CN107847618B - Hbed-二膦酸盐/酯、其放射金属轭合物和它们作为治疗诊断剂的用途 - Google Patents

Hbed-二膦酸盐/酯、其放射金属轭合物和它们作为治疗诊断剂的用途 Download PDF

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CN107847618B
CN107847618B CN201680046397.5A CN201680046397A CN107847618B CN 107847618 B CN107847618 B CN 107847618B CN 201680046397 A CN201680046397 A CN 201680046397A CN 107847618 B CN107847618 B CN 107847618B
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complex
compound
bone
hydrogen
imaging
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CN107847618A (zh
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H·F·孔
吴泽辉
S·R·崔
K·普罗埃斯尔
查智豪
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Five Eleven Pharma Inc
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    • C07—ORGANIC CHEMISTRY
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C07F9/3817—Acids containing the structure (RX)2P(=X)-alk-N...P (X = O, S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Radiology & Medical Imaging (AREA)
  • Steroid Compounds (AREA)
CN201680046397.5A 2015-07-07 2016-07-06 Hbed-二膦酸盐/酯、其放射金属轭合物和它们作为治疗诊断剂的用途 Active CN107847618B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562189652P 2015-07-07 2015-07-07
US62/189,652 2015-07-07
US201662320296P 2016-04-08 2016-04-08
US62/320,296 2016-04-08
PCT/US2016/041040 WO2017007790A1 (en) 2015-07-07 2016-07-06 Hbed-bisphosphonates, radiometal conjugates thereof and their use as theranostic agents

Publications (2)

Publication Number Publication Date
CN107847618A CN107847618A (zh) 2018-03-27
CN107847618B true CN107847618B (zh) 2021-07-16

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Country Link
US (1) US10253052B2 (cg-RX-API-DMAC10.html)
EP (1) EP3319643B1 (cg-RX-API-DMAC10.html)
JP (1) JP6792875B2 (cg-RX-API-DMAC10.html)
KR (1) KR102651945B1 (cg-RX-API-DMAC10.html)
CN (1) CN107847618B (cg-RX-API-DMAC10.html)
AU (1) AU2016289474C1 (cg-RX-API-DMAC10.html)
DK (1) DK3319643T3 (cg-RX-API-DMAC10.html)
EA (1) EA201890221A1 (cg-RX-API-DMAC10.html)
IL (1) IL256726A (cg-RX-API-DMAC10.html)
MX (1) MX377208B (cg-RX-API-DMAC10.html)
WO (1) WO2017007790A1 (cg-RX-API-DMAC10.html)

Families Citing this family (10)

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Publication number Priority date Publication date Assignee Title
DK3319643T3 (da) 2015-07-07 2020-06-15 Five Eleven Pharma Inc HBED-bisphosphonater og radiometalkonjugater deraf, anvendelige som theranostiske midler
WO2018160544A1 (en) * 2017-03-02 2018-09-07 Five Eleven Pharma Inc. Radiopharmaceutical labeling device
WO2020028825A1 (en) * 2018-08-03 2020-02-06 Board Of Regents, The University Of Texas System Method for extraction and purification of 68ga
CN109438517B (zh) * 2018-12-27 2021-01-08 北京久杰净化工程技术有限公司 一种与羰基金属核心配位的双功能连接剂的配合物及其制备方法
MX2021013055A (es) * 2019-04-26 2021-12-10 Five Eleven Pharma Inc Inhibidores de antigenos de membrana especificos de prostata (psma) como agentes diagnosticos y terapeuticos con radionuclidos.
US20230001027A1 (en) * 2019-10-01 2023-01-05 City Of Hope Metal chelating agents and methods of using the same
DE102021101216A1 (de) * 2021-01-21 2022-07-21 Johannes Gutenberg-Universität Mainz, Körperschaft des öffentlichen Rechts Markierungsvorläufer und Radiotracer zur nuklearmedizinischen Diagnose und Therapie von Prostatakrebs induzierten Knochenmetastasen
DE102022105175A1 (de) * 2022-03-04 2023-09-07 Atoms for Cure GmbH Markierungsvorläufer und Radiotracer mit drei oder mehr Targeting-Vektoren für die nuklearmedizinische Theranostik
CN119060094B (zh) * 2024-08-26 2025-09-05 广州医科大学附属第一医院（广州呼吸中心） 一种靶向成纤维细胞激活蛋白的抑制剂类放射性探针及其制备方法和应用
CN119060093B (zh) * 2024-08-26 2025-09-05 广州医科大学附属第一医院（广州呼吸中心） 一种靶向成纤维细胞激活蛋白的抑制剂类放射性探针及其制备方法和应用

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EP2468760A1 (en) * 2009-08-20 2012-06-27 Fujifilm RI Pharma Co., Ltd. Bisphosphonic acid derivative and compound thereof labeled with radioactive metal nuclide

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WO2004089925A1 (en) * 2003-04-03 2004-10-21 Semafore Pharmaceuticals, Inc. Pi-3 kinase inhibitor prodrugs
US7161000B2 (en) * 2003-05-30 2007-01-09 Sumitomo Chemical Company, Limited Method for producing phenol condensate
US10925977B2 (en) * 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
WO2009002529A2 (en) * 2007-06-26 2008-12-31 The Johns Hopkins University Labeled inhibitors of prostate specific membrane antigen (psma), biological evaluation, and use as imaging agents
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DK3319643T3 (da) 2015-07-07 2020-06-15 Five Eleven Pharma Inc HBED-bisphosphonater og radiometalkonjugater deraf, anvendelige som theranostiske midler

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EP2468760A1 (en) * 2009-08-20 2012-06-27 Fujifilm RI Pharma Co., Ltd. Bisphosphonic acid derivative and compound thereof labeled with radioactive metal nuclide

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Publication number Publication date
JP6792875B2 (ja) 2020-12-02
AU2016289474A1 (en) 2018-02-01
WO2017007790A9 (en) 2018-01-04
CN107847618A (zh) 2018-03-27
US10253052B2 (en) 2019-04-09
IL256726A (en) 2018-03-29
DK3319643T3 (da) 2020-06-15
CA2991498A1 (en) 2017-01-12
EA201890221A1 (ru) 2018-06-29
AU2016289474B2 (en) 2020-12-24
KR102651945B1 (ko) 2024-03-26
KR20180026736A (ko) 2018-03-13
AU2016289474C1 (en) 2021-04-08
US20170022224A1 (en) 2017-01-26
WO2017007790A1 (en) 2017-01-12
EP3319643B1 (en) 2020-04-22
MX2018000239A (es) 2018-05-23
EP3319643A1 (en) 2018-05-16
JP2018524352A (ja) 2018-08-30
EP3319643A4 (en) 2019-04-10
MX377208B (es) 2025-03-07
HK1254864A1 (en) 2019-07-26

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