CN107812033A - A kind of Chewable Tablets of Chinese traditional medicine for treating pet disease of digestive tract and its production and use - Google Patents
A kind of Chewable Tablets of Chinese traditional medicine for treating pet disease of digestive tract and its production and use Download PDFInfo
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- A61K2236/30—Extraction of the material
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Abstract
The invention discloses a kind of Chewable Tablets of Chinese traditional medicine, and it includes the component of following weight proportion：10 30 parts of Ramulus Et Folium Pithecellobii Lucidi extract, 10 30 parts of microcrystalline cellulose, 10 30 parts of mannitol, 13 parts of polyvinylpyrrolidone, 46 parts of beef flavor, 13 parts of hydroxypropyl cellulose, 0.6 1.2 parts of magnesium stearate.The invention also discloses the preparation method of foregoing Chewable Tablets of Chinese traditional medicine and purposes.Chewable Tablets of Chinese traditional medicine of the present invention has the effect of obvious anti-inflammation, has no drug resistance, and can effectively treat by bacterial pet disease of digestive tract；Solve the problems, such as that Ramulus Et Folium Pithecellobii Lucidi extract is extremely bitter, taste of traditional Chinese medicine is strong by flavoring simultaneously, palatability is good, actively pet can be induced to search for food, and has good market application foreground.
Description
Technical field
The present invention relates to drug field, and in particular to a kind of Chewable Tablets of Chinese traditional medicine for treating pet disease of digestive tract.
Background technology
Nowadays, increasing people likes raising pet in society, but often due to dredging for feeding management etc. be present
Suddenly, some diseases can occur unavoidably, and 50%-60% belongs to disease of digestive tract in sick dog.Dog gastroenteritis is a kind of common digestion
Tract disease, and maximum disease one of is currently endangered canine farming, clinically with the disorders of digestion, vomiting, diarrhoea, stomachache
With body temperature rise etc. be characterized.
At present, pet disease of digestive tract there is no specific short caused by directed toward bacteria, main to use antibiosis extract for treating, and city
Pet antimicrobial on face is relatively simple, easily produces drug resistance, causes the ill pet state of an illness touching refractory.In addition, illness is doted on
The cause of disease that thing very likely carries is that people stores ill bacterium altogether, if after these germs produce drug resistance, mankind's health care belt will be given
Larger harm, therefore research and develop a kind of pet antimicrobial having no drug resistance and have great importance.
Pithecellobium clypearia (Folium Archidendri) dries sprout and leaf for the pithecellobium clypearia of pulse family, and mildly bitter flavor is puckery, cold nature,
Function is clearing heat and detoxicating, cool blood detumescence, antidiarrheal, has good anti-inflammation effect, the problem of not finding Chinese medicine drug resistance in addition,
There is preferable prospect for preventing and treating pet disease.But Ramulus Et Folium Pithecellobii Lucidi extract has strong Chinese medicine odor, and it is extremely bitter
Puckery, palatability is poor, easily causes pet food refusal during use.
The content of the invention
The invention provides a kind of Chewable Tablets of Chinese traditional medicine for treating pet disease of digestive tract, and its production and use.
The invention provides a kind of Chewable Tablets of Chinese traditional medicine, and it includes the component of following weight proportion：
Wherein, described Ramulus Et Folium Pithecellobii Lucidi extract be by pithecellobium clypearia bulk drug add water to cook or organic solvent extract, extract solution
Concentrate and produce.
Wherein, the component of described weight proportion is：
Wherein, described Ramulus Et Folium Pithecellobii Lucidi extract is prepared in accordance with the following methods：Pithecellobium clypearia is taken, is crushed, mistake
10-20 mesh sieves, distilled water is added, decocted 1-3 hours, filtering, residue adds distilled water, then decocts 1-3 hours, and merging is filtered twice
Liquid, concentrated extract, dry, produce Ramulus Et Folium Pithecellobii Lucidi extract.
Wherein, described distilled water addition is 15 times of pithecellobium clypearia drug powder weight, is decocted 2 hours, and filter residue adds
15 times of distilled water, then decoct 1.5 hours；
And/or it is 1.1-1.2g/ml to concentrate medicinal extract；
And/or it is 145/85 DEG C to dry as spray drying, entry/exit temperature, feed speed 50mL.min-1。
Wherein, when described Ramulus Et Folium Pithecellobii Lucidi extract is prepared using foregoing method, not eating in described pithecellobium clypearia
The rate of transform for referring to acid is not less than 85%, and the rate of transform of quercitin is not less than 80%.
Wherein, in the rate of transform=extract in content/medicinal material of target component target component content.
The present invention also provides the preparation method of foregoing Chewable Tablets of Chinese traditional medicine, and it comprises the following steps：
(1) raw material of each weight proportion is weighed；
(2) Ramulus Et Folium Pithecellobii Lucidi extract, microcrystalline cellulose, mannitol, polyvinylpyrrolidone are taken, is well mixed, obtains equal compound；
(3) hydroxypropyl cellulose will be added in equal compound, adjusts humidity of materials with 70-90% ethanol solutions, be made soft
Material, 20 mesh sieves are crossed, particle is made, 55-60 DEG C of drying, dried pellet moisture is 3-5%；
(4) beef flavor, magnesium stearate are added in particle, tabletting, produces chewable tablets.
The present invention also provides foregoing Chewable Tablets of Chinese traditional medicine in preparation pet antibacterial, the purposes of the Chewable Tablets of Chinese traditional medicine of anti-inflammatory.
The present invention also provides foregoing Chewable Tablets of Chinese traditional medicine and is preparing treatment pet disease of digestive tract as caused by bacterium infection
Chewable Tablets of Chinese traditional medicine purposes.
Wherein, described disease of digestive tract is gastroenteritis.
Wherein, described gastroenteritis is escherichia coli gastroenteritis.
Chewable Tablets of Chinese traditional medicine of the present invention has the effect of obvious anti-inflammation, has no drug resistance, and can effectively treat and be drawn by bacterium
The pet disease of digestive tract risen；Solve the problems, such as that Ramulus Et Folium Pithecellobii Lucidi extract is extremely bitter, taste of traditional Chinese medicine is strong by flavoring simultaneously, it is agreeable to the taste
Property is good, can actively induce pet to search for food, have good market application foreground.
Obviously, according to the above of the present invention, according to the ordinary technical knowledge and customary means of this area, do not departing from
Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification, replacement or change of other diversified forms can also be made.
The embodiment of form by the following examples, the above of the present invention is remake further specifically
It is bright.But the scope that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following example.It is all to be based on the above of the present invention
The technology realized belongs to the scope of the present invention.
Embodiment
The preparation of the Chewable Tablets of Chinese traditional medicine of embodiment 1
Formula of chewable tablets：
Wherein, Ramulus Et Folium Pithecellobii Lucidi extract is prepared in accordance with the following methods：
Fresh pithecellobium clypearia is taken, the coarse powder for 20 mesh is crushed after drying, adds 15 times of amount distillation water boiling and extraction 2h, mistake
Residue adds 15 times of distilled water measured and continues to decoct 1.5h after filter, and the concentration of mixing filtrate is 1.1-1.2g/ml medicinal extract, is sprayed dry
Dry, entry/exit temperature is 145/85 DEG C, feed speed 50mL.min-1, obtain dry Ramulus Et Folium Pithecellobii Lucidi extract；Wherein, do not have forefinger sour
The rate of transform be not less than 85%, the rate of transform of quercitin is not less than 80%.
Wherein, in the rate of transform=extract in content/medicinal material of target component target component content.
The preparation flow of Chewable Tablets of Chinese traditional medicine is：Wet grain → drying → whole grain → allotment → the tabletting of dispensing → softwood → system processed.
The preparation method of Chewable Tablets of Chinese traditional medicine：
Dispensing：The raw material of each weight proportion is weighed, takes Ramulus Et Folium Pithecellobii Lucidi extract, microcrystalline cellulose, mannitol, polyvinyl pyrrole
Alkanone, it is well mixed, crosses 100 mesh sieves, obtain equal compound；
Softwood processed：After hydroxypropyl cellulose is added in equal compound, 90% ethanol solution is slow added into, adjustment material is wet
Degree, is made softwood, amount of alcohol added pinched by softwood with hand it is agglomerating after dispersible be defined；
Make wet grain and drying：The softwood made is crossed into 20 mesh sieves using extrusion particle is made, be placed in 55 DEG C of air blast and do
4h is dried in dry case, stirs mixing once every 0.5h, it is 3%-5% to control dried pellet moisture；
Whole grain and allotment：18 mesh sieves are crossed after wet grain is dried, obtain the dry particl needed for tabletting, the process is by adding ox
Meat essence adjusts taste；
Tabletting：Material after whole grain, which is added after magnesium stearate, uses tablet press machine tabletted, produces Chewable Tablets of Chinese traditional medicine.
The preparation of the Chewable Tablets of Chinese traditional medicine of embodiment 2
Formula of chewable tablets：
Wherein, Ramulus Et Folium Pithecellobii Lucidi extract is prepared in accordance with the following methods：
Fresh pithecellobium clypearia is taken, the coarse powder for 10 mesh is crushed after drying, adds 15 times of amount distillation water boiling and extraction 1h, mistake
Residue adds 15 times of distilled water measured and continues to decoct 1h after filter, and the concentration of mixing filtrate is 1.1-1.2g/ml medicinal extract, is sprayed dry
Dry, entry/exit temperature is 145/85 DEG C, feed speed 50mL.min-1, obtain dry Ramulus Et Folium Pithecellobii Lucidi extract；Wherein, do not have forefinger sour
The rate of transform be not less than 85%, the rate of transform of quercitin is not less than 80%.
Wherein, in the rate of transform=extract in content/medicinal material of target component target component content.
The preparation flow of Chewable Tablets of Chinese traditional medicine is：Wet grain → drying → whole grain → allotment → the tabletting of dispensing → softwood → system processed.
The preparation method of Chewable Tablets of Chinese traditional medicine：
Dispensing：The raw material of each weight proportion is weighed, takes Ramulus Et Folium Pithecellobii Lucidi extract, microcrystalline cellulose, mannitol, polyvinyl pyrrole
Alkanone, it is well mixed, crosses 100 mesh sieves, obtain equal compound；
Softwood processed：After hydroxypropyl cellulose is added in equal compound, 70% ethanol solution is slow added into, adjustment material is wet
Degree, is made softwood, amount of alcohol added pinched by softwood with hand it is agglomerating after dispersible be defined；
Make wet grain and drying：The softwood made is crossed into 20 mesh sieves using extrusion particle is made, be placed in 60 DEG C of air blast and do
4h is dried in dry case, stirs mixing once every 0.5h, it is 3%-5% to control dried pellet moisture；
Whole grain and allotment：18 mesh sieves are crossed after wet grain is dried, obtain the dry particl needed for tabletting, the process is by adding ox
Meat essence adjusts taste；
Tabletting：Material after whole grain, which is added after magnesium stearate, uses tablet press machine tabletted, produces Chewable Tablets of Chinese traditional medicine.
The preparation of the Chewable Tablets of Chinese traditional medicine of embodiment 3
Formula of chewable tablets：
Wherein, Ramulus Et Folium Pithecellobii Lucidi extract is prepared in accordance with the following methods：
Fresh pithecellobium clypearia is taken, the coarse powder for 20 mesh is crushed after drying, adds 15 times of amount distillation water boiling and extraction 3h, mistake
Residue adds 15 times of distilled water measured and continues to decoct 3h after filter, and the concentration of mixing filtrate is 1.1-1.2g/ml medicinal extract, is sprayed dry
Dry, entry/exit temperature is 145/85 DEG C, feed speed 50mL.min-1, obtain dry Ramulus Et Folium Pithecellobii Lucidi extract；Wherein, do not have forefinger sour
The rate of transform be not less than 85%, the rate of transform of quercitin is not less than 80%.
Wherein, in the rate of transform=extract in content/medicinal material of target component target component content.
The preparation flow of Chewable Tablets of Chinese traditional medicine is：Wet grain → drying → whole grain → allotment → the tabletting of dispensing → softwood → system processed.
The preparation method of Chewable Tablets of Chinese traditional medicine：
Dispensing：The raw material of each weight proportion is weighed, takes Ramulus Et Folium Pithecellobii Lucidi extract, microcrystalline cellulose, mannitol, polyvinyl pyrrole
Alkanone, it is well mixed, crosses 100 mesh sieves, obtain equal compound；
Softwood processed：After hydroxypropyl cellulose is added in equal compound, 80% ethanol solution is slow added into, adjustment material is wet
Degree, is made softwood, amount of alcohol added pinched by softwood with hand it is agglomerating after dispersible be defined；
Make wet grain and drying：The softwood made is crossed into 20 mesh sieves using extrusion particle is made, be placed in 55 DEG C of air blast and do
4h is dried in dry case, stirs mixing once every 0.5h, it is 3%-5% to control dried pellet moisture；
Whole grain and allotment：18 mesh sieves are crossed after wet grain is dried, obtain the dry particl needed for tabletting, the process is by adding ox
Meat essence adjusts taste；
Tabletting：Material after whole grain, which is added after magnesium stearate, uses tablet press machine tabletted, produces Chewable Tablets of Chinese traditional medicine.
The recipe determination of 4 Chewable Tablets of Chinese traditional medicine of the present invention of embodiment
(1) selection of auxiliary material
Extract, mannitol and sorbierite, sucrose, microcrystalline cellulose are pressed 1:1:1 mix wet granulation, with mobility,
Hygroscopicity is that index investigates influence of the different auxiliary material to particle, the results are shown in Table 1, mannitol and microcrystalline cellulose are optimal auxiliary material.
Ramulus Et Folium Pithecellobii Lucidi extract is water extract, and hygroscopicity is stronger, and mannitol sense of taste is refrigerant, hygroscopicity is small, so being base from mannitol
This auxiliary material.
Influence of the different auxiliary material of table 1 to particle
(2) selection of adhesive
Ramulus Et Folium Pithecellobii Lucidi extract is water extract, and stickiness is stronger, and water, 1% sucrose, 1% starch solution and second is respectively adopted in experiment
Alcohol is pelletized as adhesive, the results showed that water, 1% sucrose, 1% starch solution are too big as adhesive particle hardness, therefore select
Ethanol makees adhesive.
(3) magnesium stearate dosage is screened
Magnesium stearate screens its dosage, is optimum dose from 1.0% as a result as shown in table 2 as lubricant.
Influence of the magnesium stearate of the different amounts of table 2 to chewable tablets outward appearance
(4) the final determination of formula of chewable tablets
By trial test, it is determined that it is mannitol, microcrystalline cellulose, concentration of alcohol to influence 3 maximum factors of chewable tablets.For
The formula of further optimization chewable tablets, fixed magnesium stearate dosage is 1.0%, above-mentioned 3 factors is screened, screening side
Case is shown in Table 3.
The screening test factor level of table 3
Using outward appearance, hardness, resistance to chew characteristics, cooling feeling, fine and smooth sense, sugariness, outward appearance as inspection target, chewable tablets is carried out
Scoring.Hardness：Big 7-10 points of hardness, moderate 4-6 points of hardness, small 1-3 points of hardness；Outward appearance：Bright and clean, rounding, uniform color 7-10
Point, finish it is slightly worse, color and luster uneven 4-6 points, pitted skin, there is obvious spot 1-3 points；Mouthfeel：It is in good taste, no bitter taste 7-10
Point, mouthfeel is general, bitter highly seasoned 1-3 points with 4-6 points of bitter taste, poor taste.
Screening test scheme points the results are shown in Table 4.
The screening test result of table 4
As shown in Table 4, combination of the total score more than 15 points can be formulated as the candidate of chewable tablets, but in view of mouthfeel to chewing
The influence of piece is very big, and the chewable tablets with bitter taste can cause the food refusal of animal, therefore select total score to be more than 15, and mouthfeel score is most
High A3B3C3 is best of breed.Optimised process is (100g)：Extract 30g, mannitol 30g, microcrystalline cellulose 30g, binder
For 90% ethanol, lubricant is 1g magnesium stearate.
Beneficial effects of the present invention are proved below by way of specific pharmacodynamic experiment：
The checking of 1 Chewable Tablets of Chinese traditional medicine of the present invention of test example treatment diarrhoea
1 experiment material
1.1 Experimental agents Chewable Tablets of Chinese traditional medicine of the present invention, is prepared by embodiment 1.
1.2 pet data observe case totally 40.
2 experimental methods
The clinical case that selection Chengdu pet dog breeding base is suffered from diarrhoea in 1 year, and to being diagnosed as escherichia coli
The case of diarrhoea is treated, totally 40, is randomly divided into two groups, Enrofloxacin tablet group and pithecellobium clypearia chewable tablets group.
3 experimental results
3.1 therapeutic effect
Such as table 5：
Therapeutic effect of the pithecellobium clypearia chewable tablets of table 5 to bacterial diarrhea dog
As shown in Table 5, Chewable Tablets of Chinese traditional medicine treatment diarrhoea of the present invention, effective 18, total effective rate 90%, hence it is evident that better than grace promise
Sha Xing, it is evident in efficacy.
3.2 feeding effects
Over the course for the treatment of, morbidity dog actively searches for food pithecellobium clypearia chewable tablets, and Enrofloxacin needs gavage administration.Thus may be used
See, Chewable Tablets of Chinese traditional medicine of the present invention has the ability of active food calling, and palatability is good, solves Ramulus Et Folium Pithecellobii Lucidi extract extremely bitterness, taste of traditional Chinese medicine
The problem of strong.
To sum up, Chewable Tablets of Chinese traditional medicine of the present invention has the effect of obvious anti-inflammation, has no drug resistance, and can effectively treat by thin
Microbial pet disease of digestive tract；Solve the problems, such as that Ramulus Et Folium Pithecellobii Lucidi extract is extremely bitter, taste of traditional Chinese medicine is strong by flavoring simultaneously,
Palatability is good, actively pet can be induced to search for food, and has good market application foreground.
Claims (10)
- A kind of 1. Chewable Tablets of Chinese traditional medicine, it is characterised in that：It includes the component of following weight proportion：Wherein, described Ramulus Et Folium Pithecellobii Lucidi extract be by pithecellobium clypearia bulk drug add water to cook or organic solvent extract, extract solution concentration Produce.
- 2. Chewable Tablets of Chinese traditional medicine according to claim 1, it is characterised in that：The component of described weight proportion is：
- 3. Chewable Tablets of Chinese traditional medicine according to claim 1 or 2, it is characterised in that：Described Ramulus Et Folium Pithecellobii Lucidi extract be according to Lower section method is prepared：Pithecellobium clypearia is taken, is crushed, crosses 10-20 mesh sieves, adds distilled water, is decocted 1-3 hours, filtering is residual Slag adds distilled water, then decocts 1-3 hours, merges filtrate twice, concentrated extract, dries, produce Ramulus Et Folium Pithecellobii Lucidi extract.
- 4. Chewable Tablets of Chinese traditional medicine according to claim 3, it is characterised in that described distilled water addition is pithecellobium clypearia medicine 15 times of powder weight, decoct 2 hours, filter residue adds 15 times of distilled water, then decocts 1.5 hours；And/or it is 1.1-1.2g/ml to concentrate medicinal extract；And/or it is 145/85 DEG C to dry as spray drying, entry/exit temperature, feed speed 50mL.min-1。
- 5. the Chewable Tablets of Chinese traditional medicine according to claim 3 or 4, it is characterised in that：Described Ramulus Et Folium Pithecellobii Lucidi extract uses right It is required that when prepared by the method described in 3 or 4, the rate of transform for there be not forefinger acid in described pithecellobium clypearia is not less than 85%, quercitrin The rate of transform of glycosides is not less than 80%.
- 6. the preparation method of the Chewable Tablets of Chinese traditional medicine described in claim 1-5 any one, it is characterised in that：It includes following step Suddenly：(1) raw material of each weight proportion is weighed；(2) Ramulus Et Folium Pithecellobii Lucidi extract, microcrystalline cellulose, mannitol, polyvinylpyrrolidone are taken, is well mixed, obtains equal compound；(3) hydroxypropyl cellulose will be added in equal compound, adjusts humidity of materials with 70-90% ethanol solutions, softwood, mistake is made 20 mesh sieves, particle is made, 55-60 DEG C of drying, dried pellet moisture is 3-5%；(4) beef flavor, magnesium stearate are added in particle, tabletting, produces chewable tablets.
- 7. the Chewable Tablets of Chinese traditional medicine described in claim 1-5 any one is in preparation pet antibacterial, the use of the Chewable Tablets of Chinese traditional medicine of anti-inflammatory On the way.
- 8. the Chewable Tablets of Chinese traditional medicine described in claim 1-5 any one is preparing treatment pet alimentary canal as caused by bacterium infection The purposes of the Chewable Tablets of Chinese traditional medicine of disease.
- 9. purposes according to claim 8, it is characterised in that：Described disease of digestive tract is gastroenteritis.
- 10. purposes according to claim 9, it is characterised in that：Described gastroenteritis is escherichia coli gastroenteritis.
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Cited By (1)
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