敷药贴组合物中的原料按重量组分为:苍术10g、黄柏10g、薏米30g、川牛膝15g、怀牛膝15g、土茯苓90g、萆薢45g、车前草30g、威灵仙45g、丹参15g、鸡血藤30g、忍冬藤30g、海风藤30g、络石藤30g、桃仁g10、红花10g、猪苓30g、汉防己10g、希俭草15g、老鹳草15g、穿山龙10g、炒地龙15g、远志10g、川断20g、桑寄生15g、补骨脂30g、知母15g、黑顺片45g、独活15g、白术15g、王不留行15g、黄芪30g、官桂6g、细辛9g。
本实施例所述忍冬藤、海风藤、络石藤三味药物配伍合理严谨,能通经活络,祛除风湿热痹,养血活血、清热解毒、祛风止痛、凉血消肿;为增强这三味药配伍后的功效,三味药均采用以下方式炮制而成:选取上等新品,清水洗净,去除杂质,控水晾干,不得发霉,然后切段成5厘米长,将晾干后的干品放入5~8倍重量的童便中浸泡三日,置于通风处阴干后,再置于3~5倍重量的童便中浸泡三日后,放于空气干燥流通处阴干,而后再置于2~4倍重量的童便浸泡三日,干燥通风处予以阴干,检查无霉坏变质品后,方可入药;通过三次童便浸泡,三次阴干后能增强药物的清热解毒、凉血消肿、止痛活血之功效;所述的童便为2~8岁儿童的小便尿液,以晨尿为佳。
本实施例所述桃仁、红花、炒地龙均在控温150~200℃条件下,陶瓷锅中炒制20~40分钟使用;使用炒桃仁,能减缓生用之峻猛药效,更能增强通络、除痹、化瘀、止痉之长。
本实施例所述黑顺片、细辛、官桂、白术、远志、独活、川断、桑寄生、补骨脂,均可健脾扶阳、滋补肝肾、温寒化湿、豁痰通痹;土茯苓解毒利湿、通利关节、能除周身湿痹,能结拘挛骨痛;萆薢利湿泄浊、祛风除痹;车前草清热利湿、导邪从下窍而出;方中苍术、黄柏、牛膝、薏米可清热利湿;苍术、黄柏清热燥湿;薏米其味甘淡,其性和平,既可渗湿,又可解毒散结除痹;牛膝滋补肝肾、强壮筋骨、清热利湿、活血化瘀,又可引药下行,所以本方中怀牛膝、川牛膝同时配伍。
本实施例所述鸡血藤、丹参功同四物汤,活血补血功效大,这两味药联袂配伍其更能彰显舒筋活络、活血养血而不伤血、祛邪而不伤正之功效;王不留行活血利水消肿;木瓜、猪苓、汉防己祛除下肢酸软乏力、湿浊下注、肢体麻木;穿山龙、希签草、老鹳草,祛除祛风通络、祛除肢体麻木、屈伸不利;知母滋阴润燥通痹,黄芪固表,甘草调和诸药。
本实施例选用的具有健脾扶阳、祛风除湿、通络止痛的34味中药,先精制成80~100目的药粉后与发热体混合制成外敷药贴,贴敷于相应的经络穴位,用于治疗痛风;所述发热体包括氯化铁、铁粉和盐酸;其外敷药贴的具体制备过程为:将铁粉用20目的网筛过筛,除去大于20目的部分,将20目以下的铁粉和药粉按比例搅拌混合均匀后加入重量比为50~60的氯化铁水溶液继续搅拌均匀后放置冷却分装到包装袋备用;其中铁粉:氯化铁水溶液:药粉的重量比为30:9:10,所采用的发热体温度能持续6~8h;使用时将外敷药贴贴于人体的主穴,即关元穴和腰阳关穴,另根据人体不同的体质,贴于不同的配穴。
本实施例所述包装袋分内、外两层,其中内袋直接用于包装药粉与发热体制成的外敷药贴,内袋的表面开有一定大小和数量的小孔,用于控制空气进入的速度从而实现控制发热温度和恒温时间的目的,小孔的大小和数量根据所需发热温度和恒温时间确定;外袋采用密封性好的塑料袋隔绝空气。
本实施例所述外敷药贴根据坎离砂原理,通过热传导给药,具有远红外理疗、热疗、药疗三重功效,使用时,外敷药贴遇空气自行发热,所含挥发性成份不断从药贴中透出,在主穴及配穴中形成具有45~60℃温湿度的“药雾”,在热力的作用下,直达穴位,迅速渗入经络,促进药物吸收;外敷药贴使用时的平均温度在53℃,具有与人体辐射吸收相应波长的远红外辐射率,与人体接触后,辐射出远红外线作用于人体,产生共振吸收及穿透皮层组织,起到改善人体微循环等作用,有助于生物酶的生长,加强人体组织的再生功能,促进新陈代谢,增强免疫功能,促进血液循环,同时使血管扩张、加快血流,改善人体血液循环、促进药物透皮吸收。
本实施例所述药物配伍合理严谨,患者脾肾阳虚导致体内痰湿瘀阻经络,如果在临床中仅仅采取清热祛湿、活血化瘀、软结散坚的治疗原则,会更进一步戕伐患者已经虚弱的脾阳肾阳,导致脾肾阳虚进一步加剧,当然更无力运化体内痰湿,导致患者病情进一步加剧,本发明所述外敷药贴祛邪而不伤证,活血养血而不耗气,诸药能协同增效,在恢复患者肾阳脾阳的过程中,祛除痰湿,活血化瘀,促使患者身体各项机能恢复正常,达到治疗痛风的功效。
实施例2:
本实施例使用实施例1制备的药贴组合物,在某中西医结合中心的痛风患者观察发现效果好,并逐渐扩展到亚健康人群进行临床治疔,使用发明药物贴于穴位,每三天治疗一次,以7次为一疗程,一疗程后重新评价体质,疗效判定标准,采用综合疗效评定,参照国家卫生部发布的《中药新药临床研究指导原则》,具体疗效判定标准为:
痊愈:关节疼痛、压痛、急性红肿、活动受限的总积分下降100%;或体质评估转化分<30分,且平和质转化分≥80分;
显效:关节疼痛、压痛、急性红肿、活动受限的总积分下降≥66%;或体质评估:30分≤转化分<40分,60分≤平和质转化分<80分;
有效:关节疼痛、压痛、急性红肿、活动受限的总积分下降≥33%且<66%;或体质评估:30分≤转化分<40分,平和质转化分≥60分;
无效:关节疼痛、压痛、急性红肿、活动受限的总积分下降<33%;体质评估评分>40分。
计算公式:积分减少百分比=(治疗前积分—治疗后积分)/治疗前积分*100%。
本实施例共进行体质评估患者216人次,其中评估出来只有一种体质占有188人,两种及以上28人,并对治疗组及对照组进行统计分析,结果如表1。
表1治疗组与对照组好转率统计表
备注:“好转”包括痊愈、显效、有效;对照组:运用贴敷;P<0.01
其中治疗组中痊愈62例,显效31例,有效28例,好转率82.8%,对比结果提示,运用贴敷结合辨证施治,与单纯运用辨证论治相比,具有统计学意义(P<0.01);从上述临床治疗结果可看出,本实施例所述外敷药贴单独使用有较好效果,也可与其他中药配合使用,无副作用,操作简易,患者容易接受,具体临床病例介绍:
病例1、单某,男,53岁,痛风,症状:患者喜饮酒,嗜食海鲜,左右足第一足趾红、肿、热、痛,脚踝关节处处红肿,双手腕关节肿大,疼痛异常、拒按,西医诊断为痛风,既往有类似病史,自服秋水仙碱、别嘌呤等药物,舌胖,淡白,苔白厚腻,脉浮,关寸较大,体温38度,烦躁,失眠,纳可,便粘腻,小便黄赤,腰膝酸软,腰部、膝关节寒凉明显;
辩证:脾肾阳虚虚阳上浮痰湿瘀阻经络
治则:引火归元健脾温肾化痰祛湿活血化瘀
取所述外敷药贴贴敷3个疗程,症状消失,复查血尿酸275μmol/L,连续随访三年,未复发。
病例2:郭某,男,45岁,痛风,症状:患者体胖,体重98千克,面色恍白,长期吃牛羊内脏羊汤等民族食品,腿部关节有痛风史5年,血尿酸为573umol/L;吃海鲜,喝啤酒后复发痛风;舌胖,舌苔白薄,脉细弦略数,眠差多梦,纳可,粘腻大便,小便黄,倦怠乏力;左足大拇指,右腕关节红肿,疼痛、拒按,活动障碍,
辩证:脾肾阳虚痰湿瘀阻经络
治则:温肾健脾,活血化瘀祛除痰湿
根据体质评估,确定痰湿质,取以上贴敷3个疗程,血尿酸为253umol/L,腿部关节活动自如。
本实施例进行体质评估时采用体质评估表,体质评估表根据“中医体质量表——中医体质分类与评定表”制定;体质判定标准为:回答《中医体质分类与判定表》中的全部问题,每一问题按5级评分,计算原始分及转化分,依标准判定体质类型,其中原始分=各个条目的分值相加;转化分数=[(原始分~条目数)/(条目数×4)]×100,平和质为正常体质,气虚质、阳虚质、阴虚质、痰湿质、湿热质、瘀血质、气郁质、特禀质8种体质为偏颇体质,平和质与偏颇体质判定标准表见表3:
表3:平和质与偏颇体质判定标准表
本实施例中九种体质的穴位选配“九种体质”,依据《中医体质分类与判定》标准,该标准是我国第一部指导和规范中医体质研究及应用的文件,旨在为体质辨识及与中医体质相关疾病的防治、养生保健、健康管理提供依据,使体质分类科学化、规范化,根据患者体质选用穴位,制定相应外敷中药贴,使患者脏腑、气血、阴阳平衡,以及相关指标如三大常规,肝功肾功等达到“平和质”水平,将外敷药贴贴于人体的主穴,即关元穴和腰阳关穴,另外,根据人体不同的体质,同时贴于不同的配穴,具体为:
主穴是关元穴及腰阳关穴。关元穴属于任脉,位于下腹部,前正中线,脐下3寸;具有温肾益精,回阳补气,调理冲任,除寒通络的作用,另外,关元穴有强壮作用,为保健要穴,关为门户,元为元气,意在守住元气的关口,故关元也称“丹田”,同时也是血液灌注的地方,血液聚在关元穴,使之转化成肾精,而则肾精是强壮身体、延长寿命之本;《黄帝内经》称肾为“作强之官,伎巧出焉”,惟肾为能作强,而男女构精,人物化生,伎巧从是而出;故肾气充盛则精力充沛,通经活络,适用于风寒湿邪、瘀血阻滞等经络病症。腰阳关,经穴名;出《素问·骨空论》。别名脊阳关,背阳关,属督脉。在腰部,后正中线上,第4腰椎棘突下凹陷中;布有腰神经后支的内侧支和腰动脉后支。主治腰骶痛、下肢麻痹、痛风等。
Claims (3)
1.一种治疗痛风的外敷药贴组合物,其特征在于各原料按重量组分为:苍术10g、黄柏10g、薏米30g、川牛膝15g、怀牛膝15g、土茯苓90g、萆薢45g、车前草30g、威灵仙45g、丹参15g、鸡血藤30g、忍冬藤30g、海风藤30g、络石藤30g、桃仁g10、红花10g、猪苓30g、汉防己10g、希俭草15g、老鹳草15g、穿山龙10g、炒地龙15g、远志10g、川断20g、桑寄生15g、补骨脂30g、知母15g、黑顺片45g、独活15g、白术15g、王不留行15g、黄芪30g、官桂6g、细辛9g;所述忍冬藤、海风藤、络石藤三味药物均采用以下方式炮制而成:选取上等新品,清水洗净,去除杂质,控水晾干,不得发霉,然后切段成5厘米长,将晾干后的干品放入5~8倍重量的童便中浸泡三日,置于通风处阴干后,再置于3~5倍重量的童便中浸泡三日后,放于空气干燥流通处阴干,而后再置于2~4倍重量的童便浸泡三日,干燥通风处予以阴干,检查无霉坏变质品后备用;通过三次童便浸泡,三次阴干后能增强药物的清热解毒、凉血消肿、止痛活血之功效;所述的童便为2~8岁儿童的小便尿液,以晨尿为佳;本发明所述桃仁、红花、炒地龙均在控温150~200℃条件下,陶瓷锅中炒制20~40分钟使用,并与其他成份协同增效。
2.根据权利要求1所述的治疗痛风的外敷药贴组合物,其特征在于将选用的各味中药,先精制成80~100目的药粉后与发热体混合制成外敷药贴,贴敷于相应的经络穴位,用于治疗痛风;所述发热体包括氯化铁、铁粉和盐酸;其外敷药贴的具体制备过程为:将铁粉用20目的网筛过筛,除去大于20目的部分,将20目以下的铁粉和药粉按比例搅拌混合均匀后加入重量比为50~60的氯化铁水溶液继续搅拌均匀后放置冷却分装到包装袋备用;其中铁粉:氯化铁水溶液:药粉的重量比为30:9:10,所采用的发热体温度能持续6~8h;使用时将外敷药贴贴于人体的主穴,即关元穴和腰阳关穴,另根据人体不同的体质,贴于不同的配穴。
3.根据权利要求2所述的治疗痛风的外敷药贴组合物,其特征在于所述包装袋分内、外两层,其中内袋直接用于包装药粉与发热体制成的外敷药贴,内袋的表面开有小孔,用于控制空气进入的速度从而实现控制发热温度和恒温时间,小孔的大小和数量根据所需发热温度和恒温时间确定;外袋采用密封性好的塑料袋隔绝空气;本发明所述外敷药贴使用时,外敷药贴遇空气自行发热,所含挥发性成份不断从药贴中透出,在主穴及配穴中形成具有45~60℃温湿度的“药雾”,在热力的作用下,直达穴位,迅速渗入经络,促进药物吸收;外敷药贴使用时的平均温度在53℃,具有与人体辐射吸收相应波长的远红外辐射率,与人体接触后,辐射出远红外线作用于人体,产生共振吸收及穿透皮层组织,起到改善人体微循环等作用,有助于生物酶的生长,加强人体组织的再生功能,促进新陈代谢,增强免疫功能,促进血液循环,同时使血管扩张、加快血流,改善人体血液循环、促进药物透皮吸收。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711361078.6A CN107929616A (zh) | 2017-12-18 | 2017-12-18 | 一种治疗痛风的外敷药贴组合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711361078.6A CN107929616A (zh) | 2017-12-18 | 2017-12-18 | 一种治疗痛风的外敷药贴组合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN107929616A true CN107929616A (zh) | 2018-04-20 |
Family
ID=61944526
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201711361078.6A Pending CN107929616A (zh) | 2017-12-18 | 2017-12-18 | 一种治疗痛风的外敷药贴组合物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN107929616A (zh) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101703708A (zh) * | 2009-11-10 | 2010-05-12 | 卢速江 | 一种治疗类风湿关节炎、痛风的中药制剂及其制备方法 |
CN102836382A (zh) * | 2012-10-09 | 2012-12-26 | 彭少芳 | 一种固肾育胎外敷药贴 |
CN103055242A (zh) * | 2012-12-31 | 2013-04-24 | 彭少芳 | 一种改善体质固肾育胎的中药制剂 |
CN103127428A (zh) * | 2013-03-27 | 2013-06-05 | 谢银芳 | 一种治疗痛风性关节炎的中成药 |
-
2017
- 2017-12-18 CN CN201711361078.6A patent/CN107929616A/zh active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101703708A (zh) * | 2009-11-10 | 2010-05-12 | 卢速江 | 一种治疗类风湿关节炎、痛风的中药制剂及其制备方法 |
CN102836382A (zh) * | 2012-10-09 | 2012-12-26 | 彭少芳 | 一种固肾育胎外敷药贴 |
CN103055242A (zh) * | 2012-12-31 | 2013-04-24 | 彭少芳 | 一种改善体质固肾育胎的中药制剂 |
CN103127428A (zh) * | 2013-03-27 | 2013-06-05 | 谢银芳 | 一种治疗痛风性关节炎的中成药 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101972453B (zh) | 一种治疗风湿类风湿关节炎的中药药酒及其制备方法 | |
CN102247585A (zh) | 治疗痹症的中药组合物其制剂及制备方法 | |
CN102552759B (zh) | 治疗骨折后引起的肿胀及疼痛的中药组合物 | |
CN107693767A (zh) | 一种防治糖尿病足的外用中药组合物、其制备方法及应用 | |
CN105998432A (zh) | 一种治疗风湿的足浴粉及其制备方法 | |
CN107952047A (zh) | 一种纯中药浴足粉 | |
CN104721548B (zh) | 一种中药足部护理洗液及其制备方法 | |
CN108904614A (zh) | 治疗痛风和腿脚疼痛的中药 | |
CN102895576A (zh) | 一种药浴的配方 | |
CN102512647B (zh) | 一种治疗虚寒性腹痛的中药组合物 | |
CN102512631A (zh) | 一种治疗黄疸的中药组合物 | |
CN103585483B (zh) | 一种治疗膝骨性关节病的中药组合物及其制备方法 | |
CN107929616A (zh) | 一种治疗痛风的外敷药贴组合物 | |
CN104840569A (zh) | 一种益气补肾汤 | |
CN105816760A (zh) | 一种活血化瘀、定痛止血、殓疮生肌、消炎止痛的膏药及其制备方法 | |
CN101264256B (zh) | 治疗顽固性疼痛的中药胶囊 | |
CN105362402A (zh) | 一种治疗气虚的泡脚药、其制备方法及应用 | |
CN105125667B (zh) | 一种治疗类风湿关节炎的中成药通络伸筋丸 | |
CN108578618A (zh) | 一种补肾和治疗和预防糖尿病肾病的中药组合物 | |
CN104208369A (zh) | 治疗痛风的五藤逍遥丸 | |
CN102362992A (zh) | 一种治疗皮肌炎的中药组合物 | |
CN107137686A (zh) | 扶阳美容的中药组合物、药酒及其制备方法 | |
CN103301359B (zh) | 一种治疗痛风的中成药 | |
CN104784649A (zh) | 一种治疗肩关节周围炎的中药汤剂 | |
CN104042788B (zh) | 一种治疗血栓闭塞性脉管炎的中药组合物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180420 |
|
RJ01 | Rejection of invention patent application after publication |