CN107847528A - Tired palliative - Google Patents
Tired palliative Download PDFInfo
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- CN107847528A CN107847528A CN201680045186.XA CN201680045186A CN107847528A CN 107847528 A CN107847528 A CN 107847528A CN 201680045186 A CN201680045186 A CN 201680045186A CN 107847528 A CN107847528 A CN 107847528A
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- propolis
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
- A23L21/20—Products from apiculture, e.g. royal jelly or pollen; Substitutes therefor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Insects & Arthropods (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Jellies, Jams, And Syrups (AREA)
Abstract
The present invention provides the tired palliative using the propolis from the honeybee for belonging to Apis as active ingredient.
Description
Technical field
The present invention relates to tired palliative.
Background technology
Propolis be by apidae insect by gathered from various plants Lai the solidification such as resin obtained from waxy composition,
Utilized from ancient times as food etc., it is known that it, which has various physiologically actives,.Such as Patent Document 1 discloses include Brazil
Fragrant cocoa (Paullinia cupana) water extract, propolis water extract, DHA, phosphatidylserine, phosphatidyl choline and dimension
Raw plain E mixture has improvement for dementia, chronic fatigue syndrome etc..
Honeybee as the Apidae of output propolis, it is known to belong to Apis (Apis), stingless bee category (Trigona) or wheat
The honeybee of honeybee category (Melipona).In patent document 2, disclose using the extract of the propolis of stingless bee class output and be used as active ingredient
Antifatigue.
Prior art literature
Patent document
Patent document 1：Japanese Unexamined Patent Publication 2008-50331 publications
Patent document 2：Japanese Unexamined Patent Publication 2005-281182 publications
The content of the invention
Invent problem to be solved
In patent document 1, individually tired relevant effect is not confirmed propolis.In addition, in patent document 1, only in fact
The evaluation carried out using survey has been applied, and objective method is not used and confirms its influence for body.
Also stingless peak class is described in patent document 2, as literal meaning, it is that pricker deteriorates during evolution
Honeybee, the long lifespan after honeybee had up to more than 10 years and build nest itself, because brewageing the high honey of antibiotic property and illness rate is low by propolis
Etc. feature.However, stingless bee class has the property that bee colony (colony) can be defeated and dispersed when exposed to low temperature, therefore, it inhabites area
Domain is confined to the torrid zone, can not extensive use.In addition, in patent document 2, the propolis from the honeybee for belonging to Apis is not found
Fatigue mitigate effect.
It is an object of the present invention to provide the new application of the propolis from the honeybee for belonging to Apis.
Means for solving the problems
The present invention provide contain from belong to Apis honeybee propolis or the propolis processed material conduct effectively into
The tired palliative divided.
Above-mentioned tired palliative is preferred for orally.
The tired palliative of the present invention can be used as tired mitigation with food compositions.Food compositions include food,
Healthy food, feature sign food (functional food), dietary supplement, replenishers and specific health food.Propolis
Just used all the time as food etc., its security to organism has been established.Therefore, can absorb with long duration
The fatigue mitigation food compositions.
Present invention also contemplates that for propolis lessening fatigue, from the honeybee for belonging to Apis or its processed material.In addition,
Present invention also contemplates that for it is lessening fatigue, contain from the propolis for the honeybee for belonging to Apis or its processed material as effectively into
The preparation divided.
Present invention also contemplates that from the propolis for the honeybee for belonging to Apis or its processed material in the manufacture of tired palliative
Purposes.
Present invention also contemplates that the method to lessen fatigue, methods described is included effective dose from the honeybee for belonging to Apis
Propolis or its processed material the step of bestowing to the object for needing the propolis or its processed material.
Invention effect
According to the present invention it is possible to provide the tired palliative for containing propolis or its processed material as active ingredient.
Brief description of the drawings
[Fig. 1] is the chart of the rheological parameters' change with time for the oxygen uptake for representing per unit body weight.
[Fig. 2] is the chart for the rheological parameters' change with time for representing exercise intensity.
[Fig. 3] is to represent ventilation volume (Japanese per minute：Fen Time Change mood amount) rheological parameters' change with time chart.
[Fig. 4] is the chart for the rheological parameters' change with time for representing maximum expiration speed.
[Fig. 5] is the chart for the rheological parameters' change with time for representing energy consumption.
[Fig. 6] is the chart of the rheological parameters' change with time of the antifatigue sense after walking movement.
[Fig. 7] is the chart of the rheological parameters' change with time for the sense of fatigue that expression is felt in daily life.
Embodiment
Hereinafter, the mode for implementing the present invention is described in detail.But the invention is not restricted to following embodiment party
Formula.
The tired palliative of the present invention contains propolis or its processed material as active ingredient.
Propolis refers to the resin-like or waxy substance for forming the nest wall of honeycomb.In known propolis containing cinnamic acid derivative,
Flavonoids, vitamin, mineral matter etc..
The propolis used in present embodiment derives from the honeybee for belonging to Apidae Apis.Apidae Apis includes west
9 kinds of square honeybee (Apis mellifera), Eastern bee (Api scerana) etc., the propolis from any kind can be used.
In Apis, preferably using the propolis from apis mellifera.Apis mellifera is believed to comprise 24~28 subspecies, can be used and
Come from the propolis of any one subspecies.Particularly preferably use from Africanize honeybee (it is one of subspecies as apis mellifera
Killer bee (A.mellifera scutellata) and other apis melliferas Europe production subspecies between Hybrid)
Propolis.
Propolis can for example be obtained based on conventional method in the form of product of raising bees.Propolis can be such as Japan's production, Brazil
Production, in the production of domestic, European Countries, Oceania production, U.S.'s production etc. derive from the propolis in any place of production.In addition, propolis can come from
The arbitrary plant origins such as rosemary (Alecrim) source, eucalyptus source, white poplar source, Clusia plant origin.Propolis can
Think any grade of palm fibre, red, yellow, and green, super green (super green), extremely green (ultra green) etc..Especially lived from physiology
Property it is high, be readily available from the viewpoint of, propolis is preferably the propolis from Africanized honeybee of Brazil's production.
Propolis can be such as propolis original block.Propolis processed material can also be that crushing is for example implemented to propolis original block, is surpassed
Critical extraction, water or hydrophilic organic solvent extraction, the concentration of extract or powdered, powder the processing such as granulation after honeybee
Glue processed material.Wherein, for using hydrophilic organic solvent extraction obtained from propolis hydrophilic organic solvent extract and
Speech, the active ingredient of propolis can in a short time efficiently and it is harmonious be extracted well, so it is preferred that.As extraction
The middle hydrophilic organic solvent used, preferred alcohol.
Commercially available commodity can be used in the processed material of propolis or propolis.As the propolis comprising apis mellifera source or propolis
The concrete example of the commercially available product of processed material, can enumerate the propolis 300 of such as Yamada Bee-yard Co., Ltd, propolis liquid 30 (containing bar
West production propolis), Propolis Help, propolis grain, propolis particle APC, Propolis Mild, propolis drink, gloomy river health hall
Neo Propolis grains, propolis grain, propolis liquid, Propolis Mild liquid, eucalyptus propolis, the L ' abeille of Co. Ltd. system
Co., Ltd. L ' abeille propolis (liquid-type), L ' abeille propolis (capsule-type), L ' abeille propolis honey etc..
The tired palliative that embodiments of the present invention are related to, can be only with a kind of above-mentioned propolis original block or propolis processed material
Form is used, and also be can be combined and is used form of more than two kinds.For tired palliative total amount, in tired palliative
The content of propolis and its processed material can be more than 0.002 mass % and below 50 mass % for example in terms of solid state component, also may be used
Think more than 0.01 mass % and below 45 mass %, can also be more than 0.1 mass % and below 40 mass %.
The tired palliative that embodiments of the present invention are related to due to containing propolis or its processed material as active ingredient, because
This, fatigue during by intake motion can be mitigated and in daily life.Specifically, by absorbing embodiment party of the invention
The tired palliative that formula is related to, as being shown as be described hereinafter in embodiment, when carrying out equivalent motion, oxygen intake can be reduced
Amount, ventilation volume per minute, maximum expiration speed, exercise intensity, energy consumption etc., it is during so as to mitigate motion and daily
The sense of fatigue of body in life.Wherein, the effect for reducing the sense of fatigue felt in ventilation volume per minute and daily life is high.
That is, the tired palliative being related to by absorbing embodiments of the present invention, it is possible to increase motion function, and motion can be mitigated
When, in daily life body burden.Therefore, the tired palliative that embodiments of the present invention are related to can also be used as fitness machine
Can enhancer.
As long as the object for the tired palliative that intake embodiments of the present invention are related to it is expected that fatigue mitigates effect
People, can be anyone, especially effect is high for it the people of daily exercise amount deficiency tendency be present, for example, for because of fortune
Effect is high for high age level in 40~65 years old for moving insufficient and easy fatigue and worrying.
The tired palliative that embodiments of the present invention are related to presents aobvious after daily continuous ingestion is started after about 4 weeks at the latest
Effect is write, by continuous ingestion, higher effect can be achieved.In addition, generally, it is believed that body-building is repeated by daily
(fitness), aerobic exercise etc. tempers (training) and can improve motion function, mitigate and hold fatigable situation, but passes through
The tired palliative that is related to of intake embodiments of the present invention, even if not being trained especially, from absorb after about 4 weeks~
At such initial stage after 8 weeks, it can also realize motion function raising, fatigue mitigation and other effects.Therefore, it is especially suitable for it is expected independent of forging
The people for refining and improving motion function in the early stage, lessening fatigue.In addition, the tired palliative that embodiments of the present invention are related to
Intake can concurrently be carried out with taking exercise.
Tired palliative that embodiments of the present invention are related to can only contain the propolis or propolis as active ingredient
Processed material, in the range of effect of the present invention is not damaged, it can further contain other compositions.As other compositions, for example, can
The composition pharmaceutically allowed with enumerating is (for example, excipient, adhesive, lubricant, disintegrant, emulsifying agent, surfactant, base
Agent, cosolvent, suspending agent), the composition that allows as food (for example, mineral matter class, vitamins, flavonoid class, quinones,
Polyphenols, amino acid, nucleic acid, essential fatty acid, freshener, adhesive, sweetener, disintegrant, lubricant, colouring agent, spices,
Stabilizer, preservative, release modifying agents, surfactant, lytic agent, wetting agent).
For the tired palliative that embodiments of the present invention are related to, in terms of the conversion of active ingredient amount, for body weight
For 60kg adult, can be used with daily more than 1mg and below 550mg dosage, preferably with more than 3mg and below 500mg
Dosage use, more preferably with more than 5mg and below 450mg dosage use, further preferably with more than 7mg and 400mg with
Under dosage use.Can according to the health status of the people of intake, bestow method and with the factor such as the combination of other preparations and upper
The dosage is set appropriately in the range of stating.In addition, for the tired palliative that embodiments of the present invention are related to, with
Active ingredient amount conversion meter, for body weight be 60kg adult, even if with daily below 460mg, below 300mg or 230mg with
Under dosage use, also can fully realize fatigue mitigate effect.
The tired palliative that embodiments of the present invention are related to parenteral can also be bestowed with oral administration (intake).
For the tired palliative that embodiments of the present invention are related to, daily active ingredient amount in above-mentioned scope,
It can be bestowed once, can also be bestowed several times twice a day, three times a day etc. with one day.
The tired palliative that embodiments of the present invention are related to preferably carries out oral administration.Pass through oral administration, Neng Gougao
Effect ground absorbs the functional component of propolis to internal, so as to bring higher physiologically active.Therefore, embodiment party of the invention
The tired palliative that formula is related to is preferred for orally.
The tired palliative that embodiments of the present invention are related to can be the arbitrary shape such as solid, liquid, paste.This hair
The form for the tired palliative that bright embodiment is related to can be for example without coating tablet, sugar coated tablet, particle, powder, tablet
(tablet), capsule (hard shell capsules, soft capsule, Sealmess capsule).The tired palliative that embodiments of the present invention are related to can lead to
Crossing will for example mix with other compositions as needed and adding as the propolis of active ingredient or the processed material of propolis, is configured to
It is prepared by above-mentioned formulation.
The tired palliative that embodiments of the present invention are related to can be used as pharmaceuticals, quasi- pharmaceuticals (quasi drug, medicine
Part outer article) and food compositions use in itself, and can add in pharmaceuticals, quasi- pharmaceuticals and food compositions and enter
Exercise and use.As food compositions, the 3rd function (the health regulatory function, i.e. fatigue mitigates of food is preferably highlighted
Function, motion function improve function etc..) food.As the food compositions for the 3rd function of highlighting food, can enumerate
Such as healthy food, feature sign food (functional food), dietary supplement, replenishers and specific health food.
Pharmaceuticals, quasi- pharmaceuticals or food compositions that the tired palliative being related to by embodiments of the present invention is formed,
Or pharmaceuticals, quasi- pharmaceuticals or the food compositions of the tired palliative being related to comprising embodiments of the present invention can be used for
Fatigue mitigates purposes, motion function improves purposes.In addition, above-mentioned pharmaceuticals, quasi- pharmaceuticals or food can also be tired with mitigating
The sign of the content of labor, the content for improving motion function etc..
Can be according to species of pharmaceuticals, quasi- pharmaceuticals and food compositions etc. and to pharmaceuticals, quasi- pharmaceuticals and food group
The content for the tired palliative that embodiments of the present invention in compound are related to is set appropriately, make to absorb daily it is effective into
Component is within the above range.
The tired palliative that embodiments of the present invention are related to is as food compositions in itself or added to Combined food
In thing and in the case of carrying out use, the form of food compositions is not particularly limited, for example, can be beverage class (coffee, fruit
The cold drinks such as juice, tea beverage, fruit syrup, milk beverage, sour milk beverage, boruga, soda etc.), spread class
(custard sauce (custard cream) etc.), paste class (puree etc.), Western-style pastry class (chocolate, bagel, pie (pie), puff,
Chewing gum, jelly (jelly), candy, cookies, cake, pudding etc.), Japanese snack categories (mochi, rice cake, have filling millet cake (day
Text：Bread Head), Nagasaki formula honey cake (Japanese：カ ス テ ラ), Anmitsu formulas dessert, red bean jelly etc.), freezing point class (ice cream, ice
Rod, frost (sherbet) etc.), (curry, beef rice, mixture congee, miso shiru, soup, meat pulp (meat sauce), meaning are big for foodstuff
Sharp face, salted vegetables, jam etc.), flavoring class (baste, mix meal flavoring (Japanese：ふ り か け), delicate flavour sauce, soup stock
Deng).
Combined food using the tired palliative that embodiments of the present invention are related to as the 3rd function of highlighting food
Thing is (for example, healthy food, feature sign food (functional food), dietary supplement, replenishers or specific food for health care
Product) use or add in the food of the 3rd function of food compositions is highlighted and in the case of use in itself, remove
Beyond the form of above-mentioned food compositions, the form for highlighting the food compositions of the 3rd function of food can be exemplified by
Such as without coating tablet, sugar coated tablet, particle, powder, tablet, capsule (hard shell capsules, soft capsule, Sealmess capsule).
Use or add in itself using the tired palliative that embodiments of the present invention are related to as pharmaceuticals or quasi- pharmaceuticals
It is added in pharmaceuticals or quasi- pharmaceuticals and in the case of carrying out use, the form of pharmaceuticals or quasi- pharmaceuticals is not particularly limited,
Can be for example without coating tablet, sugar coated tablet, particle, powder, tablet, capsule (hard shell capsules, soft capsule, Sealmess capsule).
The pharmaceuticals of the tired palliative being related to added with embodiments of the present invention, quasi- pharmaceuticals or food compositions
Preparation method is not particularly limited, and can be carried out based on appropriate known method.For example, can by pharmaceuticals, quasi- pharmaceuticals or
The fatigue that embodiments of the present invention are related to is mixed in intermediate products or final products in the manufacturing process of food compositions to subtract
The modes such as light diaphoretic prescription, to obtain the pharmaceuticals for such use, quasi- pharmaceuticals or food compositions.
It is above-mentioned present invention also contemplates that for lessen fatigue, propolis or its processed material.In addition, present invention also contemplates that it is used for
It is lessening fatigue, contain the preparation of propolis or its processed material as active ingredient.Present invention also contemplates that propolis or its processed material exist
Purposes in the manufacture of tired palliative.
In addition, the invention described above is also contemplated by the method to lessen fatigue, methods described is included at the propolis of effective dose or its
The step of reason thing is bestowed to the object for needing the propolis or its processed material.
Embodiment
Hereinafter, the present invention is more specifically illustrated based on embodiment.But the invention is not restricted to following examples.
＜ test methods ＞
45 men and women of 40~65 years old that the problem of being directed to prior survey answers " usually fresh to be moved less " are selected,
As subject.It is divided into 3 groups in a manner of making age and M-F identical as far as possible, every group 15, respectively as (A) propolis
Intake and walking movement group, (B) propolis intake group, (C) walking movement group.
(A) group and (B) group were by 1 day soft capsule (trade name " propolis for absorbing propolis extract in a manner of 3 daily
300 ", Yamada Bee-yard Co., Ltd's system, Brazil's production propolis extract, honeybee source of Africanizing, 75.6mg/ grains).(A) group and
(C) group carries out weekly the walking movement (more than 30 minutes/day) of more than 3 days, continues 12 weeks.Experiment will start before (0 week),
Implement following expiration gas metabolic determinations within the 4th week and the 8th week after on-test, implement questionnaire tune within the 12nd week after on-test
Look into, to investigate the influence for health and muscle power.
(expiration gas metabolic determination)
Each subject carries out the step of 15 minutes on a treadmill in the state of expiration gas metabolic determination mask is had on
Row motion.Walking movement amounts to 15 minutes, specific as follows：It is quiet 2 minutes；It is warm-up 1 minute；Speed per minute be 60m, 80m,
100m, each 3 minutes, add up to 9 minutes；Loosen (cool down) 1 minute；2 minutes convalescences.
Using expiration gas metabolic determination device (METALYZER 3B, Colltex Ltd systems), to being exhaled in walking movement
In oxygen amount and gas concentration lwevel carry out time dependent measure.In addition, Respiration Rate in walking movement is determined (in walking movement
Respiration rate), ventilation volume per minute (respiration rate in walking movement), maximum expiration speed (in walking movement most
Big respiration rate) and energy consumption.For zmount of oxygen consumption and energy consumption, the per unit body weight of each subject is calculated
Value.It should be noted that the value of maximum expiration speed is smaller, then it represents that can more be moved in the case where not panting, energy disappears
The value of consumption is smaller, then it represents that the motion of same degree can be more carried out with less energy.
Exercise intensity is calculated by the carbon dioxide output and oxygen uptake that measure.Exercise intensity is to be taken the photograph by the oxygen in motion
Taken amount and it is quiet when the value that calculates of oxygen uptake, numerical value is bigger, then it represents that the motion carried out causes bigger burden.
For above-mentioned projects, the average value for calculating 15 minutes in walking movement.(0 week) is each before will being started with experiment
The value of project records the rheological parameters' change with time from after 4 weeks as benchmark (100%).As a result Fig. 1~5 are shown in.In figure, * mark tables
Show p value to be less than 0.05 based on 0 week.
(survey)
Before experiment will start (0 week) and the 12nd week after on-test, for the antifatigue sense after walking movement and day
The sense of fatigue often felt in life implements survey.For the antifatigue sense after walking movement, commented using visual simulation
Point (VAS) method, by it is exhausted to such worst feeling evaluation that can not take action be 0, will completely it is imperceptible it is tired so
Best feeling evaluation be 100, obtain the answer based on numerical value.For the sense of fatigue felt in daily life, it will feel
Feel that the situation less than fatigue is evaluated as 0, in the case of feeling fatigue, based on 5 grades (1：Gently, 5：Weight) degree of fatigue is carried out
Evaluation.As a result Fig. 6,7 are shown in.In figure, * marks represent p value to be less than 0.05 based on 0 week.
＜ results ＞
As the result of expiration gas metabolic determination, in (A) propolis intake+walking group, absorbed in the oxygen of per unit body weight
(Fig. 1), exercise intensity (Fig. 2), the aspect of energy consumption (Fig. 5) are measured, was observed after 4 weeks on-tests under significant numerical value
Drop.(C) in walking group, the trend of these numerical value rising be present, do not observe being remarkably decreased for numerical value.(B) in propolis intake group,
These numerical value are after 4 weeks to significantly declining in a period of after 8 weeks.In addition, in (B) propolis intake group, per minute changes
Tolerance (Fig. 3), maximum expiration speed (Fig. 4) also significantly decline.
It is tired in sense of fatigue (Fig. 6) and daily life during motion in (B) propolis intake group in addition, in Questionnaire results
Labor sense (Fig. 7) is significantly improved.
Result above shows, by absorbing propolis, in the case of amount of exercise deficiency, also shows that raising fitness machine
The effect for the relative burden for same movement amount, can be alleviated, lessening fatigue.Although in addition, also show combine into
Row propolis is also showed that in the case of absorbing with walking movement with the effect for improving motion function, lessening fatigue, but these are imitated
Fruit shows higher level in the case of intake propolis and not with walking movement.
Claims (3)
1. tired palliative, its using the processed material of the propolis from the honeybee for belonging to Apis or the propolis as effectively into
Point.
2. tired palliative as claimed in claim 1, it is used for orally.
3. tired mitigation food compositions, it includes the tired palliative described in claim 1.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015-154216 | 2015-08-04 | ||
| JP2015154216 | 2015-08-04 | ||
| PCT/JP2016/072538 WO2017022722A1 (en) | 2015-08-04 | 2016-08-01 | Anti-fatigue agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107847528A true CN107847528A (en) | 2018-03-27 |
Family
ID=57943469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680045186.XA Pending CN107847528A (en) | 2015-08-04 | 2016-08-01 | Tired palliative |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP6629859B2 (en) |
| CN (1) | CN107847528A (en) |
| TW (1) | TW201707714A (en) |
| WO (1) | WO2017022722A1 (en) |
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| SG11201705867VA (en) * | 2015-01-22 | 2017-08-30 | Yamada Bee Co Inc | Composition |
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2016
- 2016-08-01 WO PCT/JP2016/072538 patent/WO2017022722A1/en active Application Filing
- 2016-08-01 CN CN201680045186.XA patent/CN107847528A/en active Pending
- 2016-08-01 JP JP2017533062A patent/JP6629859B2/en active Active
- 2016-08-03 TW TW105124661A patent/TW201707714A/en unknown
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| CN1473921A (en) * | 2003-08-05 | 2004-02-11 | 王洪涛 | Melissa powder wine |
| CN1596736A (en) * | 2004-08-31 | 2005-03-23 | 陈季平 | Health-care food containing pseudo ginseng powder and propolis |
| RU2504222C2 (en) * | 2012-03-15 | 2014-01-20 | Государственное научное учреждение Сибирский научно-исследовательский институт переработки сельскохозяйственной продукции Российской академии сельскохозяйственных наук (ГНУ СибНИИП Россельхозакадемии) | Food product with preventive medical properties |
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| JP6629859B2 (en) | 2020-01-15 |
| JPWO2017022722A1 (en) | 2018-03-29 |
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