CN101856479B - Chinese medicament for treating psoriasis vulgaris and preparation method thereof - Google Patents
Chinese medicament for treating psoriasis vulgaris and preparation method thereof Download PDFInfo
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- CN101856479B CN101856479B CN 201010187977 CN201010187977A CN101856479B CN 101856479 B CN101856479 B CN 101856479B CN 201010187977 CN201010187977 CN 201010187977 CN 201010187977 A CN201010187977 A CN 201010187977A CN 101856479 B CN101856479 B CN 101856479B
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Abstract
The invention discloses a method for preparing a Chinese medicament for treating psoriasis vulgaris. The Chinese medicament is characterized in that: the Chinese medicament is prepared from the following components: 30 to 60g of rhubarb powder, 10 to 30g of arnebia root, 10 to 30g of licorice powder, 30 to 60g of turmeric powder, 30 to 60g of radix scutellariae powder, 50 to 80g of zinc oxide powder, 10 to 30g of salicylic acid, 10 to 50g of menthol crystal, 10 to 50g of sulfur powder, 10 to 20g of borneol powder, 0.1 to 1g of retinoic acid, and 10ml of azone, and the Chinese medicament is a topical tincture. The Chinese medicament for treating the psoriasis vulgaris has the effects of clearing heat and releasing toxin, diminishing inflammation and easing pain, and clearing damp and relieving itching, and has good treatment effect on the psoriasis vulgaris.
Description
The present invention relates to a kind of Chinese medicine, specifically relate to a kind of psoriatic medicine for external use for the treatment of, trade name is silver bits tincture varnish.
Background technology
Psoriasis is commonly called as psoriasis, and traditional Chinese medical science Gu is called " white malaria " disease, is a kind of common chronic dermatosis.Be characterized in repeatedly occurring the dry squama of multilamellar silvery white on erythema.
Psoriasis can divide Four types substantially, and first psoriasis vulgaris can betide whole body everywhere, but take scalp, lumbosacral region, patella ulnaris and extremity as common; It two is psoriasis pustulosas, comprises generalized pustular psoriasis, many acute attacks, and very fast general whole body is with high warm; It three is psoriasis arthropathica, claims again psoriasis arthropathica; It four is erythrodermic psoriasis, claims again the psoriasis exfoliative dermatitis, and above-mentioned two, three and four classes silver bits inflammation are more rare or rare.
Psoriasis not only diminishes patient's image appearance, and because very itching and repeatedly showing effect and bring misery and stress to the patient.
There is no at present specific short, mainly to embrocate with coal-tar ointment, calcipotriol ointment, mustard gas ointment part, these medicines can make skin damage disappear, but can not prevent recurrence, and the course for the treatment of is long, in addition, adopt the methods such as oral tretinoin, methotrexate or ciclosporin, though can be temporarily effective, very easily recurrence after drug withdrawal, and hemopoietic system and Liver and kidney are all had damage.
Psoriasis is more easily diagnosed, and should attention differentiate mutually with pityriasis rosea and seborrhea skin class.
Summary of the invention
Purpose of the present invention is to provide a kind of short treating period, instant effect, and what be difficult for recurrence a kind ofly treats psoriatic Traditional Chinese medicine liniment.
The technical scheme that adopts is:
A kind ofly treating psoriatic Chinese medicine, is to be prepared into by Radix Et Rhizoma Rhei powder 30-60g, Radix Arnebiae (Radix Lithospermi) powder 10-30g, Radix Glycyrrhizae powder 10-30g, curcuma powder 30-60g, Radix Scutellariae powder 30-60g, oxide powder and zinc 50-80g, salicylic acid 10-30g, Mentholum 10-50g, Cosan 10-50g, Borneolum Syntheticum powder 10-20g, tretinoin 0.1-1g and azone 10ml.
A kind of preparation method for the treatment of psoriatic Chinese medicine, to get Radix Et Rhizoma Rhei 30-60g, Radix Arnebiae (Radix Lithospermi) 10-30g, Radix Glycyrrhizae 10-30g, Rhizoma Curcumae Longae 30-60g, Radix Scutellariae 30-60g, Borneolum Syntheticum 10-20g, be ground into coarse powder, put into hermetic container, adding zinc oxide 50-80g, sulfur 10-50g and mass concentration is 75% ethanol 700ml again, after mixing, puts into room temperature dark place dipping 5 days, filter filtrate for later use; Separately get mass concentration and be 75% ethanol 300ml and joined in medicinal residues dipping 3 days, filter, merge filtrate twice, standing 24 hours, refilter, add salicylic acid 10-30g, Mentholum 10-50g, tretinoin 0.1-1g, azone 10ml in filtrate, and add 75% ethanol to 1000ml, and get final product, can be by setting metering, distributing, packaging.
The function of selected Chinese crude drug with cure mainly:
Radix Et Rhizoma Rhei: clearing away heat-fire detoxifcation, blood circulation promoting and blood stasis dispelling.
Radix Scutellariae: heat clearing and damp drying, the fire detoxifcation of dispelling.
Radix Arnebiae (Radix Lithospermi): relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Rhizoma Curcumae Longae: promoting blood circulation and stopping pain is used for all carbuncle pain infections furuncles, reducing swelling and alleviating pain.
Salicylic acid: anti-inflammation impels cutin absent-mindedness effect.
Mentholum: dispelling wind and heat pathogens rash.
Borneolum Syntheticum: anti-inflammatory, antibacterial is antipruritic.
Sulfur: killing parasites for relieving itching, impel cuticle horny layer softening nucleus formation.
Tretinoin: suppress the sebum secretion effect, powerful skin palpus cell proliferation or synthetic, the immunoregulation effect of suppressing.
Radix Glycyrrhizae: relieving spasm to stop pain coordinating the actions of various ingredients in a prescription.
Azone: anti-inflammatory anti-itch helps the effect of oozing.
Using method: be applied in lesions position, every day sooner or later respectively once.
Efficacy of drugs:
The common function of ingredients is heat-clearing and toxic substances removing, anti-inflammatory analgetic, removing dampness to relieve itching, and psoriasis is had good curative effect.
Under the applicant, hospital carries out repeatedly actual therapeutic with the psoriatic Chinese medicine for the treatment of of the present invention, and curative effect is obvious, welcome by the patient, and for declaring patent, on June 10th, 2008 rose and tested specially.
Clinical data: select 120 routine patients with psoriasis vulgaris, male 78 examples, female's 42 examples, 32.0 years old mean age (21-70 year).Course of disease 2-42.Drop shape 70 examples, speckle shape 50 examples.
Diagnostic criteria: trunk, extremity skin lesion differ in size take the dark red speckle of wellability as main, and hypertrophy is obviously plump, and conscious pruritus is covered silvery white squama on skin lesion, strike off the thin film that the visible substrate of squama has one deck light, visible petechial hemorrhage under thin film.
Efficacy determination: inclusive criteria meets diagnostic criteria and psoriatic lesion area and severity index (PASl) scoring of homeliness type and psoriasis pustulosa, and the untoward reaction that occurs in the record treatment, total mark * 100% before therapeutic index=(total mark after total mark before treatment-treatment)/treatment.Cure: therapeutic index 〉=90%, produce effects: therapeutic index is 60%-89%, progressive: therapeutic index is 20%-59%; Invalid: therapeutic index＜20%.Cure the percentage ratio that adds the produce effects number of cases and count effective percentage.
Untoward reaction: the patient has burn feeling 5 examples, is mainly that silver bits tincture varnish is wiped skin irritation symptom, and after drug withdrawal or minimizing medication number of times, irritation is alleviated very soon.
Result: after two groups of Patients with Psoriasis treatment surroundings, curative effect sees Table 1, and as seen from Table 1, the outer liniment of oral combination and simple oral capsule for treating psoriatic cure rate be X_ relatively
2=13.33, p＜0.01, difference _ have statistical significance, effective percentage comparing difference not statistically significant.
Table 1 liang group oral capsule in conjunction with externally applied liniment and simple oral capsule for treating psoriatic surrounding after curative effect relatively [example]
The specific embodiment
Embodiment one
A kind ofly treating psoriatic Chinese medicine, is to be prepared into by Radix Et Rhizoma Rhei 54g, Radix Arnebiae (Radix Lithospermi) 16g, Radix Glycyrrhizae 16g, Rhizoma Curcumae Longae 40g, Radix Scutellariae 40g, zinc oxide 72g, salicylic acid 16g, Mentholum 25g, sulfur 25g, Borneolum Syntheticum 15g, tretinoin 0.6g and azone 10ml, is external-use tincture.
Embodiment two
A kind ofly treating psoriatic Chinese medicine, is to be prepared into by Radix Et Rhizoma Rhei 30g, Radix Arnebiae (Radix Lithospermi) 10g, Radix Glycyrrhizae 10g, Rhizoma Curcumae Longae 30g, Radix Scutellariae 30g, zinc oxide 50g, salicylic acid 10g, Mentholum 10g, sulfur 10g, Borneolum Syntheticum 10g, tretinoin 0.1g and azone 10ml, is external-use tincture.
Embodiment three
A kind ofly treating psoriatic Chinese medicine, is to be prepared into by Radix Et Rhizoma Rhei 60g, Radix Arnebiae (Radix Lithospermi) 30g, Radix Glycyrrhizae 30g, Rhizoma Curcumae Longae 60g, Radix Scutellariae 60g, zinc oxide 80g, salicylic acid 30g, Mentholum 50g, sulfur 50g, Borneolum Syntheticum 20g, tretinoin 1g and azone 10ml, is external-use tincture.
Embodiment four
A kind ofly treat psoriatic preparation method, with Radix Et Rhizoma Rhei 54g, Radix Arnebiae (Radix Lithospermi) 16g, Radix Glycyrrhizae 16g, Rhizoma Curcumae Longae 40g, Radix Scutellariae 40g, five tastes Chinese herbal medicine powder is broken into coarse powder and inserts and add zinc oxide 72g, sulfur 25g and 75% ethanol 700ml in suitable hermetic container, airtight, jolting constantly, put into room temperature dark place dipping 3 days, inclining upper strata liquid, squeeze and filter merging filtrate, static 24 hours, add respectively salicylic acid 16g after filtration, Mentholum 25g, tretinoin 1g, azone 10ml, and add 75% ethanol to the 1000ml packing, and get final product.
Claims (2)
1. treat psoriatic Chinese medicine for one kind, it is characterized in that being prepared into by Radix Et Rhizoma Rhei powder 30-60g, Radix Arnebiae (Radix Lithospermi) powder 10-30g, Radix Glycyrrhizae powder 10-30g, curcuma powder 30-60g, Radix Scutellariae powder 30-60g, oxide powder and zinc 50-80g, salicylic acid 10-30g, Mentholum 10-50g, Cosan 10-50g, Borneolum Syntheticum powder 10-20g, tretinoin 0.1-1g and azone 10ml, be external-use tincture.
2. preparation method for the treatment of psoriatic Chinese medicine, it is characterized in that getting Radix Et Rhizoma Rhei 30-60g, Radix Arnebiae (Radix Lithospermi) 10-30g, Radix Glycyrrhizae 10-30g, Rhizoma Curcumae Longae 30-60g, Radix Scutellariae 30-60g, Borneolum Syntheticum 10-20g, be ground into coarse powder, put into hermetic container, adding zinc oxide 50-80g, sulfur 10-50g and mass concentration is 75% ethanol 700ml again, after mixing, puts into room temperature dark place dipping 5 days, filter filtrate for later use; Separately get mass concentration and be 75% ethanol 300ml and joined in medicinal residues dipping 3 days, filter, merge filtrate twice, standing 24 hours, refilter, filtrate adds salicylic acid 10-30g, Mentholum 10-50g, tretinoin 0.1-1g, azone 10ml, and adds 75% ethanol to 1000ml, and get final product, by setting metering, distributing, packaging.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201010187977 CN101856479B (en) | 2010-06-01 | 2010-06-01 | Chinese medicament for treating psoriasis vulgaris and preparation method thereof |
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| CN 201010187977 CN101856479B (en) | 2010-06-01 | 2010-06-01 | Chinese medicament for treating psoriasis vulgaris and preparation method thereof |
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| CN101856479A CN101856479A (en) | 2010-10-13 |
| CN101856479B true CN101856479B (en) | 2013-05-08 |
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| CN102988471B (en) * | 2012-12-14 | 2014-04-09 | 黄石市第一医院 | Compound sweet zinc cream used for treating eczema of infant and preparation method thereof |
| CN104434956B (en) * | 2013-09-25 | 2018-10-19 | 重庆华邦制药有限公司 | Treat the compound preparation of acne, psoriasis and acne rosacea |
| CN114209687A (en) * | 2021-12-20 | 2022-03-22 | 重庆华邦制药有限公司 | Composition of tretinoin external medicine |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1939522A (en) * | 2005-09-30 | 2007-04-04 | 曾雄辉 | Externally-applied medicinal composition for treating dermatosis and its making method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1939522A (en) * | 2005-09-30 | 2007-04-04 | 曾雄辉 | Externally-applied medicinal composition for treating dermatosis and its making method |
Non-Patent Citations (3)
| Title |
|---|
| 刘梅青.紫草的研究进展及在皮肤科的应用.《山西医药杂志》.2003,第32卷(第4期),357-358. * |
| 刘跃华.银屑病的外用药物治疗.《中国全科医学》.2005,第8卷(第12期),954-955. * |
| 徐参.锌制剂外用与银屑病人血浆锌含量的关系.《国际皮肤性病学杂志》.1981,(第4期),225-226. * |
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