CN107810956B - Bactericidal composition - Google Patents

Bactericidal composition Download PDF

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Publication number
CN107810956B
CN107810956B CN201711022249.2A CN201711022249A CN107810956B CN 107810956 B CN107810956 B CN 107810956B CN 201711022249 A CN201711022249 A CN 201711022249A CN 107810956 B CN107810956 B CN 107810956B
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crops
bacterial
thiabendazole
preparation
bactericidal composition
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CN107810956A (en
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陈福良
尹明明
王召
郑永权
时浩杰
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Institute of Plant Protection of Chinese Academy of Agricultural Sciences
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Institute of Plant Protection of Chinese Academy of Agricultural Sciences
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/24—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms
    • A01N43/26—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings
    • A01N43/28—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings with two hetero atoms in positions 1,3
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
    • A01N37/04—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof polybasic

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention relates to a bactericidal composition which is prepared from thiabendazole and copper succinate + glutarate in a mass ratio of 1: (0.7-3.0). The invention relates to a binary bactericidal mixture which is composed of thiabendazole and copper succinate as effective components, the target crops of the binary bactericidal mixture mainly comprise vegetables such as cucumber, tomato, hot pepper, potato and the like, fruit tree crops such as orange, grape, apple, pear and the like, economic crops such as tobacco, cotton and the like, and grain crops such as rice and the like, the binary bactericidal mixture is used for preventing and treating bacterial diseases of the crops, particularly has obvious preventing and treating effect on citrus canker, the actual indoor inhibition rate on the citrus canker is 84.5%, and the compound toxic effect ratio of the two can reach 1.48.

Description

Bactericidal composition
Technical Field
The invention relates to a binary bactericidal composition which can be used for preventing and treating bacterial diseases, particularly citrus canker, and belongs to the technical field of pesticides.
Background
Thiabendazole, which is called as "Qingkuling" in trade name and 2-benzoyl hydrazine-1, 3-dithiane in chemical name, is a novel pesticide which is exclusively produced and registered by Zhejiang Si Pest plant protection chemical Co. The composition has the effects of preventing and treating, has high drug effect, long lasting period, low residue, rain wash resistance and stable drug effect, is not easy to generate phytotoxicity, and can be used for preventing and treating bacterial diseases such as tobacco, tomato, eggplant and pepper bacterial wilt, vegetable wildfire disease, angular leaf spot, soft rot, rice streak, bacterial leaf blight, citrus canker, scab and the like.
Copper succinate + glutarate is copper salt of dibasic acid (succinic acid, glutaric acid and adipic acid) prepared by complexing copper with succinic acid, glutaric acid and adipic acid, has a protection effect and a certain removing effect, has a broad bactericidal spectrum, has better disease control effect on bacterial diseases and diseases caused by downy mildew and phytophthora in fungi than common medicaments, and is a common organic copper mixed bactericide. Low toxicity to human, livestock, fish and shellfish, and no toxicity to bee. The copper succinate + glutarate is mainly used for preventing and treating vegetable diseases: such as cucumber downy mildew, blight, powdery mildew, gummy stem blight, anthracnose, angular leaf spot, gray mold, damping-off, brown spot and the like, tomato late blight, ulcer, bacterial wilt, early blight, leaf mold, leaf spot, gray spot, spot blight, gray mold, black spot and the like, pepper leaf spot, early blight, yellow wilt, scab, anthracnose, gray mold, damping-off, powdery mildew, leaf blight, black spot, gray mold and the like, Chinese cabbage soft rot, cruciferous vegetable clubroot, radish, broccoli black rot, cabbage black rot, black spot, black shank and the like, purple cabbage black rot, cabbage bacterial black spot, black shank, celery soft rot, onion soft rot, garlic bacterial soft rot, bean wilt, potato blight and the like; fruit tree diseases: such as citrus canker, anthracnose, scab, black spot and the like, pear scab, ring rot, black spot, blight, brown spot and the like, apple rot, anthracnose, alternaria leaf spot, brown rot, epidemic rot, flower rot, rust disease, branch ulcer, ring rot and the like, grape downy mildew, anthracnose, brown spot, ring rot, damping off, fruit cracking, large brown spot, white rot and the like; economic crops: such as cotton anthracnose, brown spot, black spot, epidemic disease, stem blight, angular leaf spot, blight, verticillium wilt, damping off and the like, tobacco leaf spot, air shin disease, bacterial angular leaf spot and the like; grain crops: such as rice false smut and bacterial leaf blight; and has a stimulating effect on plant growth.
Disclosure of Invention
The invention aims to provide a binary bactericidal mixture taking thiabendazole and copper succinate as effective components, wherein target crops of the binary bactericidal mixture mainly comprise vegetables such as cucumbers, tomatoes, hot peppers and potatoes, fruit crops such as oranges, grapes, apples and pears, economic crops such as tobacco and cotton, and grain crops such as rice, and the binary bactericidal mixture is used for preventing and treating bacterial diseases of the crops, and particularly has obvious prevention and treatment effects on citrus canker and tobacco bacterial wilt.
The technical scheme adopted by the invention is as follows.
A sterilization composition comprises thiabendazole and copper succinate + glutarate in a mass ratio of 1: (0.7-3.0). Such as 1:0.8, 1:1.1, 1:1.7, 1: 2.6; preferably 1 (0.7-1.6), 1 (0.8-1.1), 1 (0.7-1.1) and 1 (1.1-1.6).
The invention also provides a preparation containing the bactericidal composition, wherein the bactericidal composition accounts for 17-36% of the total mass of the preparation.
The preparation can be any agriculturally acceptable preparation formulation, preferably various agricultural preparation formulations such as wettable powder, water dispersible granules and suspending agents, and more preferably wettable powder and suspending agents.
The preparation can also contain an auxiliary agent, and specifically can be one or more of a dispersing agent, a wetting agent, a disintegrating agent, an adhesive, a thickening agent, an emulsifying agent or a carrier.
When formulated as wettable powders, the adjuvants used include:
the dispersant is one or more selected from lignosulfonate, polycarboxylate, alkyl naphthalene sulfonate, sodium dodecyl benzene sulfonate, alkyl polyoxyethylene ether sulfonate or alkylphenol polyoxyethylene ether formaldehyde condensate;
the wetting agent is selected from one or more of sodium dodecyl sulfate, secondary alkyl sodium sulfate, fatty alcohol polyoxyethylene ether, nonylphenol polyoxyethylene ether or sorbitan fatty acid ester polyoxyethylene ether;
the carrier is one or more selected from kaolin, diatomite, attapulgite, bentonite or white carbon black.
When the water dispersible granule is prepared, the used auxiliary agents comprise:
the dispersant is selected from one or more of polycarboxylate, lignosulfonate, alkyl naphthalene sulfonate, alkylphenol polyoxyethylene ether or alkylphenol polyoxyethylene ether sulfonate;
the wetting agent is selected from one or more of naphthalene sulfonate, fatty alcohol sulfate, dodecyl benzene sulfonate, lauryl sodium sulfate, fatty alcohol polyoxyethylene ether or alkyl sulfonate;
the disintegrating agent is selected from one or more of ammonium sulfate, urea, corn starch and its derivatives, low-substituted hydroxypropyl cellulose, polyvinylpyrrolidone or sodium alginate, etc.;
the adhesive is selected from one or more of hydroxyethyl cellulose, soluble starch, polyethylene glycol, methyl cellulose, dextrin, fructose or polyvinyl alcohol;
the carrier is selected from one or more of white carbon black, kaolin, bentonite, diatomite, light calcium carbonate, gypsum, attapulgite, urea or sucrose.
When formulated as a suspension concentrate, the adjuvants used include:
the dispersant is selected from one or more of polycarboxylate, lignosulfonate, alkyl naphthalene sulfonate, Tersperse 2425, alkylphenol polyoxyethylene ether and the like;
the wetting agent is selected from one or more of alkyl sulfonate, Tersperse 2500, alkylphenol polyoxyethylene ether phosphate, phenethylphenol polyoxyethylene ether phosphate, alkyl sulfate, naphthalene sulfonate and the like;
the thickener is one or more selected from xanthan gum, polyvinyl alcohol, carboxymethyl cellulose, sodium polyacrylate, bentonite, magnesium aluminum silicate, etc.;
the antifreezing agent is one or more selected from ethylene glycol, propylene glycol, glycerol, urea, etc.;
the preservative is selected from one or more of sorbic acid, sodium benzoate, benzaldehyde, p-hydroxybenzaldehyde, sodium salicylate, 2-hydroxybiphenyl and the like;
the defoaming agent is selected from organosilicon defoaming agents.
The salts in the above adjuvant, such as polycarboxylate, lignosulfonate, etc., are sodium salt or calcium salt.
The invention also provides application of the bactericidal composition or the preparation in preventing and treating crop bacterial diseases.
The crops are vegetables, fruit trees, tobacco, cotton and grains; the vegetables are preferably selected from cucumber, tomato, pepper and potato; the fruit trees are preferably selected from oranges, grapes, apples and pears; the grain is preferably rice; further preferably, the crop is tobacco or citrus.
The bacterial diseases comprise canker, bacterial wilt, leaf spot, soft rot, epidemic diseases and the like, preferably canker and bacterial wilt, and further preferably citrus canker.
The invention has the following beneficial effects:
the invention relates to a binary bactericidal mixture which is composed of thiabendazole and copper succinate as effective components, the target crops of the binary bactericidal mixture mainly comprise vegetables such as cucumber, tomato, hot pepper, potato and the like, fruit tree crops such as orange, grape, apple, pear and the like, economic crops such as tobacco, cotton and the like, and grain crops such as rice and the like, the binary bactericidal mixture is used for preventing and treating bacterial diseases of the crops, particularly has obvious preventing and treating effect on citrus canker, the actual indoor inhibition rate of the binary bactericidal mixture on the citrus canker is 84.5%, and the compound toxic effect ratio of the two can reach 1.48.
Detailed Description
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
Example 1: 21% wettable powder (1: 1.1)
Figure BDA0001447699340000041
The thiabendazole, the copper succinate and the additive and the filler are crushed by a jet mill and then fully mixed in a mixing kettle to prepare the wettable powder. The water may be diluted to a suspension of any desired concentration.
Example 2: 18% suspending agent (1: 0.8)
Figure BDA0001447699340000051
Mixing the effective components with adjuvants, and grinding in sand mill to obtain suspending agent. The water may be diluted to a suspension of any desired concentration.
Example 3: 36% Water dispersible granule (1: 2.6)
Figure BDA0001447699340000052
The water dispersible granule can be prepared by crushing the effective components, the auxiliary agent and the filler by a jet mill, fully mixing in a mixing kettle, adding water for kneading, extruding for granulation, drying and sieving. The water may be diluted to a suspension of any desired concentration.
Effect verification
1、Indoor bioassay example
The inhibition rate of medicaments (I is thiabendazole and II is copper succinate + glutarate) with different compound proportions on citrus canker pathogenic bacteria is measured by an NY/T1156.16-2008 bacterial turbidity method.
1.1 Citrus canker pathogen was cultured on solid medium for 48 hours before measurement, a single colony was inoculated into liquid medium and cultured for 12 hours, and a bacterial suspension with a turbidity meter showing 300NTU was prepared with sterile water. Each drug-added flask was inoculated with 20. mu.L of the bacterial suspension, and cultured at 28 ℃ under shaking at 150 rpm.
1.2 when the CK turbidity reaches 400-. The bacterial growth inhibition rate (%), the expected inhibition rate (%), and the toxic effect rate are calculated according to the formula.
Bacterial growth inhibition (%) of 100 × (blank control turbidity increase-agent turbidity increase)/blank control turbidity increase
Expected inhibition rate I agent EC50Actual inhibition rate x ratio of I agent + II agent EC50Actual inhibition rate x the ratio of the medicament
The ratio of toxic effect is actual inhibition rate/expected inhibition rate
The determination standard of the toxic effect ratio is as follows: the toxic effect ratio is greater than 1.25 for synergism, less than 0.75 for antagonism, and less than or equal to 0.75 for additive effect.
The EC of each single agent was determined by linear regression analysis between the probability of bacterial inhibition (Y) and the logarithm of the concentration (X) of the series of agents50The value is obtained. Calculating EC for each single agent by regression analysis and correlation analysis using SPSS data processing software50Correlation coefficient, etc.
1.3 the single preparation of the thiabendazole and the copper succinate + glutarate has certain bacteriostatic activity on the citrus canker pathogenic bacteria, and the test results of the bacteriostatic activity are shown in Table 1.
TABLE 1 determination of the bacteriostatic activity of Tiaobacterium cyclopentadienyl and copper succinate + glutarate + adipate on citrus canker pathogen
Figure BDA0001447699340000061
1.4 the inhibition rates of the medicaments with different compounding ratios on citrus canker germs are shown in table 2.
TABLE 2 determination of bacteriostatic activity of different compounding ratio agents on citrus canker pathogens
Figure BDA0001447699340000062
Figure BDA0001447699340000071
As can be seen from Table 2, when the mass ratio of the thiabendazole to the copper succinate + glutarate is 1: at 1.1, the actual inhibition rate and the toxicity rate are the highest, and are respectively 84.5 percent and 1.485 percent; and then the mixing ratio is 1: at 0.8, the actual inhibition and toxicity rates were 78.7% and 1.424, respectively. In addition, the two compounding ratios are 1:1.7 and 1:2.6, the toxicity ratio is approximately 1.2, which is close to the synergistic effect ratio (1.25), and in practical application, the test group can show better inhibition effect by combining the factors such as auxiliary materials, dosage forms and the like.
Although the invention has been described in detail hereinabove with respect to a general description and specific embodiments thereof, it will be apparent to those skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.

Claims (8)

1. The bactericidal composition is characterized in that the active ingredients are thiabendazole and copper succinate adipate; the mass ratio of the thiabendazole to the copper succinate + glutarate is 1 (0.8-1.1).
2. A preparation is characterized by comprising the bactericidal composition as described in claim 1, wherein the bactericidal composition accounts for 17% -36% of the total mass of the preparation.
3. The preparation of claim 2, wherein the preparation is wettable powder, water dispersible granules or suspending agents.
4. Use of the fungicidal composition of claim 1 or the formulation of claim 2 or 3 for the control of bacterial diseases in crops.
5. The use according to claim 4, wherein the crops are vegetables, fruit trees, tobacco, cotton, foodstuffs.
6. Use according to claim 5, wherein the vegetables are cucumbers, tomatoes, peppers, potatoes;
the fruit trees are oranges, grapes, apples and pears;
the grain is rice.
7. Use according to claim 4, characterized in that the bacterial diseases are canker, bacterial wilt, leaf spot, soft rot, epidemic diseases.
8. Use according to claim 7, wherein the bacterial disease is citrus canker.
CN201711022249.2A 2017-10-27 2017-10-27 Bactericidal composition Expired - Fee Related CN107810956B (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104521988A (en) * 2014-12-18 2015-04-22 广西田园生化股份有限公司 Compound composition containing 2-(p-fluorophenyl)-5-methanesulfonyl-1,3,4-oxadiazole and Copper(succinate+glutarate+adipate) and preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104521988A (en) * 2014-12-18 2015-04-22 广西田园生化股份有限公司 Compound composition containing 2-(p-fluorophenyl)-5-methanesulfonyl-1,3,4-oxadiazole and Copper(succinate+glutarate+adipate) and preparation

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