CN107822742A - A kind of fibre pipe for breast prosthetic implant - Google Patents
A kind of fibre pipe for breast prosthetic implant Download PDFInfo
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- CN107822742A CN107822742A CN201711024543.7A CN201711024543A CN107822742A CN 107822742 A CN107822742 A CN 107822742A CN 201711024543 A CN201711024543 A CN 201711024543A CN 107822742 A CN107822742 A CN 107822742A
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- fat stem
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/12—Mammary prostheses and implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0059—Cosmetic or alloplastic implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0004—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof adjustable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
- A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/04—Materials or treatment for tissue regeneration for mammary reconstruction
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2389/00—Characterised by the use of proteins; Derivatives thereof
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Transplantation (AREA)
- Animal Behavior & Ethology (AREA)
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- Cardiology (AREA)
- Molecular Biology (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
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- Prostheses (AREA)
Abstract
The invention discloses a kind of fibre pipe for breast prosthetic implant, belong to face-lifting device field.The fibre pipe its by 6 parts of foam silicon carbons of mass parts, 23 parts of polycaprolactones, 17 parts of PLAs, 37 parts of PEKKs, 32 parts of fat stem cell protein hydrogels and 3 parts of dilute citric acid compositions, the polycaprolactone, PLA and PEKK are cross-linked to form porous support, and the porosity of the porous support is 43.8%, in the fat stem cell protein hydrogel, protein hydrogel is Nano chitosan BMP, and the pH of the protein hydrogel is 6.4, the fat stem cell：Chitosan：Bone morphogenic proteins quality is than 2.3:17.2:6.The fat stem cell growth that can be lived for organization survival provide angiogenic growth cell in the present invention, and after cell forms stable structure, hydrogel structure is metabolized decompositions, its position being originally present, and just turning into can the feeder vessels cavity that extends and develop.
Description
The application is the divisional application of entitled " a kind of breast prosthetic implant ".
The applying date of original application is：2016-09-24
The Application No. of original application：201610845241.5.
Technical field
The present invention relates to a kind of lift face apparatus, particularly a kind of fibre pipe for breast prosthetic implant.
Background technology
Prosthese is enlarged the bosom, and material category is more, and classification is different, can be divided into Silica hydrogel packed type and life by its intracapsular tolerant difference
Manage salt solution filling type etc.；It can be divided into injection type by its application method and insert type, general Silica hydrogel packed type is to insert type, physiology
Salt solution filling type is injection type；In addition, the material such as also superseded atoleine, liquid-state silicon gel, Elipten AG, these
Material can cause many severe complications, have toxic side effect, be prohibited use.It is existing to enlarge the bosom material still
Using Silica hydrogel and physiological saline as main flow, although biological respinse caused by Silica hydrogel and physiological saline is minimum, compared with other materials more
Add softness, naturally, still physiological saline has very strong also body-sensing, easy to leak, the effect of mamaplasty is difficult to maintain, meeting after salt solution oozes out
Breast deflating phenomenon is caused, influences profile.It is not good enough with respect to form for silicon gel artificial body and feel, and put for a long time in human body
Putting can make the intracapsular portion of salt solution easily produce mould；And the capsule contracture incidence of Silica hydrogel is higher, while there is immunity connective
Organize disease and carcinogenic risk, and Silica hydrogel generally using so for many years after, complication gradually shows, it is known that complication master
Will be by granuloma, simultaneously as Silica hydrogel is prefabricated implant, shapes and sizes are usually the fixed dimension of standard, can not
Perfectly agreed with each individual, and formality complexity is customized according to each individual, it is with high costs；No matter but which kind of
Implant, it can not all make it that being implanted human body obtains and basic stitch identical body-sensing.
The content of the invention
The goal of the invention of the present invention is：For above-mentioned problem, there is provided one kind perfect can adapt to each individual,
With excellent handle and form, while there is high security, rebound performance is good, is unlikely to deform, and histocompatbility is good, can keep away
Exempt from tissue rejection and attack, reduce implant trigger complication possibility, human body is had no toxic side effect, enable to by
It is implanted into the breast prosthetic implant that people obtains body-sensing identical with basic stitch.
The technical solution adopted by the present invention is as follows：
A kind of breast prosthetic implant of the present invention, including shell body, the shell body are hollow cavity, the shell body outline
In human breast shape, the shell body bottom caves inward, and middle part is provided with vitellarium in the shell body, in the shell body
Portion, vitellarium both sides are provided with fill area.
By adopting the above-described technical solution, outer housing bottom set depressed area, can implant be implanted into human body after,
Rest area is provided for original breast tissue, can be avoided after implant is taken out, original breast tissue shape is destroyed,
The space that may be grown is provided for intramammary histocyte simultaneously, ensures the free degree that human body organizer has.
A kind of breast prosthetic implant of the present invention, the vitellarium top are set with connecting at the top of shell body in the vitellarium
There are some stators and some fibre pipes, the stator surface is evenly equipped with some through holes, and the fibre pipe will be solid through through hole
Stator connects.
By adopting the above-described technical solution, can be capillary, nerve fibre tip by stator and fibre pipe
Deng providing growing space, ensure the blood circulation of basic stitch, so as to ensure the connection of basic stitch body and overlaying skin, so as to ensure
Implant can still bring original body-sensing.
A kind of breast prosthetic implant of the present invention, the stator include main leaf, and the main leaf is vertically located at growth
In the middle part of area, the main leaf surface is evenly equipped with three row through holes；The main leaf both sides are provided with two transverse sheets in the horizontal direction, described in each
Transverse sheet surface is evenly equipped with an exhausting hole；Both sides are provided with two risers below the main leaf, and each described riser surface is evenly equipped with one
Row through hole.
By adopting the above-described technical solution, the through hole arranged by different directions can ensure that fibre pipe is staggered,
Growth closest to the original capillary of human body, nerve fibre tip is arranged.
A kind of breast prosthetic implant of the present invention, the transverse sheet level height are less than the level height on main leaf top, the horizontal stroke
Piece level height is more than the level height on riser top；The top of the main leaf and shell body interval, the bottom of the main leaf with
Shell body bottom connection, both ends and the vitellarium inwall interval of the transverse sheet, bottom and the shell body bottom connection of the riser,
The main leaf, transverse sheet and riser are spaced.
A kind of breast prosthetic implant of the present invention, the surface area of the transverse sheet are the 40% of main leaf surface, the surface of the riser
Product is the 35% of main leaf surface.
A kind of breast prosthetic implant of the present invention, the fibre pipe are distributed in the both sides of main leaf, and each described fibre pipe is worn
Riser, transverse sheet and/or main leaf to be crossed to connect shell body bottom with top, the fibre pipe per side has three kinds to pass through mode respectively,
Including sequentially passing through transverse sheet and riser from top to bottom, main leaf, transverse sheet and riser are up to sequentially passed through down, and wear successively from top to bottom
Cross main leaf and riser.
A kind of breast prosthetic implant of the present invention, the shell body is by 27 parts of polyethers of mass parts, 13 parts of modified silica-gels, 17 parts of prestoxs
Cyclotetrasiloxane, 8 parts of methyl methacrylates, 55 parts of Silica hydrogels and 3 parts of sodium carboxymethyl starch compositions, the thickness of the shell body
For 0.8cm.
By adopting the above-described technical solution, shell body, which using Silica hydrogel as base material, has carried out modification, reduces Silica hydrogel bag
Film contracture incidence, adds the rebound performance of shell body, is unlikely to deform, can long term shape retention, it is nontoxic to human body secondary to make
With reducing granulomatous occurrence probability.
A kind of breast prosthetic implant of the present invention, the fibre pipe is by 6 parts of foam silicon carbons of mass parts, 23 parts of polycaprolactones,
17 parts of PLAs, 37 parts of PEKKs, 32 parts of fat stem cell-protein hydrogels and 3 parts of dilute citric acid compositions, it is described to gather in oneself
Ester, PLA and PEKK are cross-linked to form porous support, and the porosity of the porous support is 43.8%, and the fat is dry thin
In born of the same parents-protein hydrogel, protein hydrogel is Nano chitosan BMP, and the pH of the protein hydrogel is 6.4, described
Fat stem cell：Chitosan：Bone morphogenic proteins quality is than 2.3：17.2：6.
By adopting the above-described technical solution, fat stem cell can live for organization survival, it is thin to provide angiogenic growth for growth
Born of the same parents, after cell forms stable structure, hydrogel structure is metabolized decomposition, its position being originally present, and just turns into and is available for
Blood vessel extends and the cavity of development.
A kind of breast prosthetic implant of the present invention, it is described gel filled by mass parts filled with gel filled in the fill area
55 parts of agaroses, 13 parts of chitosans, 72 parts of Silica hydrogels, 19 parts of N- carboxymethyl chitosans and 7 parts of carboxymethyl cellulose compositions.
By adopting the above-described technical solution, packing material can reduce the risk that Silica hydrogel induces complication, have simultaneously
There is good feel, close to tissue, the adaptation that can carry out shape as needed in implantation changes material softness, so as to
Reach adapt to each individual demand, gel filled condensation performance is good, when alteration of form occurs, be not in hole,
Crack etc..
In summary, by adopting the above-described technical solution, the beneficial effects of the invention are as follows：
1st, each individual perfect can be adapted to, there is excellent handle and form, while there is high security, rebound performance is good,
It is unlikely to deform, histocompatbility is good, and tissue can be avoided to reject and attack, and reduces the possibility that implant triggers complication
Property, human body is had no toxic side effect, enables to be implanted people's acquisition body-sensing identical with basic stitch.
2nd, reduce the risk that Silica hydrogel induces complication, while there is good feel, material softness close to tissue,
The adaptation that shape can be carried out as needed in implantation changes, gel filled so as to reach each individual demand that adapts to
Condensation performance it is good, be not in hole, crack etc. when alteration of form occurs.
Brief description of the drawings
Fig. 1 is a kind of breast prosthetic implant structural representation.
Marked in figure：1 is shell body, and 2 be vitellarium, and 3 be fill area, and 4 be main leaf, and 5 be transverse sheet, and 6 be riser.
Embodiment
Below in conjunction with the accompanying drawings, the present invention is described in detail.
In order that the object, technical solution and advantage of invention are more clearly understood, below in conjunction with drawings and Examples, to this
Invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, not
For limiting the present invention.
Embodiment 1
As shown in figure 1, a kind of breast prosthetic implant, including shell body 1, shell body 1 are hollow cavity, the outline of shell body 1 is in
Human breast shape, the bottom of shell body 1 cave inward, and middle part is provided with vitellarium 2 in shell body 1, inside shell body 1, vitellarium 2
Both sides are provided with fill area 3.The top of vitellarium 2 connects with the top of shell body 1, and some stators and some fibres are provided with vitellarium 2
Dimension pipe, stator surface are evenly equipped with some through holes, and fibre pipe connects stator through through hole.Stator includes main leaf 4, main leaf
Vertically located at the middle part of vitellarium 2, the surface of main leaf 4 is evenly equipped with three row through holes；It is horizontal that the both sides of main leaf 4 are provided with two in the horizontal direction
Piece 5, each described transverse sheet surface are evenly equipped with an exhausting hole；The lower section both sides of main leaf 4 are provided with two risers 6, each described riser
Surface is evenly equipped with a row through hole.Transverse sheet level height is less than the level height on main leaf top, and transverse sheet level height is more than riser top
The level height at end；The top of main leaf is spaced with shell body 1, the bottom of main leaf and the bottom connection of shell body 1, the both ends of transverse sheet with
The inwall interval of vitellarium 2, bottom and the bottom connection of shell body 1 of riser, main leaf, transverse sheet and riser are spaced.The table of transverse sheet
Area is the 40% of main leaf surface, and the surface area of riser is the 35% of main leaf surface.Fibre pipe is distributed in the both sides of main leaf, each
Fibre pipe connects the bottom of shell body 1 with top through riser, transverse sheet and/or main leaf, and the fibre pipe per side has three kinds respectively
Through mode, including transverse sheet and riser are sequentially passed through from top to bottom, up to sequentially pass through main leaf, transverse sheet and riser down, and from upper
Main leaf and riser are sequentially passed through under.
Shell body 1 is by 27 parts of polyethers of mass parts, 13 parts of modified silica-gels, 17 parts of octamethylcy-clotetrasiloxanes, 8 parts of methyl methacrylates, 55 parts of Silica hydrogels
Formed with 3 parts of sodium carboxymethyl starches, the thickness of shell body 1 is 0.8cm.For fibre pipe by 6 parts of foam silicon carbons of mass parts, 23 parts poly-
Caprolactone, 17 parts of PLAs, 37 parts of PEKKs, 32 parts of fat stem cell-protein hydrogels and 3 parts of dilute citric acid compositions, gather
Caprolactone, PLA and PEKK are cross-linked to form porous support, and the porosity of porous support is 43.8%, fat stem cell-egg
In plain boiled water gel, protein hydrogel is Nano chitosan BMP, and the pH of protein hydrogel is 6.4, fat stem cell：Shell
Glycan：Bone morphogenic proteins quality is than 2.3：17.2：6.It is gel filled by 55 parts of fine jades of mass parts filled with gel filled in fill area 3
Lipolysaccharide, 13 parts of chitosans, 72 parts of Silica hydrogels, 19 parts of N- carboxymethyl chitosans and 7 parts of carboxymethyl cellulose compositions.
Embodiment 2
PolyethersSynthesize by the following method：
At room temperature to configuration mechanical agitation, reflux condensing tube, thermometer, dropping funel four-hole bottle in add 69.5g
（0.2mol）Hexachlorocyclotriph,sphazene and 200mL tetrahydrofurans, after stirring is dissolved after solid whole portion, it is added dropwise dissolved with 69.7g phenol
The tetrahydrofuran solution of sodium；After being added dropwise to complete, back flow reaction 3h, filter and collect filtrate；A four-hole bottle separately is taken, is sequentially added
146.5g parahydroxyben-zaldehydes, 300mL tetrahydrofurans and 414.6g Anhydrous potassium carbonates, stir completely molten to parahydroxyben-zaldehyde
Xie Hou, the filtrate of above-mentioned gained is added dropwise thereto, is added dropwise to complete rear back flow reaction 6h, is filtered after the completion of reaction, after collecting filtrate
It is concentrated into the 1/4 of original volume；Then, remaining mixture is slowly put into frozen water, quick stirring is until faint yellow creamy liquid
Body all separates out；Successively with 10% KOH solution, water, methanol detergent cream grease, until all solids separate out；Vacuum after suction filtration
Dry to weight, obtain pale yellow powder shape solid.
Embodiment 3
Modified silica-gelSynthesize by the following method：
20g silica gel is added in concentrated hydrochloric acid, 6h is heated to reflux, is washed with deionized to neutrality, is obtained after 16h is dried at 180 DEG C
To activated silica gel.8g activated silica gels are added in the toluene solvant that 80mL is dried, the second of 8mL3- chloropropyls three is slowly added dropwise thereto
TMOS, under nitrogen protection, back flow reaction 12h, filter, product is repeatedly washed with toluene, ethanol and ether successively, 80 DEG C
Lower vacuum drying 6h.6g thiosemicarbazides is added in 100mL ethanol, heating makes its dissolving, adds 8g the said goods, back flow reaction
8h, filtering, is repeatedly washed with ethanol and hot water, is dried in vacuo 12h at 80 DEG C, obtains target product.
Embodiment 4
Fat stem cell-protein hydrogel is prepared by the following method：
BMP is wrapped in Nano chitosan solution first, 2 ~ 4h of sealing and standing, under magnetic stirring, in proportion will
Fat stem cell is included in solution, and 56% sodium β-glycerophosphate is added dropwise in chitosan solution, and solution is gradually muddy, is continued
It is in limpid state to be added dropwise to solution, stops being added dropwise, adds 0.1mmol/L second acid for adjusting pH to 7.2.Filtration sterilization, sealing,
Obtain fat stem cell-protein hydrogel.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
All any modification, equivalent and improvement made within refreshing and principle etc., should be included in the scope of the protection.
Claims (2)
1. a kind of fibre pipe for breast prosthetic implant, it is characterised in that it gathers oneself by 6 parts of foam silicon carbons of mass parts, 23 parts
Lactone, 17 parts of PLAs, 37 parts of PEKKs, 32 parts of fat stem cell-protein hydrogels and 3 parts of dilute citric acid compositions, it is described
Polycaprolactone, PLA and PEKK are cross-linked to form porous support, and the porosity of the porous support is 43.8%, the fat
In fat stem cell-protein hydrogel, protein hydrogel is Nano chitosan BMP, and the pH of the protein hydrogel is
6.4, the fat stem cell：Chitosan：Bone morphogenic proteins quality is than 2.3:17.2:6.
2. the fibre pipe according to claim 1 for breast prosthetic implant, it is characterised in that the fat stem cell-egg
Plain boiled water gel is prepared by the following method：BMP is wrapped in Nano chitosan solution, 2 ~ 4h of sealing and standing, in magnetic
Power stirring under, fat stem cell is included in solution, 56% sodium β-glycerophosphate is added dropwise in chitosan solution, solution by
Gradually muddy, it is in limpid state to continue to be added dropwise to solution, stops being added dropwise, adds 0.1mmol/L second acid for adjusting pH to 7.2；Filtering
Sterilizing, sealing, obtains fat stem cell-protein hydrogel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711024543.7A CN107822742A (en) | 2016-09-24 | 2016-09-24 | A kind of fibre pipe for breast prosthetic implant |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711024543.7A CN107822742A (en) | 2016-09-24 | 2016-09-24 | A kind of fibre pipe for breast prosthetic implant |
| CN201610845241.5A CN106377342B (en) | 2016-09-24 | 2016-09-24 | A kind of breast prosthetic implant |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610845241.5A Division CN106377342B (en) | 2016-09-24 | 2016-09-24 | A kind of breast prosthetic implant |
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| CN201711024543.7A Pending CN107822742A (en) | 2016-09-24 | 2016-09-24 | A kind of fibre pipe for breast prosthetic implant |
| CN201610845241.5A Expired - Fee Related CN106377342B (en) | 2016-09-24 | 2016-09-24 | A kind of breast prosthetic implant |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101637454A (en) * | 2009-05-14 | 2010-02-03 | 华东理工大学 | Recombinant human bone morphogenetic protein-2 chitosan microballon and preparation method thereof |
| CN101828937A (en) * | 2009-03-13 | 2010-09-15 | 王影 | Method for reshaping and beautifying by using tissue engineering fat regeneration technology |
| US20110274742A1 (en) * | 2010-03-12 | 2011-11-10 | New Jersey Institute Of Technology | Cartilage Repair Systems and Applications Utilizing A Glycosaminoglycan Mimic |
| WO2012054742A2 (en) * | 2010-10-20 | 2012-04-26 | BIOS2 Medical, Inc. | Implantable polymer for bone and vascular lesions |
| CN103285424A (en) * | 2013-05-27 | 2013-09-11 | 东华大学 | Three-dimensional fiber-based aerogel tissue engineering scaffold and preparation method thereof |
| CN104984402A (en) * | 2015-07-14 | 2015-10-21 | 青岛大学 | Preparation method for hydroxyethyl chitosan in-situ hydrogel |
| CN105687239A (en) * | 2016-01-22 | 2016-06-22 | 苏州佰通生物科技有限公司 | Adipose-derived stem cell composition and preparation method thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5370688A (en) * | 1993-03-30 | 1994-12-06 | Spenco Medical Corporation | Encapsulated gel breast prosthesis and method of making |
| DE10220594A1 (en) * | 2002-05-08 | 2003-11-20 | Dekumed Ges Fuer Kunststoff Un | breast prosthesis |
| CN201445573U (en) * | 2009-07-23 | 2010-05-05 | 徐波 | Point massage mammary prosthesis |
| CN204655199U (en) * | 2015-05-18 | 2015-09-23 | 复旦大学附属妇产科医院 | Implanted human body justice breast |
| CN105435308B (en) * | 2015-12-23 | 2018-10-26 | 天津幂方科技有限公司 | A kind of breast prosthetic implant three-dimensional structure and its quick forming method |
-
2016
- 2016-09-24 CN CN201711024543.7A patent/CN107822742A/en active Pending
- 2016-09-24 CN CN201610845241.5A patent/CN106377342B/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101828937A (en) * | 2009-03-13 | 2010-09-15 | 王影 | Method for reshaping and beautifying by using tissue engineering fat regeneration technology |
| CN101637454A (en) * | 2009-05-14 | 2010-02-03 | 华东理工大学 | Recombinant human bone morphogenetic protein-2 chitosan microballon and preparation method thereof |
| US20110274742A1 (en) * | 2010-03-12 | 2011-11-10 | New Jersey Institute Of Technology | Cartilage Repair Systems and Applications Utilizing A Glycosaminoglycan Mimic |
| WO2012054742A2 (en) * | 2010-10-20 | 2012-04-26 | BIOS2 Medical, Inc. | Implantable polymer for bone and vascular lesions |
| CN103285424A (en) * | 2013-05-27 | 2013-09-11 | 东华大学 | Three-dimensional fiber-based aerogel tissue engineering scaffold and preparation method thereof |
| CN104984402A (en) * | 2015-07-14 | 2015-10-21 | 青岛大学 | Preparation method for hydroxyethyl chitosan in-situ hydrogel |
| CN105687239A (en) * | 2016-01-22 | 2016-06-22 | 苏州佰通生物科技有限公司 | Adipose-derived stem cell composition and preparation method thereof |
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| CN106377342A (en) | 2017-02-08 |
| CN106377342B (en) | 2018-01-02 |
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