CN107922334B - 多环吲哚啉和假吲哚化合物 - Google Patents

多环吲哚啉和假吲哚化合物 Download PDF

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Publication number
CN107922334B
CN107922334B CN201680039597.8A CN201680039597A CN107922334B CN 107922334 B CN107922334 B CN 107922334B CN 201680039597 A CN201680039597 A CN 201680039597A CN 107922334 B CN107922334 B CN 107922334B
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China
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compound
alkyl
group
formula
heterocycloalkyl
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Expired - Fee Related
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CN201680039597.8A
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English (en)
Chinese (zh)
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CN107922334A (zh
Inventor
P·巴尔布尔
汪翔
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University of Colorado Boulder
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University of Colorado Boulder
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CN201680039597.8A 2015-04-30 2016-04-29 多环吲哚啉和假吲哚化合物 Expired - Fee Related CN107922334B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562154792P 2015-04-30 2015-04-30
US62/154,792 2015-04-30
PCT/US2016/030233 WO2016176634A1 (en) 2015-04-30 2016-04-29 Polycyclic indoline and indolenine compounds

Publications (2)

Publication Number Publication Date
CN107922334A CN107922334A (zh) 2018-04-17
CN107922334B true CN107922334B (zh) 2021-11-23

Family

ID=57199452

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680039597.8A Expired - Fee Related CN107922334B (zh) 2015-04-30 2016-04-29 多环吲哚啉和假吲哚化合物

Country Status (6)

Country Link
US (1) US10253024B2 (https=)
EP (1) EP3288921B1 (https=)
JP (1) JP6917901B2 (https=)
CN (1) CN107922334B (https=)
CA (1) CA2983992A1 (https=)
WO (1) WO2016176634A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6845511B2 (ja) * 2015-07-09 2021-03-17 ワシントン・ユニバーシティＷａｓｈｉｎｇｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ 抗細菌性薬剤併用物の組成物及び使用方法
US10292972B1 (en) * 2017-10-26 2019-05-21 King Abdulaziz University Pharmaceutical composition for treating cancer and a method thereof
CN108864107B (zh) * 2018-08-01 2020-09-08 南通睿沣新材料技术有限公司 一种具有抑菌作用的吲哚类化合物的制备方法
CN117924299B (zh) * 2023-12-05 2024-08-16 贵州省天然产物研究中心 多并环吡咯[2,3-b]吲哚啉类化合物及其制备方法和应用以及药物组合物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155587A (en) * 1963-01-23 1964-11-03 American Cyanamid Co Stable liquid preparations of 7-chlorotetracycline
WO2008112280A1 (en) * 2007-03-12 2008-09-18 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines synthesis
WO2014165548A2 (en) * 2013-04-01 2014-10-09 The Regents Of The Univerisity Of Colorado, A Body Corporate Indoline alkaloid compounds

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US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3630200A (en) 1969-06-09 1971-12-28 Alza Corp Ocular insert
US3847770A (en) 1972-04-10 1974-11-12 Continental Can Co Photopolymerizable compositions prepared from beta hydroxy esters and polyitaconates
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4769027A (en) 1984-08-15 1988-09-06 Burroughs Wellcome Co. Delivery system
US4687610A (en) 1986-04-30 1987-08-18 E. I. Du Pont De Neumours And Company Low crystallinity polyester yarn produced at ultra high spinning speeds
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
US5354566A (en) 1993-06-02 1994-10-11 Kraft General Foods, Inc. Preparation of yeast-leavened dough crusts
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
WO2011103460A1 (en) * 2010-02-18 2011-08-25 Medivation Technologies, Inc. Fused tetracyclic pyrido[4,3-b]indole and pyrido[3,4-b]ondole derivatives and methods of use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155587A (en) * 1963-01-23 1964-11-03 American Cyanamid Co Stable liquid preparations of 7-chlorotetracycline
WO2008112280A1 (en) * 2007-03-12 2008-09-18 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines synthesis
WO2014165548A2 (en) * 2013-04-01 2014-10-09 The Regents Of The Univerisity Of Colorado, A Body Corporate Indoline alkaloid compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Antibacterial compounds in different species of Datura: A review;TANDON CHANDNI ET AL;《Advanced Synthesis & Catalysis》;20140521;第8卷(第21期);第2090-2098页 *

Also Published As

Publication number Publication date
US20180148442A1 (en) 2018-05-31
US10253024B2 (en) 2019-04-09
JP6917901B2 (ja) 2021-08-11
JP2018515466A (ja) 2018-06-14
WO2016176634A1 (en) 2016-11-03
EP3288921A1 (en) 2018-03-07
EP3288921B1 (en) 2022-06-15
CN107922334A (zh) 2018-04-17
CA2983992A1 (en) 2016-11-03
EP3288921A4 (en) 2019-01-02

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Granted publication date: 20211123