CN107802737A - 广谱抗菌剂及其制备方法 - Google Patents
广谱抗菌剂及其制备方法 Download PDFInfo
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- CN107802737A CN107802737A CN201711380808.7A CN201711380808A CN107802737A CN 107802737 A CN107802737 A CN 107802737A CN 201711380808 A CN201711380808 A CN 201711380808A CN 107802737 A CN107802737 A CN 107802737A
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- antimicrobial agent
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- spectrum antimicrobial
- dandelion
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Abstract
本发明提供一种广谱抗菌剂及其制备方法，每1000ml所述广谱抗菌剂由以下原料制成：黄柏18～24g，黄芩18～24g，板蓝根16～20g，蒲公英18～24g，黄芪22～28g，熟地黄22～28g，黄精18～22g，甘草18～22g，黄莲18～22g，中药发酵菌90～110ml，柠檬酸400～416g，水900～1100ml。本该广谱抗菌剂疗效确切、适应病症范围广，为广谱高效、强烈的杀菌消炎剂，即可口服又可外用，还可消毒，性能稳定、常温下可保存20年药效不变，无毒副作用。
Description
技术领域
本发明属于医药技术技术领域，具体涉及一种广谱抗菌剂及其制备方法。
背景技术
人们受病毒和细菌的感染，常常引起上呼吸道及呼吸系统感染、消化道及胆囊感染、泌尿感染、妇科各种病症感染。目前的广谱抗菌药物大部分是西药，其对相应得病症感染具有一定的疗效，但伴随产生各种副作用，且适应病症范围小。
发明内容
本发明的目的在于提供一种广谱抗菌剂，该广谱抗菌剂疗效确切、适应病症范围广，为广谱高效、强烈的杀菌消炎剂，即可口服又可外用，还可消毒，性能稳定、常温下可保存20年药效不变，无毒副作用；同时本发明的目的还在于提供一种上述广谱抗菌剂的制备方法。
为实现上述目的，本发明广谱抗菌剂所采用的技术方案是：每1000ml所述广谱抗菌剂由以下原料制成：黄柏18～24g，黄芩18～24g，板蓝根16～20g，蒲公英18～24g，黄芪22～28g，熟地黄22～28g，黄精18～22g，甘草18～22g ，黄莲18～22g ，中药发酵菌90～110ml，柠檬酸400～416g，水900～1100ml。
每1000ml所述广谱抗菌剂由以下原料制成：黄柏20g，黄芩20g，板蓝根18g，蒲公英20g，黄芪25g，熟地黄25g，黄精20g，甘草20g，黄莲20g，中药发酵菌100ml，柠檬酸408g，水1000ml。
上述广谱抗菌剂的制备方法，包括以下步骤：
（1）分别按上述重量称取黄柏，黄芩，板蓝根，蒲公英，黄芪，熟地黄，黄精，甘草，黄莲放入容器内并混合均匀；
（2）向容器内加入上述体积的水,煎煮4～5小时，过滤，得中药提取夜；
（3）在中药提取液中加入上述体积的发酵菌（夏天静置24小时，冬天静置3～5天），然后再加入上述重量的柠檬酸，即得所述广谱抗菌剂。
本发明广谱抗菌剂中，各中药原料的功效为：
黄柏：为芸香科黄檗属植物黄皮树或黄檗的树皮；含有生物碱类如小檗碱、黄柏碱、木兰花碱，药根碱等，还含有柠檬苦素、黄柏酮、菜油甾醇、豆甾醇等多种有效成分；性味苦、寒。归肾、膀胱、大肠经；能清热燥湿、泻火解毒；主治湿热痢疾、泄泻、黄疸、骨蒸劳热、口舌生疮、目赤肿痛，痈疽疮毒等。现代药理学证明黄柏具有抗病原微生物、解热和抗炎、抗血小板聚集等功效，对心血管系统、消化系统和中枢神经系统具有促进作用。
黄芩：为唇形科黄芩属植物黄芩的根，含有黄酮类化合物如黄芩素、黄芩黄酮Ⅰ和黄芩黄酮Ⅱ、黄芩苷、汉黄芩素、白杨素等，该含有β-谷甾醇、菜油甾醇及豆甾醇等多种有效成分；黄芩性味苦，寒；归肺、心、肝、胆、大肠经；能清热泻火、燥湿解毒，止血，安胎；主治肺热咳嗽，热病高热神昏，肝火头疼，目赤肿痛，湿热黄疸，泻痢，热淋，吐衄，崩漏，胎热不安，拥肿疔疮；现代药理学表明黄芩具有抗微生物、抗氧化、抗癌、降血压、利尿、降血脂、保护缺血再灌注损伤等功效。
板蓝根：为十字花科菘蓝属植物菘蓝的根；含有靛蓝、靛玉红及多种氨基酸，如精氨酸、谷氨酸等，还含有黑芥子苷、靛苷、色胺酮等多种有效活性成分；性味苦，寒，归心、肺、肝、胃经；能清热，解毒，凉血，利咽；主治风热感冒，流感，流脑，乙脑，大脑瘟疫，烂喉丹痧，单独等症；现代药理学证明板蓝根具有抗细菌、抗病毒、抗内毒素、抗癌等功效，同时对免疫系统具有调节作用。
蒲公英：为菊科蒲公英属植物蒲公英，碱地蒲公英、东北蒲公英异苞蒲公英、亚洲蒲公英、红梗蒲公英等多种植物的全草；含有蒲公英甾醇、胆碱、菊糖、果胶、芹菜素、芸香苷等，还含有挥发油如正己醇、樟脑、正辛醇等多种活性成分；性味苦、甘，寒，归肝、胃经；能清热解毒，消痈散结；主治乳痈、肺痈、肠痈、痄腮、瘰疬、疔毒疮肿、目赤肿痛、感冒发热、咳嗽、咽喉肿痛、胃炎、痢疾、肝炎、胆囊炎、尿路感染、蛇虫咬伤、烧烫伤等；现代药理学证明蒲公英具有抗病原微生物、抗内毒素、抗肿瘤、抗胃溃疡、利胆、保肝及调节免疫等作用。
黄芪：为豆科黄芪属植物蒙古黄芪和膜荚黄芪的根，含有黄芪苷、琼脂黄芪苷以及异黄铜等有效成分；性甘，温；归肺、脾经；能益气升阳，固表止汗，利水消肿，托毒生肌；主治一切气虚血亏之证，如脾虚泄泻，肺虚咳，脱肛，子宫下垂，自汗，盗汗，水肿，血痹，痈疽难溃或久溃不敛。现代药理学证明黄芪具有增强免疫功能、延缓衰老、抗氧化、促进造血功能、促进心血管心血管系统的功能、抗血栓、抗病毒、抗癌、抗关节炎、抗炎及镇痛的作用。
熟地黄：为玄科地黄属植物地黄得块跟，经加工蒸硒而成；含有益母草苷、桃叶珊瑚苷、梓醇、地黄苷、地黄素、紫罗兰酮苷等有效成分，苷、温，归肺、肾经。功效为补血滋阴、益精填髓；主治血虚萎黄，眩晕心悸，月经不调，崩漏不止，肝肾阴亏，超热盗汗，遗精阳痿，不孕不育，腰膝酸软，耳鸣耳聋，头晕眼花、须发早白，消渴、便秘，肾虚喘促。现代药理学研究表明，熟地黄具有促进骨髓造血系统功能、抗血液凝固、提高免疫力系统功能，提高心血管系统功能，抗氧化等作用。
黄精：一种百合科天然植物，内含甾体皂苷、多糖、具有抗病原微生物、抗疲劳、抗氧化、延缓衰老、止血的功能。
甘草：为豆科甘草属植物甘草、光皮甘草，胀果甘草的根及根茎；含有三萜皂苷如甘草甜素、乌拉尔甘草皂苷A、B等，黄铜类化合物如甘草苷元，甘草苷等，香豆类化合物，如甘草香豆素甘草酚等，生物碱如喹啉类，异喹啉类等，多糖如甘草葡聚糖GBW，甘草多糖UA、UB、UC、等，还含有甘草苯丙呋喃。正二十三烷等多种有效成分；性味甘、平，归脾、胃、心、肺经；能和中缓急、润肺、解毒、调和诸药；炙用治脾胃虚弱、倦怠食少、腹痛便溏、四肢挛急疼痛、心悸、脏躁、肺痿咳嗽；生用治咽喉疼痛、痈疮肿毒、小儿胎毒及药物、食物中毒；现代药学证明甘草具有抗微生物、抗炎、镇咳、祛痰、抗肿瘤、抗突变、抗氧化等功效，对消化系统、心血管系统、生殖系统及脑、肾功能等具有调节作用。
黄莲：含有丰富的黄莲素，可清热燥湿，泻火解毒，可去中焦湿热，心经实热等。
本发明的有效果：本发明广谱抗菌剂系中药提取液经生物发酵加工，精制而成，其疗效确切、适应病症范围广，为广谱高效、强烈的杀菌消炎剂，即可口服又可外用，还可消毒，性能稳定、常温下可保存20年药效不变，无毒副作用。
本发明广谱抗菌剂的功能与主治：
主要用于对上下消化道细菌性感染性疾患。口腔炎、咽炎、十二指肠溃疡、菌痢、急慢性肠炎、顽固性腹泻、细菌性食物中毒有较好的疗效。
主要用于后泌尿道及皮肤细菌性感染性疾患。对外阴瘙痒、滴虫性阴道炎、霉菌性阴道炎、皮肤顽癣、手、足癣、指、趾癣、烧烫伤有较好的疗效。对淋病、梅毒、尖锐湿疣等性病也有较好的辅助治疗作用。
对HIV-1型艾滋病毒具有灭活与预防作用。
具体实施方式
下面结合实施例对本发明作进一步的说明。
实施例1：本实施例的广谱抗菌剂，每1000ml所述广谱抗菌剂由以下原料制成：黄柏20g，黄芩20g，板蓝根18g，蒲公英20g，黄芪25g，熟地黄25g，黄精20甘草20g，黄莲20g，中药发酵菌100ml，柠檬酸408g，水1000ml。
上述广谱抗菌剂的制备方法包括以下步骤：
（1）分别按上述重量称取黄柏，黄芩，板蓝根，蒲公英，黄芪，熟地黄，黄精，甘草，黄莲放入容器内并混合均匀；
（2）向容器内加入上述体积的水,煎煮4～5小时，过滤，得中药提取夜；
（3）在中药提取液中加入上述体积的发酵菌（夏天静置24小时，冬天静置3～5天），然后再加入上述重量的柠檬酸，即得所述广谱抗菌剂。
实施例2：本实施例的广谱抗菌剂，每1000ml所述广谱抗菌剂由以下原料制成：黄柏18g，黄芩18g，板蓝根16g，蒲公英18g，黄芪22g，熟地黄22g，黄精18 g，甘草18g，黄莲18g，中药发酵菌90ml，柠檬酸400g，水900ml。
本实施例的广谱抗菌剂的制备方法同实施例1。
实施例3：本实施例的广谱抗菌剂，每1000ml所述广谱抗菌剂由以下原料制成：黄柏24g，黄芩24g，板蓝根20g，蒲公英24g，黄芪28g，熟地黄28g，黄精22g，甘草22g，黄莲22g，中药发酵菌110ml，柠檬酸416g，水1100ml。
本实施例的广谱抗菌剂的制备方法同实施例1。
Claims (3)
1.广谱抗菌剂，其特征在于：每1000ml所述广谱抗菌剂由以下原料制成：黄柏18～24g，黄芩18～24g，板蓝根16～20g，蒲公英18～24g，黄芪22～28g，熟地黄22～28g，黄精18～22g，甘草18～22g ，黄莲18～22g ，中药发酵菌90～110ml，柠檬酸400～416g，水900～1100ml。
2.根据权利要求1所述的广谱抗菌剂，其特征在于：每1000ml所述广谱抗菌剂由以下原料制成：黄柏20g，黄芩20g，板蓝根18g，蒲公英20g，黄芪25g，熟地黄25g，黄精20 g，甘草20g，黄莲20g，中药发酵菌100ml，柠檬酸408g，水1000ml。
3.如权利要求1或2所述的广谱抗菌剂的制备方法：其特征在于：包括以下步骤：
分别按上述重量称取黄柏，黄芩，板蓝根，蒲公英，黄芪，熟地黄，黄精，甘草，黄莲放入容器内并混合均匀；
向容器内加入上述体积的水,煎煮4～5小时，过滤，得中药提取夜；
在中药提取液中加入上述体积的发酵菌（夏天静置24小时，冬天静置3～5天），然后再加入上述重量的柠檬酸，即得所述广谱抗菌剂。
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109908304A (zh) * | 2019-04-19 | 2019-06-21 | 揭从能 | 中药组合物及其用途、外用中药制剂及其制备方法 |
| CN111317772A (zh) * | 2020-03-12 | 2020-06-23 | 翟坚 | 一种杀菌抗病毒的药酒及其制备方法 |
| CN115364169A (zh) * | 2022-04-07 | 2022-11-22 | 中国科学院合肥物质科学研究院 | 抗幽门螺杆菌的中药组合物及其制备方法与应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109908304A (zh) * | 2019-04-19 | 2019-06-21 | 揭从能 | 中药组合物及其用途、外用中药制剂及其制备方法 |
| CN109908304B (zh) * | 2019-04-19 | 2021-07-27 | 揭从能 | 中药组合物及其用途、外用中药制剂及其制备方法 |
| CN111317772A (zh) * | 2020-03-12 | 2020-06-23 | 翟坚 | 一种杀菌抗病毒的药酒及其制备方法 |
| CN115364169A (zh) * | 2022-04-07 | 2022-11-22 | 中国科学院合肥物质科学研究院 | 抗幽门螺杆菌的中药组合物及其制备方法与应用 |
| CN115364169B (zh) * | 2022-04-07 | 2024-02-06 | 中国科学院合肥物质科学研究院 | 抗幽门螺杆菌的中药组合物及其制备方法与应用 |
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