CN107822970A - 一种去屑精华液及其制备方法 - Google Patents
一种去屑精华液及其制备方法 Download PDFInfo
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- CN107822970A CN107822970A CN201711191001.9A CN201711191001A CN107822970A CN 107822970 A CN107822970 A CN 107822970A CN 201711191001 A CN201711191001 A CN 201711191001A CN 107822970 A CN107822970 A CN 107822970A
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- Prior art keywords
- dandruff
- essence
- peg
- agent
- parts
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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Abstract
本发明公开了一种去屑精华液，包括：水：100份；金属螯合剂：0.01‑0.1份；活性物：0.0001‑0.05份；去屑剂：0.1‑0.8份；保湿剂：1‑5份；乳化剂：0.01‑0.1份；香精：0.005‑0.01份；赋脂剂：0.1~2份；防腐剂：0.2‑0.5份；pH调节剂：加入量为调节去屑精华液的pH值为4.5‑7.0。本发明所述去屑精华液的配方中，由于各组分之间相互配伍，相互协作，能很好地减少因真菌和干燥引起的头屑和瘙痒问题，且由于本发明所述去屑精华液属于停留型产品，可在头皮上留置更长的时间，进一步加强了头皮的保湿和抑菌效果。
Description
技术领域
本发明涉及一种精华液及其制备方法，具体涉及一种去屑精华液及其制备方法，属于日用化学品技术领域。
背景技术
据统计，80％以上的成年人都不同程度地受到头屑的困扰。头屑已成为影响人们正常生活的一大问题。针对消费者的需要，当前市场上去屑类洗发产品层出不穷，多种多样。然而，这类产品的去屑功效却是良莠不齐。归根结底，去屑功效不仅仅取决于去屑有效成分的选择，也在很大程度上受配方技术的影响。
传统上的去屑产品多为冲洗型。无可否认，已形成的头屑最终需要用水冲洗才能除去。然而从抑制真菌以从根本上消除头屑的角度来讲，含有抗真菌有效成分的免洗型去屑产品也不失为良好的选择。由于现有产品不能很好地使有效成分全面均匀地覆盖在头皮上，固开发了此款产品。
发明内容
为解决现有技术的不足，本发明的目的在于提供一种能够有效去屑的水解蚕丝蛋白护发素及其制备方法。
为了实现上述目标，本发明采用如下的技术方案：
一种去屑精华液，包括以下组分且各组分的重量份数分别为：
水：100份；
金属螯合剂：0.01-0.1份；
活性物：0.0001-0.05份；
去屑剂：0.1-0.8份；
保湿剂：1-5份；
乳化剂：0.01-0.1份；
香精：0.005-0.01份；
赋脂剂：0.1~2份；
防腐剂：0.2-0.5份；
pH调节剂：加入量为调节去屑精华液的pH值为4.5-7.0，
所述的水、金属螯合剂、活性物、去屑剂和保湿剂共同形成A相，所述的乳化剂和香精共同形成B相，而所述的赋脂剂、防腐剂和pH调节剂则归类为C相。
进一步，上述的金属螯合剂为乙二胺四乙酸及其金属盐、谷氨酸四乙酸及其金属盐、天冬氨酸四乙酸及其金属盐、丙二胺四乙酸及其金属盐中的至少一种。
上述的活性物为透明质酸、透明质酸钠、金缕梅提取物、银耳多糖提取物、芦荟提取物、吡络烷酮羧酸锌、吡络烷酮羧酸钠、烟酰胺、泛醇、乳酸钠中的至少一种。
上述的去屑剂为月桂基吡啶氮鎓氯化物。
上述的保湿剂为甘油、丙二醇、丁二醇、泛醇、山梨糖醇、双丙甘醇、己二醇、异丙醇、木糖醇、三甲基甘氨酸、聚乙二醇、甲基葡糖醇聚醚-10、甲基葡糖醇聚醚-20、聚甘油-10、聚甘油-6中的至少一种。
上述的乳化剂为PEG-40氢化蓖麻油、PEG-40/45氢化蓖麻油、PEG-60氢化蓖麻油、异鲸蜡醇聚醚-20、聚山梨醇酯-20、PEG-80失水山梨醇月桂酸酯、PPG-6-癸基十四醇聚醚-20中的至少一种。
上述的赋脂剂为橄榄油PEG-7酯类、甘油丙烯酸酯/丙烯酸共聚物、霍霍巴蜡 PEG-120 酯类 、PEG-7甘油椰油酸酯、PEG-6辛酸/癸酸甘油酯类、PEG-20杏仁甘油酯类、PEG-60杏仁甘油酯类、PEG-90杏仁甘油酯类、PEG-42巴巴苏甘油酯类、PEG-60月见草油甘油酯类、PEG-60玉米油甘油酯类、PEG-45棕榈仁油甘油酯类、PEG-60西番莲甘油酯类中的至少一种。
上述的防腐剂为DMDMH乙内酰脲、羟苯甲酯、甲基异噻唑啉酮、乙基己基甘油、苯氧乙醇、苯甲酸、脱氢乙酸、聚氨丙基双胍、辛甘醇、苯甲酸钠、山梨酸钾中的至少一种。
而上述的pH调节剂则包括三乙醇胺、氢氧化钠、氢氧化钾、柠檬酸、乳酸中的任一种。
更进一步，一种上述的去屑精华液的制备方法，包括以下步骤：
S1：首先将A相中的去屑剂和保湿剂分散均匀无明显结块，然后将A相中的水和金属螯合剂按照质量配比加入乳化锅，在搅拌的状态下，按照质量配比加入活性物，然后加热至80-85℃，并保温20-25min，冷却至45℃，按照质量配比向其中加入分散好的去屑剂和保湿剂，得到A相；
S2：将B相中的增溶剂和香精按照质量配比混合均匀至透明，然后将A相冷却至40℃，向A相中加入B相，搅拌至透明；
S3：在搅拌的状态下，向步骤S2中搅拌至透明后的混合物中依次加入C相中的乳化剂、赋脂剂、防腐剂和pH调节剂，搅拌混合均匀后，冷却至室温，检测合格后出料得到去屑精华液，且去屑精华液的pH值在25℃直接测量的pH值为4.5-7.0。
本发明的有益之处在于：本发明所述去屑精华液的配方中，由于各组分之间相互配伍，相互协作，能很好地减少因真菌和干燥引起的头屑和瘙痒问题，且由于本发明所述去屑精华液属于停留型产品，可在头皮上留置更长的时间，进一步加强了头皮的保湿和抑菌效果。
附图说明
图1为本发明一实施例的半头对比试验总体效果对照图。
具体实施方式
以下结合附图和具体实施例对本发明作具体的介绍。
本发明中，去屑精华液的配方如下表所示：
其中，金属螯合剂为乙二胺四乙酸二钠（EDTA-2钠）、活性物为透明质酸（HA）、去屑剂为月桂基吡啶氮鎓氯化物（HS）、保湿剂为丙二醇、乳化剂为PEG-40氢化蓖麻油、赋脂剂为橄榄油PEG-7酯类和甘油丙烯酸酯/丙烯酸共聚物的混合物、防腐剂为DMDMH乙内酰脲。
当然，金属螯合剂也可以为乙二胺四乙酸、谷氨酸四乙酸及其金属盐、天冬氨酸四乙酸及其金属盐、丙二胺四乙酸及其金属盐中的至少一种。
活性物也可以为透明质酸、透明质酸钠、金缕梅提取物、银耳多糖提取物、芦荟提取物、吡络烷酮羧酸锌、吡络烷酮羧酸钠、烟酰胺、泛醇、乳酸钠中的至少一种。
保湿剂也可以为甘油、丁二醇、泛醇、山梨糖醇、双丙甘醇、己二醇、异丙醇、木糖醇、三甲基甘氨酸、聚乙二醇、甲基葡糖醇聚醚-10、甲基葡糖醇聚醚-20、聚甘油-10、聚甘油-6中的至少一种。
上述的乳化剂也可以为PEG-40/45氢化蓖麻油、PEG-60氢化蓖麻油、异鲸蜡醇聚醚-20、聚山梨醇酯-20、PEG-80失水山梨醇月桂酸酯、PPG-6-癸基十四醇聚醚-20中的至少一种。
上述的赋脂剂也可以为霍霍巴蜡 PEG-120 酯类 、PEG-7甘油椰油酸酯、PEG-6辛酸/癸酸甘油酯类、PEG-20杏仁甘油酯类、PEG-60杏仁甘油酯类、PEG-90杏仁甘油酯类、PEG-42巴巴苏甘油酯类、PEG-60月见草油甘油酯类、PEG-60玉米油甘油酯类、PEG-45棕榈仁油甘油酯类、PEG-60西番莲甘油酯类中的至少一种。
上述的防腐剂也可以为羟苯甲酯、甲基异噻唑啉酮、乙内酰脲、乙基己基甘油、苯氧乙醇、苯甲酸、脱氢乙酸、聚氨丙基双胍、辛甘醇、苯甲酸钠、山梨酸钾中的至少一种
而pH调节剂则也可以为三乙醇胺、氢氧化钠、氢氧化钾、柠檬酸、乳酸中的任一种。在本发明中，最终调节去屑精华液的pH值为4.5-7.0。
水、金属螯合剂、活性物、去屑剂和保湿剂共同形成A相，乳化剂和香精共同形成B相，而赋脂剂、防腐剂和pH调节剂则归类为C相。
以上实施例所述去屑精华液的制备方法均为：
S1：首先将A相中的去屑剂和保湿剂分散均匀无明显结块，然后将A相中的水和金属螯合剂按照质量配比加入乳化锅，在搅拌的状态下，按照质量配比加入活性物，然后加热至80-85℃，并保温20-25min，冷却至45℃，按照质量配比向其中加入分散好的去屑剂和保湿剂，得到A相；
S2：将B相中的增溶剂和香精按照质量配比混合均匀至透明，然后将A相冷却至40℃，向A相中加入B相，搅拌至透明；
S3：在搅拌的状态下，向步骤S2中搅拌至透明后的混合物中依次加入C相中的乳化剂、赋脂剂、防腐剂和pH调节剂，搅拌混合均匀后，冷却至室温，检测合格后出料得到去屑精华液，且去屑精华液的pH值在25℃直接测量的pH值为4.5-7.0。
以实施例2所述配方制备得到的去屑精华液为样本，根据头屑多少及搔痒程度选择轻度、中度和重度患者共100人，采用“半头试验法”，每2 天洗头一次，然后涂上去屑精华液（实施例2）。7天后检查头屑多少及搔痒程度，共观察3次。半头对比试验结果如表1所示。而半头对比试验总体效果如图1所示。
表1半头对比实验结果
由表1和图1可以看出：在100名受试者中，实施例2的显效占比为81%，有效的为14%，改善的为3%，无效的为2%。由此可以得出，本发明所述去屑精华液可以明显改善头屑和瘙痒问题，且在实际使用过程中，对头皮的保湿效果也非常好。
以上显示和描述了本发明的基本原理、主要特征和优点。本行业的技术人员应该了解，上述实施例不以任何形式限制本发明，凡采用等同替换或等效变换的方式所获得的技术方案，均落在本发明的保护范围内。
Claims (10)
1.一种去屑精华液，其特征在于，包括以下组分且各组分的重量份数分别为：
水：100份；
金属螯合剂：0.01-0.1份；
活性物：0.0001-0.05份；
去屑剂：0.1-0.8份；
保湿剂：1-5份；
乳化剂：0.01-0.1份；
香精：0.005-0.01份；
赋脂剂：0.1~2份；
防腐剂：0.2-0.5份；
pH调节剂：加入量为调节去屑精华液的pH值为4.5-7.0，
所述的水、金属螯合剂、活性物、去屑剂和保湿剂共同形成A相，所述的乳化剂和香精共同形成B相，而所述的赋脂剂、防腐剂和pH调节剂则归类为C相。
2.根据权利要求1所述的所述的一种去屑精华液，其特征在于，所述的金属螯合剂为乙二胺四乙酸及其金属盐、谷氨酸四乙酸及其金属盐、天冬氨酸四乙酸及其金属盐、丙二胺四乙酸及其金属盐中的至少一种。
3.根据权利要求1所述的所述的一种去屑精华液，其特征在于，所述的活性物为透明质酸、透明质酸钠、金缕梅提取物、银耳多糖提取物、芦荟提取物、吡络烷酮羧酸锌、吡络烷酮羧酸钠、烟酰胺、泛醇、乳酸钠中的至少一种。
4.根据权利要求1所述的所述的一种去屑精华液，其特征在于，所述的去屑剂为月桂基吡啶氮鎓氯化物。
5.根据权利要求1所述的所述的一种去屑精华液，其特征在于，所述的保湿剂为甘油、丙二醇、丁二醇、泛醇、山梨糖醇、双丙甘醇、己二醇、异丙醇、木糖醇、三甲基甘氨酸、聚乙二醇、甲基葡糖醇聚醚-10、甲基葡糖醇聚醚-20、聚甘油-10、聚甘油-6中的至少一种。
6.根据权利要求1所述的所述的一种去屑精华液，其特征在于，所述的乳化剂为PEG-40氢化蓖麻油、PEG-40/45氢化蓖麻油、PEG-60氢化蓖麻油、异鲸蜡醇聚醚-20、聚山梨醇酯-20、PEG-80失水山梨醇月桂酸酯、PPG-6-癸基十四醇聚醚-20中的至少一种。
7.根据权利要求1所述的所述的一种去屑精华液，其特征在于，所述的赋脂剂为橄榄油PEG-7酯类、甘油丙烯酸酯/丙烯酸共聚物、霍霍巴蜡 PEG-120 酯类 、PEG-7甘油椰油酸酯、PEG-6辛酸/癸酸甘油酯类、PEG-20杏仁甘油酯类、PEG-60杏仁甘油酯类、PEG-90杏仁甘油酯类、PEG-42巴巴苏甘油酯类、PEG-60月见草油甘油酯类、PEG-60玉米油甘油酯类、PEG-45棕榈仁油甘油酯类、PEG-60西番莲甘油酯类中的至少一种。
8.根据权利要求1所述的所述的一种去屑精华液，其特征在于，所述的防腐剂为DMDMH乙内酰脲、羟苯甲酯、甲基异噻唑啉酮、乙基己基甘油、苯氧乙醇、苯甲酸、脱氢乙酸、聚氨丙基双胍、辛甘醇、苯甲酸钠、山梨酸钾中的至少一种。
9.根据权利要求1所述的所述的一种去屑精华液，其特征在于，所述的pH调节剂包括三乙醇胺、氢氧化钠、氢氧化钾、柠檬酸、乳酸中的任一种。
10.一种权利要求1-9任一项权利要求所述的去屑精华液的制备方法，其特征在于，包括以下步骤：
S1：首先将A相中的去屑剂和保湿剂分散均匀无明显结块，然后将A相中的水和金属螯合剂按照质量配比加入乳化锅，在搅拌的状态下，按照质量配比加入活性物，然后加热至80-85℃，并保温20-25min，冷却至45℃，按照质量配比向其中加入分散好的去屑剂和保湿剂，得到A相；
S2：将B相中的增溶剂和香精按照质量配比混合均匀至透明，然后将A相冷却至40℃，向A相中加入B相，搅拌至透明；
S3：在搅拌的状态下，向步骤S2中搅拌至透明后的混合物中依次加入C相中的乳化剂、赋脂剂、防腐剂和pH调节剂，搅拌混合均匀后，冷却至室温，检测合格后出料得到去屑精华液，且去屑精华液的pH值在25℃直接测量的pH值为4.5-7.0。
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108938485A (zh) * | 2018-08-06 | 2018-12-07 | 上海优萃生物科技有限公司 | 一种防脱发的生发液及其制备方法 |
| CN109602639A (zh) * | 2019-01-31 | 2019-04-12 | 广州艾蓓生物科技有限公司 | 一种氨基酸洗护洗发水及其制备方法 |
| CN109620758A (zh) * | 2019-01-04 | 2019-04-16 | 澳宝化妆品（惠州）有限公司 | 一种双层头皮护理组合物及其制备方法 |
| CN109984980A (zh) * | 2019-04-08 | 2019-07-09 | 上海添美信息技术有限公司 | 头皮护理液及制备方法 |
| CN112006962A (zh) * | 2020-09-22 | 2020-12-01 | 沧州明辰生物科技有限公司 | 一种多效去屑精华液及其制作方法 |
| CN112516049A (zh) * | 2020-12-18 | 2021-03-19 | 广州隆翔化妆品有限公司 | 一种竹醋去屑头皮精华液及其制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102138882A (zh) * | 2010-01-29 | 2011-08-03 | 上海华银日用品有限公司 | 一种滋养保湿润发精华素及其制备方法 |
| CN107280994A (zh) * | 2017-05-04 | 2017-10-24 | 上海章华保健化妆品有限公司 | 一种水解蚕丝蛋白护发素及其制备方法 |
-
2017
- 2017-11-24 CN CN201711191001.9A patent/CN107822970A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102138882A (zh) * | 2010-01-29 | 2011-08-03 | 上海华银日用品有限公司 | 一种滋养保湿润发精华素及其制备方法 |
| CN107280994A (zh) * | 2017-05-04 | 2017-10-24 | 上海章华保健化妆品有限公司 | 一种水解蚕丝蛋白护发素及其制备方法 |
Non-Patent Citations (1)
| Title |
|---|
| 广州星柔日用化妆品有限公司: "韩之秀品茶箍深层去屑止痒洗发水", 《国产非特殊用途化妆品备案服务平台》 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108938485A (zh) * | 2018-08-06 | 2018-12-07 | 上海优萃生物科技有限公司 | 一种防脱发的生发液及其制备方法 |
| CN109620758A (zh) * | 2019-01-04 | 2019-04-16 | 澳宝化妆品（惠州）有限公司 | 一种双层头皮护理组合物及其制备方法 |
| CN109602639A (zh) * | 2019-01-31 | 2019-04-12 | 广州艾蓓生物科技有限公司 | 一种氨基酸洗护洗发水及其制备方法 |
| CN109602639B (zh) * | 2019-01-31 | 2021-12-21 | 广州艾蓓生物科技有限公司 | 一种氨基酸洗护洗发水及其制备方法 |
| CN109984980A (zh) * | 2019-04-08 | 2019-07-09 | 上海添美信息技术有限公司 | 头皮护理液及制备方法 |
| CN112006962A (zh) * | 2020-09-22 | 2020-12-01 | 沧州明辰生物科技有限公司 | 一种多效去屑精华液及其制作方法 |
| CN112516049A (zh) * | 2020-12-18 | 2021-03-19 | 广州隆翔化妆品有限公司 | 一种竹醋去屑头皮精华液及其制备方法 |
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