CN107837345A - A kind of pharmaceutical composition with antihepatitis activity - Google Patents
A kind of pharmaceutical composition with antihepatitis activity Download PDFInfo
- Publication number
- CN107837345A CN107837345A CN201711085075.4A CN201711085075A CN107837345A CN 107837345 A CN107837345 A CN 107837345A CN 201711085075 A CN201711085075 A CN 201711085075A CN 107837345 A CN107837345 A CN 107837345A
- Authority
- CN
- China
- Prior art keywords
- parts
- pharmaceutical composition
- mushroom
- radix astragali
- rheum officinale
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a kind of pharmaceutical composition with antihepatitis activity, include the raw material of following parts by weight：10~20 parts of rheum officinale, 10~20 parts of rainbow conk mushroom, 10~20 parts of stringy stonecrop, 10~20 parts of Sagina subulata, 2~4 parts of the red sage root, 5~15 parts of the Radix Astragali, 12~22 parts of matrimony vine, 5~10 parts of the fruit of glossy privet, 10~20 parts of black rice flour, 10~20 parts of red date powder.Chinese medicine composition proposed by the present invention, formed by several kinds of Chinese medicinal materials compounding, the reasonable mixture ratio of each Chinese medicine, there is liver protection, protect liver, beneficial liver, raising immunity, Chinese medicine composition is safe to use, usage amount is few, quick, ALT and Aspartate aminotransferase can effectively be reduced, and liver's damaged tissues can be quickly repaired, hepatopathy is treated from root, and preparation method is simple to operate, extraction efficiency is high, and extraction time is short.
Description
Technical field
The present invention relates to development of Chinese herb products technical field, more particularly to a kind of pharmaceutical composition with antihepatitis activity.
Background technology
Pressure is big in daily life due to people, improper diet, excessive drinking, the long-term reason such as stay up late, cause more next
More people suffers from light or heavy hepatopathy, such as hepatitis B big and small three Yang, alcoholic liver, fatty liver, hepatic sclerosis, liver tumour etc..
Nowadays, hepatopathy turns into endangers one of disease occurred frequently of human health, and the medicine for treating hepatopathy at present is mainly Western medicine, such as
DDB, but Western medicine is only cured the symptoms, not the disease, and side effect is big.
In recent years, people find many Chinese medicines with protect liver effect, such as China Patent No.：The A of CN 104873566, it is public
A kind of pharmaceutical composition with antihepatitis activity formed with Cacumen Securinegae Suffruticosae extract, glycyrrhizic acid and urso is opened；
China Patent No.：The A of CN 104825531, disclose a kind of anti-with having of forming of Cacumen Securinegae Suffruticosae extract, glycyrrhizic acid and bicyclic alcohols
The pharmaceutical composition of hepatic injury activity；China Patent No.：The B of CN 102362916, disclose it is a kind of with peach kernel, all sorts of flowers field pennycress,
The Chinese medicinal compound extract with anti-liver injury effect that plantain seed, shiny-leaved yellowhorn benevolence, Radix Angelicae Sinensis, the root of herbaceous peony, radix bupleuri and radix glycyrrhizae form；
Chinese medicine disclosed in above-mentioned patent has the effect of certain to anti-liver injury, but the dosage of Chinese medicine composition is larger, few agent
The Chinese medicine composition liver protection of amount, liver protection effect unobvious.
Based on above-mentioned the deficiencies in the prior art, the present invention proposes a kind of pharmaceutical composition with antihepatitis activity.
The content of the invention
The invention aims to solve shortcoming present in prior art, and the one kind proposed has anti-liver injury work
The pharmaceutical composition of property.
A kind of pharmaceutical composition with antihepatitis activity, include the raw material of following parts by weight：10~20 parts of rheum officinale, cloud
10~20 parts of sesame mushroom, 10~20 parts of stringy stonecrop, 10~20 parts of Sagina subulata, 2~4 parts of the red sage root, 5~15 parts of the Radix Astragali, matrimony vine 12~
22 parts, 5~10 parts of the fruit of glossy privet, 10~20 parts of black rice flour, 10~20 parts of red date powder.
Preferably, the Chinese medicine includes the raw material of following parts by weight：12~18 parts of rheum officinale, 12~18 parts of rainbow conk mushroom, hang down
12~18 parts of basin grass, 12~18 parts of Sagina subulata, 2~4 parts of the red sage root, 8~12 parts of the Radix Astragali, 15~20 parts of matrimony vine, 6~9 parts of the fruit of glossy privet,
12~18 parts of black rice flour, 12~18 parts of red date powder.
Preferably, the Chinese medicine includes the raw material of following parts by weight：15 parts of rheum officinale, 15 parts of rainbow conk mushroom, 15 parts of stringy stonecrop,
15 parts of Sagina subulata, 3 parts of the red sage root, 10 parts of the Radix Astragali, 18 parts of matrimony vine, 7 parts of the fruit of glossy privet, 15 parts of black rice flour, 15 parts of red date powder.
Preferably, the mass ratio of the rheum officinale, rainbow conk mushroom, stringy stonecrop and Sagina subulata is 1:1:1：1.
Preferably, the screen cloth that the black rice flour and red date powder are crossed more than 100 mesh before use.
Preferably, the preparation method of the described pharmaceutical composition with antihepatitis activity comprises the following steps：
S1, rheum officinale, rainbow conk mushroom, the red sage root and the Radix Astragali cut into slices respectively, and same stringy stonecrop, Sagina subulata, matrimony vine and the fruit of glossy privet
It is placed in dryer and dries together, it is standby；
S2, the tablet for taking according to the proportion relation of each raw material the rheum officinale after above-mentioned drying, rainbow conk mushroom, the red sage root and the Radix Astragali
It is placed in reaction bulb, and is extracted 1 time with ethanol, water extracts 1 time, is filtered every time after extraction, merging filtrate, ethanol is recovered under reduced pressure extremely
Relative density is 1.20~1.22 thick paste A at 60 DEG C；
S3, according to the proportion relation of each raw material stringy stonecrop, Sagina subulata, matrimony vine and the fruit of glossy privet after above-mentioned drying is taken to be placed in powder
Crush, be subsequently placed in reaction bulb in broken machine, with 6~10 times amount ethanol extract 1~3 time, every time extract 1~2 hour, every time
Filtered after extraction, merging filtrate, ethanol is recovered under reduced pressure to the thick paste B that relative density at 60 DEG C is 1.22~1.24；
S4, thick paste A and thick paste B mixed, black rice flour, red date powder, auxiliary material and the water stirring for adding corresponding parts by weight are equal
Pelletized after even, be drying to obtain the pharmaceutical composition with antihepatitis activity.
Preferably, in the S2 steps addition of ethanol be rheum officinale, rainbow conk mushroom, the red sage root and Radix Astragali gross mass 6~
10 times, the extraction time of ethanol is 0.5~1.5 hour, and the addition of the water is that rheum officinale, rainbow conk mushroom, the red sage root and the Radix Astragali are total
8~12 times of quality, the extraction time of the water is 1~3 hour.
Preferably, the auxiliary material is magnesium stearate, talcum powder, hydroxypropyl methylcellulose, calcium carbonate, pregelatinized starch and lactose
In any several mixing.
Chinese medicine composition proposed by the present invention, formed by several kinds of Chinese medicinal materials compounding, the reasonable mixture ratio of each Chinese medicine, rheum officinale,
The compounding use of rainbow conk mushroom, stringy stonecrop and Sagina subulata, the liver protection of Chinese medicine composition, protect liver, the work of beneficial liver can be significantly improved
With, while coordinate the use of the Radix Astragali, matrimony vine, the red sage root, black rice flour and red date powder again, Chinese medicine composition can be made to improve immunity
Effect, the safe to use of the Chinese medicine composition compounded, usage amount are few, quick, can effectively reduce alanine amino and turn
Enzyme and Aspartate aminotransferase are moved, and can quickly repair liver's damaged tissues, hepatopathy is treated from root, the present invention is also
Propose a kind of simple to operate, preparation method of the high Chinese medicine composition of extraction efficiency, according to the difference of medicinal material property, to medicinal material
Pre-processed, improve the extraction efficiency of medicinal material, shorten the extraction time of medicinal material.
Embodiment
The present invention is made with reference to specific embodiment further to explain.
Embodiment one
A kind of pharmaceutical composition with antihepatitis activity proposed by the present invention, including following raw material：15 parts of rheum officinale, cloud
15 parts of sesame mushroom, 15 parts of stringy stonecrop, 15 parts of Sagina subulata, 3 parts of the red sage root, 10 parts of the Radix Astragali, 18 parts of matrimony vine, 7 parts of the fruit of glossy privet, black rice flour 15
Part, 15 parts of red date powder.
Its preparation method comprises the following steps：
S1, rheum officinale, rainbow conk mushroom, the red sage root and the Radix Astragali cut into slices respectively, and same stringy stonecrop, Sagina subulata, matrimony vine and the fruit of glossy privet
It is placed in dryer and dries together, it is standby；
S2, the tablet for taking according to the proportion relation of each raw material the rheum officinale after above-mentioned drying, rainbow conk mushroom, the red sage root and the Radix Astragali
It is placed in reaction bulb, and is extracted 1 hour with the ethanol of 8 times of amounts, then extracted 2 hours with the water of 10 times of amounts, is filtered every time after extraction,
Merging filtrate, ethanol is recovered under reduced pressure to the thick paste A that relative density at 60 DEG C is 1.20~1.22；
S3, according to the proportion relation of each raw material stringy stonecrop, Sagina subulata, matrimony vine and the fruit of glossy privet after above-mentioned drying is taken to be placed in powder
Crush, be subsequently placed in reaction bulb in broken machine, extracted 2 times with the ethanol of 8 times of amounts, every time extraction 1.5 hours, every time after extraction
Filtration, merging filtrate, ethanol is recovered under reduced pressure to the thick paste B that relative density at 60 DEG C is 1.22~1.24；
S4, thick paste A and thick paste B mixed, black rice flour, red date powder, auxiliary material and the water stirring for adding corresponding parts by weight are equal
Pelletized after even, be drying to obtain the pharmaceutical composition with antihepatitis activity.
In the present invention, the auxiliary material is magnesium stearate, talcum powder, hydroxypropyl methylcellulose, calcium carbonate, pregelatinized starch and breast
The mixing of sugar.
Embodiment two
A kind of pharmaceutical composition with antihepatitis activity proposed by the present invention, including following raw material：12 parts of rheum officinale, cloud
12 parts of sesame mushroom, 12 parts of stringy stonecrop, 12 parts of Sagina subulata, 4 parts of the red sage root, 10 parts of the Radix Astragali, 16 parts of matrimony vine, 8 parts of the fruit of glossy privet, black rice flour 15
Part, 15 parts of red date powder.
Its preparation method comprises the following steps：
S1, rheum officinale, rainbow conk mushroom, the red sage root and the Radix Astragali cut into slices respectively, and same stringy stonecrop, Sagina subulata, matrimony vine and the fruit of glossy privet
It is placed in dryer and dries together, it is standby；
S2, the tablet for taking according to the proportion relation of each raw material the rheum officinale after above-mentioned drying, rainbow conk mushroom, the red sage root and the Radix Astragali
It is placed in reaction bulb, and is extracted 1.5 hours with the ethanol of 10 times of amounts, then extracted 1 hour with the water of 10 times of amounts, is filtered every time after extraction
Cross, merging filtrate, ethanol is recovered under reduced pressure to the thick paste A that relative density at 60 DEG C is 1.20~1.22；
S3, according to the proportion relation of each raw material stringy stonecrop, Sagina subulata, matrimony vine and the fruit of glossy privet after above-mentioned drying is taken to be placed in powder
Crush, be subsequently placed in reaction bulb in broken machine, extracted 2 times with the ethanol of 8 times of amounts, every time extraction 2 hours, filtered after extraction every time
Cross, merging filtrate, ethanol is recovered under reduced pressure to the thick paste B that relative density at 60 DEG C is 1.22~1.24；
S4, thick paste A and thick paste B mixed, black rice flour, red date powder, auxiliary material and the water stirring for adding corresponding parts by weight are equal
Pelletized after even, be drying to obtain the pharmaceutical composition with antihepatitis activity.
In the present invention, the auxiliary material is the mixing of talcum powder, hydroxypropyl methylcellulose, calcium carbonate and lactose.
Embodiment three
A kind of pharmaceutical composition with antihepatitis activity proposed by the present invention, including following raw material：15 parts of rheum officinale, cloud
15 parts of sesame mushroom, 15 parts of stringy stonecrop, 15 parts of Sagina subulata, 2 parts of the red sage root, 5 parts of the Radix Astragali, 12 parts of matrimony vine, 8 parts of the fruit of glossy privet, black rice flour 14
Part, 15 parts of red date powder.
Its preparation method comprises the following steps：
S1, rheum officinale, rainbow conk mushroom, the red sage root and the Radix Astragali cut into slices respectively, and same stringy stonecrop, Sagina subulata, matrimony vine and the fruit of glossy privet
It is placed in dryer and dries together, it is standby；
S2, the tablet for taking according to the proportion relation of each raw material the rheum officinale after above-mentioned drying, rainbow conk mushroom, the red sage root and the Radix Astragali
It is placed in reaction bulb, and is extracted 0.5 hour with the ethanol of 6 times of amounts, then extracted 3 hours with the water of 10 times of amounts, is filtered every time after extraction
Cross, merging filtrate, ethanol is recovered under reduced pressure to the thick paste A that relative density at 60 DEG C is 1.20~1.22；
S3, according to the proportion relation of each raw material stringy stonecrop, Sagina subulata, matrimony vine and the fruit of glossy privet after above-mentioned drying is taken to be placed in powder
Crush, be subsequently placed in reaction bulb in broken machine, extracted 2 times with the ethanol of 6 times of amounts, every time extraction 1 hour, filtered after extraction every time
Cross, merging filtrate, ethanol is recovered under reduced pressure to the thick paste B that relative density at 60 DEG C is 1.22~1.24；
S4, thick paste A and thick paste B mixed, black rice flour, red date powder, auxiliary material and the water stirring for adding corresponding parts by weight are equal
Pelletized after even, be drying to obtain the pharmaceutical composition with antihepatitis activity.
In the present invention, the auxiliary material is the mixing of magnesium stearate, hydroxypropyl methylcellulose, calcium carbonate and pregelatinized starch.
Protective effect experiment of the Chinese medicine composition proposed by the present invention to hepatic injury caused by virus hepatitis is as follows：
1st, material：Cleaning grade mouse 60, each 30 of male and female, 18~22g of body weight；Bifendate (Shanghai balance pharmacy
Factory), facing the used time is made into suspension：Alanine aminotransferase (ALT) kit, aspartate aminotransferase (AST) examination
Agent box.
2nd, packet, modeling and administration：60 mouse are randomly divided into blank group, model group, DDB group, treatment one
Three groups of group, two groups for the treatment of and treatment, and male and female number is identical in every group.
Blank group and model group give distilled water daily；DDB group gives the suspension of Bifendate every time, often
Secondary 100mg/kg body weight；Treat one group of Chinese medicine composition for giving the preparation of embodiment one, each 100mg/kg body weight；Treat two groups
Give the Chinese medicine composition of the preparation of embodiment two, each 100mg/kg body weight；Treat three groups of Chinese medicines for giving the preparation of embodiment three
Composition, each 100mg/kg body weight；Water is can't help in 4h after last dose, fasting, except the sodium chloride of blank group tail vein injection 0.9%
Outside parenteral solution, other group of tail vein injection ConA 20mg/kg body weight, eyeball is plucked after 10h and takes blood, detects each index.
3rd, experimental result
Experimental result is shown, compared with blank group, ALT, AST are significantly raised in model group mice serum, illustrate that ConA is lured
Send out the success of mouse liver injury model；Compared with model group, three groups DDB group, one group for the treatment of, two groups for the treatment of and treatment small
Mouse serum alt, AST are significantly reduced, and ALT, AST reduction situation compare biphenyl in three groups of one group for the treatment of, two groups for the treatment of and treatment
Dibasic acid esters group is good, and the effect of embodiment one is best, shows that Chinese medicine composition proposed by the present invention has the function that liver protection, protect liver.
The shadow of the how many pairs of protective effects of hepatic injury caused by virus hepatitis of Chinese medicine composition dosage proposed by the present invention
It is as follows to ring experiment：
1st, material：Cleaning grade mouse 60, each 30 of male and female, 18~22g of body weight；Bifendate (Shanghai balance pharmacy
Factory), facing the used time is made into suspension：Alanine aminotransferase (ALT) kit, aspartate aminotransferase (AST) examination
Agent box.
2nd, packet, modeling and administration：60 mouse are randomly divided into blank group, model group, DDB group, low dosage
Group, middle dose group and high dose group, and male and female number is identical in every group.
Blank group and model group give distilled water daily；DDB group gives the suspension of Bifendate every time, often
Secondary 100mg/kg body weight；Low dose group gives the Chinese medicine composition of the preparation of embodiment one, each 30mg/kg body weight；Middle dose group
Give the Chinese medicine composition of the preparation of embodiment one, each 60mg/kg body weight；High dose group gives the Chinese medicine group of the preparation of embodiment one
Compound, each 100mg/kg body weight；Water is can't help in 4h after last dose, fasting, except the sodium chloride of blank group tail vein injection 0.9% is noted
Penetrate outside liquid, other group of tail vein injection ConA 20mg/kg body weight, plucking eyeball after 10h takes blood, detects each index.
3rd, experimental result
| Group | ALT(U/L) | AST(U/L) |
| Blank group | 44.21±5.44 | 36.45±4.97 |
| Model group | 187.45±9.12 | 173.66±7.23 |
| DDB group | 49.91±6.63 | 42.53±7.42 |
| Low dose group | 68.35±5.83 | 57.65±6.14 |
| Middle dose group | 49.41±8.32 | 41.44±5.36 |
| High dose group | 45.03±6.91 | 38.12±4.85 |
Experimental result is shown, compared with blank group, ALT, AST are significantly raised in model group mice serum, illustrate that ConA is lured
Send out the success of mouse liver injury model；Compared with model group, DDB group, low dose group, middle dose group and high dose group it is small
Mouse serum alt, AST are significantly reduced, and ALT, AST are slightly higher compared with DDB group in low dose group, middle dose group and high dose
ALT, AST are suitable with DDB group in group, show that Chinese medicine composition proposed by the present invention plays liver protection, needed for liver protection effect
Dosage is few.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto,
Any one skilled in the art the invention discloses technical scope in, technique according to the invention scheme and its
Inventive concept is subject to equivalent substitution or change, should all be included within the scope of the present invention.
Claims (8)
1. a kind of pharmaceutical composition with antihepatitis activity, it is characterised in that include the raw material of following parts by weight：Rheum officinale 10
~20 parts, 10~20 parts of rainbow conk mushroom, 10~20 parts of stringy stonecrop, 10~20 parts of Sagina subulata, 2~4 parts of the red sage root, 5~15 parts of the Radix Astragali,
12~22 parts of matrimony vine, 5~10 parts of the fruit of glossy privet, 10~20 parts of black rice flour, 10~20 parts of red date powder.
2. a kind of pharmaceutical composition with antihepatitis activity according to claim 1, it is characterised in that including following
The raw material of parts by weight：12~18 parts of rheum officinale, 12~18 parts of rainbow conk mushroom, 12~18 parts of stringy stonecrop, 12~18 parts of Sagina subulata, the red sage root
2~4 parts, 8~12 parts of the Radix Astragali, 15~20 parts of matrimony vine, 6~9 parts of the fruit of glossy privet, 12~18 parts of black rice flour, 12~18 parts of red date powder.
3. a kind of pharmaceutical composition with antihepatitis activity according to claim 1, it is characterised in that including following
The raw material of parts by weight：15 parts of rheum officinale, 15 parts of rainbow conk mushroom, 15 parts of stringy stonecrop, 15 parts of Sagina subulata, 3 parts of the red sage root, 10 parts of the Radix Astragali, Chinese holly
18 parts of Qi, 7 parts of the fruit of glossy privet, 15 parts of black rice flour, 15 parts of red date powder.
4. a kind of pharmaceutical composition with antihepatitis activity according to claim 1, it is characterised in that described big
Huang, rainbow conk mushroom, the mass ratio of stringy stonecrop and Sagina subulata are 1:1:1：1.
A kind of 5. pharmaceutical composition with antihepatitis activity according to claim 1, it is characterised in that the black rice
The screen cloth that powder and red date powder are crossed more than 100 mesh before use.
6. a kind of pharmaceutical composition with antihepatitis activity according to claim 1 or 2 or 3 or 4 or 5, its feature
It is, its preparation method comprises the following steps：
S1, rheum officinale, rainbow conk mushroom, the red sage root and the Radix Astragali cut into slices respectively, and same stringy stonecrop, Sagina subulata, matrimony vine and the fruit of glossy privet are together
It is placed in dryer and dries, it is standby；
S2, according to the proportion relation of each raw material the tablet of the rheum officinale after above-mentioned drying, rainbow conk mushroom, the red sage root and the Radix Astragali is taken to be placed in
In reaction bulb, and extracted 1 time with ethanol, water extracts 1 time, is filtered every time after extraction, merging filtrate, ethanol is recovered under reduced pressure to 60 DEG C
When relative density be 1.20~1.22 thick paste A；
S3, according to the proportion relation of each raw material stringy stonecrop, Sagina subulata, matrimony vine and the fruit of glossy privet after above-mentioned drying is taken to be placed in pulverizer
Middle crushing, is subsequently placed in reaction bulb, is extracted 1~3 time with the ethanol of 6~10 times of amounts, extracted 1~2 hour every time, every time extraction
Filter afterwards, merging filtrate, ethanol is recovered under reduced pressure to the thick paste B that relative density at 60 DEG C is 1.22~1.24；
S4, thick paste A and thick paste B mixed, add corresponding parts by weight black rice flour, red date powder, auxiliary material and water stir after
Pelletized, be drying to obtain the pharmaceutical composition with antihepatitis activity.
7. a kind of preparation method of pharmaceutical composition with antihepatitis activity according to claim 6, its feature exist
In, in the S2 steps addition of ethanol be rheum officinale, rainbow conk mushroom, 6~10 times of the red sage root and Radix Astragali gross mass, ethanol carries
It is 0.5~1.5 hour to take the time, and the addition of the water is 8~12 times of rheum officinale, rainbow conk mushroom, the red sage root and Radix Astragali gross mass,
The extraction time of the water is 1~3 hour.
8. a kind of preparation method of pharmaceutical composition with antihepatitis activity according to claim 6, its feature exist
In the auxiliary material is any several in magnesium stearate, talcum powder, hydroxypropyl methylcellulose, calcium carbonate, pregelatinized starch and lactose
Mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711085075.4A CN107837345A (en) | 2017-11-07 | 2017-11-07 | A kind of pharmaceutical composition with antihepatitis activity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711085075.4A CN107837345A (en) | 2017-11-07 | 2017-11-07 | A kind of pharmaceutical composition with antihepatitis activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107837345A true CN107837345A (en) | 2018-03-27 |
Family
ID=61681503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711085075.4A Pending CN107837345A (en) | 2017-11-07 | 2017-11-07 | A kind of pharmaceutical composition with antihepatitis activity |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107837345A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108753506A (en) * | 2018-05-30 | 2018-11-06 | 贵州乔纳斯啤酒有限公司 | A kind of protect liver beer and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102106926A (en) * | 2011-01-25 | 2011-06-29 | 袁今奇 | Chinese medicinal composition for immunoregulation of chronic hepatitis B in inactive phase or carrier state |
| CN102293285A (en) * | 2011-05-24 | 2011-12-28 | 长沙清尔康生物科技有限公司 | Health-preserving liver-protecting tea and preparation method thereof |
-
2017
- 2017-11-07 CN CN201711085075.4A patent/CN107837345A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102106926A (en) * | 2011-01-25 | 2011-06-29 | 袁今奇 | Chinese medicinal composition for immunoregulation of chronic hepatitis B in inactive phase or carrier state |
| CN102293285A (en) * | 2011-05-24 | 2011-12-28 | 长沙清尔康生物科技有限公司 | Health-preserving liver-protecting tea and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 尹桂兰等编著: "《病毒性肝炎防治新进展》", 30 April 2005, 中医古籍出版社 * |
| 董明慧等: ""具有保肝作用的临床常用中药"", 《中医药导报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108753506A (en) * | 2018-05-30 | 2018-11-06 | 贵州乔纳斯啤酒有限公司 | A kind of protect liver beer and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102578423A (en) | Chinese herbal medicine feed additive for laying hen and preparation method thereof | |
| WO2012027882A1 (en) | Pharmaceutical composition for treating insomnia and preparation method thereof | |
| CN106334137B (en) | A kind of Chinese herbal feed additive preventing and treating pork pig respiratory disease | |
| CN102357154A (en) | Traditional Chinese medicine composition for preventing and treating avian infectious bronchitis and preparation method thereof | |
| CN102225183B (en) | Chinese traditional medicine composition for treating cancer and its preparation | |
| CN104225006A (en) | Traditional Chinese medicine composition capable of invigorating Qi and relaxing bowels | |
| CN105395665A (en) | Chinese herbal medicine composition capable of preventing and treating fish and shrimp white stool | |
| CN107837345A (en) | A kind of pharmaceutical composition with antihepatitis activity | |
| CN111195289B (en) | Capsule containing extracts of Ganoderma, Ganoderma spore powder and fructus Ligustri Lucidi, and its preparation method | |
| CN107890528B (en) | Traditional Chinese medicine composition for treating hyperuricemia and preparation method thereof | |
| CN102641364A (en) | Drug for treating constipation and preparation method thereof | |
| JP2018516995A (en) | Pharmaceutical composition for the treatment of depression and method for its preparation | |
| CN104547683B (en) | A kind of Chinese medicine composition for treating chronic gastritis and preparation method thereof | |
| CN103735711A (en) | Broiler chicken immunopotentiator | |
| CN104547274B (en) | Weight reducing compound containing Bitter Orang P.E and its preparation | |
| CN106387514A (en) | Traditional Chinese medicine feed additive for fish and preparation method thereof | |
| CN102274348A (en) | Chinese medicinal composition for relieving physical fatigue and preparation method thereof | |
| CN107348508B (en) | Traditional Chinese medicine health product and preparation method and application thereof | |
| CN108143905A (en) | It is a kind of to be used to treat compound medicine of chronic bronchitis and preparation method thereof | |
| CN105194579A (en) | Medicament for preventing and treating lamb dysentery | |
| CN109172756B (en) | A Chinese medicinal composition for treating hepatopathy | |
| CN105709097A (en) | Traditional Chinese medicine composition for treating endocrine dyscrasia and preparation method thereof | |
| CN112569280A (en) | Application of coptis and rhubarb composition in preparation of medicine for treating liver injury | |
| CN105749148A (en) | Traditional Chinese medicine combined extract with antifatigue effect as well as preparation method and application thereof | |
| CN104398573A (en) | Traditional Chinese medicine for treating poultry cold in four seasons and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180327 |
|
| RJ01 | Rejection of invention patent application after publication |