CN106377342A - Breast implant - Google Patents
Breast implant Download PDFInfo
- Publication number
- CN106377342A CN106377342A CN201610845241.5A CN201610845241A CN106377342A CN 106377342 A CN106377342 A CN 106377342A CN 201610845241 A CN201610845241 A CN 201610845241A CN 106377342 A CN106377342 A CN 106377342A
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- parts
- shell body
- main leaf
- riser
- prosthetic implant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/12—Mammary prostheses and implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0059—Cosmetic or alloplastic implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0004—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof adjustable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
- A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/04—Materials or treatment for tissue regeneration for mammary reconstruction
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2389/00—Characterised by the use of proteins; Derivatives thereof
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Prostheses (AREA)
Abstract
The invention discloses a breast implant, belonging to the field of plastic surgery equipment. The breast implant comprises a shell body, wherein the shell body is a hollow cavity; the outer contour of the shell body is of a human breast shape; the bottom of the shell body sinks inward; a growth area is arranged at the middle in the shell body; and filling areas are arranged on the two sides of the growth area in the shell body. The breast implant disclosed by the invention can perfectly fit each individual, has the advantages of good hand feeling and shape, high safety, good resilience, rare deformation and good tissue compatibility, can avoid the rejection and attack of human tissues, reduces the possibility of complications caused by the implant and prevents toxic and side effects on the human body; and moreover, the person with the implant can get the same feel as original tissue.
Description
Technical field
The present invention relates to a kind of face-lifting apparatus, particularly a kind of breast prosthetic implant.
Background technology
Prosthese is enlarged the bosom, and material category is more, and classification is different, can be divided into Silica hydrogel packed type and life by its intracapsular tolerant difference
Reason saline filling type etc.；Injection type can be divided into by its using method and insert type, general Silica hydrogel packed type is to insert type, physiology
Saline filling type is injection type；In addition, the materials such as the liquid paraffin also eliminated, liquid-state silicon gel, Elipten AG, these
Material all can cause many severe complications, has toxic and side effects, is prohibited use.Existing enlarge the bosom material still
With Silica hydrogel and normal saline as main flow although the biological respinse that causes of Silica hydrogel and normal saline is minimum, compared with other materials more
Plus soft, natural, but normal saline has very strong also body-sensing, easy to leak, the effect of mamaplasty is difficult to maintain, saline ooze out after meeting
Cause breast deflating phenomenon, affect profile.For silicon gel artificial body, form and feel be not good enough relatively, and puts for a long time in human body
Put and the intracapsular portion of saline can be made easily to produce mycete；And the capsule contracture incidence rate of Silica hydrogel is higher, there is immunity connective simultaneously
Organize sick and carcinogenic risk, and Silica hydrogel commonly use so for many years after, complication gradually manifest it is known that complication master
Will by granuloma, simultaneously as Silica hydrogel is prefabricated implant, shapes and sizes be usually standard fixed dimension it is impossible to
Perfectly agreed with each individual, and formality complexity is customized according to each individuality, with high costs；No matter but which kind of
Implant, all cannot make implanted human body obtain and basic stitch identical body-sensing.
Content of the invention
The goal of the invention of the present invention is：For above-mentioned problem, provide one kind perfect can adapt to each individuality,
There is excellent handle and form, there is high safety simultaneously, rebound performance is good, is unlikely to deform, histocompatibility is good, can keep away
Exempt from tissue rejection and attack, reduce implant cause complication probability, human body is had no toxic side effect, enable to by
Implantation people obtains the breast prosthetic implant of body-sensing identical with basic stitch.
The technical solution used in the present invention is as follows：
A kind of breast prosthetic implant of the present invention, including shell body, described shell body is the cavity of hollow, described shell body outline
In human breast shape, described shell body bottom caves inward, and in described shell body, middle part is provided with vitellarium, in described shell body
Portion, vitellarium both sides are provided with fill area.
Due to employing technique scheme, outer housing bottom arrange depressed area, can implant implantation human body after,
There is provided rest area for original breast tissue, it can be avoided that after taking out implant, original breast tissue shape is destroyed,
Simultaneously for intramammary histiocyte provide may growth space it is ensured that the original degree of freedom of tissue.
A kind of breast prosthetic implant of the present invention, described vitellarium top is connected with shell body top, sets in described vitellarium
There are some stators and some fiber pipes, described stator surface is evenly equipped with some through holes, and described fiber pipe will be consolidated through through hole
Stator connects.
Due to employing technique scheme, can be blood capillary, nerve fiber tip by stator and fiber pipe
Deng providing growing space it is ensured that the blood circulation of basic stitch, thus ensureing the connection of basic stitch body and overlaying skin, thus ensureing
Implant still can bring original body-sensing.
A kind of breast prosthetic implant of the present invention, described stator includes main leaf, and described main leaf is vertically located at growth
In the middle part of area, described main leaf surface is evenly equipped with three row through holes；Described main leaf both sides are provided with two transverse sheets in the horizontal direction, described in each
Transverse sheet surface is evenly equipped with an exhausting hole；Below described main leaf, both sides are provided with two risers, and each described riser surface is evenly equipped with one
Row through hole.
Due to employing technique scheme, ensure that fiber pipe is staggered by the through hole that different directions are arranged,
Growth arrangement closest to the original blood capillary of human body, nerve fiber tip.
A kind of breast prosthetic implant of the present invention, described transverse sheet level height is less than the level height on main leaf top, described horizontal stroke
Piece level height is more than the level height on riser top；The top of described main leaf and shell body are spaced, the bottom of described main leaf with
Shell body bottom connection, the two ends of described transverse sheet and vitellarium inwall interval, the bottom of described riser and shell body bottom connection,
Described main leaf, transverse sheet and riser are spaced.
A kind of breast prosthetic implant of the present invention, the surface area of described transverse sheet is the 40% of main leaf surface, the surface of described riser
Amass 35% for main leaf surface.
A kind of breast prosthetic implant of the present invention, described fiber pipe is distributed in the both sides of main leaf, and each described fiber pipe is worn
Cross riser, transverse sheet and/or main leaf to connect shell body bottom with top, the fiber pipe of every side has three kinds to pass through mode respectively,
Including sequentially passing through transverse sheet and riser from top to bottom, up to sequentially pass through main leaf, transverse sheet and riser down, and wear successively from top to bottom
Cross main leaf and riser.
A kind of breast prosthetic implant of the present invention, described shell body is by 27 parts of polyethers of mass parts
, 13 parts of modified silica-gels, 17 parts of octamethylcy-clotetrasiloxanes, 8 parts of methyl methacrylates
55 parts of Silica hydrogel and 3 parts of carboxymethyl starch sodium compositions, the thickness of described shell body is 0.8cm.
Due to employing technique scheme, shell body, with Silica hydrogel as base material, has carried out modification and has reduced Silica hydrogel bag
Film contracture incidence rate, increased the rebound performance of shell body, is unlikely to deform, can long term shape retention, nontoxic to human body secondary make
With reducing granulomatous occurrence probability.
A kind of breast prosthetic implant of the present invention, described fiber pipe by 6 parts of foam silicon carbons of mass parts, 23 parts of polycaprolactones,
17 parts of polylactic acid, 37 parts of PEKKs, 32 parts of fat stem cell-protein hydrogels and 3 parts of dilute citric acid compositions, described poly- own interior
Ester, polylactic acid and PEKK are cross-linked to form porous support, and the porosity of described porous support is 43.8%, and described fat is dry thin
In born of the same parents-protein hydrogel, protein hydrogel is Nano chitosan bone morphogenetic protein(BMP), and the pH of described protein hydrogel is 6.4, described
Fat stem cell：Shitosan：Bone morphogenic proteins quality compares 2.3：17.2：6.
Due to employing technique scheme, fat stem cell can live for organization survival in growing provides angiogenic growth thin
Born of the same parents, after cell forms stable structure, hydrogel structure is metabolized decomposition, and its position being originally present just becomes and is available for
The cavity that blood vessel extends and develops.
A kind of breast prosthetic implant of the present invention, is filled with gel filled in described fill area, described gel filled by mass parts
55 parts of agaroses, 13 parts of chitosans, 72 parts of Silica hydrogel, 19 parts of N- carboxymethyl chitosans and 7 parts of carboxymethyl cellulose compositions.
Due to employing technique scheme, packing material can reduce the risk that Silica hydrogel induces complication, have simultaneously
There is good feel, material softness changes close to tissue, the adaptation that can carry out shape in implantation as needed, thus
Reach each individual demand of adaptation, gel filled condensation performance is good, when there is alteration of form, be not in hole,
Crack etc..
In sum, due to employing technique scheme, the invention has the beneficial effects as follows：
1st, perfect can adapt to each individual, there is excellent handle and form, there is high safety simultaneously, rebound performance is good,
It is unlikely to deform, histocompatibility is good, it can be avoided that tissue rejection and attack, reduce the possibility that implant causes complication
Property, human body is had no toxic side effect, enables to implanted people and obtain body-sensing identical with basic stitch.
2nd, reduce Silica hydrogel induce complication risk, there is good feel simultaneously, material softness close to tissue,
The adaptation that shape can be carried out in implantation as needed changes, thus reaching each individual demand of adaptation, gel filled
Condensation performance good, occur alteration of form when, be not in hole, crack etc..
Brief description
Fig. 1 is a kind of breast prosthetic implant structural representation.
In figure labelling：1 is shell body, and 2 is vitellarium, and 3 is fill area, and 4 is main leaf, and 5 is transverse sheet, and 6 is riser.
Specific embodiment
Below in conjunction with the accompanying drawings, the present invention is described in detail.
In order that the purpose of invention, technical scheme and advantage become more apparent, below in conjunction with drawings and Examples, to this
Invention is further elaborated.It should be appreciated that specific embodiment described herein is only in order to explain the present invention, not
For limiting the present invention.
Embodiment 1
As shown in figure 1, a kind of breast prosthetic implant, including shell body 1, shell body 1 is the cavity of hollow, and shell body 1 outline is in
Human breast shape, shell body 1 bottom caves inward, and in shell body 1, middle part is provided with vitellarium 2, inside shell body 1, vitellarium 2
Both sides are provided with fill area 3.Vitellarium 2 top is connected with shell body 1 top, is provided with some stators and some fibres in vitellarium 2
Dimension pipe, stator surface is evenly equipped with some through holes, and stator is connected by fiber pipe through through hole.Stator includes main leaf 4, main leaf
Vertically in the middle part of vitellarium 2, main leaf 4 surface is evenly equipped with three row through holes；It is horizontal that main leaf 4 both sides are provided with two in the horizontal direction
Piece 5, each described transverse sheet surface is evenly equipped with an exhausting hole；Main leaf 4 lower section both sides are provided with two risers 6, each described riser
Surface is evenly equipped with string through hole.Transverse sheet level height is less than the level height on main leaf top, and transverse sheet level height is more than riser top
The level height at end；The top of main leaf is spaced with shell body 1, the bottom of main leaf and shell body 1 bottom connection, the two ends of transverse sheet with
Vitellarium 2 inwall interval, the bottom of riser and shell body 1 bottom connection, main leaf, transverse sheet and riser are spaced.The table of transverse sheet
Area is the 40% of main leaf surface, and the surface area of riser is the 35% of main leaf surface.Fiber pipe is distributed in the both sides of main leaf, each
Fiber pipe passes through riser, transverse sheet and/or main leaf to connect shell body 1 bottom with top, and the fiber pipe of every side has three kinds respectively
Through mode, including sequentially passing through transverse sheet and riser from top to bottom, up to sequentially pass through main leaf, transverse sheet and riser down, and from upper
To under sequentially pass through main leaf and riser.
Shell body 1 is by 27 parts of polyethers of mass parts, 13 parts of modified silica-gels, 17 parts of octamethylcy-clotetrasiloxanes, 55 parts of Silica hydrogel of 8 parts of methyl methacrylates
Form with 3 parts of carboxymethyl starch sodium, the thickness of shell body 1 is 0.8cm.By 6 parts of foam silicon carbons of mass parts, 23 parts are gathered fiber pipe
Caprolactone, 17 parts of polylactic acid, 37 parts of PEKKs, 32 parts of fat stem cell-protein hydrogels and 3 parts of dilute citric acid compositions, gather
Caprolactone, polylactic acid and PEKK are cross-linked to form porous support, and the porosity of porous support is 43.8%, fat stem cell-egg
In plain boiled water gel, protein hydrogel is Nano chitosan bone morphogenetic protein(BMP), and the pH of protein hydrogel is 6.4, fat stem cell：Shell
Polysaccharide：Bone morphogenic proteins quality compares 2.3：17.2：6.Be filled with gel filled in fill area 3, gel filled by 55 parts of fine jades of mass parts
Lipolysaccharide, 13 parts of chitosans, 72 parts of Silica hydrogel, 19 parts of N- carboxymethyl chitosans and 7 parts of carboxymethyl cellulose compositions.
Embodiment 2
PolyethersSynthesize by the following method：
Add 69.5g in configuration mechanical agitation, reflux condensing tube, thermometer, the four-hole bottle of Dropping funnel at room temperature
（0.2mol）Hexachlorocyclotriph,sphazene and 200mL oxolane, after the dissolving of solid whole portion, Deca is dissolved with 69.7g phenol for stirring
The tetrahydrofuran solution of sodium；After being added dropwise to complete, back flow reaction 3h, filters and collects filtrate；Separately take a four-hole bottle, sequentially add
146.5g hydroxy benzaldehyde, 300mL oxolane and 414.6g Anhydrous potassium carbonate, stir completely molten to hydroxy benzaldehyde
Xie Hou, the filtrate of the above-mentioned gained of Deca, is added dropwise to complete rear back flow reaction 6h thereto, filters after the completion of reaction, after collecting filtrate
It is concentrated into the 1/4 of original volume；Then, remaining mixture is slowly put in frozen water, quick stirring is up to faint yellow creamy liquid
Body all separates out；Successively with 10% KOH solution, water, methanol detergent cream grease, until all solids separate out；Vacuum after sucking filtration
It is dried to weight, obtain pale yellow powder shape solid.
Embodiment 3
Modified silica-gelSynthesize by the following method：
20g silica gel is added in concentrated hydrochloric acid, is heated to reflux 6h, is washed with deionized to neutrality, obtain after 16h is dried at 180 DEG C
To activated silica gel.In the toluene solvant that 8g activated silica gel is added 80mL to be dried, slowly Deca 8mL3- chloropropyl three second thereto
TMOS, under nitrogen protection, back flow reaction 12h, filters, product is repeatedly washed with toluene, ethanol and ether successively, 80 DEG C
Lower vacuum drying 6h.6g thiosemicarbazides are added in 100mL ethanol, heating makes it dissolve, add 8g the said goods, back flow reaction
8h, filters, is repeatedly washed with ethanol and hot water, is vacuum dried 12h, obtains target product at 80 DEG C.
Embodiment 4
Fat stem cell-protein hydrogel is prepared by the following method：
First bone morphogenetic protein(BMP) is wrapped in Nano chitosan solution, sealing and standing 2 ~ 4h, under magnetic stirring, in proportion will
Fat stem cell counts in solution, 56% sodium β-glycerophosphate is added dropwise in chitosan solution, solution is gradually muddy, continues
Dropping to solution is in limpid state, stops Deca, adds 0.1mmol/L second acid for adjusting pH to 7.2.Filtration sterilization, sealing,
Obtain fat stem cell-protein hydrogel.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all spirit in the present invention and
Any modification, equivalent and improvement of being made within principle etc., should be included within the scope of the present invention.
Claims (9)
1. a kind of breast prosthetic implant it is characterised in that：Including shell body（1）, described shell body（1）For the cavity of hollow, described
Shell body（1）Outline is in human breast shape, described shell body（1）Bottom caves inward, described shell body（1）Interior middle part sets
There is vitellarium（2）, described shell body（1）Inside, vitellarium（2）Both sides are provided with fill area（3）.
2. as claimed in claim 1 a kind of breast prosthetic implant it is characterised in that：Described vitellarium（2）Top and shell body（1）
Top connects, described vitellarium（2）Inside it is provided with some stators and some fiber pipes, described stator surface is evenly equipped with some logical
Hole, stator is connected by described fiber pipe through through hole.
3. as claimed in claim 2 a kind of breast prosthetic implant it is characterised in that：Described stator includes main leaf（4）, described master
Piece is vertically located at vitellarium（2）Middle part, described main leaf（4）Surface is evenly equipped with three row through holes；Described main leaf（4）Both sides edge
Horizontal direction is provided with two transverse sheets（5）, each described transverse sheet surface is evenly equipped with an exhausting hole；Described main leaf（4）Lower section both sides set
There are two risers（6）, each described riser surface is evenly equipped with string through hole.
4. as claimed in claim 3 a kind of breast prosthetic implant it is characterised in that：Described transverse sheet level height is less than main leaf top
Level height, described transverse sheet level height be more than riser top level height；The top of described main leaf and shell body（1）Between
Every, the bottom of described main leaf and shell body（1）Bottom connection, the two ends of described transverse sheet and vitellarium（2）Inwall is spaced, described perpendicular
The bottom of piece and shell body（1）Bottom connection, described main leaf, transverse sheet and riser are spaced.
5. a kind of breast prosthetic implant as described in claim 3 or 4 it is characterised in that：The surface area of described transverse sheet is main leaf table
The 40% of face, the surface area of described riser is the 35% of main leaf surface.
6. as claimed in claim 5 a kind of breast prosthetic implant it is characterised in that：Described fiber pipe is distributed in the both sides of main leaf,
Each described fiber pipe passes through riser, transverse sheet and/or main leaf by shell body（1）Bottom connects with top, the fiber of every side
Pipe has three kinds to pass through mode respectively, includings sequentially pass through transverse sheet and riser from top to bottom, up to sequentially passes through down main leaf, transverse sheet with
Riser, and sequentially pass through main leaf and riser from top to bottom.
7. as claimed in claim 6 a kind of breast prosthetic implant it is characterised in that：Described shell body（1）By mass parts, 27 parts are gathered
Ether, 13 parts of modified silica-gels, 17 parts of prestoxs
Cyclotetrasiloxane, 55 parts of Silica hydrogel of 8 parts of methyl methacrylates and 3 parts of carboxymethyl starch sodium compositions, described shell body（1）Thickness
Spend for 0.8cm.
8. a kind of breast prosthetic implant as described in claim 2 or 6 or 7 it is characterised in that：Described fiber pipe is by 6 parts of mass parts
Foam silicon carbon, 23 parts of polycaprolactones, 17 parts of polylactic acid, 37 parts of PEKKs, 32 parts of fat stem cell-protein hydrogels and 3
Part dilute citric acid composition, described polycaprolactone, polylactic acid and PEKK are cross-linked to form porous support, the hole of described porous support
Gap rate is 43.8%, and in described fat stem cell-protein hydrogel, protein hydrogel is Nano chitosan bone morphogenetic protein(BMP), described
The pH of protein hydrogel is 6.4, described fat stem cell：Shitosan：Bone morphogenic proteins quality compares 2.3：17.2：6.
9. as claimed in claim 8 a kind of breast prosthetic implant it is characterised in that：Described fill area（3）Inside it is filled with gel filled,
Described gel filled by 55 parts of agaroses of mass parts, 13 parts of chitosans, 72 parts of Silica hydrogel, 19 parts of N- carboxymethyl chitosans and 7 parts
Carboxymethyl cellulose forms.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711024543.7A CN107822742A (en) | 2016-09-24 | 2016-09-24 | A kind of fibre pipe for breast prosthetic implant |
| CN201610845241.5A CN106377342B (en) | 2016-09-24 | 2016-09-24 | A kind of breast prosthetic implant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610845241.5A CN106377342B (en) | 2016-09-24 | 2016-09-24 | A kind of breast prosthetic implant |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711024543.7A Division CN107822742A (en) | 2016-09-24 | 2016-09-24 | A kind of fibre pipe for breast prosthetic implant |
Publications (2)
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| CN106377342A true CN106377342A (en) | 2017-02-08 |
| CN106377342B CN106377342B (en) | 2018-01-02 |
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| CN201711024543.7A Pending CN107822742A (en) | 2016-09-24 | 2016-09-24 | A kind of fibre pipe for breast prosthetic implant |
| CN201610845241.5A Expired - Fee Related CN106377342B (en) | 2016-09-24 | 2016-09-24 | A kind of breast prosthetic implant |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201711024543.7A Pending CN107822742A (en) | 2016-09-24 | 2016-09-24 | A kind of fibre pipe for breast prosthetic implant |
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| US5370688A (en) * | 1993-03-30 | 1994-12-06 | Spenco Medical Corporation | Encapsulated gel breast prosthesis and method of making |
| DE10220594A1 (en) * | 2002-05-08 | 2003-11-20 | Dekumed Ges Fuer Kunststoff Un | breast prosthesis |
| CN201445573U (en) * | 2009-07-23 | 2010-05-05 | 徐波 | Point massage mammary prosthesis |
| CN204655199U (en) * | 2015-05-18 | 2015-09-23 | 复旦大学附属妇产科医院 | Implanted human body justice breast |
| CN105435308A (en) * | 2015-12-23 | 2016-03-30 | 天津幂方科技有限公司 | Breast implant three-dimensional structure and rapid forming method thereof |
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| CN101828937A (en) * | 2009-03-13 | 2010-09-15 | 王影 | Method for reshaping and beautifying by using tissue engineering fat regeneration technology |
| CN101637454B (en) * | 2009-05-14 | 2012-06-13 | 华东理工大学 | Recombinant human bone morphogenetic protein-2 chitosan microballon and preparation method thereof |
| US9180166B2 (en) * | 2010-03-12 | 2015-11-10 | New Jersey Institute Of Technology | Cartilage repair systems and applications utilizing a glycosaminoglycan mimic |
| US20120101593A1 (en) * | 2010-10-20 | 2012-04-26 | BIOS2 Medical, Inc. | Implantable polymer for bone and vascular lesions |
| CN103285424B (en) * | 2013-05-27 | 2016-06-22 | 东华大学 | A kind of three-dimensional fiber base aeroge tissue engineering bracket and preparation method thereof |
| CN104984402B (en) * | 2015-07-14 | 2016-10-05 | 青岛大学 | A kind of hydroxyethyl chitosan in-situ hydrogel for repairing corneal Ocular surface damage |
| CN105687239A (en) * | 2016-01-22 | 2016-06-22 | 苏州佰通生物科技有限公司 | Adipose-derived stem cell composition and preparation method thereof |
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2016
- 2016-09-24 CN CN201711024543.7A patent/CN107822742A/en active Pending
- 2016-09-24 CN CN201610845241.5A patent/CN106377342B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5370688A (en) * | 1993-03-30 | 1994-12-06 | Spenco Medical Corporation | Encapsulated gel breast prosthesis and method of making |
| DE10220594A1 (en) * | 2002-05-08 | 2003-11-20 | Dekumed Ges Fuer Kunststoff Un | breast prosthesis |
| CN201445573U (en) * | 2009-07-23 | 2010-05-05 | 徐波 | Point massage mammary prosthesis |
| CN204655199U (en) * | 2015-05-18 | 2015-09-23 | 复旦大学附属妇产科医院 | Implanted human body justice breast |
| CN105435308A (en) * | 2015-12-23 | 2016-03-30 | 天津幂方科技有限公司 | Breast implant three-dimensional structure and rapid forming method thereof |
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| CN106377342B (en) | 2018-01-02 |
| CN107822742A (en) | 2018-03-23 |
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