CN107913323B - Traditional Chinese medicine composition for treating acute icteric hepatitis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating acute icteric hepatitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating acute icteric hepatitis and a preparation method thereof, and the traditional Chinese medicine composition is prepared from raw materials of Maonan medicine, such as leaf base, artemisia parviflora, hypericum sampsonii hance, herba hyperici japonici, herba lysimachiae christinae, shrubby chastetree fruit, osbeckia chinensis, herba solani lyrata, herba hedyotis diffusae, rhizoma coptidis, radix scutellariae, barberry, scarlet sedge, herba rabdosiae japonicae, herba migratory herb, qili gal, orange peel, centipede and ardisia japonica. Has definite curative effect and good safety in clinically treating the acute icteric hepatitis.
Description
Technical Field
The invention relates to the technical field of Maonan medicines, in particular to a traditional Chinese medicine composition for treating acute icteric hepatitis and a preparation method thereof.
Background
Acute icteric hepatitis belongs to the category of jaundice in traditional Chinese medicine, mostly belongs to yang yellow, has pathogenesis of feeling evil of damp-heat, dampness-heat stagnation, accumulation of liver and gall or exuberance of heat toxin, diffusion of triple energizer, liver and gall injury, liver dysfunction and diarrhea, and bile overflow to cause body, eyes and urine to become yellow. The expression of "Huangjia's procurement of herbs in Huang Jia is recorded in the book of jin Kui Yao and Huang Mai's syndrome and treatment of jaundice. All the body is warm and yellow. Therefore, the syndrome of damp-heat in liver and gallbladder is common in clinic, and the treatment should be for clearing heat, promoting diuresis and removing jaundice.
Disclosure of Invention
The invention aims to solve the technical problem of providing a traditional Chinese medicine composition for treating acute icteric hepatitis and a preparation method thereof, wherein the traditional Chinese medicine composition has the effects of clearing heat, promoting diuresis, detoxifying, reducing swelling, invigorating spleen, tonifying qi, eliminating stagnation and removing jaundice and has a definite curative effect.
In order to solve the technical problems, the invention adopts the following technical scheme: the traditional Chinese medicine composition for treating acute icteric hepatitis is prepared from, by weight, 25-35 g of Maonan raw materials, 10-20 g of herba artemisiae scopariae, 10-20 g of hypericum sampsonii hance, 10-15 g of Japanese ardisia, 10-20 g of scattered wampee, 10-20 g of street viter, 10-20 g of clerodendranthus spicatus, 10-20 g of pittosporum majus, 8-12 g of tylophora paniculata, 10-20 g of long-noded pit viper, 8-12 g of shinyleaf pricklyash root, 8-12 g of Chinese juniper herb, 10-15 g of radix scutellariae, 10-15 g of phellodendron amurense, 8-12 g of cudweed herb, 8-12 g of common rue herb, 8-12 g of herba rabdosiae, 8-12 g of wandering sedum, 3-8 g of orange peel, 8-12 g of fallen groundsel herb and 8-12 g of ardisia crenata.
Preferably: the traditional Chinese medicine composition is prepared from, by weight, 30g of hairy south medicinal raw materials, 15g of herb of veronicastrum, 15g of hypericum sampsonii, 12g of herba hyperici japonici, 15g of herba lysimachiae, 15g of roadside vitex negundo, 15g of clerodendranthus spicatus, 15g of Japanese milkwort, 10g of Japanese ardisia, 15g of long-noded pit viper, 10g of radix cynanchi, 12g of radix scutellariae, 12g of amur corktree bark, 10g of scarlet sedge, 10g of herba rabdosiae, 10g of herba walkeridis, 10g of Qili, 5g of orange peel, 10g of centipede and 10g of ardisia crenata.
The preparation method of the traditional Chinese medicine composition for treating acute icteric hepatitis comprises the following steps: decocting 22 kinds of Chinese medicinal materials including radix astragali, herba Artemisiae Scopariae, herba Hyperici Sampsonii, herba Violae Japonicae, herba Lysimachiae, herba Stachydis Kouyangensis, fructus Gardeniae, herba Lagenariae Kwangsiensis, herba Hedyotidis Diffusae, radix Berberidis Lanceolatae, herba Scutellariae Barbatae, radix Berberidis Amurensis, radix Christiae Yunnanensis, herba corydalis Bungeanae, herba Ranunculi Ternati, radix Veronicastri Sibirici, pericarpium Citri Reticulatae, Scolopendra subspinipes, and radix Ardisiae Japonicae with 1.5 times of water, decocting with water for 60 min for 3 times, mixing 3 times of water decoctions, concentrating to 100ml, and packaging.
The invention is used for treating chronic acute icteric hepatitis based on the theory of medicines of the Maonan family. And (3) a prescription. In the formula, the leaf base, the herba artemisiae scopariae, the herba lysimachiae, the osbeckia odorata and the wandering swim herb have the effects of clearing heat and promoting diuresis, and removing food retention and promoting urination; the hypericum sampsonii hance, the mountain branch tea, the double-English-Chinese-radish and the herb of glabrous greenbrier rhizome have the effects of clearing away heat and toxic materials, promoting blood circulation and inducing diuresis; herba seu radix Thymi Japonici and herba Elsholtziae seu Geranii have effects in dispelling pathogenic wind, removing toxic substances, and relieving swelling; the Chinese thorowax roots and the centipedes which fall on the ground have the functions of tonifying spleen and promoting diuresis, and detoxifying and reducing swelling. Jiu Lai Lou is effective in clearing away stagnated heat of liver and gallbladder, calming endogenous wind and lowering qi; herba Hedyotidis Diffusae has effects of clearing away heat and toxic materials, relieving pain, and dispersing pathogen accumulation; the branch and coptis root has the effects of clearing heat and drying dampness, and purging fire for removing toxin; the tail qi of; phellodendron amurense has the effects of clearing away heat and toxic materials, purging pathogenic fire and drying dampness; scarlet sage herb and herba corydalis edulis cool blood and remove blood stasis; qilika has effects of invigorating spleen, invigorating qi, eliminating dampness, and promoting diuresis; orange peel dampness eliminating and phlegm eliminating
The main treatment is as follows: acute icteric hepatitis.
The quality standards of the medicinal materials of the invention are as follows:
1. the quality standard of the leaf base (Chinese herbal medicine name: herba hyperici japonici) is specified under the item of ' leaf base to ' 2010 edition ' in Maonan medicine.
2. Herba Artemisiae Scopariae (Chinese medicine name: herba Artemisiae Scopariae) is stem and leaf of Artemisia apillaries, and quality standard is defined under the term "herba Veronicae" in 2010 edition of Maonan medicine.
3. Hypericum sampsonii Hance (traditional Chinese medicine name: Lysimachia christinae Hance) the product is a Dichondrarean epenseForst herbaceous plant, and the quality standard is specified under the item of 'Hypericum sampsonii Hance' in the 2010 version of Maonan medicine.
4. Herba Euphorbiae Humifusae (Chinese herbal medicine name: Ardisiajaponica) is obtained from shrub or subshrubb of Ardisiajaponica (Thunb) Blume, and quality standard is specified under the item of 'herba Euphorbiae Humifusae' in 2010 edition of Maonan medicine.
5. Herba Lysimachiae foenumgraeci (Chinese medicine name: herba Lysimachiae foenumgraeci) the product is the whole herb of Siphonostegianciselensis Benth, and the quality standard is specified under the item of 'herba Lysimachiae foenumgraeci' of Maonan medicine 2010 edition.
6. The Chinese medicinal material Serisssoides (DC) is used as medicine for Serisssoides (Serissoides), and the quality standard is specified under the item of "roadside Vitex" in 2010 edition of Maonan medicine.
7. The osbeckia orange (Chinese medicine name: Glochidion puberum) product is as follows: glochidion pump (L.) Hutch, the root of agyneiapurera L, the quality standard is specified under "osmyl kumquat" item of maonan medicine 2010 edition.
8. The pittosporum tea (traditional Chinese medicine name: pittosporum tea) is a evergreen small arbor of pittosporum glabratum belonging to the family erythrinae, and the quality standard is specified under the item of pittosporum tea 2010 of Maonan medicine.
9. The product is root of RadixCodonopsis Lancelelatae, and quality standard is specified under the item of sheep papilla 2010 edition of Maonan medicine.
10. The medicine is prepared from root of Astragalum bryanaceus (Fisch.) Bunge, and has quality standard defined in the item of "JIU LAO FANG" in 2010 edition of Chinese pharmacopoeia.
11. Herba Hedyotidis Diffusae (Chinese medicine name: herba Hedyotidis Diffusae) the product is Hedyotisdiffusa (Hedyotisdiffusa) which is a yearly-used mantle herb, and the quality standard is specified under the item of 'herba Hedyotidis Diffusae' in 2010 edition of Maonan medicine.
12. Shuangying Budi (Chinese medicine name: dandelion) the product is the root of a perennial herb of Taraxacuminggollicum, and the quality standard is specified under item "Shuangying Budi" of 2010 edition Mao nan nationality medicine.
13. Achillea Wilsonii (Chinese medicine name: Coptis chinensis) the product is a dry root of Coptis chinensis Franch, and the quality standard is specified under the item of Achillea Wilsonii of Chinese pharmacopoeia 2010 edition.
14. Scutellaria baicalensis Georgi (Scutellaria baicalensis Georgi) is used as a medicine by root. The quality standard is specified under item "tail Qin" of 2010 edition Maonan medicine.
15. Berberis amurensis (Chinese medicine name: phellodendron amurensis) the product is the bark of Phellodendron amurense Rupr, and the quality standard is specified under the item of phellodendron amurensis in 2010 edition of Maonan medicine.
16. Scarlet sage (traditional Chinese medicine name: radix rubiae) is raw herb climbing vine of rubiacordifolialinn, and the quality standard is specified under item "scarlet sage" 2010 edition of Maonan medicine.
17. Herba corydalis edulis (traditional Chinese medicine name: lithospermum) the product is a Lithospermummerythrohydroshizon perennial herb, and the quality standard is specified under the item of 'herba corydalis edulis' in 2010 edition of Maonan medicine.
18. Herba migratory (traditional Chinese medicine name: copper coin grass) the product is a hydrocotylevulugaris umbelliferae herb. The quality standard is specified under item "wandering Philippine herb" 2010 edition Maonan medicine.
19. Qilika (Chinese medicine name: Atractylodes macrocephala) this product is Atractylodes macrocephala Koidz. The quality standard is specified under item 2010 version "Kilima" of Maonan medicine.
20. The quality standard of the orange peel (traditional Chinese medicine name: dried orange peel) is specified under the item of orange peel in 2010 edition of Maonan medicine.
21. Centipede fallen (traditional Chinese medicine name: goldhair hedyotis herb) the product is the whole herb of Hedyotischrystricha (Palib.) Merr, and the quality standard is specified under the item of Centipede fallen (2010 edition of Maonan medicine).
22. Ardisiacrispa (Thunb.) Hayata (Chinese medicine name: Ardisia crispa) rhizome of A.DC, and quality standard is specified under the item of 'Ardisiacrispa Hayata' in 2010 edition of Maonan medicine.
The product name of the invention is as follows: maonan group damp-removing swelling-dispersing powder Huang Fang.
The characteristics of the invention are as follows: brownish red liquid, fragrant.
The invention has the following effects: clearing away heat, promoting diuresis, removing toxic substance, relieving swelling, invigorating spleen, invigorating qi, resolving hard mass, and eliminating jaundice.
Clinical trials of the present invention:
1 clinical data
1.1 general data all cases were acute icterohepatitis patients.
1.2 diagnosis standard Western medicine refers to the diagnosis according to the diagnosis standard of viral hepatitis revised in the Western Anmo conference of the Chinese medical society in 9 months of 2000, and combines clinical conditions to make the diagnosis, wherein the main symptoms are hypodynamia, fever, skin pruritus, anorexia, nausea and vomiting, liver distending pain, abdominal distension, constipation or diarrhea, and urine-feces color change; obvious abnormality exists in liver function examination; the main signs are jaundice, hepatomegaly or hepatosplenomegaly. According to the standard of liver and gallbladder damp-heat syndrome in the guideline of clinical research of new traditional Chinese medicine, the traditional Chinese medicine distinguishes that the body and eyes are yellow, the color is bright, the hypochondriac pain, the epigastric distress and the abdominal distension are caused, the appetite is poor, the nausea and the vomiting are caused, the drowsiness and the debilitation are caused, the mouth is dry and bitter, the urine is yellow and red, the stool is dry or loose, the tongue is red, the tongue coating is yellow and greasy, and the pulse is wiry and smooth.
1.3 the inclusion standard (1) meets the diagnosis standard and the traditional Chinese medicine syndrome differentiation standard. (2) The age is not limited. (3) The course of disease is less than or equal to 15 days; (4) no other drug treatment; (5) the patients or family members sign written informed consent. (4) Voluntarily used as a tested object and can accept a tested drug dosage form to ensure a patient who finishes the treatment course.
1.4 exclusion criteria (1) disease course > 15 d. (2) Jaundice due to other reasons (drug, alcohol, obstructive, etc.). (3) With severe liver and gall (cirrhosis, liver cancer) and other systemic diseases. (4) Women in lactation and gestation periods. (5) The study is not strictly performed, or the important data is not complete.
1.5 stopping the study standard (1) and failing to insist on taking medicine according to the medical advice or automatically changing the study to other medicine treatment patients; (2) patients with acute icteric hepatitis aggravation and unable to continue treatment in the experiment; (3) serious adverse events occurred; (4) other serious complications occur during clinical trials.
2 research methods
2.1 methods of treatment
2.1.1 groups of the study adopt a clinical random comparison test method, and are randomly divided into a southern Hainan dampness-removing and swelling-dispersing powder-yellow prescription treatment group and a control group by a random digital table method according to the sequence of treatment, so as to observe the clinical curative effect. Treatment groups: 100 cases, control group: 100 cases.
2.1.2 the treatment method, two groups give reasonable diet and psychological guidance for health, reduce the worry of patients, and actively cooperate with treatment, wherein the diet guidance mainly comprises light, easy digestion, proper cold and hot, no irritation, proper amount, and nutritious liquid diet, semi-liquid diet and soft diet; the control group such as the control group which is prohibited from eating spicy and irritant food, the control group which is prohibited from smoking and drinking, the control group which is laid in bed for rest and the like adopts diammonium glycyrrhizinate and reduced glutathione for 1 time/day, and the control group is subjected to intravenous drip. The treatment group is added with 1 dose/d of the Maonan damp-removing swelling-eliminating powder prescription on the basis of the treatment of the control group, decocted with water for 3 times, mixed and taken with 300mL of juice, and taken warmly in the morning, the middle and the evening. The treatment course of both groups is 15 days, and the treatment effect is counted after 2 treatment courses.
2.2 Observation indicators and evaluation criteria
2.2.1. Safety observation
Before administration and at the end of the treatment course, the test should be repeated to normal if the test index is abnormal during the test.
(1) General physical examination;
(2) three general, renal functions;
(3) liver and spleen type-B ultrasound, liver function (ALT, TBIL, DBIL, AST);
(4) signs of clinical symptoms;
(5) the clinical curative effect.
2.2.3 the standard of therapeutic effect is drawn up according to the standard of curative effect of diagnosing the disease of traditional Chinese medicine of the State administration of traditional Chinese medicine. The jaundice is cured, other symptoms disappear, and the laboratory index is normal. The improvement is that jaundice and other symptoms are reduced, TBIL is normal or reduced, and other laboratory indexes are normal or improved. The jaundice is not reduced or deepened, and other symptoms and laboratory indexes are not improved. The total effective rate is cured and improved.
2.3 statistical analysis all data were analyzed on a computer by the SPSS version 15.0 software package, the measured data are expressed as X + -S, the comparisons between groups are tested by t, the statistical analysis of the classified variable data is tested by chi2And (6) checking. P is less than 0.05, which has statistical significance.
3 results
3.3.1, the clinical curative effect of two groups is compared with that of 100 treatment groups, 57 cases are cured, 39 cases are improved, 4 cases are invalid, and the total effective rate is 96.00 percent; the control group has 100 cases, 44 cases are cured, 46 cases are improved, 10 cases are not effective, and the total effective rate is 83.00%; the difference of the two groups of clinical curative effects is statistically significant (X)2＝2.76,P<0.01)。
3.3.2 before and after treatment, compared with two groups, the liver function is obviously improved (P is less than 0.05), and TBIL and DBIL of the treatment group are improved better than that of the control group (P is less than 0.05). See table 1.
TABLE 1 comparison of liver function before and after treatment (x. + -. s)
And (4) conclusion: the southeast hairy asiabell root dampness-removing and swelling-eliminating powder prescription prepared by the technical scheme of the invention has good effects of relieving fever, removing dampness, detoxifying, eliminating swelling, strengthening spleen, tonifying qi, dissipating stagnation and eliminating jaundice for treating acute icteric hepatitis. Has definite curative effect and good safety in clinically treating the acute icteric hepatitis.
The specific implementation mode is as follows:
example 1:
raw materials: 30g of leaf base, 15g of herb of veronicastrum herb, 15g of hypericum sampsonii hance, 12g of Japanese ardisia, 15g of scattered goldthread, 15g of street chastetree fruit, 15g of clerodendroncyrtophyllum bunge, 15g of branch tea, 15g of goat head, 10g of Chinese tylophora herb, 15g of long-noded pit viper, 10g of shinyleaf beggarticks herb, 10g of Chinese arborvitae herb, 12g of cauda baicalensis, 12g of amur corktree bark, 10g of scarlet sedge, 10g of khosam, 10g of wandering hairyvein agrimony, 10g of Qili, 5g of orange peel, 10g of centipede and 10g of ardisia crenata.
The preparation method comprises the following steps: 22 kinds of medicines of the leaf base, the herb of veronica, the hypericum sampsonii hance, the herb of rehmannia, the scattered wampee, the spicebush, the branchlet, the capejasmine, the sheep papilla, the tylophora, the long-noded pit viper, the double-English-flower-rhizome, the Chinese arborvitae, the radix scutellariae, the amur corktree bark, the red sage, the rabdosia japonicas, the wandering hairyvein agrimony, the qilika, the orange peel, the centipede, the herb of fortune ardisia, the ardisia japonica, and the herb of fortune eupatorium herb are combined according to the dosage and are decocted by 1.5 times, each time is 60 minutes, the 3 times of water decoction is continuously decocted, the 3 times of water decoction is.
Example 2:
raw materials: 25g of leaf base, 12g of herb of veronicastrum herb, 10g of hypericum sampsonii hance, 10g of herb of rehmannia, 12g of scattered goldthread, 12g of street chastetree, 12g of clerodendron bungeanum, 12g of pittosporum leaf, 12g of goat head, 8g of Chinese tylophora herb, 12g of long-noded pit viper, 8g of shinyleaf beggarweed herb, 8g of meadowrue root, 10g of radix scutellariae, 10g of amur corktree bark, 8g of scarlet sedge, 8g of khosam, 8g of wandering bristlegrass, 8g of qili, 8g of orange peel, 8g of centipede and 8g of ardisia crenata.
The preparation method comprises the following steps: 22 kinds of medicines of the leaf base, the herb of veronica, the hypericum sampsonii hance, the herb of rehmannia, the scattered wampee, the spicebush, the branchlet, the capejasmine, the sheep papilla, the tylophora, the long-noded pit viper, the double-English-flower-rhizome, the Chinese arborvitae, the radix scutellariae, the amur corktree bark, the red sage, the rabdosia japonicas, the wandering hairyvein agrimony, the qilika, the orange peel, the centipede, the herb of fortune ardisia, the ardisia japonica, and the herb of fortune eupatorium herb are combined according to the dosage and are decocted by 1.5 times, each time is 60 minutes, the 3 times of water decoction is continuously decocted, the 3 times of water decoction is.
Example 3:
raw materials: 35g of leaf base, 18g of herb of veronicastrum herb, 18g of hypericum sampsonii hance, 15g of herb of rehmannia, 18g of scattered goldthread, 18g of street chastetree fruit, 18g of clerodendron bungeanum, 18g of pittosporum tea, 18g of sheep breast head, 12g of Chinese tylophora herb, 18g of long-noded pit viper, 12g of shinyleaf beggarweed herb, 12g of meadowrue root, 15g of radix scutellariae, 15g of amur corktree bark, 12g of scarlet sedge, 12g of khosam, 12g of wandering hairyvein agrimony, 12g of chingma herb, 6g of orange peel, 12g of centipede and 12g of ardisia crenata.
The preparation method comprises the following steps: 22 kinds of medicines of the leaf base, the herb of veronica, the hypericum sampsonii hance, the herb of rehmannia, the scattered wampee, the spicebush, the branchlet, the capejasmine, the sheep papilla, the tylophora, the long-noded pit viper, the double-English-flower-rhizome, the Chinese arborvitae, the radix scutellariae, the amur corktree bark, the red sage, the rabdosia japonicas, the wandering hairyvein agrimony, the qilika, the orange peel, the centipede, the herb of fortune ardisia, the ardisia japonica, and the herb of fortune eupatorium herb are combined according to the dosage and are decocted by 1.5 times, each time is 60 minutes, the 3 times of water decoction is continuously decocted, the 3 times of water decoction is.
Claims (2)
1. A traditional Chinese medicine composition for treating acute icteric hepatitis is characterized in that: the traditional Chinese medicine composition is prepared from raw materials of Maonan medicine, including 30g of leaf base, 15g of herb of veronicastrum, 15g of hypericum sampsonii, 12g of Japanese ardisia, 15g of scattered goldthread, 15g of roadside negundo chastetree, 15g of clerodendranthus spicatus, 15g of Japanese dock, 10g of Japanese ardisia, 15g of long-noded pit viper, 10g of shinyleaf beggarticks, 10g of rhizoma coptidis, 12g of radix scutellariae, 12g of amur corktree bark, 10g of cudweed herb, 10g of herba rabdosiae, 10g of herba migratory, 10g of qilian, 5g of orange peel, 10g of centipede and 10g of ardisia crenata.
2. The method for preparing a Chinese medicinal composition for treating acute icterohepatitis as claimed in claim 1, wherein the Chinese medicinal composition comprises the following steps: decocting 22 kinds of Chinese medicinal materials including radix astragali, herba Artemisiae Scopariae, herba Hyperici Sampsonii, herba Violae Japonicae, herba Lysimachiae, herba Stachydis Kouyangensis, fructus Gardeniae, herba Lagenariae Kwangsiensis, herba Hedyotidis Diffusae, radix Berberidis Lanceolatae, herba Scutellariae Barbatae, radix Berberidis Amurensis, radix Christiae Yunnanensis, herba corydalis Bungeanae, herba Ranunculi Ternati, radix Veronicastri Sibirici, pericarpium Citri Reticulatae, Scolopendra subspinipes, and radix Ardisiae Japonicae with 1.5 times of water, decocting with water for 60 min for 3 times, mixing 3 times of water decoctions, concentrating to 100ml, and packaging.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6126942A (en) * | 1995-07-10 | 2000-10-03 | Cathay Herbal Laboratories, Pty. | Herbal compositions for hepatic disorders |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6126942A (en) * | 1995-07-10 | 2000-10-03 | Cathay Herbal Laboratories, Pty. | Herbal compositions for hepatic disorders |
Non-Patent Citations (1)
| Title |
|---|
| "曾庆骅辨治急性黄疸型肝炎的经验（附233例临床分析）";杨香生;《 江西中医药》;19941231;第25卷(第4期);第5-6页 * |
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