CN106266830A - A kind of Chinese medicine composition treating eczema - Google Patents

Abstract

The invention discloses a kind of Chinese medicine composition treating eczema, it is that the raw material containing following weight proportioning is prepared from: Rhizoma Atractylodis 20 25 parts, Cortex Phellodendri 20 25 parts, Radix Sophorae Flavescentis 30 35 parts, Cortex Dictamni 30 35 parts, Rhizoma Smilacis Glabrae 30 35 parts, the Fructus Kochiae 30 35 parts, Fructus Cnidii 30 35 parts, Galla Chinensis 20 25 parts.Clinical trial certificate, pharmaceutical composition of the present invention is to eczema patients, and the especially anal eczema patient state of an illness is evident in efficacy, and toxic and side effects is little, has the advantage of uniqueness and preferable potential applicability in clinical practice.

Description

A kind of traditional Chinese medicine composition for treating eczema

technical field

The invention relates to a traditional Chinese medicine composition for treating eczema.

Background technique

Eczema is an inflammation of the superficial dermis and epidermis caused by a variety of internal and external factors. The skin lesions are distributed symmetrically, with polymorphic lesions, severe itching, and a tendency to exudate. Repeated attacks can easily become chronic.

The pathogenesis of eczema is unclear. Internal factors can include chronic infection lesions, endocrine and metabolic changes, blood circulation disorders, neuropsychiatric factors, genetic factors, etc. Among them, genetic factors are related to individual susceptibility. External factors can be induced or aggravated by mistakes, inhalation, living environment, animal fur, and various chemicals. May be mediated by delayed-type hypersensitivity in some patients.

Western medicine treats eczema with injection of calcium, vitamin C, sodium thiosulfate or procaine to seal it, and antibiotics are added for secondary infection. Topical glucocorticoid boric acid solution, etc., but there are different side effects, should not be used for a long time, easy to relapse after drug withdrawal.

Therefore, for eczema, there is a clinical need for more effective therapeutic drugs with less side effects.

Contents of the invention

In order to solve the above problems, the invention provides a Chinese medicinal composition for the treatment of eczema, which is prepared from raw materials containing the following weight ratios:

20-25 parts of atractylodes, 20-25 parts of Cortex Phellodendri, 30-35 parts of Sophora flavescens, 30-35 parts of white fresh skin, 30-35 parts of Smilax, 30-35 parts of Kochia, 30-35 parts of Cnidium, gallnut 20-25 servings.

Further, it is a preparation prepared from raw materials with the following weight ratio:

20-25 parts of atractylodes, 20-25 parts of Cortex Phellodendri, 30-35 parts of Sophora flavescens, 30-35 parts of white fresh skin, 30-35 parts of Smilax, 30-35 parts of Kochia, 30-35 parts of Cnidium, gallnut 20-25 servings.

Further, it is a preparation prepared from raw materials with the following weight ratio:

20 parts of Atractylodes atractylodes, 20 parts of Cortex Phellodendri, 30 parts of Sophora flavescens, 30 parts of white fresh skin, 30 parts of Smilax cocos, 30 parts of Kochia chinensis, 30 parts of Cnidium chinensis, 20 parts of Galla chinensis.

Furthermore, it is a preparation prepared by using active ingredients of drug powder of raw materials, water or organic solvent extracts of raw materials, and adding auxiliary materials or auxiliary ingredients commonly used in medicines.

Further, the preparation is an external preparation; preferably, the external preparation is a decoction, tincture, ointment, gel, powder, liniment, paste or lotion.

The present invention also provides the method of aforementioned Chinese medicine composition, and it comprises the steps:

(1) take each raw material by weight ratio;

(2) adding water to extract the raw material, and taking the water extract.

Further, in step (2), the extraction method is selected from water decoction.

The present invention also provides the application of the aforementioned traditional Chinese medicine composition in the preparation of medicaments for treating eczema.

Further, the eczema is perianal eczema.

Further, the eczema is damp-heat intrinsic type eczema.

Clinical experiments show that the pharmaceutical composition of the present invention has significant curative effect on eczema patients, especially perianal eczema patients, has little toxic and side effects, and has unique advantages and good clinical application prospects.

Apparently, according to the above content of the present invention, according to common technical knowledge and conventional means in this field, without departing from the above basic technical idea of the present invention, other various forms of modification, replacement or change can also be made.

The above-mentioned content of the present invention will be further described in detail below through specific implementation in the form of examples. However, this should not be construed as limiting the scope of the above-mentioned subject matter of the present invention to the following examples. All technologies realized based on the above contents of the present invention belong to the scope of the present invention.

detailed description

The preparation of embodiment 1 medicine of the present invention

1. Prescription: Atractylodes 20g, Cortex Phellodendri 20g, Sophora flavescens 30g, Fresh Cortex 30g, Smilax Smilax 30g, Kochia chinensis 30g, Cnidium 30g, Galla chinensis 20g.

2. Take the raw materials of the prescribed amount, add 1000mL of water before cooking, stir, soak for about 30 minutes, and cook twice. Boil for 30 minutes, fry for 20 minutes for the second time, and take about 300mL of juice.

How to use: Add clear water to boil, fumigate the affected area first, then wet compress and soak the affected area when the water temperature is suitable, once in the morning and in the evening.

The preparation of embodiment 2 medicines of the present invention

1. Prescription: Atractylodes 20g, Cortex Phellodendri 20g, Sophora flavescens 30g, Fresh Cortex 30g, Smilax Smilax 30g, Kochia chinensis 30g, Cnidium 30g, Galla chinensis 20g.

2. Take the raw materials of the prescribed amount, add 1000mL of water before cooking, stir, soak for about 30 minutes, and cook twice. Boil for 30 minutes, fry for 20 minutes for the second time, and take about 300mL of juice.

How to use: Add clear water to boil, fumigate the affected area first, then wet compress and soak the affected area when the water temperature is suitable, once in the morning and in the evening.

The beneficial effects of the present invention are demonstrated through specific test examples below.

Test example 1 clinical case statistics

(1) Criteria for admitted patients (or diagnostic criteria)

Gender and age range of patients: 90 patients, aged 18-65 years, 39 females, 51 males, the shortest duration of disease is 2 months, the longest is 2 years, the shortest treatment time is 1 month, and the longest is half a year.

Diagnostic criteria:

Severe itching, pleomorphic, symmetrical skin lesions, exudative tendency in the acute phase, and lichenification in the chronic phase. Generally divided into acute eczema, subacute eczema, chronic eczema.

Acute eczema tends to occur in exposed parts such as the face, ears, hands, feet, forearms, and lower legs. In severe cases, it can diffuse throughout the body, often symmetrically distributed. Pleomorphic skin lesions, often manifested as pinhead to miliary-sized papules and papules on the basis of erythema, and in severe cases, small blisters may appear, often fused into sheets, with unclear borders, and papules around the skin lesion gradually become sparse, often due to scratching A punctate erosion surface was formed, with obvious serous exudation. Consciously itching is severe, and skin lesions can be aggravated when scratching or washing with hot water.

Subacute eczema develops for a long time after the acute eczema inflammation is alleviated or improperly handled. The redness and swelling and exudation are relieved, but there may still be papules and a small amount of papules, the skin lesions become dark red, and there may be a little scale and mild infiltration. Still consciously have severe itching. Re-exposure to allergens, new stimuli, or mismanagement can lead to acute attacks, which can develop into chronic eczema if left untreated.

Chronic eczema is caused by acute eczema or subacute eczema, and it can also be chronic due to slight and persistent stimulation. Occurs in hands, feet, legs, elbow fossa, thigh, vulva, anus, etc., symmetrically. It is manifested as infiltrating dark erythema of the affected skin with papules, scratches and scales, local skin hypertrophy, rough surface, lichenification, pigmentation and hypopigmentation in different degrees. Consciously have obvious itching, often showing paroxysmal. The condition is mild and severe, and lasts for several months or longer.

(2) Standard of treatment

(1) Referring to the modified EASI scoring method proposed by Zhao Bian, compare the curative effects before and after the experiment on five items of erythema, hard swelling (edema)/papule, exfoliation, lichenification, and exudation/scab. The specific method is as follows:

E: Erythema—red or dark red inflammatory spot, which fades under pressure;

I: Induration (edema)/papules—skin lesions are pinhead-sized papules or papules, or raised red plaques;

Ex: exfoliation - epidermal injury from scratching, including fissures on keratinized lesions and linear erosions on lesions;

L: Lichenification-a skin lesion is infiltrated hypertrophy and hyperkeratosis.

Ef: Exudation/crustation—the surface of the lesion is wet, including crusting after the exudate has dried.

The severity of each clinical manifestation is scored from 0 to 3 points, 0=none, 1=mild, 2=moderate, 3=severe. Half fractions can be recorded between the scores of various symptoms, that is, 0.5 0.

Clinical Surface Area Size Score: Lesion size was calculated using 1% of the palm of the patient's hand. The ratio of skin lesion area to the area of each part is 0-6, that is, 0 means no rash, 1 means <10%, 2 means 10%-19%, 3 means 20-49%, 4 means 50-69%, 70-89%, 6 is 90-100%. Since the upper limbs and lower limbs account for 20% and 40% of the human body’s surface area respectively, when comparing the inner and outer sides of the upper limbs and lower limbs, the scores of the outer and inner sides of the upper limbs are x0.1, and the scores of the outer and inner sides of the lower limbs are x0.2 , for easy comparison.

Efficacy evaluation: According to the change of EASI score before and after treatment, it is calculated according to "curative effect = (score before treatment - score after treatment)/score before treatment x 100%". Cured: curative effect ≥ 90%; markedly effective: 90% > curative effect ≥ 50%; effective: 50% > curative effect ≥ 30%; invalid: curative effect < 30%.

(2) The degree of itching is scored using the following criteria:

0 points: no itching;

1 point: Occasional itching, no need for medication, does not affect study and life;

2 points: paroxysmal itching, sometimes mild and sometimes severe, affecting sleep, study and life;

3 points: severe itching, seriously affecting work, study and life.

There can be one and a half points between the scores of various symptoms, that is, 0.5.

(3) Dermatology Life Quality Index Inventory (DLQI) was used to evaluate the effect of treatment on the quality of life of patients.

(3) Treatment methods

1. Administration method: After the diagnosis was made, 90 patients were given the following medicines: 20g of Atractylodes atractylodes, 20g of Phellodendron Phellodendri, 30g of Sophora flavescens, 30g of Radix Cortex, 30g of Smilax, 30g of Kochia chinensis, 30g of Cnidium chinensis, and 20g of Galla chinensis.

Take 1 dose per day, decoct 3 times in water, fumigate the affected area once in the morning and 1 time in the evening, apply wet compress and soak the affected area after the water temperature is suitable, and use continuously for 2 weeks. During the treatment period, no other western medicine and other treatments are provided.

During the treatment period, the diet should be light, avoid fat, sweet and thick flavors, avoid sweets, seafood and hot fruits, and advise to eat more vegetables. Avoid scalding with hot water, avoid washing the affected area with soap and other such substances. Avoid scratching to prevent infection.

2. Those with no obvious drug contraindications and sensitive skin.

(4) Treatment results

Treatment time: 2 weeks

Judgment of curative effect: The results are shown in Table 1 below.

Table 1 The curative effect of 90 patients after 2 weeks of treatment

treatment result Number of cases (cases) Efficient(%) get well twenty two 24.4% markedly effective 30 33.3% efficient 31 34.5% invalid 7 7.8% total 90 92.2%

It can be seen that the medicine of the present invention has high effective rate and can effectively treat eczema.

Adverse reactions: No adverse reactions were seen during the medication period. Occasionally, the skin of some patients was slightly red after treatment. The situation improved after the patients were instructed to pay attention to the water temperature. Some patients had no abnormality in blood examination, liver and kidney function.

Atractylodes atractylodes, Cortex Phellodendri, and Sophora flavescens in the prescription are all medicines for removing dampness from bitter cold, so as to get rid of dampness, the culprit of the disease. If dampness is removed, the disease will no longer be lingering and difficult to heal. The white fresh skin dispels wind, detoxifies dampness and relieves itching. Smilax smilax, Kochia chinensis and Cnidium chinensis dispel dampness and relieve itching, Galla chinensis mainly treats astringent, astringent and ulcerated skin lesions, and promotes healing. The whole prescription focuses on dehumidification, and then uses wind medicine to dispel wind and relieve itching, dampness and itching can relieve the disease and heal.

(5) Typical cases

Patient Li, male, 67 years old. Two years ago, the patient had itching symptoms in the anus, flushing, erosion and exudate after scratching, which could be relieved temporarily by external application of Dermatitis Ping, but often relapsed after a few days, lingering and difficult to heal. Acute diagnosis: perianal buttocks skin ulceration, wound flushing, fissures, scabs, a little exudate, red tongue, thick and greasy tongue coating, rapid pulse. It was diagnosed as damp-heat intrinsic type. Control suitable heat-clearing and damp-drying. Use the specific implementation method of the present invention, and suggest that the patient keeps the affected part dry, has a light diet, avoids fat, sweet and thick taste, avoids sweets, seafood and hot fruits. According to the above treatment for 1 course, the skin lesions decreased, the itching was alleviated, and the ulcerated wound was almost healed; after another 1 course of treatment, the skin lesions and itching disappeared.

The above experiments show that the pharmaceutical composition of the present invention has a significant curative effect on eczema patients, especially perianal eczema patients, with little toxic and side effects, and has unique advantages and good clinical application prospects.

Claims (10)

1. a Chinese medicine composition for the treatment of eczema, characterized in that: it is prepared from raw materials containing the following weight proportions: 20-25 parts of atractylodes, 20-25 parts of Cortex Phellodendri, 30-35 parts of Sophora flavescens, 30-35 parts of white fresh skin, 30-35 parts of Smilax, 30-35 parts of Kochia, 30-35 parts of Cnidium, gallnut 20-25 servings. 2. Chinese medicine composition according to claim 1, is characterized in that: it is the preparation that is prepared from the crude drug of following weight ratio: 20-25 parts of atractylodes, 20-25 parts of Cortex Phellodendri, 30-35 parts of Sophora flavescens, 30-35 parts of white fresh skin, 30-35 parts of Smilax, 30-35 parts of Kochia, 30-35 parts of Cnidium, gallnut 20-25 servings. 3. Chinese medicine composition according to claim 1, is characterized in that: it is the preparation that is prepared from the crude drug of following weight ratio: 20 parts of Atractylodes atractylodes, 20 parts of Cortex Phellodendri, 30 parts of Sophora flavescens, 30 parts of white fresh skin, 30 parts of Smilax cocos, 30 parts of Kochia chinensis, 30 parts of Cnidium chinensis, 20 parts of Galla chinensis. 4. The traditional Chinese medicine composition according to any one of claims 1 to 3, characterized in that: it is an active ingredient made of the drug powder of the crude drug, the water or organic solvent extract of the crude drug, plus the commonly used adjuvant in the medicine Or preparations prepared from auxiliary ingredients. 5. The traditional Chinese medicine composition according to any one of claims 1 to 4, characterized in that: the preparation is an external preparation; preferably, the external preparation is a decoction, tincture, ointment, gel, powder, Liniment, paste or lotion. 6. A method for preparing the Chinese medicine composition described in any one of claims 1 to 5, characterized in that: it comprises the steps of: (1) take each raw material by weight ratio; (2) adding water to extract the raw material, and taking the water extract. 7. The method according to claim 6: in step (2), the extraction method is selected from decoction. 8. The use of the traditional Chinese medicine composition according to any one of claims 1 to 5 in the preparation of a medicine for treating eczema. 9. The use according to claim 9, characterized in that: the eczema is perianal eczema. 10. The use according to claim 8 or 9, characterized in that: the eczema is damp-heat intrinsic type eczema.