CN107875214A - A kind of traditional Chinese herb medicine for treating empyrosis and preparation method thereof - Google Patents

A kind of traditional Chinese herb medicine for treating empyrosis and preparation method thereof Download PDF

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Publication number
CN107875214A
CN107875214A CN201711380538.XA CN201711380538A CN107875214A CN 107875214 A CN107875214 A CN 107875214A CN 201711380538 A CN201711380538 A CN 201711380538A CN 107875214 A CN107875214 A CN 107875214A
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ointment
preparation
frankincense
myrrh
red
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王于法
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/739—Sanguisorba (burnet)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether

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Abstract

The ointment prepared the invention provides a kind of Chinese medicine composition for treating empyrosis and by said composition.The ointment of the present invention has obvious anti-inflammatory, anti-infective, the protection surface of a wound, reduction transudation, and can be obviously promoted regeneration, wound healing, while can also suppress scar hyperplasia.

Description

A kind of traditional Chinese herb medicine for treating empyrosis and preparation method thereof
Technical field
The invention belongs to tcm field, and in particular to a kind of traditional Chinese herb medicine for treating empyrosis and preparation method thereof.
Background technology
Burn is body injury typical in daily life, is because the factors such as physics, chemistry, unwrapping wire act on Body and caused by a kind of extremely complex wound row illness.In recent years, burn treating research work in China's has a great development, But the death rate of China's burn patient is still maintained at 2.25-5.41%.
Modern medicine since the concept of wound sepsis is proposed, also pay attention to and develop by the treatment to burn patient, doctor trained in Western medicine The application of local topical medicine, mainly antibacterial and various growth factor externally applied drugs, but easily cause scar hyperplasia, and exist The problems such as cost is high, storage life is short.And the traditional Chinese medical science and Chinese medicine have long history and rich experience in terms of burn and scald is treated, Extensive attention is received.Although there are many external use burn treating medicines in the market, all respectively there are advantage and disadvantage.Some is made without antibacterial With some is unfavorable for wound healing.In numerous Chinese herbal medicines, develop can promoting blood circulation and removing blood stasis, anti-inflammatory analgetic, it is anti-infective, promote be cured Close, reduce scar, and economic cheap externally applied drug, turn into the emphasis of burn and scald treatment.
The content of the invention
The problem of existing for prior art, it is an object of the invention to provide a kind of Chinese medicine for treating empyrosis is soft Cream, there is promoting blood circulation and removing blood stasis, anti-inflammatory analgetic, anti-infective, promoting healing, scar after can effectively reducing more.
Present invention also offers a kind of preparation method for the traditional Chinese herb medicine for treating empyrosis, this method passes through for difference Medicinal material carry out different method and carry out pre-treatment, improve the utilization rate of medicinal material, and method is simple to operation.
The present invention uses following technical scheme to achieve the above object.
A kind of Chinese medicine composition for treating empyrosis, is made up of the bulk drug of following parts by weight：Myrrh 30-50, giant knotweed It is 80-100, rheum officinale 80-100, frankincense 30-50, propolis 30-60, Asian puccoon 30-60, coptis 80-100, red sage root 60-120, red Mountain tallow 6-20, root of Dahurain angelica 120-150, Radix Sangusorbae 300-450, sesame oil 1000-1500.
Further, the bulk drug of optimization is：Myrrh 30-50, giant knotweed 80-100, rheum officinale 80-100, frankincense 30-45, Propolis 30-45, Asian puccoon 30-45, coptis 80-90, red sage root 60-90, red halloysite 12-15, root of Dahurain angelica 120-150, Radix Sangusorbae 300-450, sesame oil 1000-1200.
Further, the bulk drug of optimization is：Myrrh 45, giant knotweed 90, rheum officinale 90, frankincense 45, propolis 30, Asian puccoon 30th, the coptis 90, the red sage root 90, red halloysite 15, the root of Dahurain angelica 150, Radix Sangusorbae 450, sesame oil 1000.
A kind of ointment of the treatment empyrosis containing above-mentioned Chinese medicine composition, in addition to chitosan, hyaluronic acid.
The molecular weight of the hyaluronic acid is 100-200 ten thousand.
The percentage by weight that the chitosan accounts for ointment with hyaluronic acid is respectively 3-5%, 1-5%.
A kind of preparation method of the ointment of above-mentioned treatment empyrosis, comprises the following steps：
（1）By giant knotweed, rheum officinale, Asian puccoon, the coptis, the red sage root, the root of Dahurain angelica, Radix Sangusorbae break it is broken after compound is made；
（2）By step after sesame oil is heated（1）Middle compound immerses extraction 30-40min；After filter cleaner, add propolis and melt Change is mixed into ointment；
（3）Myrrh, frankincense and red halloysite are respectively crushed into powder, add step while hot（2）Ointment in；
（4）Step（3）Middle ointment is cooled to 60-90 DEG C and adds chitosan and hyaluronic acid, mixes as ointment.
The step（2）Middle sesame oil heating-up temperature is 180-200 DEG C.
The step（3）It is most fine powder that middle myrrh, frankincense, which crush, and it is fine powder that red halloysite, which crushes,.
Advantages of the present invention and have the beneficial effect that：
The ointment of the present invention has obvious anti-inflammatory, anti-infective, the protection surface of a wound, reduction transudation, and can be obviously promoted group Regeneration, wound healing are knitted, while scar hyperplasia can also be suppressed.
Embodiment
Essence for a better understanding of the present invention, below by specific embodiment and clinical testing data to the present invention's Technical scheme is further elaborated.
The pharmacological action of each medicinal material is in the Traditional Chinese medicine composition formula for the treatment of empyrosis provided by the invention：Myrrh：Dissipate Stasis of blood analgesic therapy, detumescence and promoting granulation；Giant knotweed：It is clearing heat and detoxicating, blood stasis removing analgesic；Rheum officinale：Removing pattogenic heat from the blood and toxic material from the body, removing blood stasis and hemostasis；Frankincense：Blood-activating and qi-promoting stops Bitterly, detumescence and promoting granulation；Propolis：Moisturizing myogenic；Anti-inflammatory analgetic；Asian puccoon：Cool blood, promoting blood circulation, it is clearing heat and detoxicating；The coptis：Purging intense heat and detonicating；It is red Ginseng：Promoting blood circulation, inducing meastruation to relieve menalgia, cool blood to disappear carbuncle；Red halloysite：Hemostasis, myogenic sore；The root of Dahurain angelica：Detumescence and apocenosis；Radix Sangusorbae：Convergence Hemostasis；Sesame oil：Removing toxic substances, analgesic, detumescence, myogenic.
Embodiment 1 treats the preparation of the traditional Chinese herb medicine of empyrosis.
Bulk drug：
Myrrh 45g, the g of giant knotweed 90, the g of rheum officinale 90, the g of frankincense 45, the g of propolis 30, the g of Asian puccoon 30, the g of the coptis 90, the red sage root 90th, the g of red halloysite 15, the g of the root of Dahurain angelica 150, the g of Radix Sangusorbae 450, the g of sesame oil 2000.
（1）By giant knotweed, rheum officinale, Asian puccoon, the coptis, the red sage root, the root of Dahurain angelica, Radix Sangusorbae break it is broken after compound is made；
（2）Sesame oil is heated to 200 DEG C, by step（1）Middle compound immerses extraction 30min；After filter cleaner, propolis is added Fusing is mixed into ointment；
（3）It is most fine powder that myrrh, frankincense, which are crushed, and it is fine powder that red halloysite, which crushes, adds step while hot（2）Ointment in；
（4）Step（3）Middle ointment is cooled to 70 DEG C and adds 60g chitosans and 40g hyaluronic acids（Mean molecule quantity 1,500,000）, mix For ointment.
The clinical laboratory data of embodiment 2
Case：Using various burn and scalds of Ointment in Treatment prepared in embodiment 1 totally 128；Wherein, I degree burn 58, shallow II degree Burn 23, deep ii degree burn 6, scald 41；
Various burn and scalds totally 22 are treated as comparison medicament using peace letter Nano Silver auxiliary material；Wherein, I degree burn 7, shallow II degree Burn 7, deep ii degree burn 4, scald 4.
Administrated method：Having bubble, person punctures rear coating in advance, and after debridement, the surface of a wound is coated with traditional Chinese herb medicine；II degree burns victims Wrapped up；Once, after 7 days dressing in 2 days is once for daily dressing in first 7 days.
As a result：
I degree is burnt：Using traditional Chinese herb medicine topical agent, exposure is handled, and pain disappears in 10-20min, red and swollen in 2 days to disappear, 2- Heal within 3 days；Nanometer silver dressing is believed using peace, has constant pain sense in 1-2 days, 3 days or so red and swollen regression, heals within 4 days or so.
Shallow II degree burn：Using traditional Chinese herb medicine topical agent, exposure processing, 30min or so pain relief, sepage after 2 days Reduce, oedema mitigates or disappeared, and heals within 7-10 days, scar is slight, slight pigementation；Believe Nanometer silver dressing using pacifying, 1-2 days Inside there is constant pain sense, sepage reduction after 2 days, red and swollen mitigation in 3 days or so, heal within 10 days or so, there is peony scar, slight increasing Raw projection.
Deep ii degree burn：Using traditional Chinese herb medicine topical agent, wrapping processing, sepage in 3-5 days is reduced, 7 days or so small areas Burn edema extinction, large-area burns oedema mitigate, and heal within 15-25 days, peony scar, almost without hyperplasia projection；Using peace Believe Nanometer silver dressing, sepage in 7 days or so reduces, 15 days or so edema extinctions, healed after 20 days, there is peony hyperplasia projection scar Trace.
Scald：The person that has bubble uses traditional Chinese herb medicine coating after puncturing in advance, exposure processing, and pain disappears in 10min, and 1 It is red and swollen in it to disappear, heal within 2-3 days, former Lao Pi comes off within 5 days or so；Nanometer silver dressing is believed using peace, has constant pain in 3 days Sense, 5 days or so red and swollen regression, heals for 7 days or so.

Claims (6)

1. a kind of Chinese medicine composition for treating empyrosis, it is characterised in that be made up of the bulk drug of following parts by weight：Myrrh 30-50, giant knotweed 80-100, rheum officinale 80-100, frankincense 30-50, propolis 30-60, Asian puccoon 30-60, coptis 80-100, pellet Join 60-120, red halloysite 6-20, root of Dahurain angelica 120-150, Radix Sangusorbae 300-450, sesame oil 1000-1500.
2. a kind of ointment of the treatment empyrosis containing Chinese medicine composition as claimed in claim 1, it is characterised in that also wrap Include chitosan and hyaluronic acid.
3. ointment according to claim 2, it is characterised in that the chitosan and hyaluronic acid account for the weight percent of ointment Than being respectively 3-5%, 1-5%.
4. a kind of preparation method of ointment as claimed in claim 2, it is characterised in that comprise the following steps：
（1）By giant knotweed, rheum officinale, Asian puccoon, the coptis, the red sage root, the root of Dahurain angelica, Radix Sangusorbae break it is broken after compound is made；
（2）By step after sesame oil is heated（1）Middle compound immerses extraction 30-40min；After filter cleaner, add propolis and melt Change is mixed into ointment；
（3）Myrrh, frankincense and red halloysite are respectively crushed into powder, add step while hot（2）Ointment in；
（4）Step（3）Middle ointment is cooled to 60-90 DEG C and adds chitosan and hyaluronic acid, mixes as ointment.
5. preparation method according to claim 4, it is characterised in that step（2）Middle sesame oil heating-up temperature is 180-200 ℃。
6. preparation method according to claim 4, it is characterised in that step（3）It is most fine powder that middle myrrh, frankincense, which crush, It is fine powder that red halloysite, which crushes,.
CN201711380538.XA 2017-12-20 2017-12-20 A kind of traditional Chinese herb medicine for treating empyrosis and preparation method thereof Pending CN107875214A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1204516A (en) * 1997-07-07 1999-01-13 刘明锁 Burns oil and method for preparation thereof
CN101703598A (en) * 2009-12-04 2010-05-12 河南科技大学 Chinese medicinal ointment for treating burn or sore and ulcer and preparation method thereof
CN104208176A (en) * 2013-06-03 2014-12-17 谭汉卿 Traditional Chinese medicine oil treating burn and scald
CN107007682A (en) * 2017-04-11 2017-08-04 杭州雀皇生物科技有限公司 It is a kind of to treat herbal mixture gel of burn and scald and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1204516A (en) * 1997-07-07 1999-01-13 刘明锁 Burns oil and method for preparation thereof
CN101703598A (en) * 2009-12-04 2010-05-12 河南科技大学 Chinese medicinal ointment for treating burn or sore and ulcer and preparation method thereof
CN104208176A (en) * 2013-06-03 2014-12-17 谭汉卿 Traditional Chinese medicine oil treating burn and scald
CN107007682A (en) * 2017-04-11 2017-08-04 杭州雀皇生物科技有限公司 It is a kind of to treat herbal mixture gel of burn and scald and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
杨秀婷 等: "中药油膏纱布治疗晚期创面的临床观察", 《中医正骨》 *

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Application publication date: 20180406