CN107929336A - 一种川芎提取物肠溶微丸的制备工艺 - Google Patents
一种川芎提取物肠溶微丸的制备工艺 Download PDFInfo
- Publication number
- CN107929336A CN107929336A CN201710980864.8A CN201710980864A CN107929336A CN 107929336 A CN107929336 A CN 107929336A CN 201710980864 A CN201710980864 A CN 201710980864A CN 107929336 A CN107929336 A CN 107929336A
- Authority
- CN
- China
- Prior art keywords
- macroreticular resin
- pill
- rhizoma chuanxiong
- coated micro
- small
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006187 pill Substances 0.000 title claims abstract description 14
- 239000000284 extract Substances 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000011347 resin Substances 0.000 claims abstract description 37
- 229920005989 resin Polymers 0.000 claims abstract description 37
- 241000112528 Ligusticum striatum Species 0.000 claims abstract description 15
- 238000001035 drying Methods 0.000 claims abstract description 8
- 239000012141 concentrate Substances 0.000 claims abstract description 6
- 239000004925 Acrylic resin Substances 0.000 claims abstract description 5
- 229920000178 Acrylic resin Polymers 0.000 claims abstract description 5
- 239000011248 coating agent Substances 0.000 claims abstract description 5
- 238000000576 coating method Methods 0.000 claims abstract description 5
- 238000000605 extraction Methods 0.000 claims abstract description 5
- 239000003814 drug Substances 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 229940079593 drug Drugs 0.000 claims description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 11
- 238000007654 immersion Methods 0.000 claims description 8
- 238000002791 soaking Methods 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 5
- 239000000047 product Substances 0.000 claims description 5
- 239000008367 deionised water Substances 0.000 claims description 4
- 229910021641 deionized water Inorganic materials 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 238000009413 insulation Methods 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 4
- 238000002390 rotary evaporation Methods 0.000 claims description 4
- 238000001291 vacuum drying Methods 0.000 claims description 4
- 230000006837 decompression Effects 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 abstract description 4
- 239000004615 ingredient Substances 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000002085 irritant Substances 0.000 description 2
- 231100000021 irritant Toxicity 0.000 description 2
- 239000008141 laxative Substances 0.000 description 2
- 230000002475 laxative effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 206010022678 Intestinal infections Diseases 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000002702 enteric coating Substances 0.000 description 1
- 238000009505 enteric coating Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种川芎提取物肠溶微丸的制备工艺，主要是将中药川芎提取浓缩，再将大孔树脂进行处理。将制得的川芎提取浓缩液与大孔树脂进行混合均匀并干燥，得到肠溶微丸的丸心。将此丸心用丙烯酸树脂进行流化床包衣，再行干燥，即可得到川芎提取物肠溶微丸。本发明制备的川芎提取物肠溶微丸，可以避免川芎的挥发性成分的丢失，增加了其有效成分在肠道的浓度，同时，还能掩盖其不良气味，改善患者的服药顺应性。本法制备川芎提取物肠溶微丸工艺简洁，具有很大的经济价值。
Description
技术领域
本发明“一种川芎提取物肠溶微丸的制备工艺”属于中药制剂领域，尤其属于中药肠溶微丸制剂领域。
背景技术
传统的中药口服制剂，如丸剂、散剂、颗粒剂、片剂、胶囊剂及液体制剂等，大多在胃内崩解或溶解，对胃粘膜有刺激性，影响到患者的胃口等。有些药物由于含有不良嗅味，使得患者的服药顺应性下降。此外，胃液中的盐酸也常常会对药物的有效成分起到破坏的作用，从而影响到药物的疗效。肠道是药物吸收的主要部位。肠道感染时，尤其需要有足够浓度的药物或中药的有效成分作用于病灶局部，既提高了疗效，减少了副作用的发生，也降低了药物的用量。因此，药性寒凉，或对上消化道有刺激性，或有难闻气味及易挥发的药物，均非常适合制备成肠溶制剂。川芎由于具有特殊的气味，很多患者难以接受。同时，川芎气味的挥发，也会导致有效成分的降低，从而引起疗效的下降。因此，川芎肠溶制剂必将受到医生和患者的青睐。
发明内容
本发明“一种川芎提取物肠溶微丸的制备工艺”，其特征在于首先将大孔树脂按照下法进行处理：将大孔树脂加入5~10倍重量的去离子水中，于50~60℃保温浸泡12~24小时，每2~4小时换一次水，将沥干水分的大孔树脂再加入5~10倍重量的60% ~80% 食用酒精，于室温浸泡2~3次，每次浸泡2~4小时，将经酒精浸泡处理后的大孔树脂置真空旋转蒸发干燥器中回收酒精后，再转移到真空干燥箱中于50~60℃减压干燥4~8小时，过60~80目筛去细粉，得到处理后的大孔树脂颗粒。同时，将川芎饮片倒入5~10倍量的水中，煎煮提取两次，每次煎煮1~1.5小时，过滤，合并滤液，55~80℃减压浓缩至相对密度为1.05~1.10，将此川芎浓缩液1~3份，与处理后的大孔树脂7~9份混合均匀，再于50~80℃减压干燥8~24小时，得到含药大孔树脂丸心。将含药大孔树脂丸心用流化床包衣法包上衣层重量为含药大孔树脂丸心重量3%~10%的丙烯酸树脂II，继续干燥即得成品。
川芎具有活血行气、祛风止痛的功效。本发明产品川芎提取物肠溶微丸，将川芎提取浓缩液吸附在经过处理后的大孔树脂上，制备成含药微丸丸心，再包裹上肠溶衣，使得川芎的气味被掩盖，患者的服药顺应性得到极大的改善，挥发性成分更加稳定，有效成分的浓度在肠道明显增加，疗效将得以提升。
具体实施方式
实施例1
将大孔树脂加入5倍重量的去离子水中，于50℃保温浸泡12小时，每2小时换一次水，将沥干水分的大孔树脂再加入5倍重量的60%食用酒精，于室温浸泡2次，每次浸泡2小时，将经酒精浸泡处理后的大孔树脂置真空旋转蒸发干燥器中回收酒精后，再转移到真空干燥箱中于55℃减压干燥6小时，过60目筛去细粉，得到处理后的大孔树脂颗粒。同时，将川芎饮片倒入8倍量的水中，煎煮提取两次，每次煎煮1小时，过滤，合并滤液，55℃减压浓缩至相对密度为1.05，将此川芎浓缩液1份，与处理后的大孔树脂9份混合均匀，再于60℃减压干燥8小时，得到含药大孔树脂丸心。将含药大孔树脂丸心用流化床包衣法包上衣层重量为含药大孔树脂丸心重量3%的丙烯酸树脂II，继续干燥即得成品。
实施例2
首先将大孔树脂按照下法进行处理：将大孔树脂加入10倍重量的去离子水中，于60℃保温浸泡24小时，每4小时换一次水，将沥干水分的大孔树脂再加入10倍重量的80% 食用酒精，于室温浸泡3次，每次浸泡4小时，将经酒精浸泡处理后的大孔树脂置真空旋转蒸发干燥器中回收酒精后，再转移到真空干燥箱中于60℃减压干燥8小时，过80目筛去细粉，得到处理后的大孔树脂颗粒。同时，将川芎饮片倒入10倍量的水中，煎煮提取两次，每次煎煮1.5小时，过滤，合并滤液， 80℃减压浓缩至相对密度为1.10，将此川芎浓缩液3份，与处理后的大孔树脂7份混合均匀，再于80℃减压干燥24小时，得到含药大孔树脂丸心。将含药大孔树脂丸心用流化床包衣法包上衣层重量为含药大孔树脂丸心重量5%的丙烯酸树脂II，继续干燥即得成品。
Claims (3)
1.一种川芎提取物肠溶微丸的制备工艺，其特征在于：将川芎饮片倒入5~10倍量的水中，煎煮提取两次，每次煎煮1~1.5小时，过滤，合并滤液，55~80℃减压浓缩至相对密度为1.05~1.10，将此川芎浓缩液1~3份，与处理后的大孔树脂7~9份混合均匀，再于50~80℃减压干燥8~24小时，得到含药大孔树脂丸心。
2.根据权利要求1所述的一种川芎提取物肠溶微丸的制备工艺，其特征在于：所述的处理后的大孔树脂的处理方式是，将大孔树脂加入5~10倍重量的去离子水中，于50~60℃保温浸泡12~24小时，每2~4小时换一次水，将沥干水分的大孔树脂再加入5~10倍重量的60% ~80% 食用酒精，于室温浸泡2~3次，每次浸泡2~4小时，将经酒精浸泡处理后的大孔树脂置真空旋转蒸发干燥器中回收酒精后，再转移到真空干燥箱中于50~60℃减压干燥4~8小时，过60~80目筛去细粉，得到处理后的大孔树脂颗粒。
3.根据权利要求1所述的一种川芎提取物肠溶微丸的制备工艺，其特征在于：将权利要求1中的含药大孔树脂丸心用流化床包衣法包上衣层重量为含药大孔树脂丸心重量3%~10%的丙烯酸树脂II，干燥即得成品。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710980864.8A CN107929336A (zh) | 2017-10-20 | 2017-10-20 | 一种川芎提取物肠溶微丸的制备工艺 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710980864.8A CN107929336A (zh) | 2017-10-20 | 2017-10-20 | 一种川芎提取物肠溶微丸的制备工艺 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107929336A true CN107929336A (zh) | 2018-04-20 |
Family
ID=61936281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710980864.8A Pending CN107929336A (zh) | 2017-10-20 | 2017-10-20 | 一种川芎提取物肠溶微丸的制备工艺 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107929336A (zh) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813899A (zh) * | 2005-12-02 | 2006-08-09 | 王衡新 | 一种抗癌的中药制剂及其制备方法 |
| CN101313942A (zh) * | 2007-05-30 | 2008-12-03 | 江苏正大天晴药业股份有限公司 | 一种治疗肾病的中药组合物 |
| CN102133256A (zh) * | 2010-03-09 | 2011-07-27 | 成都中医药大学 | 大花红景天提取物及其制备方法 |
| CN107158063A (zh) * | 2017-05-11 | 2017-09-15 | 临沂大学 | 一种利用金银花有效部位组合物制成的肠溶微丸及其制备方法 |
-
2017
- 2017-10-20 CN CN201710980864.8A patent/CN107929336A/zh active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813899A (zh) * | 2005-12-02 | 2006-08-09 | 王衡新 | 一种抗癌的中药制剂及其制备方法 |
| CN101313942A (zh) * | 2007-05-30 | 2008-12-03 | 江苏正大天晴药业股份有限公司 | 一种治疗肾病的中药组合物 |
| CN102133256A (zh) * | 2010-03-09 | 2011-07-27 | 成都中医药大学 | 大花红景天提取物及其制备方法 |
| CN107158063A (zh) * | 2017-05-11 | 2017-09-15 | 临沂大学 | 一种利用金银花有效部位组合物制成的肠溶微丸及其制备方法 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105148019A (zh) | 一种用于治疗骨折的药物制剂 | |
| CN103830674B (zh) | 一种治疗脂肪瘤的药物组合物及制备方法和用途 | |
| CN101254226B (zh) | 一种都梁复方中药软胶囊 | |
| CN101194964B (zh) | 一种治疗头痛的包衣片剂及其制备方法 | |
| CN107890528B (zh) | 一种治疗高尿酸血症的中药组合物及其制备方法 | |
| CN107929336A (zh) | 一种川芎提取物肠溶微丸的制备工艺 | |
| CN107929342A (zh) | 一种苍术提取物肠溶微丸的制备工艺 | |
| CN107753537A (zh) | 一种防风提取物肠溶微丸的制备工艺 | |
| CN107519228A (zh) | 一种银花提取物肠溶微丸的制备工艺 | |
| CN107753534A (zh) | 一种当归提取物肠溶微丸的制备工艺 | |
| CN107744540A (zh) | 一种连翘提取物肠溶微丸的制备工艺 | |
| CN107595904A (zh) | 一种穿心莲提取物肠溶微丸的制备工艺 | |
| CN107519222A (zh) | 一种独活提取物肠溶微丸的制备工艺 | |
| CN107595917A (zh) | 一种木香提取物肠溶微丸的制备工艺 | |
| CN108079135A (zh) | 一种紫花地丁干膏粉及提取方法和紫花地丁胶囊及制法 | |
| CN107625895A (zh) | 一种天麻提取物肠溶微丸的制备工艺 | |
| CN107753603A (zh) | 一种地榆提取物肠溶微丸的制备工艺 | |
| CN107961275A (zh) | 一种黄连提取物肠溶微丸的制备工艺 | |
| CN107753587A (zh) | 一种黄连提取物肠溶微丸的制备工艺 | |
| CN107823274A (zh) | 一种大黄提取物肠溶微丸的制备工艺 | |
| CN108042636A (zh) | 一种黄柏提取物肠溶微丸的制备工艺 | |
| CN108042605A (zh) | 一种龙胆草提取物肠溶微丸的制备工艺 | |
| CN107669794A (zh) | 一种五味子提取物肠溶微丸的制备工艺 | |
| CN107753558A (zh) | 一种黄芩提取物肠溶微丸的制备工艺 | |
| CN107456480A (zh) | 一种苦参提取物肠溶微丸的制备工艺 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180420 |
|
| WD01 | Invention patent application deemed withdrawn after publication |