CN101856479A - Chinese medicament for treating psoriasis vulgaris and preparation method thereof - Google Patents
Chinese medicament for treating psoriasis vulgaris and preparation method thereof Download PDFInfo
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- CN101856479A CN101856479A CN201010187977A CN201010187977A CN101856479A CN 101856479 A CN101856479 A CN 101856479A CN 201010187977 A CN201010187977 A CN 201010187977A CN 201010187977 A CN201010187977 A CN 201010187977A CN 101856479 A CN101856479 A CN 101856479A
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Abstract
The invention discloses a method for preparing a Chinese medicament for treating psoriasis vulgaris. The Chinese medicament is characterized in that: the Chinese medicament is prepared from the following components: 30 to 60g of rhubarb powder, 10 to 30g of arnebia root, 10 to 30g of licorice powder, 30 to 60g of turmeric powder, 30 to 60g of radix scutellariae powder, 50 to 80g of zinc oxide powder, 10 to 30g of salicylic acid, 10 to 50g of menthol crystal, 10 to 50g of sulfur powder, 10 to 20g of borneol powder, 0.1 to 1g of retinoic acid, and 10ml of azone, and the Chinese medicament is a topical tincture. The Chinese medicament for treating the psoriasis vulgaris has the effects of clearing heat and releasing toxin, diminishing inflammation and easing pain, and clearing damp and relieving itching, and has good treatment effect on the psoriasis vulgaris.
Description
The present invention relates to a kind of Chinese medicine, specifically relate to the psoriatic medicine for external use of a kind of treatment, trade name is a silver bits tincture varnish.
Background technology
Psoriasis is commonly called as psoriasis, and traditional Chinese medical science Gu is called " white malaria " disease, is a kind of common chronic dermatosis.Be characterized on erythema, occurring repeatedly the silvery white dry squama of multilamellar.
Psoriasis substantially can divide four types, and first psoriasis vulgaris can betide whole body everywhere, but is common with scalp, lumbosacral region, patella ulnaris and extremity; It two is psoriasis pustulosas, comprises generalized pustular psoriasis, many acute attacks, and very fast general whole body is with hyperpyrexia; It three is psoriasis arthropathica, claims psoriasis arthropathica again; It four is erythrodermic psoriasis, claims the psoriasis exfoliative dermatitis again, and above-mentioned two, three and four classes silver bits inflammation is more rare or rare.
Psoriasis not only diminishes patient's image appearance, and because of very itching and showing effect repeatedly and bring misery and stress to the patient.
Still there is not specific short at present, mainly be to embrocate with coal-tar ointment, calcipotriol ointment, mustard gas ointment part, these medicines can make skin damage disappear, but can not prevent recurrence, and the course of treatment is long, in addition, adopt methods such as oral tretinoin, methotrexate or ciclosporin, though can be temporarily effective, very easily recur after the drug withdrawal, and hemopoietic system and Liver and kidney are all had damage.
Psoriasis is more easily diagnosed, and should attention differentiate mutually with pityriasis rosea and seborrhea skin class.
Summary of the invention
Purpose of the present invention provides a kind of short treating period, instant effect, is difficult for the psoriatic Traditional Chinese medicine liniment of a kind of treatment of recurrence.
The technical scheme that adopts is:
The psoriatic Chinese medicine of a kind of treatment is to be prepared into by Radix Et Rhizoma Rhei powder 30-60g, Radix Arnebiae (Radix Lithospermi) powder 10-30g, Radix Glycyrrhizae powder 10-30g, curcuma powder 30-60g, Radix Scutellariae powder 30-60g, oxide powder and zinc 50-80g, salicylic acid 10-30g, Mentholum 10-50g, Cosan 10-50g, Borneolum Syntheticum powder 10-20g, tretinoin 0.1-1g and azone 10ml.
The psoriatic preparation method of Chinese medicine of a kind of treatment, be to get Radix Et Rhizoma Rhei 30-60g, Radix Arnebiae (Radix Lithospermi) 10-30g, Radix Glycyrrhizae 10-30g, Rhizoma Curcumae Longae 30-60g, Radix Scutellariae 30-60g, Borneolum Syntheticum 10-20g, be ground into coarse powder, put into hermetic container, add zinc oxide 50-80g, sulfur 10-50g and mass concentration again and be 75% ethanol 700ml, after mixing, put into room temperature dark place dipping 5 days, filter filtrate for later use; Other gets mass concentration is that 75% ethanol 300ml joined in the medicinal residues dipping 3 days, filter, merge filtrate twice, left standstill 24 hours, refilter, add salicylic acid 10-30g, Mentholum 10-50g, tretinoin 0.1-1g, azone 10ml in the filtrate, and add 75% ethanol to 1000ml, that is, can be by setting the metering packing.
The function of selected Chinese crude drug with cure mainly:
Radix Et Rhizoma Rhei: clearing away heat-fire detoxifcation, blood circulation promoting and blood stasis dispelling.
Radix Scutellariae: heat clearing and damp drying, the fire detoxifcation of dispelling.
Radix Arnebiae (Radix Lithospermi): relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Rhizoma Curcumae Longae: promoting blood circulation and stopping pain is used for all carbuncle pain infections furuncles, reducing swelling and alleviating pain.
Salicylic acid: anti-inflammation impels cutin absent-mindedness effect.
Mentholum: dispelling wind and heat pathogens rash.
Borneolum Syntheticum: anti-inflammatory, antibacterial is antipruritic.
Sulfur: killing parasites for relieving itching, impel cuticle horny layer softening nucleus formation.
Tretinoin: suppress the sebum secretion effect, powerful skin palpus cell proliferation or synthetic, the immunoregulation effect of suppressing.
Radix Glycyrrhizae: relieving spasm to stop pain coordinating the actions of various ingredients in a prescription.
Azone: anti-inflammatory anti-itch helps the effect of oozing.
Using method: be applied in lesions position, every day sooner or later respectively once.
Efficacy of drugs:
The common function that medicine is formed is heat-clearing and toxic substances removing, anti-inflammatory analgetic, removing dampness to relieve itching, and psoriasis is had better curative effect.
Hospital carries out repeatedly actual therapeutic with the psoriatic Chinese medicine of treatment of the present invention under the applicant, and curative effect is obvious, welcome by the patient, and for declaring patent, on June 10th, 2008 rose and tested specially.
Clinical data: select 120 routine patients with psoriasis vulgaris, male 78 examples, women 42 examples, 32.0 years old mean age (21-70 year).Course of disease 2-42.Drop shape 70 examples, speckle shape 50 examples.
Diagnostic criteria: trunk, extremity skin lesion differ in size based on the dark red speckle of wellability, and hypertrophy is obviously plump, and conscious pruritus is covered silvery white squama on the skin lesion, strike off the thin film that the visible substrate of squama has one deck light, visible petechial hemorrhage under the thin film.
Efficacy determination: the standard of including in meets diagnostic criteria and the psoriatic lesion area and serious index (PAS1) scoring of homeliness type and psoriasis pustulosa, and the untoward reaction that occurs in the record treatment, total mark * 100% before therapeutic index=(total mark before the treatment-treatment back total mark)/treatment.Cure: therapeutic index 〉=90%, produce effects: therapeutic index is 60%-89%, progressive: therapeutic index is 20%-59%; Invalid: therapeutic index＜20%.Cure the percentage ratio that adds produce effects example number and count effective percentage.
Untoward reaction: the patient has burn feeling 5 examples, mainly is that silver bits tincture varnish is wiped skin irritation symptom, behind drug withdrawal or the minimizing medication number of times, and the very fast alleviation of irritation.
The result: the back curative effect sees Table 1 around two groups of psoriasis vulgaris patient treatments, and as seen from Table 1, outer liniment of oral combination and simple oral capsule for treating psoriatic cure rate be X relatively
2=13.33, p＜0.01, difference has statistical significance, effective percentage comparing difference not statistically significant.
Table 1 liang group oral capsule compares [example] in conjunction with back curative effect around externally applied liniment and the simple oral capsule for treating psoriatic
| Group | The example number | Treatment | Produce effects | Progressive | Invalid | Cure rate | Effective percentage |
| The simple oral capsule | ??50 | ??33 | ??13 | ??4 | ??0 | ??66.0 | ??92.0 |
| Oral capsule is in conjunction with externally applied liniment | ??70 | ??58 | ??10 | ??2 | ??0 | ??82.6 | ??97.1 |
The specific embodiment
Embodiment one
The psoriatic Chinese medicine of a kind of treatment is to be prepared into by Radix Et Rhizoma Rhei 54g, Radix Arnebiae (Radix Lithospermi) 16g, Radix Glycyrrhizae 16g, Rhizoma Curcumae Longae 40g, Radix Scutellariae 40g, zinc oxide 72g, salicylic acid 16g, Mentholum 25g, sulfur 25g, Borneolum Syntheticum 15g, tretinoin 0.6g and azone 10ml, is external-use tincture.
Embodiment two
The psoriatic Chinese medicine of a kind of treatment is to be prepared into by Radix Et Rhizoma Rhei 30g, Radix Arnebiae (Radix Lithospermi) 10g, Radix Glycyrrhizae 10g, Rhizoma Curcumae Longae 30g, Radix Scutellariae 30g, zinc oxide 50g, salicylic acid 10g, Mentholum 10g, sulfur 10g, Borneolum Syntheticum 10g, tretinoin 0.1g and azone 10ml, is external-use tincture.
Embodiment three
The psoriatic Chinese medicine of a kind of treatment is to be prepared into by Radix Et Rhizoma Rhei 60g, Radix Arnebiae (Radix Lithospermi) 30g, Radix Glycyrrhizae 30g, Rhizoma Curcumae Longae 60g, Radix Scutellariae 60g, zinc oxide 80g, salicylic acid 30g, Mentholum 50g, sulfur 50g, Borneolum Syntheticum 20g, tretinoin 1g and azone 10ml, is external-use tincture.
Embodiment four
The psoriatic preparation method of a kind of treatment, be with Radix Et Rhizoma Rhei 54g, Radix Arnebiae (Radix Lithospermi) 16g, Radix Glycyrrhizae 16g, Rhizoma Curcumae Longae 40g, Radix Scutellariae 40g, five tastes Chinese herbal medicine powder is broken into coarse powder and inserts adding zinc oxide 72g, sulfur 25g and 75% ethanol 700ml in the suitable hermetic container, airtight, jolting constantly, put into room temperature dark place dipping 3 days, inclining upper strata liquid, squeeze and filter merging filtrate, static 24 hours, add salicylic acid 16g after the filtration respectively, Mentholum 25g, tretinoin 1g, azone 10ml, and add 75% ethanol to the 1000ml packing, promptly.
Claims (2)
1. treat psoriatic preparation method of Chinese medicine for one kind, it is characterized in that being prepared into, be external-use tincture by Radix Et Rhizoma Rhei powder 30-60g, Radix Arnebiae (Radix Lithospermi) powder 10-30g, Radix Glycyrrhizae powder 10-30g, curcuma powder 30-60g, Radix Scutellariae powder 30-60g, oxide powder and zinc 50-80g, salicylic acid 10-30g, Mentholum 10-50g, Cosan 10-50g, Borneolum Syntheticum powder 10-20g, tretinoin 0.1-1g and azone 10ml.
2. the psoriatic preparation method of Chinese medicine of a kind of treatment according to claim 1, it is characterized in that getting Radix Et Rhizoma Rhei 30-60g, Radix Arnebiae (Radix Lithospermi) 10-30g, Radix Glycyrrhizae 10-30g, Rhizoma Curcumae Longae 30-60g, Radix Scutellariae 30-60g, Borneolum Syntheticum 10-20g, be ground into coarse powder, put into hermetic container, add zinc oxide 50-80g, sulfur 10-50g and mass concentration again and be 75% ethanol 700ml, after mixing, put into room temperature dark place dipping 5 days, filter filtrate for later use; Other gets mass concentration is that 75% ethanol 300ml joined in the medicinal residues dipping 3 days, filter, merge filtrate twice, left standstill 24 hours, refilter, filtrate adds salicylic acid 10-30g, Mentholum 10-50g, tretinoin 0.1-1g, azone 10ml, and adds 75% ethanol to 1000ml, that is, can be by setting the metering packing.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201010187977 CN101856479B (en) | 2010-06-01 | 2010-06-01 | Chinese medicament for treating psoriasis vulgaris and preparation method thereof |
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| CN 201010187977 CN101856479B (en) | 2010-06-01 | 2010-06-01 | Chinese medicament for treating psoriasis vulgaris and preparation method thereof |
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| CN101856479A true CN101856479A (en) | 2010-10-13 |
| CN101856479B CN101856479B (en) | 2013-05-08 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988471A (en) * | 2012-12-14 | 2013-03-27 | 黄石市第一医院 | Compound sweet zinc cream used for treating eczema of infant and preparation method thereof |
| CN104434956A (en) * | 2013-09-25 | 2015-03-25 | 重庆华邦制药有限公司 | Compound preparation for treating acne, psoriasis and acne rosacea |
| CN114209687A (en) * | 2021-12-20 | 2022-03-22 | 重庆华邦制药有限公司 | Composition of tretinoin external medicine |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1939522A (en) * | 2005-09-30 | 2007-04-04 | 曾雄辉 | Externally-applied medicinal composition for treating dermatosis and its making method |
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2010
- 2010-06-01 CN CN 201010187977 patent/CN101856479B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1939522A (en) * | 2005-09-30 | 2007-04-04 | 曾雄辉 | Externally-applied medicinal composition for treating dermatosis and its making method |
Non-Patent Citations (3)
| Title |
|---|
| 《中国全科医学》 20050630 刘跃华 银屑病的外用药物治疗 954-955 1-2 第8卷, 第12期 2 * |
| 《国际皮肤性病学杂志》 19811231 徐参 锌制剂外用与银屑病人血浆锌含量的关系 225-226 1-2 , 第4期 2 * |
| 《山西医药杂志》 20030831 刘梅青 紫草的研究进展及在皮肤科的应用 357-358 1-2 第32卷, 第4期 2 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988471A (en) * | 2012-12-14 | 2013-03-27 | 黄石市第一医院 | Compound sweet zinc cream used for treating eczema of infant and preparation method thereof |
| CN104434956A (en) * | 2013-09-25 | 2015-03-25 | 重庆华邦制药有限公司 | Compound preparation for treating acne, psoriasis and acne rosacea |
| CN104434956B (en) * | 2013-09-25 | 2018-10-19 | 重庆华邦制药有限公司 | Treat the compound preparation of acne, psoriasis and acne rosacea |
| CN114209687A (en) * | 2021-12-20 | 2022-03-22 | 重庆华邦制药有限公司 | Composition of tretinoin external medicine |
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| CN101856479B (en) | 2013-05-08 |
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