CN102793785B - Chinese rhubarb-baical skullcap root-amur corktree bark itching-relieving liniment and preparation method thereof - Google Patents
Chinese rhubarb-baical skullcap root-amur corktree bark itching-relieving liniment and preparation method thereof Download PDFInfo
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Abstract
The invention relates to an external pharmaceutical composition liniment and a preparation method thereof and especially relates to a Chinese rhubarb-baical skullcap root-amur corktree bark itching-relieving liniment and a preparation method thereof. Based on 1000 parts by weight of the Chinese rhubarb-baical skullcap root-amur corktree bark itching-relieving liniment, the Chinese rhubarb-baical skullcap root-amur corktree bark itching-relieving liniment comprises 20 to 30 parts by weight of lightyellow sophora root, 20 to 30 parts by weight of Chinese rhubarb, 20 to 30 parts by weight of baical skullcap root, 20 to 30 parts by weight of amur corktree bark, 10 to 15 parts by weight of gentiana scabra bunge and 20 to 30 parts by weight of raw cape jasmine fruit. The preparation method comprises the following steps of mixing the above traditional Chinese medicines according to the weight part ratio, crushing the mixture into fine powder, sieving, uniformly mixing, adding 3 to 10 parts by weight of completely swelled sodium carboxymethylcellulose into the mixed fine powder, adding 5 to 15 parts by weight of melted phenol into the mixture obtained by the previous step, uniformly stirring, and adding the balance water into the mixture obtained by the previous step. The Chinese rhubarb-baical skullcap root-amur corktree bark itching-relieving liniment has the effects of clearing away heat and toxins, inducing astringency and relieving itching, treating acute-stage skin diseases such as red and swollen skin, hot itching and exudation caused by obstruction of evil syndromes, has functions of heating removal and convergence, is suitable for treating various acute-stage skin damages with a small amount of exudation, is prepared from pure traditional Chinese medicines, is safe in use, has no irritation, can be used for a long time, and has a low cost.
Description
Technical field
The present invention relates to externally-applied liniment of a kind of pharmaceutical composition and preparation method thereof, be specifically related to a kind of SANHUANG antipruritic application agent and preparation method thereof.
Background technology
At present clinically for acne, rosacea, furunculosis, eczema, dermatitis (acute stage, have and slightly do not ooze out person), the case such as herpes zoster (vesicle person appears in acute stage), the following Drug therapy of usual employing, such as conventional Acne treatment medicine for external use has: 1. tretinoin: as tretinoin emulsifiable paste (15 ~ 20 yuan), Avita Gel (35 yuan), isotretinoin gel (more than 50 yuan) etc., but can occur slight irritant reaction (as local flushing, desquamation or burn feeling) after medication.2. antibiotics: as 1% ~ 2% erythromycin ointment (1 ~ 2 yuan), lincomycin VB6 ointment (about 30 yuan), be suitable for the erythra of infection.This two classes medicine limited use, some patients has sense of discomfort.Conventional treatment rosacea medicine for external use has more than 0.75% Metrogel 20g(20 unit), have antibacterial action, short-period used is effective; Compound sulfur lotion or 5% sulphur ointment (5 ~ 10 yuan), have certain curative effect, but often have skin wound repair and pungent taste.Conventional treatment furunculosis medicine for external use has: about mupirocin ointment 5g(15 unit) limited use.Conventional treatment eczema, the medicine for external use of dermatitis have external glucocorticoid paste or 25% ~ 40% zinc oxid oil or paste (being generally hospital-made); Be mostly ointment in the product of listing, life-time service Hormonal ointment easily produces various untoward reaction, and has been unsuitable for the person of oozing out.The medicine for external use of conventional treatment herpes zoster (vesicle person appears in acute stage) has: with Calamine Lotion 100ml, 3% acyclovir ointment 10g, 1% Denavir 10g when bleb liquid is not broken; With 3% boric acid solution 200ml, mupirocin ointment 5g after herpes ulceration.
Summary of the invention
The object of the invention is according to above-mentioned the deficiencies in the prior art part, provide a kind of SANHUANG antipruritic application agent and preparation method thereof, this liniment is pure Chinese medicinal preparation, and for the disease that skin pyretic toxicity is had an itch, effect clearly.
The object of the invention realizes being completed by following technical scheme:
A kind of SANHUANG antipruritic application agent, it is characterized in that described liniment calculates with 1000 total weight parts, its crude drug composition and the weight portion shared by consumption are respectively: Radix Sophorae Flavescentis 20-30, Radix Et Rhizoma Rhei 20-30, Radix Scutellariae 20-30, Cortex Phellodendri 20-30, Radix Gentianae 10-15, Gardenia 20-30.
A preparation method for SANHUANG antipruritic application agent, is characterized in that above-mentioned raw materials medicine to form, according to above-mentioned weight portion, mixes, is ground into fine powder, cross mesh sieve afterwards, mixing; Add the sodium carboxymethyl cellulose 3-10 weight portion of complete swelling, then add the phenol 5-15 weight portion melted, stir evenly, the adjustment total amount to 1000 that adds water weight portion, to obtain final product.
Advantage of the present invention is, heat-clearing and toxic substances removing, relieving iching by astringing, the acute stage red swelling of the skin, the pruritus due to heat that cause for skin, the dermatosis such as to ooze out because of hyperactivity of toxic heat, and existing heat clearing away effect, has again astriction, is suitable for acute stage with the various skin lesion oozed out on a small quantity; Pure Chinese medicinal preparation, use safety, non-stimulated, can life-time service; Price is lower.
Detailed description of the invention
By the following examples feature of the present invention and other correlated characteristic are described in further detail, so that the understanding of technical staff of the same trade:
Embodiment one:
Crude drug composition and consumption are: Radix Sophorae Flavescentis 25g, Radix Et Rhizoma Rhei 25g, Radix Scutellariae 25g, Cortex Phellodendri 25g.
By above-mentioned raw materials composition according to above-mentioned weight portion, mix, be ground into fine powder, cross 80 mesh sieves afterwards, mixing; Add the sodium carboxymethyl cellulose 5g of complete swelling, then add the phenol 10g melted, stir evenly, the adjustment total amount that adds water is to 1000ml.
Described in the present embodiment, the using method of liniment is as follows:
By adopt above-mentioned preparation method liniment be distributed into bottle by 100 ml/ bottles.Partial smearing, 1 time every night, with front shaking up.It within 2 weeks, was 1 course for the treatment of.
Embodiment two: the present embodiment and the difference of embodiment one be crude drug form different, the present embodiment for the patient having acne conditions.
Crude drug forms: Radix Sophorae Flavescentis 25g, Radix Et Rhizoma Rhei 25g, Radix Scutellariae 25g, Cortex Phellodendri 25g, Herba Hedyotidis Diffusae 30, Herba Taraxaci 30.It within 2 weeks, was 1 course for the treatment of.
The state of an illness symptom of acne: whelk, blackhead, serious symptom have pustule, tuberosity, cyst.
Below that the present embodiment and contrast groups are applied to clinical report: often organize patient 20 people.
| Group | Treatment time (week) | Clinical cure (example) | Take a turn for the better (example) | Do not heal (example) |
| Adopt tretinoin group | 2 | 1 | 3 | 16 |
| Adopt tretinoin group | 4 | 4 | 4 | 12 |
| Embodiment one group | 2 | 0 | 6 | 14 |
| Embodiment one group | 4 | 8 | 8 | 4 |
| Embodiment two groups | 2 | 4 | 6 | 10 |
| Embodiment two groups | 4 | 12 | 4 | 4 |
With reference to " disease of tcm Standardization of diagnosis and curative effect ", above-mentioned acne criterion of therapeutical effect is as follows:
Clinical cure: skin lesion is disappeared, subjective symptoms disappears;
Take a turn for the better: subjective symptoms obviously alleviates, and skin lesion disappears more than 30%;
Do not heal: skin lesion and symptom are all unchanged or disappear less than 30%.
Can be seen by above-mentioned example table, compared with existing medicine, embodiment one is all better than contrast groups medicine with the effect of embodiment two, and the effect of embodiment two is better than the effect of embodiment one, price, far below upper two class medicines, has no side effect, and the patient of 100% to react above-described embodiment medicine clearing heat and anti-inflammatory functions strong, can take effect rapidly, without uncomfortable sensation.
Embodiment three: the present embodiment and the difference of embodiment one be crude drug form different, the present embodiment for the patient having rosacea disease.
Crude drug forms: Radix Sophorae Flavescentis 25g, Radix Et Rhizoma Rhei 25g, Radix Scutellariae 25g, Cortex Phellodendri 25g, the Radix Rehmanniae 30, Cortex Mori 30.It within 2 weeks, was 1 course for the treatment of.
Rosacea state of an illness symptom: nose flushing, time excited obviously, pimple, pustule, telangiectasis is obvious, and pachyderma, finally forms pachydermatosis.
Below that the present embodiment and contrast groups are applied to clinical report: often organize patient 20 people.
| Group | Treatment time (week) | Clinical cure (example) | Take a turn for the better (example) | Do not heal (example) |
| Compound sulfur lotion or 5% sulphur ointment | 2 | 0 | 2 | 18 |
| Compound sulfur lotion or 5% sulphur ointment | 4 | 2 | 6 | 12 |
| Embodiment one group | 2 | 0 | 8 | 12 |
| Embodiment one group | 4 | 4 | 12 | 4 |
| Embodiment three groups | 2 | 4 | 10 | 6 |
| Embodiment three groups | 4 | 8 | 8 | 4 |
With reference to " disease of tcm Standardization of diagnosis and curative effect ", above-mentioned acne rosacea criterion of therapeutical effect is as follows:
Clinical cure: skin lesion disappears.
Take a turn for the better: part skin lesion alleviates, or disappear more than 30%.
Do not heal: skin lesion is unchanged or disappear less than 30%.
Can be seen by above-mentioned example table, compared with existing medicine, embodiment one is all better than contrast groups medicine with the effect of embodiment three, and the effect of embodiment three is better than the effect of embodiment one, and the patient of 100% reacts the heat clearing away of above-described embodiment medicine, removing heat from blood, antiinflammation are strong, instant effect, non-stimulated sensation, can life-time service.
Embodiment four: the present embodiment and the difference of embodiment one be crude drug form different, the present embodiment for the patient having furunculosis disease.
Crude drug forms: Radix Sophorae Flavescentis 25g, Radix Et Rhizoma Rhei 25g, Radix Scutellariae 25g, Cortex Phellodendri 25g, Flos Chrysanthemi Indici 30, Flos Lonicerae 20.It within 1 week, was 1 course for the treatment of.
Furunculosis state of an illness symptom: the pityriasis rubra pimple of cerise exceeding skin, greatly cumulative, pain, becomes pus in 2-3 days, namely heals after bursting.Whole body distributes everywhere, or at certain position recurrent exerbation.
Below that the present embodiment and contrast groups are applied to clinical report: often organize patient 20 people.
| Group | Treatment time (week) | Clinical cure (example) | Take a turn for the better (example) | Do not heal (example) |
| Mupirocin ointment | 0.5 | 2 | 8 | 10 |
| Mupirocin ointment | 1 | 4 | 6 | 10 |
| Embodiment one group | 0.5 | 2 | 10 | 8 |
| Embodiment one group | 1 | 8 | 8 | 4 |
| Embodiment four groups | 0.5 | 4 | 6 | 10 |
| Embodiment four groups | 1 | 4 | 14 | 2 |
With reference to " disease of tcm Standardization of diagnosis and curative effect ", above-mentioned furunculosis criterion of therapeutical effect is as follows:
Clinical cure: furuncle and phyma dissipates or rear healing of bursting, and General Symptoms disappears.
Take a turn for the better: send out furuncle and phyma number again and reduce, symptom alleviates.
Do not heal: furuncle and phyma this more that rise, can not control.
Can be seen by above-mentioned example table, compared with existing medicine, embodiment one is all better than comparative example medicine with the effect of embodiment four, and the effect of embodiment four is better than the effect of embodiment one, above-described embodiment medicine has good antipyretic and antidote functions, furunculosis for recurrent exerbation has good curative effect, and can reduce recurrence.
Embodiment five: the present embodiment and the difference of embodiment one be crude drug form different, the present embodiment for the patient having eczema, dermatitis (acute stage has and slightly do not ooze out person) disease.
Crude drug forms: Radix Sophorae Flavescentis 25g, Radix Et Rhizoma Rhei 25g, Radix Scutellariae 25g, Cortex Phellodendri 25g, Rhizoma Smilacis Glabrae 30.It within 2 weeks, was 1 course for the treatment of.
The state of an illness symptom of eczema, dermatitis (acute stage has and slightly do not ooze out person): acute eczema has erythema, pimple, vesicle, oozes out, symmetrical, acutely scratches where it itches.
Below that the present embodiment and contrast groups are applied to clinical report: often organize patient 20 people.
| Group | Treatment time (week) | Clinical cure (example) | Take a turn for the better (example) | Do not heal (example) |
| External glucocorticoid paste | 2 | 0 | 8 | 12 |
| External glucocorticoid paste | 4 | 2 | 10 | 8 |
| Embodiment one group | 2 | 0 | 10 | 10 |
| Embodiment one group | 4 | 4 | 10 | 6 |
| Embodiment five groups | 2 | 2 | 12 | 6 |
| Embodiment five groups | 4 | 8 | 10 | 2 |
With reference to " disease of tcm Standardization of diagnosis and curative effect ", above-mentioned eczema criterion of therapeutical effect is as follows:
Clinical cure: skin lesion disappears.
Take a turn for the better: skin lesion disappears more than 30%.
Do not heal: skin lesion disappears less than 30%.
Can be seen by above-mentioned example table, compared with existing medicine, embodiment one is all better than comparative example medicine with the effect of embodiment five, and the effect of embodiment five is better than the effect of embodiment one, is applicable to acute stage eczema, dermatitis has and slightly do not ooze out person, heat clearing away, antiinflammatory and astriction are obvious, owing to being the Chinese medicine preparation without hormone, can use safely in tender and lovely skin places such as faces, and can life-time service, and the patient of 100% reacts instant effect, without uncomfortable sensation.
Embodiment six: the present embodiment and the difference of embodiment one be crude drug form different, the present embodiment for the patient having herpes zoster (vesicle person appears in acute stage) disease.
Crude drug forms: Radix Sophorae Flavescentis 25g, Radix Et Rhizoma Rhei 25g, Radix Scutellariae 25g, Cortex Phellodendri 25g, Radix Gentianae 15, Gardenia 30.It within 1 week, was 1 course for the treatment of.
Herpes zoster (vesicle person appears in acute stage) state of an illness symptom: one-sided skin has the vesicle of Semen phaseoli radiati size, in zonal distribution, sharp ache.
Below that the present embodiment and contrast groups are applied to clinical report: often organize patient 20 people.
| Group | Treatment time (week) | Clinical cure (example) | Take a turn for the better (example) | Do not heal (example) |
| With Calamine Lotion, acyclovir ointment, Denavir | 1 | 0 | 4 | 16 |
| With Calamine Lotion, acyclovir ointment, Denavir | 2 | 0 | 8 | 12 |
| Boric acid solution, mupirocin ointment | 1 | 0 | 4 | 16 |
| Boric acid solution, mupirocin ointment | 2 | 0 | 6 | 14 |
| Embodiment one group | 1 | 0 | 8 | 12 |
| Embodiment one group | 2 | 3 | 11 | 6 |
| Embodiment six groups | 1 | 6 | 8 | 6 |
| Embodiment six groups | 2 | 10 | 6 | 4 |
With reference to " disease of tcm Standardization of diagnosis and curative effect ", above-mentioned Herpes Zoster standard is as follows:
Clinical cure: deflorescence, clinical sign disappears, without pain sequela.
Take a turn for the better: deflorescence about 30%, pain obviously alleviates.
Do not heal: deflorescence, less than 30%, still has pain.
Can be seen by above-mentioned example table, compared with existing medicine, embodiment one is all better than comparative example medicine with the effect of embodiment six, and the effect of embodiment six is better than the effect of embodiment one, and the patient of 100% reacts above-described embodiment medicine instant effect, without uncomfortable sensation, the existing heat clearing away effect of this medicine liniment, there is astriction again, be suitable for the various skin lesion of herpes zoster acute stage when there is vesicle.
The sodium carboxymethyl cellulose that those skilled in the art obviously know in above-described embodiment Chinese medicine component is as thickening agent, and phenol is as antiseptic, and the number of its addition obviously can increase and decrease according to concrete needs in right amount, does not repeat them here.
Claims (2)
1. a SANHUANG antipruritic application agent, it is characterized in that described liniment calculates with 1000 total weight parts, its crude drug composition and the weight portion shared by consumption are respectively: Radix Sophorae Flavescentis 20-30, Radix Et Rhizoma Rhei 20-30, Radix Scutellariae 20-30, Cortex Phellodendri 20-30, Radix Gentianae 10-15, Gardenia 20-30.
2. a preparation method for SANHUANG antipruritic application agent as claimed in claim 1, is characterized in that described method is formed by described crude drug, according to above-mentioned weight portion, mixes, is ground into fine powder, crosses mesh sieve afterwards, mixing; Add the sodium carboxymethyl cellulose 3-10 weight portion of complete swelling, then add the phenol 5-15 weight portion melted, stir evenly, the adjustment total amount to 1000 that adds water weight portion, to obtain final product.
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| CN201210301307.6A CN102793785B (en) | 2011-07-19 | 2011-07-19 | Chinese rhubarb-baical skullcap root-amur corktree bark itching-relieving liniment and preparation method thereof |
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| CN103110747B (en) * | 2012-12-10 | 2014-08-13 | 宋爱民 | External traditional Chinese medicine preparation for treating contact dermatitis |
| CN103340805B (en) * | 2013-07-26 | 2015-04-22 | 付永旭 | Tea tree acne-cleaning and poison-drawing cream and preparation method thereof |
| CN103893376B (en) * | 2014-04-16 | 2017-05-31 | 李国宣 | A kind of Chinese medicine composition for treating skin eczema bleb and preparation method thereof |
| CN104474257A (en) * | 2014-12-20 | 2015-04-01 | 钱家美 | Preparation for treating acnes |
| CN104523529A (en) * | 2015-01-08 | 2015-04-22 | 江苏省中医院 | Traditional Chinese medicine wet tissue for skin decontamination, preparation method thereof and traditional Chinese medicine composition |
| CN105012474B (en) * | 2015-08-29 | 2018-10-26 | 江西致恩堂中医药科技有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating acne |
| CN112472734A (en) * | 2020-11-16 | 2021-03-12 | 江西中医药大学 | Traditional Chinese medicine for treating dermatitis and eczema, treatment bag and use method |
| CN112516044A (en) * | 2020-12-10 | 2021-03-19 | 广东诗妃化妆品有限公司 | Traditional Chinese medicine acne-removing and oil-controlling essence and preparation method thereof |
| CN116270900A (en) * | 2023-04-27 | 2023-06-23 | 赤水芝绿金钗石斛生态园开发有限公司 | External composition containing dendrobium nobile extract and preparation method and application thereof |
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