CN107875272A - 一种治疗中老年人性功能减退的药物及其制备方法 - Google Patents
一种治疗中老年人性功能减退的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗中老年人性功能减退的药物及其制备方法,该药物生晒参、当归、黄芪、枸杞、锁阳、大云、补骨脂、杜仲、川断、韭菜种子、桂枝、天雄、制附子、巴戟、炙麻黄、鹿胶、龟胶、海狗肾、淫羊藿、熟地和九牛造制备而成。所述药物能够显著改善机体的免疫状况,具有滋阴补肾、温肾壮阳、益髓填精的功效,对中老年人性功能减退症状具有很好的疗效,安全无毒副作用。
Description
技术领域
本发明涉及一种治疗中老年人性功能减退的药物及其制备方法,属于药品技术的领域。
背景技术
随着社会的不断发展,人们的生活节奏不断加快,特别是生活在大都市的人们,工作压力、经济压力、饮食不规律、熬夜,时刻在透支着人们的健康,令人倦怠、疲乏、精力不集中,表现在性生活方面即为肾虚及性功能减退。此外,伴随着人的衰老,体内的性激素水平均会呈现明显的下降趋势,从而导致性功能减退。然而,提高性生活质量作为提高生活质量方面至关重要的因素,对于性功能减退这一症状的治疗有待进一步完善。
长期以来,西医西药在治疗肾虚及性功能减退方面,效果并不理想,长期服用,容易对药物产生依赖性,并对机体产生副作用,严重损害患者自身的肝肾功能。
发明内容
本发明的目的在于,提供一种治疗中老年人性功能减退的药物及其制备方法。所述药物能够显著改善机体的免疫状况,具有滋阴补肾、温肾壮阳、益髓填精的功效,对中老年人性功能减退症状具有很好的疗效,安全无毒副作用。
为解决上述技术问题,本发明采用以下技术方案实现:一种治疗中老年人性功能减退的药物,按重量份计算,主要由生晒参20-25份、当归12-15份、黄芪15-20份、枸杞20-25份、锁阳20-25份、大云15-20份、补骨脂30-40份、杜仲20-25份、川断20-25份、韭菜种子30-40份、桂枝15-20份、天雄15-20份、制附子15-20份、巴戟10-15份、炙麻黄10-15份、鹿胶20-25份、龟胶20-25份、海狗肾20-40份、淫羊藿25-35份、熟地20-25份和九牛造20-25份制备而成。
前述的治疗中老年人性功能减退的药物中,按照重量份计算,主要由生晒参22-23份、当归13-14份、黄芪17-18份、枸杞22-23份、锁阳22-23份、大云17-18份、补骨脂33-37份、杜仲22-23份、川断22-23份、韭菜种子33-37份、桂枝17-18份、天雄17-18份、制附子17-18份、巴戟12-13份、炙麻黄12-13份、鹿胶22-23份、龟胶22-23份、海狗肾23-27份、淫羊藿28-32份、熟地22-23份和九牛造22-23份制备而成。
前述的治疗中老年人性功能减退的药物中,按照重量份计算,主要由生晒参22.5份、当归13.5份、黄芪17.5份、枸杞22.5份、锁阳22.5份、大云17.5份、补骨脂35份、杜仲25份、川断22.5份、韭菜种子35份、桂枝17.5份、天雄17.5份、制附子17.5份、巴戟12.5份、炙麻黄12.5份、鹿胶22.5份、龟胶22.5份、海狗肾25份、淫羊藿30份、熟地22.5份和九牛造22.5份制备而成。
一种前述的治疗中老年人性功能减退的药物的制备方法,取上述药物,与常规药用辅料或不加辅料组合,制成常规药物制剂。
前述的治疗中老年人性功能减退的药物的制备方法中,所述药物制剂为口服制剂。
前述的治疗中老年人性功能减退的药物的制备方法中,所述口服制剂为汤剂、片剂、胶囊剂、颗粒剂、丸剂或汤剂。
前述的治疗中老年人性功能减退的药物的制备方法中,所述的汤剂,是按下述方法制备:取上述药材,加8-10倍量的水浸泡10-15分钟,先大火煎煮10-15min,再继续用小火煎煮15-25min,煎煮3次,过滤,滤液,浓缩,即得。
前述的治疗中老年人性功能减退的药物的制备方法中,所述的片剂:是按下述方法制备:取上述药材,用6倍量70%的乙醇回流提取2次,每次1小时,提取液过滤,滤液回收乙醇并浓缩成50-60℃时相对密度为1.20-1.25的浸膏,浸膏与浸膏量20%的淀粉和浸膏量10%的微晶纤维素混匀,压片,包薄膜衣,即得。
前述的治疗中老年人性功能减退的药物的制备方法中,所述的胶囊剂;是按下述方法制备:取上述药材,加8-10倍量的水浸泡10-15分钟,先大火煎煮10-15min,再继续用小火煎煮15-25min,煎煮3次,过滤,合并滤液,滤液浓缩成50-60℃时相对密度为1.20-1.25的浸膏,浸膏与浸膏量30%的淀粉和浸膏量0.7%的硬脂酸镁混匀,用60%的乙醇制粒,干燥,粉碎,填充胶囊,即得。
前述的治疗中老年人性功能减退的药物的制备方法中,所述的颗粒剂;是按下述方法制备:取上述药材,加8-10倍量的水浸泡10-15分钟,先大火煎煮10-15min,再继续用小火煎煮15-25min,煎煮3次,过滤,合并滤液,滤液浓缩成50-60℃时相对密度为1.15-1.20的浸膏,浸膏与浸膏量20%的淀粉和浸膏量20%的糊精粉混合制粒,干燥,即得。
本发明所述药物主要由生晒参、当归、黄芪、枸杞、锁阳、大云、补骨脂、杜仲、川断、韭菜种子、桂枝、天雄、制附子、巴戟、炙麻黄、鹿胶、龟胶、海狗肾、淫羊藿、熟地和九牛造,其中,生晒参,是把鲜参清洗干净后,用烘干设备,烘干的人参;治男女一切虚症,自汗眩晕、头痛反胃,阂症、滑泻久痢、小便频数、淋沥劳倦、内伤中风、中暑痹瘘、吐血、嗽血、下血、血淋、血崩、胎前产后诸病。近代中医常用人参补气救脱,益血复脉、养心安神、生津止渴、补肺定喘健脾止泻、托毒合疮等。当归,(学名:Angelica sinensis,)其根可入药,是最常用的中药之一。具有补血和血,调经止痛,润燥滑肠、抗癌、抗老防老、免疫之功效,性味:甘、辛、温;归经:归肝、心、脾经。功效主治:补血;活血;调经止痛;润燥滑肠。主血虚诸证;月经不调;经闭;痛经;症瘕结聚;崩漏;虚寒腹痛;痿痹;肌肤麻木;肠燥便难;赤痢后重;痈疽疮疡;跌扑损伤。黄芪,Astragalus membranaceus ,性味:甘,微温。归经:归肺、脾、肝、肾经。其有增强机体免疫功能、保肝、利尿、抗衰老、抗应激、降压和较广泛的抗菌作用。枸杞,枸杞属,有解热止咳之效用。性味:枸杞子:甘,平。枸杞叶:苦、甘;性凉。功能:枸杞子:养肝,滋肾,润肺。枸杞叶:补虚益精,清热明目。锁阳(学名:Cynomorium songaricum Rupr.),能补肾、益精、润燥,主治阳痿遗精、腰膝酸软、肠燥便秘,对瘫痪和改善性机能衰弱有一定的作用。中药材大云又名肉苁蓉,英文名Desertliving Cistanche,具有补肾助阳,润肠通便,软坚散结的功效。主 治:月经不调,闭经,不孕,阳痿,遗精,小便淋漓,声哑失音,便秘,虚寒泄泻,症瘕。【性味归经】:甘酸咸,温。①《本经》:“味甘,微温。”②《别录》:“酸咸,无毒。”③《本草正》:“味甘咸微辛酸,微温。”④《玉楸药解》:“甘咸,气平。”入肾、大肠、脾、肝、膀胱经。①《本草经疏》:“入肾、心包络、命门。”②《本草经解》:“入足厥阴肝经、足太阴脾经、足少阴肾经。”③《玉楸药解》:“入足厥阴肝、足少阴肾、手阳明大肠经”。补骨脂(学名:Psoraleacorylifolia Linn.)果实入药,有补肾壮阳、补脾健胃之功能,并可治牛皮癣等皮肤病;药性:苦、辛、温。归肾、脾经;功效:补肾壮阳,固精缩尿,肾虚腰痛,小便频数,小儿遗尿,肾漏,温脾止泻,纳气平喘。杜仲(学名Eucommia ulmoides Oliver),为杜仲科植物;其味甘,性温。有补益肝肾、强筋壮骨、调理冲任、固经安胎的功效。 可治疗肾阳虚引起的腰腿痛或酸软无力,肝气虚引起的胞胎不固,阴囊湿痒等症。在《神农本草经》中被列为上品。川断,又名续断,为多年生草本植物川续断的根,功能主治:补肝肾,续筋骨,调血脉。治腰背酸痛,足膝无力,胎漏,崩漏,带下,遗精,跌打损伤,金疮,痔漏,痈疽疮肿。韭菜种子,Tuber OnionSeed ,【性味】:性温,味辛、甘。【功能主治】:补肝肾,暖腰膝,助阳,固精。用于阳痿、遗精、遗尿小便频数、腰膝酸软、冷痛、白带过多。桂枝,中药名。属樟目,樟科中等大乔木,辛、甘,温。归心、肺、膀胱经。具有发汗解肌,温通经脉,助阳化气,平冲降气的功效。常用于风寒感冒,脘腹冷痛,血寒经闭,关节痹痛,痰饮,水肿,心悸等。天雄,中药名。为毛茛科乌头属植物乌头Aconitum carmichaeli Debx.形长的块根;具有祛风散寒,益火助阳之功效。主治风寒湿痹,历节风痛,四肢拘挛,心腹冷痛,痃癖症瘕;性味归经:味辛,性热,入肾经。制附子为毛茛科植物乌头Aconitum carmichaeli Debx.的子根的加工品。【性味与归经】辛、甘,大热;有毒。归心、肾、脾经。【功能与主治】回阳救逆,补火助阳,逐风寒湿邪。用于亡阳虚脱,肢冷脉微,阳痿,宫冷,心腹冷痛,虚寒吐泻,阴寒水肿,阳虚外感,寒湿痹痛。巴戟,Morindaoffcinalis How,性微温,味辛甘,功能补肾阳,壮筋骨。主治肾虚、腰膝酸软宫冷、月经不调、少腹冷痛、风湿痹痛等。炙麻黄,为麻黄科植物草麻黄、木贼麻黄或中麻黄的草质茎。主治伤寒表实,发热恶寒无汗、头痛鼻塞、骨节疼痛;咳嗽气喘;风水浮肿,小便不利;风邪顽痹,皮肤不仁,风疹瘙痒。鹿胶,以鹿角为原材料进行加工熬制而成。肾虚;精血不足;虚劳羸瘦;头晕耳鸣;腰膝酸软,阳痿滑精;宫寒不孕;胎动不安;崩漏带下;吐血;衄血;咯血;尿备;阴疽疮疡;味甘;咸;性温.归肝,肾性。龟胶,Colla Carapacis et Plastri Testudinis,具有滋阴、补血,止血的功效,用于主治阴虚血亏、劳热骨蒸、吐血、衄血、烦热惊悸、肾虚腰痛、脚膝痿弱、崩漏、带下等症状。海狗肾,中药名。为海狮科动物海狗Callorhimus ursinusLinnaeus、海豹科动物斑海豹Phoca largha Pallas或点斑海豹Phoca vitulina Linnaeus的阴茎和睾丸。具有温肾壮阳,填精补髓之功效。常用于阳虚祛寒,阳痿遗精,早泄,腰膝痿软,心腹疼痛;性味:味咸,性热。归经:归肝、肾经。淫羊藿(学名:Epimedium brevicornuMaxim.)多年生草本植物,淫羊藿全草供药用。主治阳萎早泄,腰酸腿痛,四肢麻木,半身不遂,神经衰弱,健忘,耳鸣,目眩等症。淫羊藿(学名:Epimedium brevicornu Maxim.)多年生草本植物,淫羊藿全草供药用。主治阳萎早泄,腰酸腿痛,四肢麻木,半身不遂,神经衰弱,健忘,耳鸣,目眩等症。淫羊藿味辛甘性温,走肝肾二经。熟地为玄参科植物地黄(学名:Rehmannia glutinosa)的块根,是一种上好中药材,具有补血滋阴功效,可用于血虚萎黄,眩晕,心悸失眠,月经不调,崩漏等症,亦可用于肾阴不足的潮热骨蒸、盗汗、遗精、消渴等症;【药性】甘,微温。归肝、肾经。【功效】补血养阴,填精益髓。九牛造,Euphorbia hylonomaHand .Mazz.,生于山地林下或林缘草丛中。通便,利水,消积,破瘀,止痛。治二便不通,积聚腹胀,胸膈不利,肝硬化腹水,急性肠炎,消化不良,劳伤,跌打损伤,瘀血作痛,无名肿毒。
本发发明采用上述药物为原料制成药物,各原料具有很好的协同作用,共奏滋阴补肾、温肾壮阳、益髓填精的功效,对中老年人性功能减退症状具有很好的疗效,安全无毒副作用。
实验例:
先后应用本发明药物治疗33例,取得较好的疗效,现总结如下:
一、年龄分布:
性功能减退病例33例,具体年龄分布为:25-35岁3例;36-46岁9例;47-60岁11例,60岁以上10例。
二、试验方法:
选该病病人33例,服用本本发明药物(按实施例进行制备),每日服三次(白天二次,临睡前服用 一次),每次2克、十五天为一治疗程,一般服用三个疗程。
三、试验结果:
患者总数33例, 治愈29例,明显好转2例,无效2例。
四、安全性评价:
33例病人在服药期间未发生任何不良反应。
五、典型病例
孙XX,男、28岁,婚后因阳事不举,早泄,腰膝酸软前来就诊,查体 ,发育良好,营养中等,表情焦虑,阴茎无先天畸形,全身主要脏器无器质性 疾病,在采集病史过程中得悉该病人有长期手淫、烟酒嗜好史。舌苔黑褐色,脉弦细。口服本发明药物(按实施例进行制备)一疗程后自觉腰膝酸明显好转,性具出现灼热感,二疗程后,阳根思动,黎明时能过夫妻生活。
李XX,男,46岁,自述一年来性欲大减,过性生活时阴茎松软,难举,严重影响正常夫妻生活。查体:身体发育正常,营养良好,主要脏器无明显阳性体征,多项生化检验指标除血脂略偏高外基本属正常值,病人曾有过性生活过频、夫妻关系欠融洽史;服用本发明药物(按实施例进行制备)三个疗程后,自我感觉良好,性欲正常。
张XX,男,55岁,神疲乏力、腰膝酸软、阳痿早泄、夜尿频多、性功能减退,服用本发明药物(按实施例进行制备)三个疗程后,神疲乏力、腰膝酸软、阳痿早泄、夜尿频多、性功能减退等症状消失,体力充沛。
李XX,男61岁,男,神疲乏力、腰膝酸软、阳痿早泄、夜尿频多、性功能减退,服用本发明药物(按实施例进行制备)2个疗程后,神疲乏力、腰膝酸软、阳痿早泄、夜尿频多、性功能减退等症状有所改善,体力好转,服用三个疗程后神疲乏力、腰膝酸软、阳痿早泄、夜尿频多、性功能减退等症状消失,体力充沛。
与现有技术相比,本发明所述药物能够显著改善机体的免疫状况,具有滋阴补肾、温肾壮阳、益髓填精的功效,对中老年人性功能减退症状具有很好的疗效,安全无毒副作用。
下面结合实施例对发明作进一步的说明,但并不作为对本发明限制的依据。
具体实施方式:
实施例1.
配方:生晒参22.5g、当归13.5g、黄芪17.5g、枸杞22.5g、锁阳22.5g、大云17.5g、补骨脂35g、杜仲25g、川断22.5g、韭菜种子35g、桂枝17.5g、天雄17.5g、制附子17.5g、巴戟12.5g、炙麻黄12.5g、鹿胶22.5g、龟胶22.5g、海狗肾25g、淫羊藿30g、熟地22.5g和九牛造22.5g。
工艺:取上述药材,加9倍量的水浸泡13分钟,先大火煎煮15min,再继续用小火煎煮20min,煎煮3次,过滤,滤液,浓缩,即得汤剂。
用法用量:口服,每日3次,每次每日100-200ml。
实施例2.
配方:生晒参23g、当归14g、黄芪18g、枸杞23g、锁阳23g、大云18g、补骨脂37g、杜仲23g、川断23g、韭菜种子37g、桂枝18g、天雄18g、制附子18g、巴戟13g、炙麻黄13g、鹿胶23g、龟胶23g、海狗肾27g、淫羊藿32g、熟地23g和九牛造23g。
工艺:取上述药材,用6倍量70%的乙醇回流提取2次,每次1小时,提取液过滤,滤液回收乙醇并浓缩成50-60℃时相对密度为1.20-1.25的浸膏,浸膏与浸膏量20%的淀粉和浸膏量10%的微晶纤维素混匀,压片,包薄膜衣,即得片剂。
规格:每片0.5g。
用法用量:每日3次,每次2片,口服。
实施例3.
配方:生晒参22g、当归13g、黄芪17g、枸杞22g、锁阳22g、大云17g、补骨脂33g、杜仲22g、川断22g、韭菜种子33g、桂枝17g、天雄17g、制附子17g、巴戟12g、炙麻黄12g、鹿胶22g、龟胶22g、海狗肾23g、淫羊藿28g、熟地22g和九牛造22g。
工艺: 取上述药材,加8倍量的水浸泡10分钟,先大火煎煮10min,再继续用小火煎煮15min,煎煮3次,过滤,合并滤液,滤液浓缩成50-60℃时相对密度为1.20-1.25的浸膏,浸膏与浸膏量30%的淀粉和浸膏量0.7%的硬脂酸镁混匀,用60%的乙醇制粒,干燥,粉碎,填充胶囊,即得颗粒剂。
规格:5g每袋。
用法用量:每日3次,每次5-10g,口服。
Claims (10)
1.一种治疗中老年人性功能减退的药物,其特征在于:按重量份计算,主要由生晒参20-25份、当归12-15份、黄芪15-20份、枸杞20-25份、锁阳20-25份、大云15-20份、补骨脂30-40份、杜仲20-25份、川断20-25份、韭菜种子30-40份、桂枝15-20份、天雄15-20份、制附子15-20份、巴戟10-15份、炙麻黄10-15份、鹿胶20-25份、龟胶20-25份、海狗肾20-40份、淫羊藿25-35份、熟地20-25份和九牛造20-25份制备而成。
2.如权利要求1所述的治疗中老年人性功能减退的药物,其特征在于:按照重量份计算,主要由生晒参22-23份、当归13-14份、黄芪17-18份、枸杞22-23份、锁阳22-23份、大云17-18份、补骨脂33-37份、杜仲22-23份、川断22-23份、韭菜种子33-37份、桂枝17-18份、天雄17-18份、制附子17-18份、巴戟12-13份、炙麻黄12-13份、鹿胶22-23份、龟胶22-23份、海狗肾23-27份、淫羊藿28-32份、熟地22-23份和九牛造22-23份制备而成。
3.如权利要求2所述的治疗中老年人性功能减退的药物,其特征在于:按照重量份计算,主要由生晒参22.5份、当归13.5份、黄芪17.5份、枸杞22.5份、锁阳22.5份、大云17.5份、补骨脂35份、杜仲25份、川断22.5份、韭菜种子35份、桂枝17.5份、天雄17.5份、制附子17.5份、巴戟12.5份、炙麻黄12.5份、鹿胶22.5份、龟胶22.5份、海狗肾25份、淫羊藿30份、熟地22.5份和九牛造22.5份制备而成。
4.一种如权利要求1-3中任一项所述的治疗中老年人性功能减退的药物的制备方法,其特征在于:取上述药物,与常规药用辅料或不加辅料组合,制成常规药物制剂。
5.如权利要求4所述的治疗中老年人性功能减退的药物的制备方法,其特征在于:所述药物制剂为口服制剂。
6.如权利要求5所述的治疗中老年人性功能减退的药物的制备方法,其特征在于:所述口服制剂为汤剂、片剂、胶囊剂、颗粒剂、丸剂或汤剂。
7.如权利要求6所述的治疗中老年人性功能减退的药物的制备方法,其特征在于:所述的汤剂,是按下述方法制备:取上述药材,加8-10倍量的水浸泡10-15分钟,先大火煎煮10-15min,再继续用小火煎煮15-25min,煎煮3次,过滤,滤液,浓缩,即得。
8.如权利要求6所述的治疗中老年人性功能减退的药物的制备方法,其特征在于:所述的片剂:是按下述方法制备:取上述药材,用6倍量70%的乙醇回流提取2次,每次1小时,提取液过滤,滤液回收乙醇并浓缩成50-60℃时相对密度为1.20-1.25的浸膏,浸膏与浸膏量20%的淀粉和浸膏量10%的微晶纤维素混匀,压片,包薄膜衣,即得。
9.如权利要求6所述的治疗中老年人性功能减退的药物的制备方法,其特征在于:所述的胶囊剂;是按下述方法制备:取上述药材,加8-10倍量的水浸泡10-15分钟,先大火煎煮10-15min,再继续用小火煎煮15-25min,煎煮3次,过滤,合并滤液,滤液浓缩成50-60℃时相对密度为1.20-1.25的浸膏,浸膏与浸膏量30%的淀粉和浸膏量0.7%的硬脂酸镁混匀,用60%的乙醇制粒,干燥,粉碎,填充胶囊,即得。
10.如权利要求6所述的治疗中老年人性功能减退的药物的制备方法,其特征在于:所述的颗粒剂;是按下述方法制备:取上述药材,加8-10倍量的水浸泡10-15分钟,先大火煎煮10-15min,再继续用小火煎煮15-25min,煎煮3次,过滤,合并滤液,滤液浓缩成50-60℃时相对密度为1.15-1.20的浸膏,浸膏与浸膏量20%的淀粉和浸膏量20%的糊精粉混合制粒,干燥,即得。
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CN109674944A (zh) * | 2019-01-25 | 2019-04-26 | 龙步明 | 一种治疗中老年性功能减退的保健制剂 |
CN115624595A (zh) * | 2022-08-11 | 2023-01-20 | 陈冬 | 一种养生肾宝茶 |
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CN115624595A (zh) * | 2022-08-11 | 2023-01-20 | 陈冬 | 一种养生肾宝茶 |
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