CN1077641A - The Chinese patent medicine Naozhenning of treatment combined external head injuries - Google Patents
The Chinese patent medicine Naozhenning of treatment combined external head injuries Download PDFInfo
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- CN1077641A CN1077641A CN93100741A CN93100741A CN1077641A CN 1077641 A CN1077641 A CN 1077641A CN 93100741 A CN93100741 A CN 93100741A CN 93100741 A CN93100741 A CN 93100741A CN 1077641 A CN1077641 A CN 1077641A
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- naozhenning
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- 239000003814 drug Substances 0.000 title claims abstract description 39
- 238000011282 treatment Methods 0.000 title claims abstract description 11
- 206010019196 Head injury Diseases 0.000 title claims abstract description 5
- 210000000582 semen Anatomy 0.000 claims abstract description 30
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims abstract description 15
- 241000237636 Pheretima Species 0.000 claims abstract description 12
- 241000244155 Taenia Species 0.000 claims abstract description 12
- 239000000203 mixture Substances 0.000 claims description 7
- 239000002775 capsule Substances 0.000 claims description 3
- 239000002552 dosage form Substances 0.000 claims 3
- 230000000694 effects Effects 0.000 abstract description 9
- 230000017531 blood circulation Effects 0.000 abstract description 5
- 230000001737 promoting effect Effects 0.000 abstract description 5
- 210000005036 nerve Anatomy 0.000 abstract description 4
- 230000002490 cerebral effect Effects 0.000 abstract description 3
- 208000014674 injury Diseases 0.000 abstract description 3
- 244000052769 pathogen Species 0.000 abstract description 3
- 230000001717 pathogenic effect Effects 0.000 abstract description 3
- 210000000952 spleen Anatomy 0.000 abstract description 3
- 230000008733 trauma Effects 0.000 abstract description 3
- 230000036592 analgesia Effects 0.000 abstract description 2
- 230000000147 hypnotic effect Effects 0.000 abstract description 2
- 238000002560 therapeutic procedure Methods 0.000 abstract description 2
- 231100000419 toxicity Toxicity 0.000 abstract description 2
- 230000001988 toxicity Effects 0.000 abstract description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 239000008187 granular material Substances 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- 238000001256 steam distillation Methods 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- 239000000341 volatile oil Substances 0.000 description 6
- 239000000706 filtrate Substances 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 208000011580 syndromic disease Diseases 0.000 description 5
- 239000007788 liquid Substances 0.000 description 4
- 238000005303 weighing Methods 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 3
- 230000008014 freezing Effects 0.000 description 3
- 238000007710 freezing Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000023555 blood coagulation Effects 0.000 description 2
- 230000001914 calming effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- -1 filter Substances 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 208000029028 brain injury Diseases 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 238000005453 pelletization Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000012109 statistical procedure Methods 0.000 description 1
- 238000009495 sugar coating Methods 0.000 description 1
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- 210000001519 tissue Anatomy 0.000 description 1
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Abstract
A kind of Chinese patent medicine Naozhenning for the treatment of combined external head injuries, Chinese and western medicine does not all have the desirable medicine of special for treating combined external head injuries at present, the present invention has broken the Therapeutic Method of traditional traditional Chinese medical science to cerebral trauma, based on promoting blood circulation to remove obstruction in the collateral, invigorating the spleen to clear away damp pathogen, calm the nerves, Fructus Alpiniae Oxyphyllae is auxilliary, select the Radix Rehmanniae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Pheretima, Cortex Moutan, Radix Salviae Miltiorrhizae, Poria, Pericarpium Citri Reticulatae, Caulis Bambusae In Taenia, Semen Ziziphi Spinosae (parched), Semen Platycladi ten Chinese medicine is simply formed, obtained beyond thought curative effect, this medical instrument has hypnosis, calm, effect is told in analgesia and town, do not have any toxicity and side effect, clinical effective rate reaches more than 90%.
Description
The present invention is a kind of Chinese patent medicine for the treatment of postcerebrotraumatic syndrome.
Postcerebrotraumatic syndrome is a kind of commonly encountered diseases, symptoms such as most of patients has headache, dizziness, feels sick, vomiting, insomnia, but still there is not comparatively ideal medicine to treating this disease both at home and abroad at present, doctor trained in Western medicine does not have the medicine of special for treating cerebral trauma, can only symptomatic treatment (seeing high medical college teaching material " surgery " third edition that the People's Health Publisher publishes), then with the principle methods treatments of adopting warm medicine blood circulation promoting and blood stasis dispelling of " cold then blood clotting ", the curative effect majority is also unsatisfactory more for the traditional Chinese medical science.
The present invention aims to provide different special for treating postcerebrotraumatic syndrome of a kind of and traditional Chinese traditional treatment method and the high pure Chinese patent medicine preparation of curative effect.
For reaching above-mentioned purpose, every dose in preparation of the present invention is made up of following 11 flavor Chinese medicine ingredients:
Radix Rehmanniae 7-12g Radix Angelicae Sinensis 7-12g Rhizoma Chuanxiong 5-10g Pheretima 5-10g
Cortex Moutan 6-11g Radix Salviae Miltiorrhizae 15-20g Poria 10-15g Pericarpium Citri Reticulatae 10-15g
Caulis Bambusae In Taenia 6-11g Semen Ziziphi Spinosae (parched) 6-11g Semen Platycladi 6-11g
The treatment mechanism of above-mentioned prescription is: with promoting blood circulation to remove obstruction in the collateral treatment headache, dizziness, with invigorating the spleen to clear away damp pathogen treatment nausea and vomiting, with the benefiting intelligence and curing insomnia, forgetful of calming the nerves, its resultant effect helps the recovery of cerebral trauma.
For postcerebrotraumatic syndrome, because Traditional Chinese medical theory is thought " cold then blood clotting ", so all adopt the warm nature blood circulation promoting medicine to carry out activating blood and resolving stasis and treating, this prescription has then been broken this traditional Therapeutic Method, adopt " promoting blood circulation to remove obstruction in the collateral " to be aided with invigorating the spleen to clear away damp pathogen again, the method of Fructus Alpiniae Oxyphyllae of calming the nerves is executed and is controlled, and has obtained beyond thought therapeutic effect.
According to 484 routine clinical cases are observed, this medicine effective percentage reaches more than 90%, wherein 184 routine clinicaling curative effect contrast observation's materials to Shanxi Medical College's first Affiliated Hospital's department of neurology and People's Hospital of Shanxi Prov.'s department of neurology carry out statistical procedures, conclusion is: this medicine is extremely remarkable with the cure rate difference of Western medicine, P＜0.01, effective percentage (comprising cure rate and obvious effective rate) difference is extremely remarkable, P＜0.01.
According to pharmacological research, conclusion is: this medicine has hypnosis, calmness, analgesia and town to tell effect.
According to acute toxicity test, conclusion is: its mouse oral LD
50Greater than 25g/kg, illustrate that this medicine is extremely low to white mice toxicity.
A large amount of these medicines of clinical trial certificate are in the reparation that promotes the brain injury tissue, correct the not normal and controlling symptoms aspect of vegetative nerve positive effect is arranged, it is unified normally really to have reached elimination symptom and pathology functional rehabilitation, therefore obtained satisfied curative effect, the rare effective Chinese medicine of treatment postcerebrotraumatic syndrome both at home and abroad of being known as at present.
Embodiment 1, every dose prescription:
Radix Rehmanniae 7g Radix Angelicae Sinensis 8g Rhizoma Chuanxiong 5g Pheretima 6g Cortex Moutan 5g
Radix Salviae Miltiorrhizae 16g Poria 12g Pericarpium Citri Reticulatae 11g Caulis Bambusae In Taenia 6g Semen Ziziphi Spinosae (parched) 11g
Semen Platycladi 6g
Embodiment 2, every dose prescription:
Radix Rehmanniae 10g Radix Angelicae Sinensis 12g Rhizoma Chuanxiong 6g Pheretima 5g Cortex Moutan 6g
Radix Salviae Miltiorrhizae 19g Poria 15g Pericarpium Citri Reticulatae 15g Caulis Bambusae In Taenia 9g Semen Ziziphi Spinosae (parched) 9g
Semen Platycladi 8g
Embodiment 3, every dose prescription:
Radix Rehmanniae 12g Radix Angelicae Sinensis 10g Rhizoma Chuanxiong 9g Pheretima 9g Cortex Moutan 9g
Radix Salviae Miltiorrhizae 18g Poria 10g Pericarpium Citri Reticulatae 12g Caulis Bambusae In Taenia 10g Semen Ziziphi Spinosae (parched) 8g
Semen Platycladi 9g
Embodiment 4, every dose prescription:
Radix Rehmanniae 8g Radix Angelicae Sinensis 9g Rhizoma Chuanxiong 10g Pheretima 10g Cortex Moutan 10g
Radix Salviae Miltiorrhizae 20g Poria 13g Pericarpium Citri Reticulatae 14g Caulis Bambusae In Taenia 11g Semen Ziziphi Spinosae (parched) 6g
Semen Platycladi 10g
Embodiment 5, every dose prescription:
Radix Rehmanniae 9g Radix Angelicae Sinensis 7g Rhizoma Chuanxiong 8g Pheretima 8g Cortex Moutan 11g
Radix Salviae Miltiorrhizae 15g Poria 11g Pericarpium Citri Reticulatae 10g Caulis Bambusae In Taenia 8g Semen Ziziphi Spinosae (parched) 10g
Semen Platycladi 11g
Embodiment 6, take by weighing medicine by aforementioned formula, decoct with water concentratedly, make the Naozhenning decoct.
Embodiment 7,
(1): take by weighing medicine by aforementioned prescription composition.
(2): with being ground into coarse powder after the Radix Rehmanniae, the Poria oven dry, with Cortex Moutan, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Semen Ziziphi Spinosae (parched), the direct crushing screening of Semen Platycladi.
(3): after Cortex Moutan, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Rhizoma Chuanxiong be soaked in water 24 hours, carry out steam distillation, distillate freezing 24 hours is told volatile oil, medicinal residues behind the steam distillation, reuse decocting in water are carried three times, each one hour, merge medicinal liquid, filter, filtrate is condensed into paste, and is standby.
(4): with the Radix Rehmanniae, Radix Salviae Miltiorrhizae, Poria, Caulis Bambusae In Taenia (broken section), Semen Ziziphi Spinosae (parched), Pheretima, Semen Platycladi, carry three times with decocting in water respectively, each one hour, filter, filtrate merging be condensed into the thick paste shape, standby.
(5): the thick paste of (3), (4) step preparation with an amount of dextrin mixing, is added an amount of Icing Sugar, mixed pelletization secondary, 50 ℃ of oven dry of granule, granulate.
(6): with the granule behind the granulate, add volatile oil (earlier with the fine powder mixing behind the granulate), the fine powder mix homogeneously of described liquid medicine steam distillation gained of (3) step, place after 24 hours, be distributed into every bag of 15g.
Make the Naozhenning electuary with said method.
Embodiment 8,
(1): take by weighing medicine by aforementioned prescription composition.
(2): with being ground into coarse powder after the Radix Rehmanniae, the Poria oven dry, with Cortex Moutan, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Semen Ziziphi Spinosae (parched), the direct crushing screening of Semen Platycladi.
(3): after Cortex Moutan, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Rhizoma Chuanxiong be soaked in water 24 hours, carry out steam distillation, distillate freezing 24 hours is told volatile oil.Medicinal residues behind the steam distillation, reuse decocting in water are carried three times, and each one hour, merge medicinal liquid, filtration, filtrate and be condensed into paste, add appropriate amount of starch, dry, pulverized 80 mesh sieves, standby.
(4): with the Radix Rehmanniae, Radix Salviae Miltiorrhizae, Poria, Caulis Bambusae In Taenia (broken section), Semen Ziziphi Spinosae (parched), Pheretima, Semen Platycladi are carried three times with decocting in water respectively, and each one hour, 80 mesh sieves are crossed in dry, pulverizing, and were standby.
(5): two parts powder of above-mentioned (3), (4) described preparation is sieved, mix secondary.
(6): aforementioned (3) step gained volatile oil is added in the powder of mixing, mixed the back thoroughly airtight 24 hours, be sub-packed in the capsule then.
Make the Naozhenning capsule with said method.
Embodiment 9,
(1): take by weighing medicine by aforementioned prescription composition.
(2): with being ground into coarse powder after the Radix Rehmanniae, the Poria oven dry, with Cortex Moutan, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Semen Ziziphi Spinosae (parched), the direct crushing screening of Semen Platycladi.
(3): after Cortex Moutan, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Rhizoma Chuanxiong be soaked in water 24 hours, carry out steam distillation, distillate freezing 24 hours is told volatile oil.Medicinal residues behind the steam distillation, reuse decocting in water are carried three times, and each one hour, merge medicinal liquid, to filter, filtrate is condensed into paste, adds appropriate amount of starch, and drying was pulverized 80 mesh sieves, and was standby.
(4): with the Radix Rehmanniae, Radix Salviae Miltiorrhizae, Poria, Caulis Bambusae In Taenia (broken section), Semen Ziziphi Spinosae (parched), Pheretima, Semen Platycladi, carry three times with decocting in water respectively, each one hour, filter, filtrate merging be condensed into the thick paste shape, add appropriate amount of starch, dry, mistake 80 mesh sieves, standby.
(5): two parts raw material of (3), (4) described preparation is added appropriate amount of auxiliary materials, mixing, granulation, dry granulate, standby.
(6): above-mentioned (3) step gained volatile oil is added in the granule of mixing, mix back sealing 24 hours thoroughly, tabletting, sugar coating.
Make the Naozhenning tablet with said method.
Claims (6)
1, a kind of Chinese patent medicine Naozhenning for the treatment of combined external head injuries is characterized in that: this medicine by the Radix Rehmanniae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Pheretima, Cortex Moutan, Radix Salviae Miltiorrhizae, Poria, Pericarpium Citri Reticulatae, Caulis Bambusae In Taenia, Semen Ziziphi Spinosae (parched), Semen Platycladi ten simply Chinese medicine form.
2, Chinese patent medicine Naozhenning as claimed in claim 1 is characterized in that: described ten simply every dose of composition proportion of Chinese medicine be:
Radix Rehmanniae 7-12g Radix Angelicae Sinensis 7-12g Rhizoma Chuanxiong 5-10g
Pheretima 5-10g Cortex Moutan 6-11g Radix Salviae Miltiorrhizae 15-20g
Poria 10-15g Pericarpium Citri Reticulatae 10-15g Caulis Bambusae In Taenia 6-11g
Semen Ziziphi Spinosae (parched) 6-11g Semen Platycladi 6-11g
3, Chinese patent medicine Naozhenning as claimed in claim 1 or 2 is characterized in that: this medicine is the decoct dosage form.
4, Chinese patent medicine Naozhenning as claimed in claim 1 or 2 is characterized in that: this medicine is the electuary dosage form.
5, Chinese patent medicine Naozhenning as claimed in claim 1 or 2 is characterized in that: this medicine is the capsule dosage form.
6, Chinese patent medicine Naozhenning as claimed in claim 1 or 2 is characterized in that: this medicine is a Tabules.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN92111513 | 1992-10-09 | ||
| CH92111513.X | 1992-10-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1077641A true CN1077641A (en) | 1993-10-27 |
| CN1047524C CN1047524C (en) | 1999-12-22 |
Family
ID=4945382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93100741A Expired - Lifetime CN1047524C (en) | 1992-10-09 | 1993-01-01 | Chinese patent medicine, "Naozhenning" for treatment of brain trauma syndrome |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1047524C (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103386080A (en) * | 2013-07-08 | 2013-11-13 | 张秀菊 | Medicine composite for curing combined external head injuries in clinical nursing |
| CN105194311A (en) * | 2015-10-21 | 2015-12-30 | 孔德华 | Traditional Chinese medicine preparation for rehabilitation of brain trauma and preparation method thereof |
| CN106822611A (en) * | 2016-12-28 | 2017-06-13 | 华北理工大学 | A kind of Chinese medicine composition for nursing postcerebrotraumatic syndrome and preparation method thereof |
| CN107179380A (en) * | 2017-06-21 | 2017-09-19 | 山西振东安特生物制药有限公司 | Naozhenning TLC Identification |
| CN107184848A (en) * | 2017-06-19 | 2017-09-22 | 山西振东安特生物制药有限公司 | The new pharmaceutical use of Naozhenning preparation |
-
1993
- 1993-01-01 CN CN93100741A patent/CN1047524C/en not_active Expired - Lifetime
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103386080A (en) * | 2013-07-08 | 2013-11-13 | 张秀菊 | Medicine composite for curing combined external head injuries in clinical nursing |
| CN103386080B (en) * | 2013-07-08 | 2014-10-22 | 张秀菊 | Medicine composite for curing combined external head injuries in clinical nursing |
| CN105194311A (en) * | 2015-10-21 | 2015-12-30 | 孔德华 | Traditional Chinese medicine preparation for rehabilitation of brain trauma and preparation method thereof |
| CN106822611A (en) * | 2016-12-28 | 2017-06-13 | 华北理工大学 | A kind of Chinese medicine composition for nursing postcerebrotraumatic syndrome and preparation method thereof |
| CN107184848A (en) * | 2017-06-19 | 2017-09-22 | 山西振东安特生物制药有限公司 | The new pharmaceutical use of Naozhenning preparation |
| WO2018233471A1 (en) * | 2017-06-19 | 2018-12-27 | 山西振东安特生物制药有限公司 | New pharmaceutical use of naozhenning preparation |
| CN107184848B (en) * | 2017-06-19 | 2021-11-19 | 山西振东安特生物制药有限公司 | New pharmaceutical use of Naozhenning preparation |
| CN107179380A (en) * | 2017-06-21 | 2017-09-19 | 山西振东安特生物制药有限公司 | Naozhenning TLC Identification |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1047524C (en) | 1999-12-22 |
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Owner name: NONE Free format text: FORMER OWNER: TIAN CHENGXING Effective date: 20020708 Owner name: SHANXI ANTE BIOLOGICAL PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: WU GUOBIN |
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| C41 | Transfer of patent application or patent right or utility model | ||
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Effective date of registration: 20020708 Address after: No. 87, South inner ring street, Shanxi, Taiyuan Patentee after: Shanxi Ante Biological Pharmaceutical Co., Ltd. Address before: Shanxi worker's Medical College of Taiyuan city Shanxi Province Co-patentee before: Tian Chengxing Patentee before: Wu Guobin |
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Expiration termination date: 20130104 Granted publication date: 19991222 |