CN107835637A - 作为激酶抑制剂的杂环化合物 - Google Patents
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- 230000009529 traumatic brain injury Effects 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 239000008243 triphasic system Substances 0.000 description 1
- IHIXIJGXTJIKRB-UHFFFAOYSA-N trisodium vanadate Chemical compound [Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O IHIXIJGXTJIKRB-UHFFFAOYSA-N 0.000 description 1
- 230000004565 tumor cell growth Effects 0.000 description 1
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 description 1
- 230000005951 type IV hypersensitivity Effects 0.000 description 1
- 208000027930 type IV hypersensitivity disease Diseases 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000007998 vessel formation Effects 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562163369P | 2015-05-18 | 2015-05-18 | |
| US62/163,369 | 2015-05-18 | ||
| US201562203070P | 2015-08-10 | 2015-08-10 | |
| US62/203,070 | 2015-08-10 | ||
| PCT/US2016/033111 WO2016187324A1 (en) | 2015-05-18 | 2016-05-18 | Heterocyclic compounds as kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107835637A true CN107835637A (zh) | 2018-03-23 |
Family
ID=57320732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680041168.4A Pending CN107835637A (zh) | 2015-05-18 | 2016-05-18 | 作为激酶抑制剂的杂环化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US10392402B2 (enExample) |
| EP (1) | EP3297437A4 (enExample) |
| JP (1) | JP2018515623A (enExample) |
| CN (1) | CN107835637A (enExample) |
| AU (1) | AU2016264220A1 (enExample) |
| CA (1) | CA3024113A1 (enExample) |
| HK (1) | HK1248070A1 (enExample) |
| IL (1) | IL255750A (enExample) |
| WO (1) | WO2016187324A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110382481A (zh) * | 2016-11-21 | 2019-10-25 | 转化药物开发有限责任公司 | 作为激酶抑制剂的杂环化合物 |
| CN112367982A (zh) * | 2018-04-24 | 2021-02-12 | 转化药物开发有限责任公司 | 作为激酶抑制剂的酰胺化合物、组合物和治疗方法 |
| CN115175900A (zh) * | 2020-01-07 | 2022-10-11 | 达萨玛治疗公司 | Sarm1的抑制剂 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210069016A1 (en) * | 2008-11-13 | 2021-03-11 | Gholam A. Peyman | Neurodegenerative Disorder Treatment Method |
| CA2939021C (en) | 2014-02-11 | 2022-07-12 | Bayer Pharma Aktiengesellschaft | Benzimidazol-2-amines as midh1 inhibitors |
| WO2015121210A1 (en) | 2014-02-11 | 2015-08-20 | Bayer Pharma Aktiengesellschaft | Benzimidazol-2-amines as midh1 inhibitors |
| JP2018515623A (ja) * | 2015-05-18 | 2018-06-14 | トランスレイショナル・ドラッグ・ディベロップメント・エルエルシー | キナーゼ阻害剤としての複素環式化合物 |
| AU2020273376C1 (en) * | 2016-10-24 | 2024-02-29 | Translational Drug Development, Llc | Amide compounds as kinase inhibitors, compositions and methods of treatment |
| WO2020142745A1 (en) * | 2019-01-04 | 2020-07-09 | Translational Drug Development, Llc | Methods of treating graft versus host disease and neoplastic disease with amide compounds |
| EP4059928A4 (en) * | 2019-11-15 | 2023-11-15 | Wuhan LL Science and Technology Development Co., Ltd. | Rock inhibitor, preparation method therefor and use thereof |
| EP3845276B1 (en) | 2019-12-31 | 2025-01-29 | Industrial Technology Research Institute | Beta-amino acid derivative, kinase inhibitor and pharmaceutical composition containing the same, and use of the same |
| US12404265B2 (en) | 2020-08-04 | 2025-09-02 | Nura Bio, Inc. | Substituted pyridine derivatives as SARM1 inhibitors |
| CN116438171A (zh) | 2020-09-16 | 2023-07-14 | 努拉生物公司 | 作为sarm1抑制剂的取代的吡啶衍生物 |
| JP2024528036A (ja) | 2021-07-28 | 2024-07-26 | ヌラ バイオ，インク． | Ｓａｒｍ１阻害剤としての置換ピリジン誘導体 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011130740A2 (en) * | 2010-04-16 | 2011-10-20 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Pyridylthiazole-based ureas as inhibitors of rho associated protein kinase (rock) and methods of use |
| US20140051708A1 (en) * | 2011-04-11 | 2014-02-20 | Nerviano Medical Sciences S.R.L. | Pyrazolyl-pyrimidine derivatives as kinase inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2620818A1 (en) | 2005-09-02 | 2007-03-08 | Astellas Pharma Inc. | Amide derivatives as rock inhibitors |
| EP2234486A4 (en) * | 2007-12-19 | 2011-09-14 | Scripps Research Inst | BENZIMIDAZOLES AND ANALOGS AS INHIBITORS OF RHO-KINASE |
| US20090258907A1 (en) | 2008-04-09 | 2009-10-15 | Abbott Laboratories | Compounds useful as inhibitors of rock kinases |
| US20130129677A1 (en) | 2009-02-27 | 2013-05-23 | Siga Technologies, Inc. | Thienopyridine Derivatives for the Treatment and Prevention of Dengue Virus Infections |
| AR078793A1 (es) * | 2009-10-27 | 2011-12-07 | Orion Corp | Derivados de carboxamidas no esteroidales y acil hidrazona moduladores de receptores androgenicos de tejido selectivo (sarm), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer de prostata entre otros |
| US8697911B2 (en) * | 2010-07-07 | 2014-04-15 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
| JP2018515623A (ja) * | 2015-05-18 | 2018-06-14 | トランスレイショナル・ドラッグ・ディベロップメント・エルエルシー | キナーゼ阻害剤としての複素環式化合物 |
-
2016
- 2016-05-18 JP JP2018512823A patent/JP2018515623A/ja not_active Withdrawn
- 2016-05-18 WO PCT/US2016/033111 patent/WO2016187324A1/en not_active Ceased
- 2016-05-18 AU AU2016264220A patent/AU2016264220A1/en not_active Abandoned
- 2016-05-18 HK HK18107657.9A patent/HK1248070A1/zh unknown
- 2016-05-18 US US15/574,800 patent/US10392402B2/en active Active
- 2016-05-18 EP EP16797227.2A patent/EP3297437A4/en not_active Withdrawn
- 2016-05-18 CA CA3024113A patent/CA3024113A1/en not_active Abandoned
- 2016-05-18 CN CN201680041168.4A patent/CN107835637A/zh active Pending
-
2017
- 2017-11-19 IL IL255750A patent/IL255750A/en unknown
-
2019
- 2019-08-26 US US16/551,694 patent/US10633393B2/en active Active
-
2020
- 2020-04-27 US US16/859,977 patent/US20200255448A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011130740A2 (en) * | 2010-04-16 | 2011-10-20 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Pyridylthiazole-based ureas as inhibitors of rho associated protein kinase (rock) and methods of use |
| US20140051708A1 (en) * | 2011-04-11 | 2014-02-20 | Nerviano Medical Sciences S.R.L. | Pyrazolyl-pyrimidine derivatives as kinase inhibitors |
Non-Patent Citations (2)
| Title |
|---|
| REGISTRY: "1392231-17-2", 《STN ON THE WEB》 * |
| 仇缀佰主编: "《药物设计学》", 30 June 2008, 高等教育出版社 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110382481A (zh) * | 2016-11-21 | 2019-10-25 | 转化药物开发有限责任公司 | 作为激酶抑制剂的杂环化合物 |
| CN112367982A (zh) * | 2018-04-24 | 2021-02-12 | 转化药物开发有限责任公司 | 作为激酶抑制剂的酰胺化合物、组合物和治疗方法 |
| CN112367982B (zh) * | 2018-04-24 | 2024-05-07 | 转化药物开发有限责任公司 | 作为激酶抑制剂的酰胺化合物、组合物和治疗方法 |
| CN115175900A (zh) * | 2020-01-07 | 2022-10-11 | 达萨玛治疗公司 | Sarm1的抑制剂 |
| CN115175900B (zh) * | 2020-01-07 | 2025-06-20 | 达萨玛治疗公司 | Sarm1的抑制剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018515623A (ja) | 2018-06-14 |
| US20200255448A1 (en) | 2020-08-13 |
| HK1248070A1 (zh) | 2018-10-12 |
| AU2016264220A1 (en) | 2018-01-04 |
| EP3297437A4 (en) | 2019-02-27 |
| US20200017520A1 (en) | 2020-01-16 |
| IL255750A (en) | 2018-01-31 |
| US10633393B2 (en) | 2020-04-28 |
| US10392402B2 (en) | 2019-08-27 |
| EP3297437A1 (en) | 2018-03-28 |
| US20180141959A1 (en) | 2018-05-24 |
| CA3024113A1 (en) | 2016-11-24 |
| WO2016187324A1 (en) | 2016-11-24 |
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