CN107865936A - One kind treats DOMS compound safflower folium artemisiae argyi transdermal agent and preparation method thereof - Google Patents
One kind treats DOMS compound safflower folium artemisiae argyi transdermal agent and preparation method thereof Download PDFInfo
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Abstract
One kind treats DOMS compound safflower folium artemisiae argyi transdermal agent and preparation method thereof, including emulsion bases, skin penetration enhancer, and the mass ratio of the emulsion bases and skin penetration enhancer is 18:1；The emulsion bases is by Chinese medicine extract, feedstock emulsion according to 11:4 mass ratio is formed；In the Chinese medicine extract, each component in parts by weight, 240 250 parts of safflower, 90 95 parts of the Fen, Aralia woods root of folium artemisiae argyi 150 160,85 89 parts of laurusleaf jasmine herb, 60 68 parts of the saltbush that crawls, 52 60 parts of longpeduncle kadsura stem, 52 56 parts of ball Jia Opulus, 44 48 parts of geranium wilfordii, 40 45 parts of whiteflower violet herb with root, 35 40 parts of branchy paliurus root, 33 37 parts of twotooth achyranthes leaf, 31 35 parts of dioecious balanophora herb, 30 34 parts of, Bi Collettiis；Its preparation technology science, rationally, effectively, technological process is shorter, and cost is relatively low.The present invention has the function that to alleviate DOMS, enhancing muscular endurance, and it can effectively be solved in the prior art, and western medicine has the problem of certain side effect and treatment by Chinese herbs drug effect are slow, drug absorption effect is poor.
Description
Technical field
The present invention relates to field of traditional Chinese, and DOMS compound safflower folium artemisiae argyi transdermal agent is treated more particularly to one kind
And preparation method thereof.
Background technology
DOMS can divide acute and retardance two parts.Acute DOMS refers to rest during motion or after motion
The pain once just felt, it is more relevant with lactic acid accumulation；But Delayed Onset Muscle Soreness is that a couple of days after exercise occurs, more with
Muscle overuses, and causes tissue or fiber to be slightly broken relevant, and aching about can be in 5-7 day naturally with unconformable symptom
Alleviate.
The reason for causing DOMS has a lot, not single to only have hyperkinesia just to cause to ache, other as Changes in weather,
Medication etc. may also cause to ache.DOMS is common subjective symptoms, is sent out in muscle, tendon and vessel, ligament, fat and subcutaneous group
Knit.The sick generation also with fatigue, is caught cold relevant, such as keeps a kind of posture for a long time, summer and autumn sleep not lid quilt wind-engaging
It is cold to cause the disease, in the course of time, the tissue degeneratiaon of involvement can be made, cause in great pain, in arrested anxious, hold up sample pain to small
Leg, it is impossible to lie down, lie on one's side, it is impossible to which long-time is sat, vertical, fatiguability is weak, and whole body is listless and aching heavy, and affected part is cold, and daytime feels the back of the body
Portion's sleepiness is heavy, and as there is a weight tenesmus, after tired or very cold aggravates, and takes a turn for the better when fine day or warmer climate, has a strong impact on people
Routine work and quality of life.
Prevent or alleviate DOMS, can help to alleviate by taking exercise to keep fit or smear for a long time
The medicament of DOMS is completed.
Being presently used for the emulsifiable paste of alleviation DOMS mainly has the Ibuprofen cream of Fenbid 5% of Sino-U.S. SmithKline.Brufen
Emulsifiable paste mainly uses nonsteroidal anti-inflammatory drug brufen, and its mechanism of action is the synthesis for suppressing prostaglandin, so as to play analgesia
Antiinflammation, although curative effect is preferable, there is certain side effect, it is long-term use of to be not suitable for patient.In addition, the Moschus emulsifiable paste of Chinese medicine
Or emplastrum is also used for relaxing tendons and activating collaterals, alleviate myalgia, but specific aim is not strong, and curative effect is slower, and during use, the medicine passes through
The speed and efficiency of skin are all relatively low, so that therapeutic effect of the Transdermal absorption medicine in dept. of dermatology's clinic is not ideal；And
And for some allergic constitutions patient, skin may be caused to itch, redden, the allergic phenomena such as purple plague purpura.
The content of the invention
It is an object of the invention to provide one kind to treat DOMS compound safflower folium artemisiae argyi transdermal agent and preparation method thereof, tool
Play the role of to alleviate DOMS, enhancing muscular endurance, and it can effectively solve western medicine present in prior art
With the problem of certain side effect and treatment by Chinese herbs drug effect are slow, drug absorption effect is poor；It has curative for effect, transmission
A variety of advantages such as the speed and efficiency of skin are all higher, Pure natural nontoxic side effect, excitant are small.
The purpose of the present invention is achieved through the following technical solutions：
One kind treats DOMS compound safflower folium artemisiae argyi transdermal agent, including emulsion bases, skin penetration enhancer, the emulsion
The mass ratio of matrix and skin penetration enhancer is 18:1；The emulsion bases is by Chinese medicine extract, feedstock emulsion according to 11:4
Mass ratio form；In the Chinese medicine extract, each component in parts by weight, safflower 240-250 parts, folium artemisiae argyi 150-160 Fen, Aralias
Wooden root 90-95 parts, laurusleaf jasmine herb 85-89 parts, saltbush 60-68 parts of crawling, longpeduncle kadsura stem 52-60 parts, ball Jia Opulus 52-56 parts,
Geranium wilfordii 44-48 parts, whiteflower violet herb with root 40-45 parts, branchy paliurus root 35-40 parts, twotooth achyranthes leaf 33-37 parts, dioecious balanophora herb 31-35 parts, Bi
Collettii 30-34 parts.
As preferable：
In the Chinese medicine extract, each component in parts by weight, 250 parts of safflower, 95 parts of the Fen, Aralia woods root of folium artemisiae argyi 150, laurusleaf jasmine herb
85 parts, 68 parts of the saltbush that crawls, 52 parts of longpeduncle kadsura stem, 56 parts of ball Jia Opulus, 44 parts of geranium wilfordii, 45 parts of whiteflower violet herb with root, branchy paliurus root 35
Part, 37 parts of twotooth achyranthes leaf, 31 parts of dioecious balanophora herb, 30 parts of, Bi Collettiis.
As preferable：
In the Chinese medicine extract, each component in parts by weight, 240 parts of safflower, 90 parts of the Fen, Aralia woods root of folium artemisiae argyi 160, laurusleaf jasmine herb
89 parts, 60 parts of the saltbush that crawls, 60 parts of longpeduncle kadsura stem, 52 parts of ball Jia Opulus, 48 parts of geranium wilfordii, 40 parts of whiteflower violet herb with root, branchy paliurus root 40
Part, 33 parts of twotooth achyranthes leaf, 35 parts of dioecious balanophora herb, 34 parts of, Bi Collettiis.
As preferable：
In the Chinese medicine extract, each component in parts by weight, 245 parts of safflower, 93 parts of the Fen, Aralia woods root of folium artemisiae argyi 155, laurusleaf jasmine herb
87 parts, 64 parts of the saltbush that crawls, 56 parts of longpeduncle kadsura stem, 54 parts of ball Jia Opulus, 46 parts of geranium wilfordii, 43 parts of whiteflower violet herb with root, branchy paliurus root 37
Part, 35 parts of twotooth achyranthes leaf, 33 parts of dioecious balanophora herb, 32 parts of, Bi Collettiis.
In the feedstock emulsion, each component in parts by weight, 70 parts of glycerin monostearate, 112.5 parts of stearic acid, glycerine
85 parts, 85 parts of albolene, 10 parts of lauryl sodium sulfate, 1 part of P-hydroxybenzoic acid sodium.
The skin penetration enhancer by propane diols, ledum terpenes, decyl methyl sulfoxide, Rou Dou guan acid isopropyl esters form by
According to 1:4:2:1 mass ratio is formed.
Described one kind treats DOMS compound safflower folium artemisiae argyi transdermal agent, and its preparation method concretely comprises the following steps：
Step 1, stock：
（1）In parts by weight, high-quality Chinese medicine extract raw material is weighed：Safflower, folium artemisiae argyi, Aralia woods root, laurusleaf jasmine herb, shore of crawling
Lamb's-quarters, longpeduncle kadsura stem, ball Jia Opulus, geranium wilfordii, whiteflower violet herb with root, branchy paliurus root, twotooth achyranthes leaf, dioecious balanophora herb, Bi Collettiis, clean and clean
Afterwards, it is standby；
（2）In parts by weight, high-quality feedstock emulsion is weighed：Glycerin monostearate, stearic acid, glycerine, albolene, 12
Sodium alkyl sulfate, P-hydroxybenzoic acid sodium, it is standby；
（3）In parts by weight, high-quality skin penetration enhancer raw material is weighed：Propane diols, ledum terpenes, decyl methyl sulfoxide,
Rou Dou guan acid isopropyl esters, it is standby；
The preparation of step 2, Chinese medicine extract：
（1）Take clean and the safflower after cleaning, folium artemisiae argyi, Aralia woods root, laurusleaf jasmine herb, the saltbush that crawls, longpeduncle kadsura stem, ball Jia Opulus,
Geranium wilfordii, whiteflower violet herb with root, branchy paliurus root, twotooth achyranthes leaf, dioecious balanophora herb, Bi Collettiis, it is well mixed, Traditional Chinese drug mixture is obtained, by solid-liquid ratio 1:
12 mass ratio adds pure water, after soaking 4-6 hours, decocts 1.5 hours, filtering, takes filtrate；Filter residue adds 8 times of water, decocts
After boiling 1 hour, filtrate is filtered to take；Filter residue adds 6 times of water, after decocting 0.5 hour, filtering；Three times after filtrate, use is micro- for mixing
Membrane filtration is filtered in hole, obtains filtered fluid, filtered fluid is placed in vacuum decker, after being concentrated into the parts by weight of Traditional Chinese drug mixture, system
Obtain Chinese medicine extract；
The preparation of step 3, emulsion bases：
（1）In parts by weight, glycerin monostearate, stearic acid, glycerine, albolene, the dodecane in feedstock emulsion are weighed
Base sodium sulphate, P-hydroxybenzoic acid sodium, it is standby；
（2）By Chinese medicine extract, feedstock emulsion according to 11:4 mass ratio, Chinese medicine extract is weighed, it is standby；
（3）Standby glycerin monostearate, stearic acid, albolene are taken, is placed in and decocts inside container, heat the same of fusing
When, it is mixed evenly, and it is 80 DEG C to keep heating-up temperature, obtains oil phase, it is standby；
（4）Lauryl sodium sulfate, glycerine are taken, is placed in another decoction container, after being mixed evenly, adds standby Chinese medicine
Extract solution, it is mixed evenly again, and is heated to 80 DEG C, adds P-hydroxybenzoic acid sodium, after dissolving, add standby oil
Phase, white thin paste is stirred at same direction, it is standby after cooling；
The preparation of step 4, skin penetration enhancer：
In mass ratio, propane diols, ledum terpenes, decyl methyl sulfoxide, Rou Dou guan acid isopropyl esters are taken, is placed in inside stainless steel,
It is mixed evenly, skin penetration enhancer is made, it is standby；
The preparation of step 5, transdermal agent：
In mass ratio, emulsion bases, skin penetration enhancer are weighed, is placed in and decocts in container, bottom temperature heating, lasting stirring mixes
Close, after being well mixed, hang 2-4 hours, after cooling, obtain one kind and treat DOMS compound safflower folium artemisiae argyi transdermal agent.
Also include 30 parts of Herba Menthae powder in the transdermal agent.
In the raw material of Chinese medicine extract：Safflower, invigorate blood circulation, stasis eliminatings analgesic；Controlling through closing, abdominal mass, difficult labour, stillborn foetus, production
Lochia, hemostasis are had a pain afterwards, carbuncle swells, injury from falling down；Folium artemisiae argyi, warming channel for arresting bleeding, eliminating cold to stop pain；External application removing dampness to stop itchin；For telling
Blood, bleeding from five sense organs or subcutaneous tissue, uterine bleeding, menorrhalgia, blood under threatened abortion, few abdomen crymodynia, through uncomfortable, uterus cold infertile of trembling with fear；Control pruitus outside；Aralia wood
Root, wind-damp dispelling, diuresis, scattered blood stasis, detumescence poison；Treating rheumatic arthritis, nephritic dropsy, cirrhotic ascites, acute, chronic hepatitis,
Stomachache, stranguria with turbid discharge, metrorrhagia, traumatic injury, scrofula, carbuncle swells；Laurusleaf jasmine herb, there is the effect of clearing heat and promoting diuresis, eliminating stasis to subdue swelling；For dysentery
Disease, heat gonorrhea, oedema, traumatic injury；Crawl saltbush, dispelling wind and eliminating dampness, invigorate blood circulation, removing toxicity for detumescence；Cure mainly：Arthralgia pain due to rheumatism；Under band；
Irregular menstruation；Pyogenic skin infection and carbuncle-abscess；Dermatitis；Longpeduncle kadsura stem, relaxing tendons and activating collaterals；Regulating qi-flowing for relieving pain；Reinforcing spleen to promote digestion；Astringe the lung and promote the production of body fluid；Main bruise damage
Wound；Fracture；Internal lesion caused by overexertion；Lumbago due to wind-wetness evil；Joint pain；Dyspepsia is stagnated；Stomachache；Abdominal distension；Chronic cough shortness of breath；Tianjin is few thirsty；Irregular menstruation；
Infantile enuresis；Scald；Ball Jia Opulus, hemostasis, swelling and pain relieving, reunion of bone；Cure mainly fracture, traumatic injury, traumatism and bleeding；Old stork
Grass, wind-dispelling, promoting blood circulation are clearing heat and detoxicating；Treatment of rheumatalgia pain, contraction, ulcer, bruise, enteritis, dysentery；Whiteflower violet herb with root, there is heat-clearing
Removing toxic substances, the effect of eliminating stasis to subdue swelling；Go out for sore swollen toxin, laryngalgia, acute mastitis, acute appendicitis, jaundice, red eye, swell pain, traumatic injury, knife wound
Blood；Branchy paliurus root, there is wind-damp dispelling, dissipate paralysis blood, detoxication；Had sore throat for treating, discharging fresh blood stool, rheumatalgia, traumatic injury；
Twotooth achyranthes leaf, dispellieg cold and dampness；Strengthening the bones and muscles；Diuresis of blood circulation promoting；Main cold-dampness Impotence numbness；Lumbocrural pain；Leaching is closed；Chronic malaria；Dioecious balanophora herb, kidney-nourishing are supported
It is cloudy；Clearing away heat to stop bleeding；Main lumbago due to the kidney deficiency；Consumptive disease bleeding；Hemorrhoid hemorrhage；Bi Collettii, dampness removing remove turbid, wind expelling stagnation removing；Drenched for cream, in vain
It is turbid, leukorrhea, arthralgia pain due to rheumatism, articular instability, lumbocrural pain.
Beneficial effects of the present invention：One kind of the present invention treats DOMS compound safflower folium artemisiae argyi transdermal agent, has slow
Solve DOMS, strengthen the effect of muscular endurance, and it can effectively solve prior art western medicines in treatment and have necessarily
Side effect and the problem for the treatment of by Chinese herbs drug effect is slow, drug absorption effect is poor；It has curative for effect, transdermal speed
With a variety of advantages such as efficiency is all higher, Pure natural nontoxic side effect, excitant are small；Its preparation technology science, reasonable, effective, work
Skill flow is shorter, and cost is relatively low, suitable for industrialized production, has high social benefit and economic benefit.
One kind of the present invention treats DOMS compound safflower folium artemisiae argyi transdermal agent, and formula handed down from one's ancestors is mutually tied with many experiments
Close, finally using safflower, folium artemisiae argyi, Aralia woods root, laurusleaf jasmine herb, the saltbush that crawls, longpeduncle kadsura stem, ball Jia Opulus, geranium wilfordii, ploughshare head
The ten pleasant impression Chinese medicines such as grass, branchy paliurus root, twotooth achyranthes leaf, dioecious balanophora herb, Bi Collettiis are made, and have prepared one kind and have been applied to DOMS portion
Position, blood Rapid Circulation, relaxing tendons and activating collaterals, pain of alleviation, the medicament for strengthening muscular endurance of painful area, its component can be promoted
Science, reasonable compatibility, support mutually, effective for treatment DOMS, distending pain, numbness, good effect, drug safety, and through facing
Bed treatment has obtained fully proving；And add in a medicament by propane diols, ledum terpenes, decyl methyl sulfoxide, Rou Dou guans
Sour isopropyl ester is formed according to 1:4:2:The skin penetration enhancer that 1 optimum quality ratio is prepared so that this medicament with skin
Skin is contacted in use, the transdermal speed of medicament and efficiency are all higher, so that the effect of Transdermal absorption medicine is preferable.
In the present invention, appropriate Herba Menthae powder can also be added, the flavour of a drug of the present invention can be effectively improved.
In skin penetration enhancer, ledum terpenes are that a kind of new natural percutaneous absorption extracted from Philus antennatus promotees
Enter agent, it, which not only has, preferably promotees the effect of oozing, but also can with good stability and biomembrane inertia, ledum terpenes
Stratum Corneum class lipid bilayer, which produces to disturb, simultaneously causes it to become disordered state, changes the conformation of cuticula, relaxation they it
Between adhesion result in fine duct, so as to improve the permeability of polar medicine passage in the cell；Propane diols can penetrate into
Cuticula simultaneously forms accumulation wherein, dissolubility and distribution property of the increase medicine in cuticula.But the effect being used alone
It is often bad, it can play and cooperate with while increase medicine and accelerator solubility is played if being shared with other accelerator
Effect；Ledum terpenes embody preferable synergy with propane diols；Decyl methyl sulfoxide just has facilitation in low concentration,
Ability is oozed to the rush of polar medicine and is more than non-polar drug；Rou Dou guan acid isopropyl esters, have to skin and fabulous permeate, moisten and soft
Change acts on；It will be made up of propane diols, ledum terpenes, decyl methyl sulfoxide, Rou Dou guan acid isopropyl esters according to 1:4:2:1 optimal matter
The skin penetration enhancer that amount ratio is mixed with so that the transdermal speed of medicament, efficiency, effect are all more preferable.
Embodiment
Embodiment 1
One kind treats DOMS compound safflower folium artemisiae argyi transdermal agent, including emulsion bases, skin penetration enhancer, the emulsion
The mass ratio of matrix and skin penetration enhancer is 18:1；The emulsion bases is by Chinese medicine extract, feedstock emulsion according to 11:4
Mass ratio form；In the Chinese medicine extract, each component in parts by weight, safflower 240-250 parts, folium artemisiae argyi 150-160 Fen, Aralias
Wooden root 90-95 parts, laurusleaf jasmine herb 85-89 parts, saltbush 60-68 parts of crawling, longpeduncle kadsura stem 52-60 parts, ball Jia Opulus 52-56 parts,
Geranium wilfordii 44-48 parts, whiteflower violet herb with root 40-45 parts, branchy paliurus root 35-40 parts, twotooth achyranthes leaf 33-37 parts, dioecious balanophora herb 31-35 parts, Bi
Collettii 30-34 parts.
Embodiment 2
In the Chinese medicine extract, each component in parts by weight, 250 parts of safflower, 95 parts of the Fen, Aralia woods root of folium artemisiae argyi 150, laurusleaf jasmine herb
85 parts, 68 parts of the saltbush that crawls, 52 parts of longpeduncle kadsura stem, 56 parts of ball Jia Opulus, 44 parts of geranium wilfordii, 45 parts of whiteflower violet herb with root, branchy paliurus root 35
Part, 37 parts of twotooth achyranthes leaf, 31 parts of dioecious balanophora herb, 30 parts of, Bi Collettiis.
Embodiment 3
In the Chinese medicine extract, each component in parts by weight, 240 parts of safflower, 90 parts of the Fen, Aralia woods root of folium artemisiae argyi 160, laurusleaf jasmine herb
89 parts, 60 parts of the saltbush that crawls, 60 parts of longpeduncle kadsura stem, 52 parts of ball Jia Opulus, 48 parts of geranium wilfordii, 40 parts of whiteflower violet herb with root, branchy paliurus root 40
Part, 33 parts of twotooth achyranthes leaf, 35 parts of dioecious balanophora herb, 34 parts of, Bi Collettiis.
Embodiment 4
In the Chinese medicine extract, each component in parts by weight, 245 parts of safflower, 93 parts of the Fen, Aralia woods root of folium artemisiae argyi 155, laurusleaf jasmine herb
87 parts, 64 parts of the saltbush that crawls, 56 parts of longpeduncle kadsura stem, 54 parts of ball Jia Opulus, 46 parts of geranium wilfordii, 43 parts of whiteflower violet herb with root, branchy paliurus root 37
Part, 35 parts of twotooth achyranthes leaf, 33 parts of dioecious balanophora herb, 32 parts of, Bi Collettiis.
Embodiment 5
In the feedstock emulsion, each component in parts by weight, 70 parts of glycerin monostearate, 112.5 parts of stearic acid, glycerine 85
Part, 85 parts of albolene, 10 parts of lauryl sodium sulfate, 1 part of P-hydroxybenzoic acid sodium.
Embodiment 6
The skin penetration enhancer is made up of according to 1 propane diols, ledum terpenes, decyl methyl sulfoxide, Rou Dou guan acid isopropyl esters:
4:2:1 mass ratio is formed.
Embodiment 7
Described one kind treats DOMS compound safflower folium artemisiae argyi transdermal agent, and its preparation method concretely comprises the following steps：
Step 1, stock：
（1）In parts by weight, high-quality Chinese medicine extract raw material is weighed：Safflower, folium artemisiae argyi, Aralia woods root, laurusleaf jasmine herb, shore of crawling
Lamb's-quarters, longpeduncle kadsura stem, ball Jia Opulus, geranium wilfordii, whiteflower violet herb with root, branchy paliurus root, twotooth achyranthes leaf, dioecious balanophora herb, Bi Collettiis, clean and clean
Afterwards, it is standby；
（2）In parts by weight, high-quality feedstock emulsion is weighed：Glycerin monostearate, stearic acid, glycerine, albolene, 12
Sodium alkyl sulfate, P-hydroxybenzoic acid sodium, it is standby；
（3）In parts by weight, high-quality skin penetration enhancer raw material is weighed：Propane diols, ledum terpenes, decyl methyl sulfoxide,
Rou Dou guan acid isopropyl esters, it is standby；
The preparation of step 2, Chinese medicine extract：
（1）Take clean and the safflower after cleaning, folium artemisiae argyi, Aralia woods root, laurusleaf jasmine herb, the saltbush that crawls, longpeduncle kadsura stem, ball Jia Opulus,
Geranium wilfordii, whiteflower violet herb with root, branchy paliurus root, twotooth achyranthes leaf, dioecious balanophora herb, Bi Collettiis, it is well mixed, Traditional Chinese drug mixture is obtained, by solid-liquid ratio 1:
12 mass ratio adds pure water, after soaking 4-6 hours, decocts 1.5 hours, filtering, takes filtrate；Filter residue adds 8 times of water, decocts
After boiling 1 hour, filtrate is filtered to take；Filter residue adds 6 times of water, after decocting 0.5 hour, filtering；Three times after filtrate, use is micro- for mixing
Membrane filtration is filtered in hole, obtains filtered fluid, filtered fluid is placed in vacuum decker, after being concentrated into the parts by weight of Traditional Chinese drug mixture, system
Obtain Chinese medicine extract；
The preparation of step 3, emulsion bases：
（1）In parts by weight, glycerin monostearate, stearic acid, glycerine, albolene, the dodecane in feedstock emulsion are weighed
Base sodium sulphate, P-hydroxybenzoic acid sodium, it is standby；
（2）By Chinese medicine extract, feedstock emulsion according to 11:4 mass ratio, Chinese medicine extract is weighed, it is standby；
（3）Standby glycerin monostearate, stearic acid, albolene are taken, is placed in and decocts inside container, heat the same of fusing
When, it is mixed evenly, and it is 80 DEG C to keep heating-up temperature, obtains oil phase, it is standby；
（4）Lauryl sodium sulfate, glycerine are taken, is placed in another decoction container, after being mixed evenly, adds standby Chinese medicine
Extract solution, it is mixed evenly again, and is heated to 80 DEG C, adds P-hydroxybenzoic acid sodium, after dissolving, add standby oil
Phase, white thin paste is stirred at same direction, it is standby after cooling；
The preparation of step 4, skin penetration enhancer：
In mass ratio, propane diols, ledum terpenes, decyl methyl sulfoxide, Rou Dou guan acid isopropyl esters are taken, is placed in inside stainless steel,
It is mixed evenly, skin penetration enhancer is made, it is standby；
The preparation of step 5, transdermal agent：
In mass ratio, emulsion bases, skin penetration enhancer are weighed, is placed in and decocts in container, bottom temperature heating, lasting stirring mixes
Close, after being well mixed, hang 2-4 hours, after cooling, obtain one kind and treat DOMS compound safflower folium artemisiae argyi transdermal agent.
Embodiment 8
Also include 30 parts of Herba Menthae powder in the transdermal agent.
Embodiment 9
One kind treats DOMS compound safflower folium artemisiae argyi transdermal agent, including emulsion bases, skin penetration enhancer, the emulsion
The mass ratio of matrix and skin penetration enhancer is 18:1；The emulsion bases is by Chinese medicine extract, feedstock emulsion according to 11:4
Mass ratio form；
In the Chinese medicine extract, safflower 245g, folium artemisiae argyi 155g, Aralia wood roots 93g, laurusleaf jasmine herb 87g, crawl saltbush 64g, spices
Blood rattan 56g, ball Jia Opulus 54g, geranium wilfordii 46g, whiteflower violet herb with root 43g, branchy paliurus root 37g, twotooth achyranthes leaf 35g, dioecious balanophora herb 33g, Bi
Collettii 32g；
In the feedstock emulsion, glycerin monostearate 70g, stearic acid 112.5g, glycerine 85g, albolene 85g, dodecane
Base sodium sulphate 10g, P-hydroxybenzoic acid sodium 1g；
The skin penetration enhancer is made up of according to 1 propane diols, ledum terpenes, decyl methyl sulfoxide, Rou Dou guan acid isopropyl esters:
4:2:1 mass ratio is formed.
Embodiment 10
Clinical treatment：
Choose 100 patients, male 50, women 50, age reckling 23 years old, the maximum 61 years old, the course of disease most short person 1 day,
Most elder 10 days, all patients have the symptom ached that DOMS touches.
Treatment method
DOMS is treated with compound safflower folium artemisiae argyi transdermal agent to be treated using one kind of the present invention, wherein one day smears 2
It is secondary, treat 1 day.
Criterion of therapeutical effect
Recovery from illness：Patient muscle's pain symptom disappears, and activity freely, feels feeling relaxed.
It is effective：Myalgia persistently mitigates, and has a slight arrested anxious, aching and tired sense, and activity is unrestricted.
It is invalid：The pretherapy and post-treatment state of an illness is unchanged.
After treatment, all the symptom of the myalgia of 100 patients disappears, and activity freely, feels feeling relaxed, entirely
Portion meets the standard of recovery from illness.
Adverse reaction and toxic side effect monitoring
By detect the blood pressure of patient, pulse, whether there is Nausea and vomiting, the clinical symptoms of dizziness judge adverse reaction.If
Human normal systolic pressure is determined between 90-140mmHg, and for diastolic pressure between 60-90mmHg, human normal pulse is 60-100
Beat/min, blood pressure, the pulse of patient are measured during treatment, it is found that recorded blood pressure and pulse is all within normal range (NR)
It is interior, occur without departing from the phenomenon of normal interval, and Nausea and vomiting, the clinical symptoms of dizziness do not occur.This illustrates this hair
Bright pharmaceutical composition does not have obvious adverse reaction, and then proves that the medicine does not have obvious toxic side effect for human body.
Claims (8)
1. one kind treats DOMS compound safflower folium artemisiae argyi transdermal agent, including emulsion bases, skin penetration enhancer, its feature
It is：The mass ratio of the emulsion bases and skin penetration enhancer is 18:1；The emulsion bases is by Chinese medicine extract, emulsion
Raw material is according to 11:4 mass ratio is formed；In the Chinese medicine extract, each component in parts by weight, safflower 240-250 parts, folium artemisiae argyi
150-160 Fen, Aralia wood root 90-95 parts, laurusleaf jasmine herb 85-89 parts, saltbush 60-68 parts of crawling, longpeduncle kadsura stem 52-60 parts, ball
Jia Opulus 52-56 parts, geranium wilfordii 44-48 parts, whiteflower violet herb with root 40-45 parts, branchy paliurus root 35-40 parts, twotooth achyranthes leaf 33-37 parts, deer are celestial
Careless 31-35 parts, Bi Collettii 30-34 parts.
2. one kind according to claim 1 treats DOMS compound safflower folium artemisiae argyi transdermal agent, it is characterised in that：It is described
In Chinese medicine extract, each component in parts by weight, 95 parts 250 parts of safflower, folium artemisiae argyi 150 of Fen, Aralia woods root, 85 parts of laurusleaf jasmine herb, is crawled
68 parts of crawl saltbush, 52 parts of longpeduncle kadsura stem, 56 parts of ball Jia Opulus, 44 parts of geranium wilfordii, 45 parts of whiteflower violet herb with root, 35 parts of branchy paliurus root, the root of bidentate achyranthes
37 parts of cauline leaf, 31 parts of dioecious balanophora herb, 30 parts of, Bi Collettiis.
3. one kind according to claim 1 treats DOMS compound safflower folium artemisiae argyi transdermal agent, it is characterised in that：It is described
In Chinese medicine extract, each component in parts by weight, 90 parts 240 parts of safflower, folium artemisiae argyi 160 of Fen, Aralia woods root, 89 parts of laurusleaf jasmine herb, is crawled
60 parts of crawl saltbush, 60 parts of longpeduncle kadsura stem, 52 parts of ball Jia Opulus, 48 parts of geranium wilfordii, 40 parts of whiteflower violet herb with root, 40 parts of branchy paliurus root, the root of bidentate achyranthes
33 parts of cauline leaf, 35 parts of dioecious balanophora herb, 34 parts of, Bi Collettiis.
4. one kind according to claim 1 treats DOMS compound safflower folium artemisiae argyi transdermal agent, it is characterised in that：It is described
In Chinese medicine extract, each component in parts by weight, 93 parts 245 parts of safflower, folium artemisiae argyi 155 of Fen, Aralia woods root, 87 parts of laurusleaf jasmine herb, is crawled
64 parts of crawl saltbush, 56 parts of longpeduncle kadsura stem, 54 parts of ball Jia Opulus, 46 parts of geranium wilfordii, 43 parts of whiteflower violet herb with root, 37 parts of branchy paliurus root, the root of bidentate achyranthes
35 parts of cauline leaf, 33 parts of dioecious balanophora herb, 32 parts of, Bi Collettiis.
5. one kind according to claim 1 treats DOMS compound safflower folium artemisiae argyi transdermal agent, it is characterised in that：It is described
In feedstock emulsion, each component in parts by weight, 70 parts of glycerin monostearate, 112.5 parts of stearic acid, 85 parts of glycerine, Bai Fanshi
85 parts of woods, 10 parts of lauryl sodium sulfate, 1 part of P-hydroxybenzoic acid sodium.
6. one kind according to claim 1 treats DOMS compound safflower folium artemisiae argyi transdermal agent, it is characterised in that：It is described
Skin penetration enhancer is made up of according to 1 propane diols, ledum terpenes, decyl methyl sulfoxide, Rou Dou guan acid isopropyl esters:4:2:1
Mass ratio is formed.
7. one kind according to claim 1-6 any one treats DOMS compound safflower folium artemisiae argyi transdermal agent, it is special
Sign is：Its preparation method concretely comprises the following steps：
Step 1, stock：
（1）In parts by weight, high-quality Chinese medicine extract raw material is weighed：Safflower, folium artemisiae argyi, Aralia woods root, laurusleaf jasmine herb, shore of crawling
Lamb's-quarters, longpeduncle kadsura stem, ball Jia Opulus, geranium wilfordii, whiteflower violet herb with root, branchy paliurus root, twotooth achyranthes leaf, dioecious balanophora herb, Bi Collettiis, clean and clean
Afterwards, it is standby；
（2）In parts by weight, high-quality feedstock emulsion is weighed：Glycerin monostearate, stearic acid, glycerine, albolene, 12
Sodium alkyl sulfate, P-hydroxybenzoic acid sodium, it is standby；
（3）In parts by weight, high-quality skin penetration enhancer raw material is weighed：Propane diols, ledum terpenes, decyl methyl sulfoxide,
Rou Dou guan acid isopropyl esters, it is standby；
The preparation of step 2, Chinese medicine extract：
（1）Take clean and the safflower after cleaning, folium artemisiae argyi, Aralia woods root, laurusleaf jasmine herb, the saltbush that crawls, longpeduncle kadsura stem, ball Jia Opulus,
Geranium wilfordii, whiteflower violet herb with root, branchy paliurus root, twotooth achyranthes leaf, dioecious balanophora herb, Bi Collettiis, it is well mixed, Traditional Chinese drug mixture is obtained, by solid-liquid ratio 1:
12 mass ratio adds pure water, after soaking 4-6 hours, decocts 1.5 hours, filtering, takes filtrate；Filter residue adds 8 times of water, decocts
After boiling 1 hour, filtrate is filtered to take；Filter residue adds 6 times of water, after decocting 0.5 hour, filtering；Three times after filtrate, use is micro- for mixing
Membrane filtration is filtered in hole, obtains filtered fluid, filtered fluid is placed in vacuum decker, after being concentrated into the parts by weight of Traditional Chinese drug mixture, system
Obtain Chinese medicine extract；
The preparation of step 3, emulsion bases：
（1）In parts by weight, glycerin monostearate, stearic acid, glycerine, albolene, the dodecane in feedstock emulsion are weighed
Base sodium sulphate, P-hydroxybenzoic acid sodium, it is standby；
（2）By Chinese medicine extract, feedstock emulsion according to 11:4 mass ratio, Chinese medicine extract is weighed, it is standby；
（3）Standby glycerin monostearate, stearic acid, albolene are taken, is placed in and decocts inside container, heat the same of fusing
When, it is mixed evenly, and it is 80 DEG C to keep heating-up temperature, obtains oil phase, it is standby；
（4）Lauryl sodium sulfate, glycerine are taken, is placed in another decoction container, after being mixed evenly, adds standby Chinese medicine
Extract solution, it is mixed evenly again, and is heated to 80 DEG C, adds P-hydroxybenzoic acid sodium, after dissolving, add standby oil
Phase, white thin paste is stirred at same direction, it is standby after cooling；
The preparation of step 4, skin penetration enhancer：
In mass ratio, propane diols, ledum terpenes, decyl methyl sulfoxide, Rou Dou guan acid isopropyl esters are taken, is placed in inside stainless steel,
It is mixed evenly, skin penetration enhancer is made, it is standby；
The preparation of step 5, transdermal agent：
In mass ratio, emulsion bases, skin penetration enhancer are weighed, is placed in and decocts in container, bottom temperature heating, lasting stirring mixes
Close, after being well mixed, hang 2-4 hours, after cooling, obtain one kind and treat DOMS compound safflower folium artemisiae argyi transdermal agent.
8. one kind according to claim 1-7 any one treats DOMS compound safflower folium artemisiae argyi transdermal agent, it is special
Sign is：Also include 30 parts of Herba Menthae powder in the transdermal agent.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN203263843U (en) * | 2013-05-31 | 2013-11-06 | 梁俊平 | Pain-relieving plaster paste |
| CN103550631A (en) * | 2013-11-12 | 2014-02-05 | 魏钰 | Medicine for treating sore muscle |
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2016
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN203263843U (en) * | 2013-05-31 | 2013-11-06 | 梁俊平 | Pain-relieving plaster paste |
| CN103550631A (en) * | 2013-11-12 | 2014-02-05 | 魏钰 | Medicine for treating sore muscle |
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