CN107823622A - A kind of pharmaceutical composition for treating cold urticaria and its production and use - Google Patents
A kind of pharmaceutical composition for treating cold urticaria and its production and use Download PDFInfo
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- A61K36/236—Ligusticum (licorice-root)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/9068—Zingiber, e.g. garden ginger
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Abstract
The invention discloses a kind of pharmaceutical composition for treating cold urticaria, and it is made up of the bulk drug of following weight proportion：25 30 parts of the Radix Astragali, 15 20 parts of the bighead atractylodes rhizome, windproof 10 15 parts, Chinese ephedra 5 10,10 15 parts of cassia twig, 5 10 parts of RADIX ACONITI LATERALIS PREPARATA, 15 parts of rhizoma zingiberis, 10 15 parts of Radix Angelicae Sinensis, 10 15 parts of Ligusticum wallichii, 15 20 parts of the root of herbaceous peony, 10 15 parts of stiff silkworm, 10 15 parts of cicada slough, 10 15 parts of tribulus terrestris, 10 15 parts of honey-fried licorice root.Present invention also offers the preparation method of aforementioned pharmaceutical compositions and purposes.Pharmaceutical composition of the present invention, compatibility is precise and appropriate, and each flavour of a drug complement each other, and to alleviating cold urticaria conditions of patients, preventing from recurring evident in efficacy, can more effectively treat cold urticaria, new selection is provided for clinical application.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for treating cold urticaria and its production and use.
Background technology
Cold urticaria (cold urticaria, CU) is one kind of physical urticaria, shows as receiving cold stimulation
After break out, severe patient can suffer a shock, threat to life.It is divided into acquired and familial according to heredity is whether there is.Acquired cold
Property nettle rash (acquired cold urticaria, ACU) is divided into primary (primary acquired cold again
Urticaria, PACU) and the major class of Secondary cases 2, the former is most common, accounts for 72%~96%；The latter is mostly occurred in cryoglobulin blood
On the disease of the basis such as disease, cold fibremia, CTD.
TCM thinks that this cause of disease affection by exopathogenic cold-wind, space between skin and muscles occlusion, qi depression to blood stasis, channels knot, which gather, to be formed；Or due to yang-energy
Deficiency, qi and blood two is empty, and skin is lost in warm, feels the heresy of chill, fleshy exterior of controlling long again；Or due to instability of surface, battalion, which defends, to become estranged, chill
Heresy take advantage of a weak point, visitor in skin space between skin and muscles, make to gather through kank, the ying blood stasis of blood is stagnant and falls ill.This sick initial stage shows the deficiency of vital energy more, can enter one
Step develops into the deficiency of yang, the long then qi deficiency to blood stasis of disease, therefore this sick basic pathogenesis is asthenia in origin and asthenia in superficiality, and the heart qi deficiency, spleen, kidney-yang deficiency are this,
Blood stasis is marks, long then simulataneous insufficiency and excessive.
Western medical treatment is more mainly based on the application of antihistamine, but clinical efficacy differs.Cyproheptadine is recognized always in the past
To be the first choice for treating cold urticaria, but more recently by facts have proved that cyproheptadine (cyproheptadine), ketoboidies be fragrant, oral color
Sweet acid sodium, H2 ARBs can only achieve the purpose temporarily controlled, stop to cold urticaria patient outcome and bad
Easily recurrence even symptom aggravates earlier above after medication, i.e., western medical treatment is basic without it is ruled by law, and easily recurrence.
Chinese medicine is with a long history, and patient acceptability is good.A kind of prescription effectively treated is needed badly to treat this disease, is alleviated
Itch and skin lesion, recurrent number is reduced, extend the paracmasis, make the life better patient quality.
The content of the invention
It is an object of the invention to provide a kind of pharmaceutical composition for treating cold urticaria.
Another object of the present invention is to provide the preparation method and purposes of described pharmaceutical composition.
The invention provides a kind of pharmaceutical composition for treating cold urticaria, and it is by the raw material of following weight proportion
Medicine is prepared：
Radix Astragali 25-30 parts, bighead atractylodes rhizome 15-20 parts, windproof 10-15 parts, Chinese ephedra 5-10, cassia twig 10-15 parts, RADIX ACONITI LATERALIS PREPARATA 5-10
Part, rhizoma zingiberis 1-5 parts, Radix Angelicae Sinensis 10-15 parts, Ligusticum wallichii 10-15 parts, root of herbaceous peony 15-20 parts, stiff silkworm 10-15 parts, cicada slough 10-15 parts, pierce puncture
Lamb's-quarters 10-15 parts, honey-fried licorice root 10-15 parts.
Preferably, aforementioned pharmaceutical compositions are prepared by the bulk drug of following weight proportion：
30 parts of the Radix Astragali, 15 parts of the bighead atractylodes rhizome, windproof 10 parts, 10 parts of Chinese ephedra, 10 parts of cassia twig, 10 parts of RADIX ACONITI LATERALIS PREPARATA, 5 parts of rhizoma zingiberis, Radix Angelicae Sinensis
10 parts, 10 parts of Ligusticum wallichii, 20 parts of the root of herbaceous peony, 10 parts of stiff silkworm, 10 parts of cicada slough, 15 parts of tribulus terrestris, 15 parts of honey-fried licorice root.
Aforementioned pharmaceutical compositions, it is the primary medicinal powder by the bulk drug, or water or extractive with organic solvent are work
Property composition, the preparation being prepared plus pharmaceutically acceptable auxiliary material or complementary composition.
The preparation is external preparation.
Preferably, the external preparation is lotion, decoction, liniment, powder or paste.
A kind of method for preparing aforementioned pharmaceutical compositions, it comprises the following steps：
B) bulk drug of each weight proportion is weighed；
B) by the primary medicinal powder of bulk drug, or water or extractive with organic solvent are active component, plus can pharmaceutically connect
The auxiliary material or complementary composition received are prepared into preparation.
Purposes of the aforementioned pharmaceutical compositions in the medicine for preparing treatment cold urticaria.
Cold urticaria of the present invention is the urticaria of the traditional Chinese medical science.
Further, skin lesion and itch of the cold urticaria for all cold urticaria patients.
Further, the cold urticaria includes yang deficiency of spleen and stomache, Qi deficiency blood stasis type, the blood-deficiency and wind-dry of the traditional Chinese medical science
Type.
Pharmaceutical composition of the present invention is by the Radix Astragali, bighead atractylodes rhizome, windproof, Chinese ephedra, cassia twig, RADIX ACONITI LATERALIS PREPARATA, rhizoma zingiberis, Radix Angelicae Sinensis, Ligusticum wallichii, white
Chinese herbaceous peony, stiff silkworm, cicada slough, tribulus terrestris, the four traditional Chinese medicine thing of honey-fried licorice root ten composition.
The big gas mended all over the body up and down of the Radix Astragali in side, bighead atractylodes rhizome invigorating the spleen dehumidifying, the windproof medicine of dispelling wind and arresting itching three go the meaning of Yupingfeng with
The solid table of wind-dispelling is antipruritic, treats both principal and secondary aspect of disease；Chinese ephedra opening pores space between skin and muscles so that ailment said due to cold or exposure is outgoing road.Cassia twig warming meridian, monkshood mend fire
It is supporing yang, rouse oneself kidney yang, the warm medicine of spleen three of conjunction rhizoma zingiberis shares passages through which vital energy circulates temperature and led to, and middle-jiao yang, function of the spleen and stomach rouses oneself, and life-gate fire excess makes a concerted effort to drive away cold-evil.Radix Angelicae Sinensis,
Ligusticum wallichii, promoting circulation of blood and enriching blood, mend and supply cloudy blood without the stagnant and root of herbaceous peony.Pathogen usually intruding into collateral in protracted disease event enters network with stiff silkworm, cicada slough worm medicine and picks heresy, tribulus terrestris
Soothing the liver calmness is antipruritic, honey-fried licorice root coordinating the drug actions of a prescription.
Pharmaceutical composition of the present invention, compatibility is precise and appropriate, and each flavour of a drug complement each other, to alleviate cold urticaria conditions of patients,
Prevent from recurring evident in efficacy, can more effectively treat cold urticaria, new selection is provided for clinical application.
According to the above of the present invention, according to the ordinary technical knowledge and customary means of relevant art, not
Under the premise of departing from the above-mentioned basic fundamental thought of the present invention, the modification, replacement or change of other diversified forms can also be made.
The embodiment of form by the following examples, the above of the present invention is remake further specifically
It is bright.But the scope that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following example.It is all to be based on the above of the present invention
The technology realized belongs to the scope of the present invention.
Embodiment
The preparation of 1 pharmaceutical composition of the present invention of embodiment
1. raw material：Radix Astragali 30g, bighead atractylodes rhizome 15g, windproof 10g, Chinese ephedra 10g, cassia twig 10g, RADIX ACONITI LATERALIS PREPARATA 10g, rhizoma zingiberis 5g, Radix Angelicae Sinensis
10g, Ligusticum wallichii 10g, root of herbaceous peony 20g, stiff silkworm 10g, cicada slough 10g, tribulus terrestris 15g, honey-fried licorice root 15g.
2. preparation method：Weigh the bulk drug of above-mentioned weight proportion；Instrument material of boiling medicine is ceramics.Clear water 2000ml is taken,
Endured slowly with slow fire 15 minutes again after being boiled by fire.The dregs of a decoction are filtered out with gauze after boiling, the decoction endured is poured into foot bath
In, the appropriate cold water that adds makes decoction cover ankle, and temperature keeps 42-50 DEG C (a little higher than body temperature) to be advisable.
The preparation of 2 pharmaceutical composition of the present invention of embodiment
1. raw material：Radix Astragali 25g, bighead atractylodes rhizome 20g, windproof 15g, Chinese ephedra 5g, cassia twig 15g, RADIX ACONITI LATERALIS PREPARATA 5g, rhizoma zingiberis 1g, Radix Angelicae Sinensis
15g, Ligusticum wallichii 15g, root of herbaceous peony 15g, stiff silkworm 15g, cicada slough 15g, tribulus terrestris 10g, honey-fried licorice root 10g.
2. preparation method：Weigh the bulk drug of above-mentioned weight proportion；Instrument of boiling medicine is marmite.Take clear water 2500ml, big fire
Endured slowly with slow fire 20 minutes again after boiling.The dregs of a decoction are filtered out with gauze after boiling, the decoction endured is poured into foot bath, are fitted
Amount, which adds cold water, makes decoction cover ankle, and temperature keeps 42-50 DEG C (a little higher than body temperature) to be advisable.
Beneficial effects of the present invention are proved below by way of specific clinical test：
The clinical efficacy of the present composition of test example 1
1st, clinical data
Out-patient 67 is chosen, is met《Clinical dermatology》The diagnosis of relevant cold urticaria in fourth edition
Standard.
Sex and the range of age：Age 18-65 year, women 47, male 20 is total course of disease most short March, most long 35 years,
It is treatment time in most short January, most long 3 years.
All patients are randomly divided into two groups.The money such as treatment group 34, control group 33, two groups of patient ages, sex, courses of disease
Material compares no significant difference (P ＞ 0.05), has comparativity.
1.1 diagnostic criteria：
Clinical symptoms typical case, cold pressor test is positive, meets the clinical diagnosis of primary acquired cold urticaria, and 1
It is unused in month to cross Glucocorticoid, not used antihistamine, no serious organ and systemic disease in 4 days.
1.2 inclusive criteria
The case for meeting 1.1 section diagnostic criteria is included.
2nd, treatment method
Experimental group：Give the medicine of the embodiment of the present invention 1.
Specifically medication is：Night lavipeditum 1 time, both feet are put into foot bath by patient, to steep ankle as degree, immersion
20~30min, entire patient's low-grade fever, forehead or back is set to perspire slightly, lavipeditum terminates to use towel biped, one time a day, 4
Week is 1 course for the treatment of.During treatment, not equipped with other Western medicine and other therapies.
Control group：Only oral Loratadine (trade name：Clarityne) 10 milligrams, once a day.4 weeks are 1 course for the treatment of.
Diet is light during treatment, avoids delicious food savoury, avoids sweet food, seafood food and hot fruit, advises more food vegetables.The course for the treatment of
Terminate to carry out therapeutic evaluation, 8 weeks observation Repigmentation situations of clinical cure follow-up of patients.
3rd, observation of curative effect
3.1 criterion of therapeutical effect：
Curative effect judging standard is recorded by 4 grades of point systems, and standards of grading are as shown in table 1：
The standards of grading of table 1
| 0 point | 1 point | 2 points | 3 points | |
| Itch | Nothing | Slightly | Moderate | Severe |
| Wheal maximum gauge (centimetre) | Nothing | ＜ 0.5 | 0.5~2.0 | ＞ 2.0 |
| Wheal quantity (individual) | Nothing | 1~6 | 7~12 | ＞ 12 |
| Wheal seizure frequency (times/day) | Nothing | ＜ 3/ day | 3~4 times | ＞ 5 times |
In table 1, the grade classification on itch：0 point is：Without gargalesthesia；1 point is slightly：Itch occasionally has breaking-out, or only at night
Between or quiet environment under occur, and relatively limit to, mild degree, do not influence work and sleep；2 points of moderates are:Itch is frequently broken out, can
Occur simultaneously at number, degree is heavier, or even influences work and sleep；3 points of severes are:Itch is persistently broken out, in general hair, degree
Weight, influences work and sleep, can change with skin scratch, scab, pigmentation, eczema, liver mossization etc..
Symptom integral declines integration × 100% before index=(being integrated before treatment after integration-treatment)/treatment.
It is basic to cure integral exponential >=90%；Effective is >=60 but ＜ 90%；Take a turn for the better as >=20 but ＜ 60%；Invalid integration
For 20%.
Cure and effective percentage adds up to effective percentage.
3.2 treatment results
As shown in table 2, table 3
The effect for the treatment of group example patient of table 2 is after treatment in 4 weeks
| Treatment results | Case load (example) | Efficient (%) |
| Recovery from illness | 7 | 20.5 |
| It is effective | 9 | 26.5 |
| Effectively | 15 | 44.2 |
| It is invalid | 3 | 8.8 |
| Amount to | 34 | 91.2 |
The effect of control group group example patient of table 3 is after treatment in 4 weeks
| Treatment results | Case load (example) | Efficient (%) |
| Recovery from illness | 2 | 5.8 |
| It is effective | 6 | 17.6 |
| Effectively | 14 | 41.2 |
| It is invalid | 11 | 35.4 |
| Amount to | 33 | 64.6 |
As a result it is 91.2% to show treatment group's total effective rate, and control group total effective rate is 64.6%, P ＜ 0.05, and difference has
It is statistically significant.
Adverse reaction：Adverse reaction is had no during medication, skin is micro- red after accidental some patientss treatment, advises patient to pay attention to water
Situation improves after temperature.Some patientss are had a blood test as, hepatic and renal function is without exception.
3.3 model case
Patient Zhang, male, 27 years old.Patient was diagnosed as the annual winter exacerbation of cold urticaria before 5 years in outer court, went out
Shi Jiyi breaks out, so that have a strong impact on its normal work.Long-term Oral Chinese holly Desloratadine piece 8.8mg, once a day, medication period
Between can reduce breaking-out probability to a certain extent, but still be difficult to return normal life.Patient's readme break out when acute pruritus, all over the body without
There is pale asphyxia wheal in rule.Readme is usually cold, and easily diarrhoea combines pale tongue after eating cold food, and tongue is white, and indentation is with crackle, deeptensepulse
It is slow.It is hypoactivity of spleen-YANG type after diagnosing.Suitable tonifying middle-Jiao and Qi is controlled, warm spleen is dispeled cold.Using the specific implementation method of the present invention, and suggest suffering from
Person keeps diet light, avoids delicious food savoury, avoids sweet food, seafood food and hot fruit.By the above-mentioned course for the treatment of of treatment 1, skin lesion is reduced,
Itch mitigates；Again after the course for the treatment of of medication 1, skin lesion, itch disappear.
Above-mentioned experiment shows that pharmaceutical composition of the present invention is evident in efficacy to alleviating cold urticaria conditions of patients.
To sum up, pharmaceutical composition of the present invention, compatibility is precise and appropriate, and each flavour of a drug complement each other, to alleviating cold urticaria patient
The state of an illness, prevent from recurring evident in efficacy, can more effectively treat cold urticaria, new choosing is provided for clinical application
Select.
Claims (7)
- A kind of 1. pharmaceutical composition for treating cold urticaria, it is characterised in that：It is by the bulk drug of following weight proportion It is prepared：Radix Astragali 25-30 parts, bighead atractylodes rhizome 15-20 parts, windproof 10-15 parts, Chinese ephedra 5-10, cassia twig 10-15 parts, RADIX ACONITI LATERALIS PREPARATA 5-10 parts, do Ginger 1-5 parts, Radix Angelicae Sinensis 10-15 parts, Ligusticum wallichii 10-15 parts, root of herbaceous peony 15-20 parts, stiff silkworm 10-15 parts, cicada slough 10-15 parts, tribulus terrestris 10- 15 parts, honey-fried licorice root 10-15 parts.
- 2. pharmaceutical composition according to claim 1, it is characterised in that：It is by following weight proportion bulk drug prepare and Into：30 parts of the Radix Astragali, 15 parts of the bighead atractylodes rhizome, windproof 10 parts, 10 parts of Chinese ephedra, 10 parts of cassia twig, 10 parts of RADIX ACONITI LATERALIS PREPARATA, 5 parts of rhizoma zingiberis, 10 parts of Radix Angelicae Sinensis, 10 parts of Ligusticum wallichii, 20 parts of the root of herbaceous peony, 10 parts of stiff silkworm, 10 parts of cicada slough, 15 parts of tribulus terrestris, 15 parts of honey-fried licorice root.
- 3. pharmaceutical composition according to claim 1 or claim 2, it is characterised in that：It is the primary medicinal powder by the bulk drug, or Person's water or extractive with organic solvent are active component, are prepared plus pharmaceutically acceptable auxiliary material or complementary composition Preparation.
- 4. pharmaceutical composition according to claim 3, it is characterised in that：The preparation is external preparation.
- 5. pharmaceutical composition according to claim 4, it is characterised in that：The external preparation be lotion, decoction, liniment, dissipate Agent or paste.
- A kind of 6. method for preparing claim 1-5 any one described pharmaceutical compositions, it is characterised in that：It includes following step Suddenly：A) bulk drug of each weight proportion is weighed；B) by the primary medicinal powder of bulk drug, or the active component of water or extractive with organic solvent, plus pharmaceutically acceptable Auxiliary material or complementary composition are prepared into preparation.
- 7. purposes of the claim 1-5 any one described pharmaceutical composition in the medicine for preparing treatment cold urticaria.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711353257.5A CN107823622A (en) | 2017-12-15 | 2017-12-15 | A kind of pharmaceutical composition for treating cold urticaria and its production and use |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711353257.5A CN107823622A (en) | 2017-12-15 | 2017-12-15 | A kind of pharmaceutical composition for treating cold urticaria and its production and use |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107875352A (en) * | 2017-12-15 | 2018-04-06 | 成都中医药大学附属医院 | A kind of pharmaceutical composition for treating acne conglobata and its production and use |
| CN115737776A (en) * | 2022-12-20 | 2023-03-07 | 杜启雪 | Chinese herbal medicine prescription for treating allergic rhinitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7235265B2 (en) * | 2005-10-31 | 2007-06-26 | Ross Rosen | Herbal skin formulation |
| CN103520353A (en) * | 2013-10-11 | 2014-01-22 | 成都中医药大学附属医院 | Medicament for treating urticaria, and preparation method and application thereof |
| CN105412902A (en) * | 2016-01-22 | 2016-03-23 | 王志龙 | Traditional Chinese medicine decoction for treating chronic urticaria |
| CN107875352A (en) * | 2017-12-15 | 2018-04-06 | 成都中医药大学附属医院 | A kind of pharmaceutical composition for treating acne conglobata and its production and use |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7235265B2 (en) * | 2005-10-31 | 2007-06-26 | Ross Rosen | Herbal skin formulation |
| CN103520353A (en) * | 2013-10-11 | 2014-01-22 | 成都中医药大学附属医院 | Medicament for treating urticaria, and preparation method and application thereof |
| CN105412902A (en) * | 2016-01-22 | 2016-03-23 | 王志龙 | Traditional Chinese medicine decoction for treating chronic urticaria |
| CN107875352A (en) * | 2017-12-15 | 2018-04-06 | 成都中医药大学附属医院 | A kind of pharmaceutical composition for treating acne conglobata and its production and use |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107875352A (en) * | 2017-12-15 | 2018-04-06 | 成都中医药大学附属医院 | A kind of pharmaceutical composition for treating acne conglobata and its production and use |
| CN115737776A (en) * | 2022-12-20 | 2023-03-07 | 杜启雪 | Chinese herbal medicine prescription for treating allergic rhinitis |
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