CN107854385A - Pure biological nimbin formulation of tooth-paste - Google Patents
Pure biological nimbin formulation of tooth-paste Download PDFInfo
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- CN107854385A CN107854385A CN201711489266.7A CN201711489266A CN107854385A CN 107854385 A CN107854385 A CN 107854385A CN 201711489266 A CN201711489266 A CN 201711489266A CN 107854385 A CN107854385 A CN 107854385A
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- Prior art keywords
- parts
- nimbin
- formulation
- tooth
- pure biological
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of pure biological nimbin formulation of tooth-paste, include by mass fraction：Nimbin, glycerine, organic essential oil, saleratus power, calcium carbonate, saccharin, pigment and liquorice liquid；The beneficial effects of the invention are as follows：Inventive formulation is reasonable, each composition coordinating and unifying in raw material, promotes to support each other, improves the distinctive anti-inflammatory of nimbin, and the effect of sterilization, and toothpaste smell is pleasant, good mouthfeel.
Description
Technical field
The present invention relates to formulation of tooth-paste, and in particular to pure biological nimbin formulation of tooth-paste.
Background technology
Print chinaberry is Meliaceae melia plant, is a kind of fast-growing deciduous tree for being grown on tropical and subtropical zone, in the 1960s,
One German botanist carries out having encountered a plague of locusts by chance when biology is investigated in India, at that time, has a group locust to cover the sky and the earth ground
A piece of crop is pressed to, in no time, this piece crop is just nibbled all gone by locust, but wherein has the safe nothing of one tree
Illness, here it is neem tree.This scientist researchs and analyses, and in the seed of neem tree, leaf and bark, contains a kind of material ---
Nimbin, just because of its presence, the magical function of making neem tree have worm to cure the disease.Afterwards after further study, from print chinaberry
The compositions such as the nimbin extracted in fruit are wide spectrum recognized in the world, efficient, less toxic, degradable, noresidue insecticide
And there is no the resistance to the action of a drug, to nearly all plant insect, indoor bedbug, flea, fly, mosquito etc. all have repelling and killing efficacy.Experiment
Prove, print chinaberry is to preventing and treating more than 400 kinds of agricultural of 10 mesh, storage and sanitary insect pest, particularly to Semiptera, Lepidoptera, coleoptera etc.
Insect has special efficacy, and to people and animals and surrounding environment without any pollution.
The content of the invention
It is an object of the invention to provide a kind of pure biological nimbin formulation of tooth-paste, solves traditional toothpaste shield tooth, anti-inflammatory
The problem of function is general.
To solve above-mentioned technical problem, the present invention uses following technical scheme：
Pure biological nimbin formulation of tooth-paste, is included by mass fraction：1~3 part of nimbin, 8~15 parts of glycerine, 5~9 parts
Organic essential oil, 20~40 parts of saleratus power, 0.2~1 part of calcium carbonate, 0.2~0.5 part of saccharin, 2~3 parts of pigment and
0.5~3 part of liquorice liquid.Further technical scheme is to include in above-mentioned by mass fraction：2~3 parts of nimbin, 10
~13 parts of glycerine, 6~8 parts of organic essential oil, 25~35 parts of saleratus power, 0.4~0.8 part of calcium carbonate, 0.3~0.4
The saccharin, 2~3 parts of pigment and 1.5~2.5 parts of liquorice liquid of part.
Further technical scheme is to include in above-mentioned by mass fraction：2 parts of nimbin, 11 parts of glycerine, 7 parts
Organic essential oil, 30 parts of saleratus power, 0.6 part of calcium carbonate, 0.3 part of saccharin, 3 parts of pigment and 2 parts of liquorice liquid.
Further technical scheme is that the extracting method of wherein described nimbin is in above-mentioned：By the print chinaberry kind of peeling
Volumetric concentration is inserted than in the ethanol solution more than 90%, the print chinaberry kind of peeling then is carried out into cutting stirring by high speed blade
Crushing is obtained printing chinaberry kind mixed liquor, and the print chinaberry kind mixed liquor after crushing is put into container and carries out heating volatilization, will finally be added
Liquid after heat volatilization is filtered and filter residue, and obtains nimbin powder.
In the technical program, by using ethanol solution as extractant, the efficiency that nimbin extracts can be improved, simultaneously
Because ethanol solution is volatile, therefore by way of continuous heating, nimbin can be caused when extracting filtering, by the way that ethanol is waved
Hair, is so avoided that ethanol is attached thereto, and then improves the efficiency of nimbin extraction.
Further technical scheme is that the feed liquid mass ratio of above-mentioned middle print chinaberry kind and ethanol solution is 1：8~10.
Further technical scheme is that the temperature of above-mentioned middle heating volatilization is 55~65 DEG C.
Further technical scheme is that the liquid after being volatilized in above-mentioned to heating cools, wherein the speed to cool
For 1~2 DEG C/min, the fluid temperature after heating volatilization drops to less than 40 DEG C.
In the technical program, by continued down, it is avoided that ethanol condenses again in volatilization, so as to influence nimbin
Purity.
Compared with prior art, the beneficial effects of the invention are as follows：
Inventive formulation is reasonable, each composition coordinating and unifying in raw material, promotes to support each other, it is peculiar to improve nimbin
Anti-inflammatory, the effect of sterilization, and toothpaste smell is pleasant, good mouthfeel.
For the present invention using natural plants nimbin as raw material, abundance, technique is simple, and cost is low, and contributes to green warp
The development of Ji.
The extracting method of nimbin is simple in the present invention, and the solvent used is volatile, and does not pollute the environment, green ring
Protect.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
Embodiment 1：
Pure biological nimbin formulation of tooth-paste, is included by mass fraction：1 part of nimbin, 15 parts of glycerine, 5 parts of organic essential oil,
40 parts of saleratus power, 0.2 part of calcium carbonate, 0.5 part of saccharin, 2 parts of pigment and 3 parts of liquorice liquid.
Embodiment 2：
Pure biological nimbin formulation of tooth-paste, is included by mass fraction：3 parts of nimbin, 8 parts of glycerine, 9 parts of organic essential oil,
20 parts of saleratus power, 1 part of calcium carbonate, 0.2 part of saccharin, 3 parts of pigment and 0.5 part of liquorice liquid.
Embodiment 3：
Pure biological nimbin formulation of tooth-paste, is included by mass fraction：3 parts of nimbin, 10 parts of glycerine, 8 parts of organic essential oil,
25 parts of saleratus power, 0.8 part of calcium carbonate, 0.3 part of saccharin, 3 parts of pigment and 1.5 parts of liquorice liquid.
Embodiment 4：
Pure biological nimbin formulation of tooth-paste, is included by mass fraction：2 parts of nimbin, 13 parts of glycerine, 6 parts of organic essential oil,
35 parts of saleratus power, 0.4 part of calcium carbonate, 0.4 part of saccharin, 2 parts of pigment and 2.5 parts of liquorice liquid.
Embodiment 5：
Pure biological nimbin formulation of tooth-paste, is included by mass fraction：2 parts of nimbin, 11 parts of glycerine, 7 parts of organic essential oil,
30 parts of saleratus power, 0.6 part of calcium carbonate, 0.3 part of saccharin, 3 parts of pigment and 2 parts of liquorice liquid.
Embodiment 6：
Pure biological nimbin formulation of tooth-paste, is included by mass fraction：3 parts of nimbin, 10 parts of glycerine, 8 parts of organic essential oil,
25 parts of saleratus power, 0.8 part of calcium carbonate, 0.3 part of saccharin, 3 parts of pigment and 1.5 parts of liquorice liquid.
The extracting method of wherein nimbin is：It is big that the 100g print chinaberry kinds removed the peel are inserted into the volumetric concentration ratio that quality is 800g
In 90% ethanol solution, the print chinaberry kind of peeling is then carried out by cutting stirring by 1000~1200r/min high speed blade
Crushing is obtained printing chinaberry kind mixed liquor, and the print chinaberry kind mixed liquor after crushing is put into container and carries out heating volatilization, wherein heating
Temperature be 65 DEG C, and the solid-to-liquid ratio for being heated to solute and solution is 1：2~3, the liquid after then being volatilized to heating drops
Temperature, wherein the speed to cool is 2 DEG C/min, the liquid after finally heating is volatilized is filtered and filter residue, and obtains nimbin
Powder.
Embodiment 7：
Pure biological nimbin formulation of tooth-paste, is included by mass fraction：3 parts of nimbin, 10 parts of glycerine, 8 parts of organic essential oil,
25 parts of saleratus power, 0.8 part of calcium carbonate, 0.3 part of saccharin, 3 parts of pigment and 1.5 parts of liquorice liquid.
The extracting method of wherein nimbin is：The 100g print chinaberry kinds removed the peel are inserted into the volumetric concentration ratio that quality is 1000g
In ethanol solution more than 95%, the print chinaberry kind of peeling is then carried out by cutting by 1100~1200r/min high speed blade and stirred
Breading is broken to be obtained printing chinaberry kind mixed liquor, and the print chinaberry kind mixed liquor after crushing is put into container and carries out heating volatilization, wherein adding
The temperature of heat is 55 DEG C, and the solid-to-liquid ratio for being heated to solute and solution is 1：2~3, the liquid after then being volatilized to heating is carried out
Cooling, wherein the speed to cool is 1 DEG C/min, the liquid after finally heating is volatilized is filtered and filter residue, and obtains printing chinaberry
Plain powder.
Embodiment 8：
Pure biological nimbin formulation of tooth-paste, is included by mass fraction：2 parts of nimbin, 9 parts of glycerine, 6 parts of organic essential oil,
30 parts of saleratus power, 0.6 part of calcium carbonate, 0.5 part of saccharin, 2.2 parts of pigment and 2 parts of liquorice liquid.
The extracting method of wherein nimbin is：It is big that the 100g print chinaberry kinds removed the peel are inserted into the volumetric concentration ratio that quality is 900g
In 95% ethanol solution, the print chinaberry kind of peeling is then carried out by cutting stirring by 1100~1150r/min high speed blade
Crushing is obtained printing chinaberry kind mixed liquor, and the print chinaberry kind mixed liquor after crushing is put into container and carries out heating volatilization, wherein heating
Temperature be 60 DEG C, and the solid-to-liquid ratio for being heated to solute and solution is 1：2~3, the liquid after then being volatilized to heating drops
Temperature, wherein the speed to cool is 1.5 DEG C/min, the liquid after finally heating is volatilized is filtered and filter residue, and obtains printing chinaberry
Plain powder.
Application examples 1：
The toothpaste for using the patient with gingivitis this formula to make, the wherein people of male 10, the people of women 10, when in use, take
This toothpaste is brushed teeth, and is carried out every time after the meal, and maintain 3 minutes, 15 days after, have 12 people, alleviated gingivitis symptom substantially mitigates, 8 people
Effectively alleviate the exacerbation situation of gingivitis.
Although reference be made herein to invention has been described for multiple explanatory embodiments of the invention, however, it is to be understood that
Those skilled in the art can be designed that a lot of other modifications and embodiment, and these modifications and embodiment will fall in this Shen
Please be within disclosed spirit and spirit.More specifically, can be to master in the range of disclosure and claim
The building block and/or layout for inscribing composite configuration carry out a variety of variations and modifications.Except what is carried out to building block and/or layout
Outside modification and improvement, to those skilled in the art, other purposes also will be apparent.
Claims (7)
- A kind of 1. pure biological nimbin formulation of tooth-paste, it is characterised in that：Include by mass fraction：1~3 part of nimbin, 8~15 The glycerine, 5~9 parts of organic essential oil, 20~40 parts of saleratus power, 0.2~1 part of calcium carbonate, 0.2~0.5 part of sugar of part Essence, 2~3 parts of pigment and 0.5~3 part of liquorice liquid.
- 2. pure biological nimbin formulation of tooth-paste according to claim 1, it is characterised in that：Include by mass fraction：2~3 The nimbin, 10~13 parts of glycerine, 6~8 parts of organic essential oil, 25~35 parts of saleratus power, 0.4~0.8 part of carbon of part Sour calcium, 0.3~0.4 part of saccharin, 2~3 parts of pigment and 1.5~2.5 parts of liquorice liquid.
- 3. pure biological nimbin formulation of tooth-paste according to claim 2, it is characterised in that：Include by mass fraction：2 parts Nimbin, 11 parts of glycerine, 7 parts of organic essential oil, 30 parts of saleratus power, 0.6 part of calcium carbonate, 0.3 part of saccharin, 3 parts Pigment and 2 parts of liquorice liquid.
- 4. pure biological nimbin formulation of tooth-paste according to claim 1, it is characterised in that：The extraction of wherein described nimbin Method is：The print chinaberry kind of peeling is inserted into volumetric concentration than that in the ethanol solution more than 90%, then will be removed the peel by high speed blade Print chinaberry kind carry out cutting stirring crushing obtain print chinaberry kind mixed liquor, the print chinaberry kind mixed liquor after crushing is put into container Row heating volatilization, the liquid after finally heating is volatilized is filtered and filter residue, and obtains nimbin powder.
- 5. pure biological nimbin formulation of tooth-paste according to claim 4, it is characterised in that：The print chinaberry kind and ethanol solution Feed liquid mass ratio be 1：8~10.
- 6. pure biological nimbin formulation of tooth-paste according to claim 4, it is characterised in that：It is described heating volatilization temperature be 55~65 DEG C.
- 7. pure biological nimbin formulation of tooth-paste according to claim 4, it is characterised in that：Liquid after being volatilized to heating enters Row cooling, wherein the speed to cool is 1~2 DEG C/min, until the fluid temperature after heating volatilization drops to less than 40 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711489266.7A CN107854385A (en) | 2017-12-29 | 2017-12-29 | Pure biological nimbin formulation of tooth-paste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711489266.7A CN107854385A (en) | 2017-12-29 | 2017-12-29 | Pure biological nimbin formulation of tooth-paste |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107854385A true CN107854385A (en) | 2018-03-30 |
Family
ID=61707709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711489266.7A Pending CN107854385A (en) | 2017-12-29 | 2017-12-29 | Pure biological nimbin formulation of tooth-paste |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1304716A (en) * | 2000-12-14 | 2001-07-25 | 云南天兴生物开发有限公司生物化工研究所 | Medicinal toothpaste and its preparing process |
| US20160022568A1 (en) * | 2013-03-18 | 2016-01-28 | Theranovis Gmbh & Co. Kg | Composition for oral care |
| CN106619156A (en) * | 2016-12-25 | 2017-05-10 | 江西宜信堂医疗科技有限公司 | Toothpaste and preparation method thereof |
| CN106619196A (en) * | 2015-10-29 | 2017-05-10 | 陈刚 | Making method of toothpaste |
-
2017
- 2017-12-29 CN CN201711489266.7A patent/CN107854385A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1304716A (en) * | 2000-12-14 | 2001-07-25 | 云南天兴生物开发有限公司生物化工研究所 | Medicinal toothpaste and its preparing process |
| US20160022568A1 (en) * | 2013-03-18 | 2016-01-28 | Theranovis Gmbh & Co. Kg | Composition for oral care |
| CN106619196A (en) * | 2015-10-29 | 2017-05-10 | 陈刚 | Making method of toothpaste |
| CN106619156A (en) * | 2016-12-25 | 2017-05-10 | 江西宜信堂医疗科技有限公司 | Toothpaste and preparation method thereof |
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Application publication date: 20180330 |