CN107837340A - A kind of medicine for treating hypertension and preparation method thereof - Google Patents
A kind of medicine for treating hypertension and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of medicine for treating hypertension and preparation method thereof, the medicine is mainly made by the bark of eucommia, tortoise plastron, Ramulus Taxilli, yncaria stem with hooks, rhizoma Gastrodiae, the root of herbaceous peony, beggar-ticks, selfheal, radix scutellariae, rhizoma alismatis, spina date seed, chrysanthemum indicum and radix cyathulae.The medicine has nourishing and suppressing Yang, calming liver and clearing heat, calms the nerves and rushes down the effect of turbid.Hypertension for the deficiency of liver-yin and kidney-yin is demonstrate,proved, and is had no toxic side effect.
Description
Technical field
The present invention relates to a kind of medicine for treating hypertension and preparation method thereof, belong to the field of medicine technology.
Technical background
Hypertension refers to that arterial systolic blood pressure and/or diastolic pressure increase under quiescent condition (>=140/90mmHg), is often accompanied by
The organ functional such as fat and sugar metabolic disorder and the heart, brain, kidney and retina or organic change, characterized by organ is remolded
Systemic disease.Rest more than 5 minutes, more than 2 times the non-blood pressure >=140/90mmHg measured on the same day can be diagnosed as high blood
Pressure, its clinical manifestation have headache, dizziness, tinnitus, palpitation, insomnia, extremity numbness.
The commonly dizziness of hypertension early stage, headache, neck plate tight, fatigue, palpitaition etc..Only can be in tired, spirit tightly
Open, blood pressure rise occurs after anxious state of mind, and recover normal after rest.As the course of disease extends, blood pressure significantly persistently raises,
Various symptoms gradually occur.Now it is referred to as benign hypertension.The common clinical symptoms of benign hypertension have head
Bitterly, dizzy, absent minded, failure of memory, extremity numbness, enuresis nocturna increase, palpitaition, uncomfortable in chest, weak etc..The disease of hypertension
Shape has certain association with blood pressure level, and most symptoms can aggravate after nervous or fatigue, and blood pressure can raise rapidly after early morning activity,
There is Hypertension in morning, cause cardiocerebrovasculaevents events to mostly occur in the morning.The even meeting when blood pressure is suddenly increased to a certain degree
There are the symptoms such as severe headache, vomiting, palpitaition, dizziness, clouded in mind, twitch can occur when serious, it is high that this just belongs to radical type
Blood pressure and hypertension critical illness, infringement and the lesion of the organs such as the serious heart, brain, kidney can occur in a short time more, such as apoplexy, the heart
Stalk, renal failure etc..Symptom has no consistent relation with the elevated level of blood pressure.The clinical manifestation of secondary hypertension is mainly relevant
The sings and symptoms of protopathy, hypertension are only one of its symptoms.The blood pressure rise of secondary hypertension patient can have it certainly
Body feature, the hypertension as caused by aortic coaractation can be only limitted to upper limbs；Blood pressure increases in paroxysmal caused by pheochromocytoma.
Therefore the understanding to high blood pressure is improved, has extremely important meaning to early prevention, timely treatment.Doctor trained in Western medicine thinks
Hypertension is a kind of disease that can not be cured, and the stabilization of blood pressure can only be maintained by enalapril meleate.But actual conditions be with
The extension of time, the state of an illness gradually aggravate, and serious meeting causes the diseases such as patient's cerebral hemorrhage, cerebral embolism, hemiplegia, and side effect is very big.
The content of the invention：
It is an object of the present invention to provide a kind of medicine for treating hypertension and preparation method thereof.The medicine, which has, to be grown
Cloudy checking exuberance of yang, calming liver and clearing heat, calms the nerves and rushes down the effect of turbid.Hypertension for the deficiency of liver-yin and kidney-yin is demonstrate,proved, and is had no toxic side effect.
In order to solve the above technical problems, the present invention is realized using following technical scheme：A kind of medicine for treating hypertension, is pressed
Listed as parts by weight, mainly by bark of eucommia 1-20 parts, tortoise plastron 1-20 parts, Ramulus Taxilli 5-25 parts, yncaria stem with hooks 2-22 parts, rhizoma Gastrodiae 1-20 parts, white
Chinese herbaceous peony 5-25 parts, beggar-ticks 20-40 parts, selfheal 5-25 parts, radix scutellariae 1-20 parts, rhizoma alismatis 1-20 parts, spina date seed 1-20 parts, chrysanthemum indicum
5-25 parts and radix cyathulae 1-20 parts are made.
The medicine of foregoing treatment hypertension, is calculated by weight, is mainly posted by bark of eucommia 5-15 parts, tortoise plastron 5-15 parts, mulberry
Raw 10-20 parts, yncaria stem with hooks 8-16 parts, rhizoma Gastrodiae 5-15 parts, root of herbaceous peony 10-20 parts, beggar-ticks 25-35 parts, selfheal 10-20 parts, radix scutellariae
5-15 parts, rhizoma alismatis 5-15 parts, spina date seed 5-15 parts, chrysanthemum indicum 10-20 parts and radix cyathulae 5-15 parts are made.
The medicine of foregoing treatment hypertension, is calculated by weight, mainly by 10 parts of the bark of eucommia, 10 parts of tortoise plastron, Ramulus Taxilli 15
Part, 12 parts of yncaria stem with hooks, 10 parts of rhizoma Gastrodiae, 15 parts of the root of herbaceous peony, 30 parts of beggar-ticks, 15 parts of selfheal, 10 parts of radix scutellariae, 10 parts of rhizoma alismatis, spina date seed
10 parts of 10 parts, 15 parts of chrysanthemum indicum and radix cyathulae are made.
A kind of preparation method of the medicine of aforementioned therapies hypertension, takes said medicine, can add auxiliary material, can also be not added with auxiliary
Material, according to common process, is made oral formulations.
The preparation method of the medicine of foregoing treatment hypertension, the oral formulations are capsule, tablet, granule or ball
Agent.
The preparation method of the medicine of foregoing treatment hypertension, the capsule so make：Above-mentioned 13 taste medicinal material removes
Outside yncaria stem with hooks, add 6-10 times to measure water immersion 0.5-1.5h, extracted 2 times, each 0.5-1.5h, the filtration of 200 mesh sieves, merged with decocting method
Filtrate, be concentrated under reduced pressure (- 0.08Mpa, 73-77 DEG C) to relative density 1.15-1.25 (60 DEG C of heat are surveyed) clear cream, standby：Another hook taking
The 1/2 of rattan recipe quantity, coarse powder is crushed to, the 1st time plus 4 times amount warm water extracts 0.5 hour, the filtration of 200 mesh sieves, the 2nd time plus 3 times amount
Warm water extracts 0.5 hour, merging filtrate, will extract the leaching that relative density is 1.1-1.2 when filtrate is concentrated into relative 60-70 DEG C
It cream, dry, pulverize, obtain yncaria stem with hooks dry extract, it is standby；Take remaining yncaria stem with hooks to be ground into fine powder again, cross 100 eye mesh screens,60Co8kGy
Dose sterilizes 48 hours, standby；12 taste medicinal material clear creams are finally added to the starch of clear cream amount 20%, mixed, are pelletized, are done
Dry, whole grain, particle adds yncaria stem with hooks fine powder and yncaria stem with hooks dry extract, mixes, and loads capsule, produces.
The preparation method of the medicine of foregoing treatment hypertension, the tablet so make：Above-mentioned 13 taste medicinal material removes hook
Outside rattan, add 6-10 times to measure water immersion 0.5-1.5h, extracted 2 times, each 0.5-1.5h with decocting method, the filtration of 200 mesh sieves, merge filter
Liquid, be concentrated under reduced pressure (- 0.08Mpa, 73-77 DEG C) to relative density 1.15-1.25 (60 DEG C of heat are surveyed) clear cream, standby：Another hook taking rattan
The 1/2 of recipe quantity, coarse powder is crushed to, the 1st time plus 4 times amount warm water extracts 0.5 hour, the filtration of 200 mesh sieves, the 2nd time plus 3 times amount temperature
Flooding 0.5 hour, merging filtrate, the medicinal extract that relative density is 1.1-1.2 when filtrate is concentrated into relative 60-70 DEG C will be extracted,
It dry, pulverize, obtain yncaria stem with hooks dry extract, it is standby；Take remaining yncaria stem with hooks to be ground into fine powder again, cross 100 eye mesh screens,60Co8kGy agent
Radiation sterilization 48 hours is measured, it is standby；12 taste medicinal material clear creams are finally added to the starch of clear cream amount 20%, mixed, are pelletized, are done
Dry, whole grain, particle adds the magnesium stearate of yncaria stem with hooks fine powder, yncaria stem with hooks dry extract and clear cream amount 20%, mixes, tabletting, bag film
Clothing, produce.
The preparation method of the medicine of foregoing treatment hypertension, the granule so make：Above-mentioned 13 taste medicinal material removes
Outside yncaria stem with hooks, add 6-10 times to measure water immersion 0.5-1.5h, extracted 2 times, each 0.5-1.5h, the filtration of 200 mesh sieves, merged with decocting method
Filtrate, be concentrated under reduced pressure (- 0.08Mpa, 73-77 DEG C) to relative density 1.15-1.25 (60 DEG C of heat are surveyed) clear cream, standby：Another hook taking
The 1/2 of rattan recipe quantity, coarse powder is crushed to, the 1st time plus 4 times amount warm water extracts 0.5 hour, the filtration of 200 mesh sieves, the 2nd time plus 3 times amount
Warm water extracts 0.5 hour, merging filtrate, will extract the leaching that relative density is 1.1-1.2 when filtrate is concentrated into relative 60-70 DEG C
It cream, dry, pulverize, obtain yncaria stem with hooks dry extract, it is standby；Take remaining yncaria stem with hooks to be ground into fine powder again, cross 100 eye mesh screens,60Co8kGy
Dose sterilizes 48 hours, standby；12 taste medicinal material clear creams are finally added to the starch of clear cream amount 20%, mixed, are pelletized, are done
Dry, whole grain, particle adds the dextrin of yncaria stem with hooks fine powder, yncaria stem with hooks dry extract and clear cream amount 20%, mixes, and pelletizes, and dries, whole grain,
Produce.
The preparation method of the medicine of foregoing treatment hypertension, the pill so make：Above-mentioned 13 taste medicinal material removes hook
Outside rattan, add 6-10 times to measure water immersion 0.5-1.5h, extracted 2 times, each 0.5-1.5h with decocting method, the filtration of 200 mesh sieves, merge filter
Liquid, be concentrated under reduced pressure (- 0.08Mpa, 73-77 DEG C) to relative density 1.15-1.25 (60 DEG C of heat are surveyed) clear cream, standby：Another hook taking rattan
The 1/2 of recipe quantity, coarse powder is crushed to, the 1st time plus 4 times amount warm water extracts 0.5 hour, the filtration of 200 mesh sieves, the 2nd time plus 3 times amount temperature
Flooding 0.5 hour, merging filtrate, the medicinal extract that relative density is 1.1-1.2 when filtrate is concentrated into relative 60-70 DEG C will be extracted,
It dry, pulverize, obtain yncaria stem with hooks dry extract, it is standby；Take remaining yncaria stem with hooks to be ground into fine powder again, cross 100 eye mesh screens,60Co8kGy agent
Radiation sterilization 48 hours is measured, it is standby；12 taste medicinal material clear creams are finally added to the starch yncaria stem with hooks fine powder and yncaria stem with hooks of clear cream amount 15%
Dry extract, mixing, general ball, dry, coating, produce.
Medicine of the present invention is mainly by the bark of eucommia, tortoise plastron, Ramulus Taxilli, yncaria stem with hooks, rhizoma Gastrodiae, the root of herbaceous peony, beggar-ticks, selfheal, Huang
A kind of reed mentioned in ancient books, rhizoma alismatis, spina date seed, chrysanthemum indicum and radix cyathulae are made.Wherein, the bark of eucommia (scientific name Eucommia ulmoides
Oliver), also known as bakelite, it is Eucommiaceae plant.The dry bark of the medicinal bark of eucommia, as the Eucommiaceae plant bark of eucommia, it is middle name of the country
Your tonic herb.Its is sweet, warm-natured.Tonify the liver and kidney, strengthen muscles and bones, coordinating Chong and Conception Vessels, strengthen meridian and miscarriage prevention the effect of.Kidney yang can be treated
Pain in waist and lower extremities caused by void is aching and limp powerless, and born of the same parents' tire caused by liver- qi invasion is not solid, and scrotum is wet the disease such as to itch.《Sheng Nong's herbal classic》Middle quilt
It is classified as top grade.Tortoise plastron, Chinese medicine name.For Testudinidae animal tortoise Chinemys reevesii (Gray) carapace and plastron.With taste
Cloudy checking exuberance of yang, the strong bone of kidney-nourishing, blood-nourishing bushing, Gu through stopping the effect of collapsing.It is usually used in deficiency of Yin hectic fever, hectic fever due to yin night sweat, has a dizzy spell, empty wind
It is interior dynamic, muscles and bones impotence, have a guilty conscience forgetful, uterine bleeding warp is more.Nature and flavor：Taste is salty, sweet, cold nature.Channel tropism：Return liver, kidney, the heart channel of Hang-Shaoyin.Ramulus Taxilli
(scientific name：Taxillus sutchuenensis (Lecomte) Danser), nature and flavor：Bitter sweet, put down.Channel tropism：Enter liver and kidney channel.Function
Cure mainly：Filling liver kidney, strengthening the bones and muscles, curing rheumatism, degrading the channel, beneficial blood are antiabortive.Soreness of waist and knee joint is controlled, muscles and bones impotence is weak, hemiplegia, tinea pedis, chill
Arthritis with fixed pain caused by dampness, threatened abortion metrorrhagia, lack of lactation after delivery.Chronic cough is controlled, tongue indulges dizziness.Yncaria stem with hooks, (Classification system：Uncaria
Rhynchophylla (Miq.) Miq.ex Havil.), yncaria stem with hooks is used as medicine with the stem branch of buckle, and it has a The flat liver of heat-clearing, and ceases wind is fixed
Practioners are taken by surprise at practising is imitated, and modern pharmacology experiment also confirms that yncaria stem with hooks has antihypertensive effect, therefore has very high medical value.Rhizoma Gastrodiae (scientific name：
Gastrodia elata Bl.), nature and flavor：It is sweet, put down.Channel tropism：Enter Liver Channel.Effect：Ceases wind, arresting convulsion.Control dizziness pupil, intermittent headache head
Bitterly, extremity numbness, hemiplegia, aphasia, pediatric epilepsy scared move wind.The root of herbaceous peony (scientific name：Paeonia lactiflora
Pall. white flower Chinese herbaceous peony, smooth liver and relieve pain, nourishing blood for regulating menstruation, astringing YIN to stop sweating) are also referred to as.For dizziness of having a headache, hypochondriac pain, stomachache, four limbs contraction
Bitterly, blood deficiency chlorosis, irregular menstruation, spontaneous perspiration, night sweat.Beggar-ticks (scientific name：Bidens pilosa L.), for the conventional grass of folks of china
Medicine, there is the effect of clearing heat and detoxicating, blood-stasis-dissipating blood-circulation-promoting, cure mainly the infection of the upper respiratory tract, abscess of throat, acute appendicitis, acute icteric
Boil, venomous snake bite, treating swelling and pain by traumatic injury are controlled in hepatitis, gastroenteritis, pain in rheumatoid joints, malaria, external application.Nature and flavor：It is sweet, light, bitter, property
It is slightly cold.Channel tropism：Liver, lung, large intestine channel.Effect：Clearing heat and detoxicating, eliminating stasis to subdue swelling, for appendicitis, ephritis, cholecystitis, enteritis, thin
Bacterium property dysentery, hepatitis, peritonitis, the infection of the upper respiratory tract, tonsillitis, laryngitis, amenorrhoea, scald, venomous snake bite, traumatic injury,
The diseases such as skin infection, child convulsion, infantile malnutrition due to digestive disturbances or intestinalparasites.Selfheal (scientific name：Prunella vulgaris L), it is that the labiate summer is withered
Careless Prunella vulgaris L. drying fruit ear.The property of medicine：It is pungent, bitter, tremble with fear.Return liver, gallbladder channel.Effect：Clearing heat-fire, improving eyesight,
Mass dissipating and swelling eliminating.Radix scutellariae (Classification system：Scutellaria baicalensis Georgi), the root of radix scutellariae is used as medicine, bitter, property
It is cold, there are heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, antiabortive and other effects.Cure mainly the warm heat disease, infection of the upper respiratory tract, cough with lung heat, damp and hot
The diseases such as jaundice, pneumonia, dysentery, hemoptysis, hot eyes, fetal irritability, hypertension, carbuncle swells furuncle sore.The clinical antibiotic property of radix scutellariae compares the coptis
It is good, and do not develop immunity to drugs.Nature and flavor：Hardship, tremble with fear.Channel tropism：Enter the heart, lung, courage, large intestine channel.Rhizoma alismatis (scientific name：Alisma
Plantago-aquatica Linn.), perennial aquatic or swampweed sheet.Nature and flavor：It is sweet, tremble with fear.Channel tropism：Enter kidney, bladder warp.Work(
Effect：Li Shui, excreting dampness, expel the heat-evil.Control difficult urination, oedema turgor, vomiting, rush down dysentery, phlegm and retained fluid, tinea pedis, gonorrhoea, hematuria.Spina date seed,
Ziziphus jujuba Mill.var.spinosa, effect：Nourishing the liver, calming heart, calm the nerves, arrest sweating.[performance] is sweet, sour, mild-natured.
Chrysanthemum indicum (scientific name：Dendranthema indicum) it is composite family herbaceos perennial, chrysanthemum indicum cold nature, have evacuation wind
Heat, subdhing swelling and detoxicating.The diseases such as furunculosis carbuncle swells, abscess of throat, wind-fire red eye, dizziness of having a headache can be treated.Radix cyathulae, Chinese medicine name.For
Amaranthaceous plant radix cyathulae Cyathula officinalis Kuan dry root.Sweet, slight bitter, it is mild-natured.Return liver and kidney channel.Have
Dispelling stasis of blood and stimulating the menstrual flow, it is easing joint movement, the effect of inducing diuresis for treating strangurtia.For Amenorrhea abdominal mass, placenta retension, injury from falling down, arthralgia pain due to rheumatism, atrophy
Muscle contraction, cards such as hematuria blood drenches etc. are demonstrate,proved.
Medicine is made using above-mentioned raw materials in the present invention, and each component has synergy well, and our institute's main symptom is waited, and is liver
Kidney-yin deficiency, liver-yang is partially high, caused by liver wind agitation.Liver-yang is partially high, wind-yang and up-boring, then sees head distending pain, dizziness；Irascibility disturbs the heart, therefore
Have no peace of mind, night sleeps dreaminess.Card category asthenia in origin and asthenia in superficiality, controls suitable suppressing hyperactive liver for calming endogenous wind, tonifies the liver and kidney.Bark of eucommia compatibility Ramulus Taxilli help liver in side
Kidney, it is altogether monarch drug in a prescription with Zhi Qiben.Rhizoma Gastrodiae, yncaria stem with hooks enter Liver Channel, with The flat liver of heat-clearing, relieving spasm by calming endogenous wind；Kidney storing essence, blood stored in the liver, liver kidney are same
Source, from internal organs inhibition and generation relation, tortoiseshell nourishing and suppressing Yang is selected, strengthen water to contain edema with the liver involved, i.e. Pei Qiben；Febrile disease complicated by wind, most easily consumption is robbed
Liquid, therefore purged heat again with root of herbaceous peony enriching yin, soft liver relaxing muscles and tendons, water is strengthened with fire processed；Four medicines share yin-nourishing and increase liquid, and relaxing muscles and tendons emergency is flat to strengthen
The power of liver ceases wind, it is altogether ministerial drug.Radix scutellariae, selfheal, chrysanthemum indicum, beggar-ticks are clearing heat and detoxicating, clearing liver-fire, to roll over its high sun；Acid
Jujube kernel, sweet acid enter liver, can nourishing the liver blood, beneficial irritability and calming heart is refreshing, the work(for having relieving restlessness of calming the nerves；Rhizoma alismatis dampness removing and to rush down kidney turbid, help Kidney-Yin
Regain its position；It is adjutant.Radix cyathulae bleed blood is descending, suddenly controls its mark, to make medicine.All medicines share, altogether into suppressing hyperactive liver for calming endogenous wind, enriching yin
Checking exuberance of yang, calm the nerves and rush down turbid agent.
Experimental example：Pharmacodynamic study
Applicant has carried out Pharmacodynamics research to the present invention, illustrates beneficial effects of the present invention by experimental data.
1 Experimental agents
Medicine of the present invention：Prepared according to method described in experimental example 1；
Nifedipine capsules：Shandong Xinhua Pharmaceutical Factory produces.
2 experimental animals
Spontaneous hypertensive rat (SHR) is purchased from Chongqing City's Institute of Botany, rearing conditions:Room temperature (25 ± 2) DEG C, manually
12h/d is illuminated, by sex sub-cage rearing, per 5, cage, free water, is fed with 21% high protein block, it is daily to add block 1 time,
Change fresh tap water 2 times.It is grouped at random by body weight and blood pressure, i.e. blank control group (giving physiological saline), of the present invention group of (medication
Measure as 0.1g/kg), Nifedipine group (dosage 0.1g/kg), every group 10, each group animal is administered with capsule 's content.
3 experimental methods
SHR male and female dual-purposes, body weight (220 ± 20) g.Rat is put into (37 ± 1) DEG C electrothermostat before pressure measurement and heated,
Used after 10minType rat computer blood pressure heart rate instrument indirect determination rat tail artery systolic pressure (SBP).It is every before formal experiment
Its pressure measurement is trained once, about 2 weeks, after rat adapts to environment, blood pressure stabilization.Each group rat is taken, is administered daily 1 time.Continuously give
Medicine 20d, determines SBP daily.
4 experimental results
After successive administration, present invention group and Nifedipine group blood pressure slowly decline, and have conspicuousness poor with blank control group ratio
It is different, refer to table 1.
The each group SHR successive administrations 20d of table 1 antihypertensive effect compares (x ± s, n=10)
Note：Compared with blank group*P ＜ 0.05；Compared with Nifedipine group+P>0.05。
As a result show, medicine of the present invention can reduce hypertension, and curative effect is suitable with nifedipine.
Beneficial effect：Medicine of the present invention has nourishing and suppressing Yang, calming liver and clearing heat, calms the nerves and rushes down the effect of turbid.For liver kidney
The hypertension card of the deficiency of Yin, has no toxic side effect.
Embodiment：
Invention is further described with reference to embodiment, but is not intended as the foundation limited the present invention.
Embodiment 1.
Formula：Bark of eucommia 10kg, tortoise plastron 10kg, Ramulus Taxilli 15kg, yncaria stem with hooks 12kg, rhizoma Gastrodiae 10kg, root of herbaceous peony 15kg, beggar-ticks
30kg, selfheal 15kg, radix scutellariae 10kg, rhizoma alismatis 10kg, spina date seed 10kg, chrysanthemum indicum 15kg and radix cyathulae 10kg.
Technique：Above-mentioned 13 taste medicinal material adds 8 times of amount water immersion 1h, extracted 2 times, each 1h with decocting method in addition to yncaria stem with hooks,
200 mesh sieves filter, merging filtrate, are concentrated under reduced pressure (- 0.08Mpa, 73-77 DEG C) to relative density 1.15-1.25 (60 DEG C of heat are surveyed)
Clear cream, it is standby：The 1/2 of another hook taking rattan recipe quantity, is crushed to coarse powder, and the warm water extraction 0.5 of the 1st time plus 4 times 40-50 DEG C of amount is small
When, 200 mesh sieves filtration, the warm water of the 2nd time plus 3 times 40-50 DEG C of amount is extracted 0.5 hour, merging filtrate, and extraction filtrate is concentrated into
Relative density is 1.1-1.2 medicinal extract during with respect to 60-70 DEG C, dry, pulverize, obtains yncaria stem with hooks dry extract, standby；Take again remaining
Yncaria stem with hooks is ground into fine powder, crosses 100 eye mesh screens,60Co8kGy doses sterilize 48 hours, standby；It is finally that 12 taste medicinal materials are clear
Cream adds the starch of clear cream amount 20%, mixes, and pelletizes, and dries, whole grain, and particle adds yncaria stem with hooks fine powder and yncaria stem with hooks dry extract, mixes
It is even, load capsule, produce capsule.
Specification：0.5g/ grains.
Usage and dosage:Each 5-6 grains, it is daily 2-3 times.
Embodiment 2.
Formula：Bark of eucommia 15kg, tortoise plastron 15kg, Ramulus Taxilli 20kg, yncaria stem with hooks 16kg, rhizoma Gastrodiae 15kg, root of herbaceous peony 20kg, beggar-ticks
35kg, selfheal 20kg, radix scutellariae 15kg, rhizoma alismatis 15kg, spina date seed 15kg, chrysanthemum indicum 20kg and radix cyathulae 15kg.
Technique：Above-mentioned 13 taste medicinal material in addition to yncaria stem with hooks, add 10 times amount water immersion 1.5h, with decocting method extract 2 times, every time
0.5-1.5h, the filtration of 200 mesh sieves, merging filtrate, (- 0.08Mpa, 73-77 DEG C) is concentrated under reduced pressure to relative density 1.15-1.25
(60 DEG C of heat are surveyed) clear cream, it is standby：The 1/2 of another hook taking rattan recipe quantity, it is crushed to coarse powder, the warm water of the 1st time plus 4 times 40-50 DEG C of amount
Extraction 0.5 hour, 200 mesh sieves filtration, the extraction of the 2nd time plus 3 times 40-50 DEG C of amount 0.5 hour, merging filtrate, will extract filtrate
Relative density is 1.1-1.2 medicinal extract when being concentrated into relative 60-70 DEG C, dry, pulverize, obtains yncaria stem with hooks dry extract, standby；Take again
Remaining yncaria stem with hooks is ground into fine powder, crosses 100 eye mesh screens,60Co8kGy doses sterilize 48 hours, standby；Finally by 12 tastes
Medicinal material clear cream adds the starch of clear cream amount 20%, mixes, and pelletizes, and dries, whole grain, and particle adds yncaria stem with hooks fine powder, yncaria stem with hooks dry extract
The magnesium stearate of powder and clear cream amount 20%, mix, tabletting, film coating, produce tablet.
Specification：0.5g/ pieces.
Usage and dosage：Each 2-3 pieces, it is daily 2-3 times.
Embodiment 3.
Formula：Bark of eucommia 5kg, tortoise plastron 5kg, Ramulus Taxilli 10kg, yncaria stem with hooks 8kg, rhizoma Gastrodiae 5kg, root of herbaceous peony 10kg, beggar-ticks 25kg,
Selfheal 10kg, radix scutellariae 5kg, rhizoma alismatis 5kg, spina date seed 5kg, chrysanthemum indicum 10kg and radix cyathulae 5kg.
Technique：Above-mentioned 13 taste medicinal material in addition to yncaria stem with hooks, add 6 times amount water immersion 0.5h, with decocting method extract 2 times, every time
0.5h, the filtration of 200 mesh sieves, merging filtrate, (- 0.08Mpa, 73-77 DEG C) is concentrated under reduced pressure to (60 DEG C of relative density 1.15-1.25
Heat is surveyed) clear cream, it is standby：The 1/2 of another hook taking rattan recipe quantity, it is crushed to coarse powder, the warm water extraction of the 1st time plus 4 times 40-50 DEG C of amount
0.5 hour, the filtration of 200 mesh sieves, the 2nd time plus 3 times amount warm water extracted 0.5 hour, merging filtrate, extraction filtrate is concentrated into relatively
Relative density is 1.1-1.2 medicinal extract at 60-70 DEG C, dry, pulverize, obtains yncaria stem with hooks dry extract, standby；Remaining yncaria stem with hooks is taken again
Fine powder is ground into, crosses 100 eye mesh screens,60Co8kGy doses sterilize 48 hours, standby；Finally 12 taste medicinal material clear creams are added
Enter the starch of clear cream amount 20%, mix, pelletize, dry, whole grain, particle adds yncaria stem with hooks fine powder, yncaria stem with hooks dry extract and clear cream amount
20% dextrin, mix, pelletize, dry, whole grain, produce granule.
Specification：5g/ bags.
Usage and dosage:Each 5-10g, it is daily 2-3 times.
Claims (9)
- A kind of 1. medicine for treating hypertension, it is characterised in that：Calculate by weight, mainly by bark of eucommia 1-20 parts, tortoise plastron 1-20 Part, Ramulus Taxilli 5-25 parts, yncaria stem with hooks 2-22 parts, rhizoma Gastrodiae 1-20 parts, root of herbaceous peony 5-25 parts, beggar-ticks 20-40 parts, selfheal 5-25 parts, Radix scutellariae 1-20 parts, rhizoma alismatis 1-20 parts, spina date seed 1-20 parts, chrysanthemum indicum 5-25 parts and radix cyathulae 1-20 parts are made.
- 2. the medicine for the treatment of hypertension as claimed in claim 1, it is characterised in that：Calculate by weight, mainly by bark of eucommia 5- 15 parts, tortoise plastron 5-15 parts, Ramulus Taxilli 10-20 parts, yncaria stem with hooks 8-16 parts, rhizoma Gastrodiae 5-15 parts, root of herbaceous peony 10-20 parts, beggar-ticks 25-35 Part, selfheal 10-20 parts, radix scutellariae 5-15 parts, rhizoma alismatis 5-15 parts, spina date seed 5-15 parts, chrysanthemum indicum 10-20 parts and radix cyathulae 5-15 Part is made.
- 3. the medicine for the treatment of hypertension as claimed in claim 2, it is characterised in that：Calculate by weight, mainly by the bark of eucommia 10 Part, 10 parts of tortoise plastron, 15 parts of Ramulus Taxilli, 12 parts of yncaria stem with hooks, 10 parts of rhizoma Gastrodiae, 15 parts of the root of herbaceous peony, 30 parts of beggar-ticks, 15 parts of selfheal, radix scutellariae 10 parts of 10 parts, 10 parts of rhizoma alismatis, 10 parts of spina date seed, 15 parts of chrysanthemum indicum and radix cyathulae are made.
- A kind of 4. preparation method for the medicine that hypertension is treated as any one of claim 1-3, it is characterised in that：Take Medicine is stated, auxiliary material can be added, auxiliary material can also be not added with, according to common process, oral formulations are made.
- 5. the preparation method of the medicine for the treatment of hypertension as claimed in claim 4, it is characterised in that：The oral formulations are glue Wafer, tablet, granule or pill.
- 6. the preparation method of the medicine of the medicine for the treatment of hypertension as claimed in claim 5, it is characterised in that：The capsule So make：Above-mentioned 13 taste medicinal material in addition to yncaria stem with hooks, add 6-10 times measure water immersion 0.5-1.5h, with decocting method extract 2 times, every time 0.5-1.5h, 200 mesh sieves filtration, merging filtrate, is concentrated under reduced pressure（-0.08Mpa、73-77℃）To relative density 1.15-1.25 （60 DEG C of heat are surveyed）Clear cream, it is standby：The 1/2 of another hook taking rattan recipe quantity, is crushed to coarse powder, and the 1st time plus 4 times amount warm water extraction 0.5 is small When, the filtration of 200 mesh sieves, the 2nd time plus 3 times amount warm water is extracted 0.5 hour, merging filtrate, and extraction filtrate is concentrated into relative 60-70 DEG C when relative density be 1.1-1.2 medicinal extract, dry, pulverize, obtain yncaria stem with hooks dry extract, it is standby；Remaining yncaria stem with hooks is taken to crush again Into fine powder, 100 eye mesh screens are crossed,60Co8kGy doses sterilize 48 hours, standby；Finally 12 taste medicinal material clear creams are added clear The starch of cream amount 20%, mix, pelletize, dry, whole grain, particle adds yncaria stem with hooks fine powder and yncaria stem with hooks dry extract, mixes, and loads glue Capsule, produce.
- 7. the preparation method of the medicine of the medicine for the treatment of hypertension as claimed in claim 5, it is characterised in that：The tablet this Sample makes：Above-mentioned 13 taste medicinal material in addition to yncaria stem with hooks, add 6-10 times measure water immersion 0.5-1.5h, with decocting method extract 2 times, every time 0.5-1.5h, 200 mesh sieves filtration, merging filtrate, is concentrated under reduced pressure（-0.08Mpa、73-77℃）To relative density 1.15-1.25 （60 DEG C of heat are surveyed）Clear cream, it is standby：The 1/2 of another hook taking rattan recipe quantity, is crushed to coarse powder, and the 1st time plus 4 times amount warm water extraction 0.5 is small When, the filtration of 200 mesh sieves, the 2nd time plus 3 times amount warm water is extracted 0.5 hour, merging filtrate, and extraction filtrate is concentrated into relative 60-70 DEG C when relative density be 1.1-1.2 medicinal extract, dry, pulverize, obtain yncaria stem with hooks dry extract, it is standby；Remaining yncaria stem with hooks is taken to crush again Into fine powder, 100 eye mesh screens are crossed,60Co8kGy doses sterilize 48 hours, standby；Finally 12 taste medicinal material clear creams are added clear The starch of cream amount 20%, mix, pelletize, dry, whole grain, particle adds yncaria stem with hooks fine powder, yncaria stem with hooks dry extract and clear cream amount 20% Magnesium stearate, mix, tabletting, film coating, produce.
- 8. the preparation method of the medicine of the medicine for the treatment of hypertension as claimed in claim 5, it is characterised in that：The granule So make：Above-mentioned 13 taste medicinal material in addition to yncaria stem with hooks, add 6-10 times measure water immersion 0.5-1.5h, with decocting method extract 2 times, every time 0.5-1.5h, 200 mesh sieves filtration, merging filtrate, is concentrated under reduced pressure（-0.08Mpa、73-77℃）To relative density 1.15-1.25 （60 DEG C of heat are surveyed）Clear cream, it is standby：The 1/2 of another hook taking rattan recipe quantity, is crushed to coarse powder, and the 1st time plus 4 times amount warm water extraction 0.5 is small When, the filtration of 200 mesh sieves, the 2nd time plus 3 times amount warm water is extracted 0.5 hour, merging filtrate, and extraction filtrate is concentrated into relative 60-70 DEG C when relative density be 1.1-1.2 medicinal extract, dry, pulverize, obtain yncaria stem with hooks dry extract, it is standby；Remaining yncaria stem with hooks is taken to crush again Into fine powder, 100 eye mesh screens are crossed,60Co8kGy doses sterilize 48 hours, standby；Finally 12 taste medicinal material clear creams are added clear The starch of cream amount 20%, mix, pelletize, dry, whole grain, particle adds yncaria stem with hooks fine powder, yncaria stem with hooks dry extract and clear cream amount 20% Dextrin, mix, pelletize, dry, whole grain, produce.
- 9. the preparation method of the medicine of the medicine for the treatment of hypertension as claimed in claim 5, it is characterised in that：The pill this Sample makes：Above-mentioned 13 taste medicinal material in addition to yncaria stem with hooks, add 6-10 times measure water immersion 0.5-1.5h, with decocting method extract 2 times, every time 0.5-1.5h, 200 mesh sieves filtration, merging filtrate, is concentrated under reduced pressure（-0.08Mpa、73-77℃）To relative density 1.15-1.25 （60 DEG C of heat are surveyed）Clear cream, it is standby：The 1/2 of another hook taking rattan recipe quantity, is crushed to coarse powder, and the 1st time plus 4 times amount warm water extraction 0.5 is small When, the filtration of 200 mesh sieves, the 2nd time plus 3 times amount warm water is extracted 0.5 hour, merging filtrate, and extraction filtrate is concentrated into relative 60-70 DEG C when relative density be 1.1-1.2 medicinal extract, dry, pulverize, obtain yncaria stem with hooks dry extract, it is standby；Remaining yncaria stem with hooks is taken to crush again Into fine powder, 100 eye mesh screens are crossed,60Co8kGy doses sterilize 48 hours, standby；Finally 12 taste medicinal material clear creams are added clear The starch yncaria stem with hooks fine powder and yncaria stem with hooks dry extract of cream amount 15%, mixing, general ball, dry, coating, produce.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710751616 | 2017-08-28 | ||
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113786430A (en) * | 2021-10-09 | 2021-12-14 | 上海优童医药科技有限公司 | Traditional Chinese medicine extract for reducing blood pressure and preparation method thereof |
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| KR20110045619A (en) * | 2009-10-27 | 2011-05-04 | 임기원 | Manufacturing method of fresh mulberry leaves annularity |
| CN106176622A (en) * | 2016-08-30 | 2016-12-07 | 欣龙控股（集团）股份有限公司 | A kind of isorhynchophylline slow releasing preparation treating hypertension and preparation method thereof |
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