CN107874258A - A kind of method for preparing cod liver oil capsule using thick cod-liver oil extract - Google Patents
A kind of method for preparing cod liver oil capsule using thick cod-liver oil extract Download PDFInfo
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- CN107874258A CN107874258A CN201711161891.9A CN201711161891A CN107874258A CN 107874258 A CN107874258 A CN 107874258A CN 201711161891 A CN201711161891 A CN 201711161891A CN 107874258 A CN107874258 A CN 107874258A
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- 239000003026 cod liver oil Substances 0.000 title claims abstract description 116
- 235000012716 cod liver oil Nutrition 0.000 title claims abstract description 116
- 239000002775 capsule Substances 0.000 title claims abstract description 27
- 238000000034 method Methods 0.000 title claims abstract description 25
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 33
- 238000003756 stirring Methods 0.000 claims abstract description 19
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000007853 buffer solution Substances 0.000 claims abstract description 15
- XPFJYKARVSSRHE-UHFFFAOYSA-K trisodium;2-hydroxypropane-1,2,3-tricarboxylate;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound [Na+].[Na+].[Na+].OC(=O)CC(O)(C(O)=O)CC(O)=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O XPFJYKARVSSRHE-UHFFFAOYSA-K 0.000 claims abstract description 14
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 8
- 239000008346 aqueous phase Substances 0.000 claims abstract description 8
- 239000007864 aqueous solution Substances 0.000 claims abstract description 8
- 239000000835 fiber Substances 0.000 claims abstract description 8
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000007901 soft capsule Substances 0.000 claims abstract description 8
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 8
- 229940046009 vitamin E Drugs 0.000 claims abstract description 8
- 239000011709 vitamin E Substances 0.000 claims abstract description 8
- 239000007788 liquid Substances 0.000 claims abstract description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 21
- 210000004185 liver Anatomy 0.000 claims description 14
- 239000003921 oil Substances 0.000 claims description 10
- 235000019198 oils Nutrition 0.000 claims description 10
- 239000001509 sodium citrate Substances 0.000 claims description 8
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 6
- 239000005909 Kieselgur Substances 0.000 claims description 3
- 238000004062 sedimentation Methods 0.000 claims description 3
- 229910052710 silicon Inorganic materials 0.000 claims description 3
- 239000010703 silicon Substances 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 241000251468 Actinopterygii Species 0.000 abstract description 11
- 239000003205 fragrance Substances 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 26
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 9
- 239000002253 acid Substances 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 238000005406 washing Methods 0.000 description 5
- 239000001913 cellulose Substances 0.000 description 4
- 229920002678 cellulose Polymers 0.000 description 4
- 239000004744 fabric Substances 0.000 description 4
- 150000002978 peroxides Chemical class 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 239000004745 nonwoven fabric Substances 0.000 description 3
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 2
- 235000005979 Citrus limon Nutrition 0.000 description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 235000020995 raw meat Nutrition 0.000 description 2
- 235000019155 vitamin A Nutrition 0.000 description 2
- 239000011719 vitamin A Substances 0.000 description 2
- 229940045997 vitamin a Drugs 0.000 description 2
- 241000283153 Cetacea Species 0.000 description 1
- 244000248349 Citrus limon Species 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 229920001131 Pulp (paper) Polymers 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000004332 deodorization Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 201000000909 keratomalacia Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
- A23L5/27—Removal of unwanted matter, e.g. deodorisation or detoxification by chemical treatment, by adsorption or by absorption
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
- A23L5/27—Removal of unwanted matter, e.g. deodorisation or detoxification by chemical treatment, by adsorption or by absorption
- A23L5/276—Treatment with inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Mycology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Edible Oils And Fats (AREA)
Abstract
The invention discloses a kind of method for preparing cod liver oil capsule using thick cod-liver oil extract, and it passes through following steps：（1）Thick cod-liver oil is provided, washed using citric acid sodium citrate buffer solution；（2）The NaOH aqueous solution and diatomite are added in the thick cod-liver oil described in step 1, aqueous phase is removed after stirring；（3）Dry fiber element nonwoven strip is added in the cod-liver oil, pulls the nonwoven strip after stirring out；（4）Atlapulgite is added in the cod-liver oil to dry；（5）The cod-liver oil of step 4 is distilled untill no liquid steams at reduced pressure conditions；（6）Vitamin E will be added in the cod-liver oil of step 5, be filled in soft capsule, obtain cod liver oil capsule.The preparation-obtained cod liver oil capsule of method of the present invention has the fragrance of ocean fish, higher without obvious fishlike smell, its acceptance.
Description
Technical field
It is especially a kind of to prepare cod liver oil capsule using thick cod-liver oil extract the present invention relates to the preparation of dietetic product
Method.
Background technology
Cod-liver oil is (also referred to as " liver oil ") oil extracted in a kind of marine fishes liver from cod etc., usually yellow to orange
Red transparent oily liquid, band have a fish like smell.The grease that the cod-liver oil of narrow sense is refined by extra large fish liver.The cod-liver oil of broad sense
Also include the liver oil of the extra large beasts such as whale, sea dog.It is usually used in preventing and treating yctalopia, keratomalacia etc., to epidermises such as breathing unexposed layer mucous membranes
Tissue also has protective effect.Vitamin A and D are mainly contained in cod-liver oil, the major function of vitamin A is to maintain body normal
Growth, reproduction, vision, epithelial tissue be sound and anti-infectious immunity function.
Cod-liver oil is during taking, because it has obvious fishlike smell, in child or when taking of sensitive group
Often compliance is bad.
At present, thick cod-liver oil is handled there is an urgent need to one kind, the method for reducing its fishlike smell.
The content of the invention
In order to overcome deficiency of the prior art, it is an object of the invention to provide one kind to utilize thick cod-liver oil extract system
The method of standby cod liver oil capsule, so as to obtain without the higher fish oil product of obvious fishlike smell, acceptance.
The technical solution adopted for the present invention to solve the technical problems is：One kind prepares fish liver using thick cod-liver oil extract
The method of oil capsule, it is characterised in that：It passes through following steps：
（1）Thick cod-liver oil is provided, washed under 3-5 degrees Celsius using the citric acid-sodium citrate buffer solution that pH is 6-6.5
2-4 times；Wherein, citric acid and sodium citrate add up to 0.2-0.4mol/L in citric acid-sodium citrate buffer solution；
（2）The 20-25% NaOH aqueous solution of 5-10% volumes and the silicon of 1-3% weight are added in the thick cod-liver oil described in step 1
Diatomaceous earth, aqueous phase is removed after stirring 10-15 minutes；
（3）The dry fiber element nonwoven strip of 0.5-1.0% weight is added in the cod-liver oil, this is pulled out after stirring 10-15 minutes
Nonwoven strip；
（4）The atlapulgite that 0.5-1.0% weight is added in the cod-liver oil dries 2-4 hours；
（5）The cod-liver oil of step 4 is distilled untill no liquid steams at reduced pressure conditions；
（6）Reach 30-60mg/100g cod-liver oil by vitamin E is added in the cod-liver oil of step 5, be filled in soft capsule, obtain
Cod liver oil capsule.
In currently preferred aspect, in step 1, described thick cod-liver oil is to prepare as follows：Will be new
After fresh cod liver is cleaned and drained, the homogenate of equivalent water is added, adds 10% sodium hydroxide to be heated to 80 after adjusting pH to 9.0
Degree Celsius stirring 30 minutes, adds the sodium chloride of cod liver weight 8% and stirs, and subsequent standing sedimentation and centrifuges,
Obtained faint yellow oil layer.
In currently preferred aspect, in step 1, there is provided thick cod-liver oil, at 4 deg. celsius using the lemon that pH is 6.3
Lemon acid-sodium citrate buffer solution carries out washing 3 times, and citric acid and sodium citrate close wherein in citric acid-sodium citrate buffer solution
It is calculated as 0.32mol/L.
In currently preferred aspect, in step 2, the 22% of 7% volume is added in the thick cod-liver oil described in step 1
The diatomite of the NaOH aqueous solution and 2.0% weight, stirring remove aqueous phase after 12 minutes.
In currently preferred aspect, in step 3, the dry fiber element nothing of 0.75% weight is added in the cod-liver oil
Cloth is spun, stirring pulls the nonwoven strip out after 12 minutes.
In currently preferred aspect, in step 3, described nonwoven strip is cut into width 2-4mm, thickness 80-
120 grams every square metre.
In currently preferred aspect, in step 4, the atlapulgite that 0.75% weight is added in the cod-liver oil is dried
3.5 hour.
In currently preferred aspect, in step 6, reach 42mg/ by vitamin E is added in the cod-liver oil of step 5
100g cod-liver oil, is filled in soft capsule, obtains cod liver oil capsule.
The preparation-obtained cod liver oil capsule of method of the present invention has the fragrance of ocean fish, without obvious fish raw meat
Taste, its acceptance are higher.
Embodiment
Unless additionally illustrating, in following embodiment, " thick cod-liver oil " is prepared as follows：By fresh cod
After liver is cleaned and drained, the homogenate of equivalent water is added, adds 10% sodium hydroxide to be heated to 80 degrees Celsius after adjusting pH to 9.0
Stirring 30 minutes, add the sodium chloride of cod liver weight 8% and stir, subsequent standing sedimentation and centrifuge what is obtained
Faint yellow oil layer.The step of thick cod-liver oil is undried, washing.
Unless additionally illustrating, " nonwoven strip " is purchased from Kimberly-Clark Corporation, and it has 2.5mm width and 90
Gram every square metre of thickness, it is completely as made by wood pulp cellulose.
Embodiment 1
In the present embodiment, a kind of method for preparing cod liver oil capsule using thick cod-liver oil extract, it passes through following steps：
（1）Thick cod-liver oil is provided, carries out washing 3 times using the citric acid-sodium citrate buffer solution that pH is 6.3 at 4 deg. celsius；
Wherein, citric acid and sodium citrate add up to 0.32mol/L in citric acid-sodium citrate buffer solution；
（2）The 22% NaOH aqueous solution of 7% volume and the diatomite of 2.0% weight are added in the thick cod-liver oil described in step 1, is stirred
Aqueous phase is removed after mixing 12 minutes；
（3）The dry fiber element nonwoven strip of 0.75% weight is added in the cod-liver oil, stirring pulls the non-woven fabrics out after 12 minutes
Bar；
（4）The atlapulgite that 0.75% weight is added in the cod-liver oil is dried 3.5 hours；（5）The cod-liver oil of step 4 is being subtracted
Distillation is untill no liquid steams under the conditions of pressure；
（6）Reach 42mg/100g cod-liver oil by vitamin E is added in the cod-liver oil of step 5, be filled in soft capsule, obtain fish
Liver oil capsule.
Embodiment 2
In the present embodiment, a kind of method for preparing cod liver oil capsule using thick cod-liver oil extract, it passes through following steps：
（1）Thick cod-liver oil is provided, washing 2 times is carried out using the citric acid-sodium citrate buffer solution that pH is 6.5 under 3 degrees Celsius；
Wherein, citric acid and sodium citrate add up to 0.4mol/L in citric acid-sodium citrate buffer solution；
（2）The 25% NaOH aqueous solution of 5% volume and the diatomite of 1% weight are added in the thick cod-liver oil described in step 1, is stirred
Aqueous phase is removed after 15 minutes；
（3）The dry fiber element nonwoven strip of 0.5% weight is added in the cod-liver oil, stirring pulls the non-woven fabrics out after 15 minutes
Bar；
（4）The atlapulgite that 0.5% weight is added in the cod-liver oil is dried 4 hours；
（5）The cod-liver oil of step 4 is distilled untill no liquid steams at reduced pressure conditions；
（6）Reach 60mg/100g cod-liver oil by vitamin E is added in the cod-liver oil of step 5, be filled in soft capsule, obtain fish
Liver oil capsule.
Embodiment 3
In the present embodiment, a kind of method for preparing cod liver oil capsule using thick cod-liver oil extract, it passes through following steps：
（1）Thick cod-liver oil is provided, carries out washing 4 times using the citric acid-sodium citrate buffer solution that pH is 6 at 5 c；Its
In, citric acid and sodium citrate add up to 0.2mol/L in citric acid-sodium citrate buffer solution；
（2）The 20% NaOH aqueous solution of 10% volume and the diatomite of 3% weight are added in the thick cod-liver oil described in step 1, is stirred
Aqueous phase is removed after mixing 10 minutes；
（3）The dry fiber element nonwoven strip of 1.0% weight is added in the cod-liver oil, stirring pulls the non-woven fabrics out after 10 minutes
Bar；
（4）The atlapulgite that 1.0% weight is added in the cod-liver oil is dried 2 hours；
（5）The cod-liver oil of step 4 is distilled untill no liquid steams at reduced pressure conditions；
（6）Reach 30mg/100g cod-liver oil by vitamin E is added in the cod-liver oil of step 5, be filled in soft capsule, obtain fish
Liver oil capsule.
Comparative example 1
In this comparative example, the difference of its method and embodiment 1 is：Do not perform step 1.
Comparative example 2
In this comparative example, the difference of its method and embodiment 1 is：Step 1 and 2 reverse execution.
Comparative example 3
In this comparative example, the difference of its method and embodiment 1 is：Do not perform step 3.
First, embodiment 1-3 and comparative example 1-3 cod-liver oil recovery test
In this experiment, embodiment 1-3 and comparative example the 1-3 rate of recovery are investigated, and by initiation material and finally
The weight of product is all recorded in table 1.
Table 1：The embodiment 1-3 and comparative example 1-3 cod-liver oil rate of recovery
| Group number | Thick cod-liver oil weight/g | Refined cod-liver oil weight/g | The rate of recovery/% |
| Embodiment 1 | 200.0 | 142.9 | 71.43 |
| Embodiment 2 | 200.0 | 138.9 | 69.45 |
| Embodiment 3 | 200.0 | 141.0 | 70.51 |
| Comparative example 1 | 200.0 | 145.0 | 72.50 |
| Comparative example 2 | 200.0 | 129.6 | 64.82 |
| Comparative example 3 | 200.0 | 152.6 | 76.29 |
During from table 1 it can be appreciated that by step 1 and 2 reverse execution, its yield has declined.And enter without using step 3
When row cellulose non-woven cloth is adsorbed, yield has risen.
2nd, embodiment 1-3 and comparative example 1-3 cod-liver oil acid number and peroxide value Experimental Comparison
In this experiment, the step 5 product cod-liver oil of each embodiment is measured according to GB/T 5009.37-2003 method
Acid number, the peroxide value of the step 5 product cod-liver oil of each embodiment is measured according to GB/T 5538-2005 method, it is tried
Result is tested to be recorded in table 2.
Table 2：The acid number and peroxide value of embodiment 1-3 and comparative example 1-3 cod-liver oil.
| Group number | Acid number mg/g | Peroxide value mg/g |
| Embodiment 1 | 1.07 | 2.52 |
| Embodiment 2 | 1.10 | 2.67 |
| Embodiment 3 | 1.13 | 2.49 |
| Comparative example 1 | 1.72 | 3.11 |
| Comparative example 2 | 1.54 | 2.84 |
| Comparative example 3 | 2.15 | 2.65 |
It can be seen that, embodiment 1-3 and comparative example 1-3 can produce preferable acid number and peroxidating in the present embodiment
Value.It is worth noting that, the horizontal slightly lifting of acid number in comparative example 1-3.
3rd, embodiment 1-3 and comparative example 1-3 cod-liver oil smelling is tested
In this experiment, the smelling experiment of each group cod-liver oil has been carried out.
In this experiment, 20 subjects are recruited, and each subject is required smelling embodiment 1-3 and comparative example
5 grams of 1-3 cod-liver oil sample, and provide the sequence of the order of severity of its " fishlike smell ".Come first place, that is, fish raw meat
Taste it is the most serious be designated as 0 point, secondly be 1 point, 2 points, 3 points, 4 points and 5 points（5 points of fishlike smell is most light）.Its result of the test is remembered
Record is in table 3.
Table 3：The smelling result of embodiment 1-3 and comparative example 1-3 cod-liver oil sample.
| Group number | Smelling call |
| Embodiment 1 | 89 |
| Embodiment 2 | 68 |
| Embodiment 3 | 76 |
| Comparative example 1 | 23 |
| Comparative example 2 | 34 |
| Comparative example 3 | 10 |
Data more than can see, and the smelling result in embodiment 1-3 shows preferably, hence it is evident that is better than comparative example 1-
3.Wherein, in the experiment adsorbed without using cellulose non-woven cloth, smelling result is worst.From this, cellulose without
Deodorization tool of the adsorption step of cloth progress for cod-liver oil is spun to have obvious benefits.
Claims (8)
- A kind of 1. method for preparing cod liver oil capsule using thick cod-liver oil extract, it is characterised in that：It passes through following steps：（1）Thick cod-liver oil is provided, washed under 3-5 degrees Celsius using the citric acid-sodium citrate buffer solution that pH is 6-6.5 2-4 times；Wherein, citric acid and sodium citrate add up to 0.2-0.4mol/L in citric acid-sodium citrate buffer solution；（2）The 20-25% NaOH aqueous solution of 5-10% volumes and the silicon of 1-3% weight are added in the thick cod-liver oil described in step 1 Diatomaceous earth, aqueous phase is removed after stirring 10-15 minutes；（3）The dry fiber element nonwoven strip of 0.5-1.0% weight is added in the cod-liver oil, this is pulled out after stirring 10-15 minutes Nonwoven strip；（4）The atlapulgite that 0.5-1.0% weight is added in the cod-liver oil dries 2-4 hours；（5）The cod-liver oil of step 4 is distilled untill no liquid steams at reduced pressure conditions；（6）Reach 30-60mg/100g cod-liver oil by vitamin E is added in the cod-liver oil of step 5, be filled in soft capsule, obtain Cod liver oil capsule.
- 2. a kind of method for preparing cod liver oil capsule using thick cod-liver oil extract according to claim 1, its feature exist In：In step 1, described thick cod-liver oil is to prepare as follows：After fresh cod liver is cleaned and drained, The homogenate of equivalent water is added, adds 10% sodium hydroxide to adjust and is heated to 80 degrees Celsius after pH to 9.0 and stirs 30 minutes, add cod The sodium chloride of liver weight 8% and stir, subsequent standing sedimentation and centrifuge, obtained faint yellow oil layer.
- 3. a kind of method for preparing cod liver oil capsule using thick cod-liver oil extract according to claim 1, its feature exist In：In step 1, there is provided thick cod-liver oil, washed at 4 deg. celsius using the citric acid-sodium citrate buffer solution that pH is 6.3 Wash 3 times, wherein citric acid and sodium citrate add up to 0.32mol/L in citric acid-sodium citrate buffer solution.
- 4. a kind of method for preparing cod liver oil capsule using thick cod-liver oil extract according to claim 1, its feature exist In：In step 2, the 22% NaOH aqueous solution of 7% volume and the silicon of 2.0% weight are added in the thick cod-liver oil described in step 1 Diatomaceous earth, stirring remove aqueous phase after 12 minutes.
- 5. a kind of method for preparing cod liver oil capsule using thick cod-liver oil extract according to claim 1, its feature exist In：In step 3, the dry fiber element nonwoven strip of 0.75% weight is added in the cod-liver oil, stirring pulls this out after 12 minutes Nonwoven strip.
- 6. a kind of method for preparing cod liver oil capsule using thick cod-liver oil extract according to claim 5, its feature exist In：In step 3, described nonwoven strip is cut into width 2-4mm, and thickness is 80-120 grams every square metre.
- 7. a kind of method for preparing cod liver oil capsule using thick cod-liver oil extract according to claim 1, its feature exist In：In step 4, the atlapulgite that 0.75% weight is added in the cod-liver oil is dried 3.5 hours.
- 8. a kind of method for preparing cod liver oil capsule using thick cod-liver oil extract according to claim 1, its feature exist In：In step 6, vitamin E will be added in the cod-liver oil of step 5 and reaches 42mg/100g cod-liver oil, be filled in soft capsule, Obtain cod liver oil capsule.
Priority Applications (1)
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