CN107744468B - Automatic sub-packaging system and sub-packaging method for radioactive isotope liquid medicine capsules - Google Patents
Automatic sub-packaging system and sub-packaging method for radioactive isotope liquid medicine capsules Download PDFInfo
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- CN107744468B CN107744468B CN201610742473.8A CN201610742473A CN107744468B CN 107744468 B CN107744468 B CN 107744468B CN 201610742473 A CN201610742473 A CN 201610742473A CN 107744468 B CN107744468 B CN 107744468B
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Abstract
The invention relates to an automatic sub-packaging system and an automatic sub-packaging method for a radioactive isotope liquid medicine capsule. The system comprises a support table and a shielding hot chamber arranged on the support table; a subpackaging platform is arranged in the hot chamber, and a robot, a subpackaging device, a pre-filled capsule tray assembly and a mother liquor circulating device connected with the subpackaging device through a power device are arranged on the subpackaging platform; the robot, the split charging device and the power device are all connected with the controller, and the controller controls the components to act according to the liquid medicine and the condition of a patient so as to realize the automatic quantitative split charging of the liquid medicine capsules. The isotope liquid medicine capsule automatic subpackaging system and the subpackaging method have the advantages of high automation degree, high production efficiency, high subpackaging precision, simplicity and convenience in operation and good shielding performance, and meanwhile, the system can select an economic mode or an efficient mode, provides a larger selection space for users with different requirements, and has great application value.
Description
Technical Field
The invention relates to the field of medicine subpackage, in particular to an automatic subpackage system and a subpackage method for a radioactive isotope liquid medicine capsule.
Background
The radioactive isotope medicament is widely applied to clinic, a plurality of methods can realize automatic dilution and subpackage of isotope liquid medicine, but the isotope liquid medicine is generally an oral solution which is finally taken by a patient after being subpackaged; oral solutions have many disadvantages, such as contamination and damage to the oral cavity, esophagus, etc., and in order to solve these problems, scholars at home and abroad have proposed a scheme of replacing oral solutions with capsules.
However, the production of the prior radioactive isotope liquid medicine capsule is basically still manual subpackage, and the manual subpackage capsule method has the following problems:
a. the dosage of isotope medicament components in the capsule is not accurate: too low affects the treatment effect, and too high may cause harm to the patient;
b. improper protection measures for the subpackaging personnel: if the protection is enough, the operation intensity is high, and if the operation intensity is reduced, the radioactivity protection is poor, and the mental stress of operators is high;
c. the subpackaging efficiency is low;
d. and the statistics of the relevant information of the patient are difficult.
Disclosure of Invention
The invention aims to provide an automatic sub-packaging system for a radioactive isotope liquid medicine capsule, which solves the problems that the existing isotope liquid medicine capsule cannot realize automatic sub-packaging and the existing sub-packaging technology is inaccurate, low in efficiency and improper in protection.
Another object of the present invention is to provide an automatic dispensing method of the above automatic dispensing system for radioisotope liquid medicine capsule.
The technical scheme for solving the technical problems is as follows: an automatic sub-packaging system for a radioactive isotope liquid medicine capsule comprises a supporting table and a shielding hot chamber arranged on the supporting table;
a split charging platform is arranged in the hot chamber, and a robot, a split charging device, a pre-filled capsule tray assembly and a mother liquor circulating device connected with the split charging device through a power device are arranged on the split charging platform;
the robot, the subpackaging device and the power device are all connected with a controller, and the controller controls the components to act according to the liquid medicine and the condition of a patient so as to realize automatic quantitative subpackaging of the liquid medicine capsules.
On the basis of the technical scheme, the invention can be further improved as follows.
Further, the automatic sub-packaging system for the radioisotope liquid medicine capsule further comprises two shielding transmission devices which are respectively arranged at one side and the lower end of the shielding hot chamber.
Further, the shielding transmission device is a shielding transmission chamber or a shielding transmission drawer; a side chamber shielding door is arranged on the shielding transfer chamber; and a shielding drawer cover plate is arranged on the shielding transmission drawer.
Furthermore, a lifting device connected with the controller is further arranged on the subpackaging platform, an activity measuring device is further arranged on the automatic subpackaging system, and the lifting device is connected with the activity measuring device in a matched manner;
the activity measuring apparatus includes an ionization well and an activity meter connected to the ionization well.
Further, the lifting device comprises a lifting device bracket and a lifting device bracket vertically connected to the lifting device bracket; at least one positioning hole is arranged in the lifting device bracket.
Further, the sub-packaging device comprises a sub-packaging device body, a sub-packaging needle base arranged in the sub-packaging device body and a sub-packaging needle fixed on the sub-packaging needle base. Further, the sub-packaging device further comprises a contact pin driving device arranged on the sub-packaging device main body and used for driving the sub-packaging needle base to move, and a clamping component arranged on the lower base of the sub-packaging device main body and used for clamping and fixing the capsule.
Further, the mother liquor circulating device comprises a mother liquor bottle, a mother liquor shielding tank for placing the mother liquor bottle, and a liquor taking needle, a reflux needle and an exhaust needle which are inserted on the mother liquor bottle; the liquid taking needle is connected with the power device through a pipeline and then connected to the split charging device; the reflux needle is connected with the split charging device.
Further, the pre-filled capsule tray assembly further comprises a shielding canister and a shielding canister plug.
Furthermore, still be equipped with hot chamber shield door and the organic glass door that has the glove port on the shielding hot chamber, be equipped with shielding formula peep hole on the hot chamber shield door.
Further, the power device is a pump group consisting of one or a plurality of peristaltic pumps.
The automatic subpackaging method of the automatic subpackaging system for the radioactive isotope liquid medicine capsule comprises the following steps:
calculating to obtain required dosage data of the liquid medicine subpackage according to the isotope liquid medicine mother liquor and the patient data, and outputting the data to a controller;
respectively arranging the mother liquor circulating device and the pre-filled capsule tray assembly to prepare the radioisotope liquid medicine mother liquor and the pre-filled capsule in place;
the controller controls the robot to clamp the pre-filled capsules from the pre-filled capsule tray assembly and move the pre-filled capsules to the sub-packaging device for sub-packaging so as to quantitatively inject the isotope liquid medicine into the pre-filled capsules;
the manipulator of controller control robot presss from both sides from filling in advance on the capsule tray subassembly and gets and fills in the capsule to move to the partial shipment device, the coordinated control power device carries out the partial shipment simultaneously, thereby pours into the isotope liquid medicine ration in filling in the capsule in advance.
Further, the automatic sub-packaging method of the automatic sub-packaging system for the radioisotope liquid medicine capsule further comprises the following steps:
the controller controls a manipulator of the robot to clamp the filled isotope capsule to the lifting device, and the lifting device transports the filled isotope capsule to the activity measuring equipment for measurement;
comparing the measurement result with the liquid medicine subpackaging dose data obtained by initial calculation, and if subpackaging is correct, directly clamping the capsule into a liquid medicine capsule tank tray set by the robot;
comparing the measurement result with the initially calculated required dosage data of the liquid medicine subpackage, and if the subpackage is correct, controlling the robot to directly clamp the capsule into a shielding tank of the pre-filled capsule tray assembly and covering a shielding plug;
and if the split charging is incorrect, controlling the robot to clamp the capsule to the initial position of the pre-filled capsule in the pre-filled capsule tray assembly, and correcting after the split charging of all capsules is finished.
Further, the specific method for sequentially arranging the mother liquor circulating device and the pre-filled capsule tray assembly comprises the following steps:
pulling out the shielding type transfer drawer, putting the mother liquor shielding tank in, and closing the shielding type transfer drawer;
opening a side chamber shielding door, placing the pre-filled capsule tray assembly into a shielding transfer chamber, and closing the side chamber shielding door;
opening a shielding door of the hot chamber, opening a shielding drawer cover plate through a glove hole on an organic glass door with the glove hole, taking out the mother liquor shielding tank, then covering the shielding drawer cover plate, and inserting a liquor taking needle, a reflux needle and an exhaust needle into a mother liquor bottle;
the pre-filled capsule tray assembly is then removed, slid to a predetermined position for securement, and the hot chamber shield door is closed.
Further, the specific method for performing split charging by adopting the split charging device comprises the following steps:
a manipulator of the robot clamps the pre-filled capsule from the pre-filled capsule tray assembly and moves the pre-filled capsule to a station of a sub-packaging device, the manipulator places the pre-filled capsule in a capsule positioning hole for positioning, the clamping device clamps and fixes the pre-filled capsule, and a contact pin driving device drives a sub-packaging needle base and a sub-packaging needle to insert the pre-filled capsule; according to the required dosage data of the liquid medicine subpackaging, a power device injects a quantitative solution into the prefilled capsule through the subpackaging needle;
after the injection is finished, the contact pin driving device drives the sub-packaging needle base and the sub-packaging needle to be pulled out of the pre-filled capsule and reset.
Further, the specific method for performing split charging by adopting the split charging device comprises the following steps:
a manipulator of the robot clamps the pre-filled capsule from the pre-filled capsule tray assembly and moves to a station of the subpackaging device, and the manipulator clamps the pre-filled capsule and moves vertically upwards until the pre-filled capsule is pierced by a subpackaging needle; according to the required dosage data of the liquid medicine subpackaging, the power device injects the quantitative isotope liquid medicine into the prefilled capsule through the subpackaging needle;
and after the injection is finished, the manipulator clamps the prefilled capsule and pulls out the prefilled capsule from the split charging needle.
The invention creatively realizes the full automation and the controllability of the split charging of the radioactive isotope liquid medicine capsule by arranging the automatic split charging system which comprises the robot, the split charging device controlled by the controller, the power device, the mother liquor circulating device and the like, so that the flexible production of the radioactive isotope capsule product is realized, and simultaneously, the dosage of each capsule can be automatically adjusted according to the requirement, thereby effectively realizing the safe, accurate and automatic production of the radioactive capsule.
By adopting the automatic subpackaging system, the nuclear radiation influence on operators is greatly reduced, and the safety of the production process is effectively improved; meanwhile, the sub-packaging of the capsules is effectively carried out according to the calculation result, the dosage of each capsule can be automatically adjusted according to the production process, the sub-packaging precision is higher, the flexibility is better, and the production efficiency is further greatly improved.
This system is through setting up the partial shipment device of isostructure for the partial shipment process can switch between economic mode and high-efficient mode, for the user provides bigger selection space, reduces partial accessory, reduce cost.
Drawings
FIG. 1 is a main structure view of an automatic sub-packaging system for radioisotope liquid medicine capsules according to the present invention;
FIG. 2 is a partial structural view of the automatic sub-packaging system for radioisotope liquid medicine capsule of the present invention;
FIG. 3 is a schematic structural diagram of the dispensing platform;
FIG. 4 is a schematic view of the lifting device;
FIG. 5 is a schematic structural diagram of the racking device in the high efficiency mode;
fig. 6 is a schematic structural diagram of the racking device in the economy mode.
In the drawings, the components represented by the respective reference numerals are listed below:
1. a shielded hot chamber; 11. a shielding type peep window; 12. a hot room shield door; 13. a plastic glazing door; 14. a side chamber isolation door; 15. a racking platform; 151. a lifting device; 1511. a lifting device bracket; 1512. a lifting device support; 1513. positioning holes; 152. a dispensing device; 1521. a pin driving device; 1522. a separate packaging device main body; 1523. a clamping member; 1524. capsule positioning holes; 1525. a split needle; 1526. a sub-packaging needle base; 153. a mother liquor circulating device; 1531. a liquid taking needle; 1532. a reflux needle; 1533. an exhaust needle; 1534. mother liquor bottle; 1535. a mother liquor shielding tank; 154. a peristaltic pump; 155. a robot; 1551. a manipulator; 156. a pre-filled capsule tray assembly; 1561. a shielding can plug; 1562. a shielding can; 1563. a tray; 2. a support table; 3. a shielded transmission drawer; 31. a shielding drawer cover plate; 4. a shielded transfer chamber; 41. a side room shield door; 5. an activity meter; 6. an ionization well; 7. A controller; 8. a shield ring.
Detailed Description
The principles and features of this invention are described below in conjunction with the following drawings, which are set forth by way of illustration only and are not intended to limit the scope of the invention.
Example 1: automatic sub-packaging system for radioactive isotope liquid medicine capsules
According to an embodiment of the present application, as shown in fig. 1 and 2, the automatic sub-packaging system for radioisotope liquid medicine capsules comprises a supporting platform 2, a shielding hot chamber 1 is arranged on the supporting platform 2, a shielding transfer chamber 4 is arranged on the right side of the shielding hot chamber 1, and a shielding transfer drawer 3 is arranged at the lower end of the shielding hot chamber 1; a side chamber shielding door 41 is arranged on the shielding transfer chamber 4; a shielding drawer cover plate 31 is arranged on the shielding transmission drawer 3; the shielding hot chamber 1 is also provided with a hot chamber shielding door 12 and an organic glass door 13 with a glove hole, and the hot chamber shielding door 12 is provided with a shielding type peeping window 11; a side chamber isolation door 14 is arranged at the joint of the shielding transfer chamber 4 and the shielding hot chamber 1; the exterior of the shielded hot room 1 can be provided with an activity measuring device; the activity measuring device comprises an ionization well 6 arranged in the lower space of the support platform 2 and an activity meter 5 arranged outside the shielding hot chamber; a shielding ring 8 can be further arranged in the space at the lower part of the support table 2, and the part of the ionization well 6 extending out of the shielding hot chamber is wrapped by the shielding ring to prevent nuclear radiation.
As shown in fig. 3, a dispensing platform 15 is arranged in the shielding hot chamber 1, and a robot 155, a dispensing device 152, a pre-filled capsule tray assembly 156, a power device and a mother liquor circulating device 153 are arranged on the dispensing platform 15; a controller 7 is arranged in the space at the lower part of the support table 2; the robot 155, the subpackaging device 152 and the power device are all connected with the controller 7; wherein, the robot 155 is provided with a manipulator 1551, and the controller 7 controls the manipulator to act;
in an embodiment of the present application, a lifting device 151 may be further disposed in the dispensing platform 15, and is connected with the activity measuring apparatus in a matching manner to measure the dispensed liquid medicine capsule, and perform related correction according to the measurement result; as shown in fig. 4, the lifting device 151 is composed of a lifting device bracket 1511 and a lifting device support 1512 vertically connected to the lifting device bracket, wherein one or more positioning holes 1513 are provided in the lifting device bracket 1511.
As shown in fig. 5, in an embodiment of the present application, the sub-packaging device 152 may be composed of a sub-packaging device main body 1522, a sub-packaging needle base 1526 disposed in the sub-packaging device main body, a sub-packaging needle 1525 fixed on the sub-packaging needle base, a needle inserting driving device 1521 for driving the sub-packaging needle base to move, a clamping member 1523 for clamping and fixing the capsule and a capsule positioning hole 1524 disposed on the lower base of the sub-packaging device main body, under the structure, the automatic sub-packaging system may be produced in a high efficiency mode, and the specific process is as follows:
the manipulator 1551 clamps the pre-filled capsule from the pre-filled capsule tray assembly 156 and moves the pre-filled capsule to the station of the sub-packaging device 152, the manipulator 1551 places the pre-filled capsule in the capsule positioning hole 1524 for positioning, the manipulator leaves, the clamping part 1523 clamps and fixes the pre-filled capsule, and the inserting needle driving device 1521 drives the sub-packaging needle base 1526 and the sub-packaging needle 1525 to insert into the pre-filled capsule; based on the calculation, the power unit injects a metered amount of solution through the dispensing needle 1525 into the pre-filled capsule;
after the injection is completed, the needle insertion driving device 1521 drives the dispensing needle base 1526 and the dispensing needle 1525 to be pulled out of the filled capsule and reset, thereby completing the efficient dispensing mode.
As shown in fig. 6, in an embodiment of the present application, the dispensing device can be composed of a dispensing device main body 1522, a dispensing needle base 1526 disposed in the dispensing device main body, and a dispensing needle 1525 fixed on the dispensing needle base, under this structure, the automatic dispensing system can be produced in an economic mode, and the specific process is:
the manipulator 1551 picks up the pre-filled capsules from the pre-filled capsule tray assembly 156 and moves the pre-filled capsules to the station of the sub-packaging device 152; at the station of the dispensing device 152, the manipulator 1551 holds the pre-filled capsule and moves vertically upwards until the pre-filled capsule is pierced by the dispensing needle 1525; based on the calculation, the power unit injects a metered amount of solution through the dispensing needle 1525 into the pre-filled capsule; after the injection is completed, the manipulator 1551 holds the filled capsule and pulls it out of the dispensing needle.
On the basis of the structure, when the system comprises the lifting device, the working process is as follows:
after the holding member 1523 releases the filled capsule, the manipulator 1551 holds the filled capsule to the lifting device 151 station; the manipulator 1551 places the filled capsules in the positioning holes 1513 of the lifting device bracket 1511, the manipulator 1551 leaves, and the lifting device bracket 1511 carries the filled capsules to descend into the ionization well 6 for measurement; after the measurement is completed, the lifting device bracket 1511 lifts up to the initial position carrying the filled capsule; and (3) comparing and analyzing the measurement result with the initially calculated required dosage data of the liquid medicine subpackaging:
if the split charging is not accurate and needs to be corrected, the manipulator 1551 clamps the filled capsules to be placed to the initial position on the pre-filled capsule tray assembly 156, and correction operation is performed after the split charging of all the capsules is finished;
if the correction is not needed, the manipulator 1551 clamps the filled capsule and puts the filled capsule into the shielding can 1562, and the manipulator 1551 clamps the shielding can plug 1561 to plug the container opening of the shielding can; stopping the machine until all capsules in the pre-filled capsule tray assembly 156 are completely filled, opening the hot chamber shielding door 12, opening the side chamber isolation door 14 through a glove hole on the organic glass door 13 with a glove hole, conveying the pre-filled capsule tray assembly 156 into the shielding transfer chamber 4, closing the side chamber isolation door 14, opening the side chamber shielding door 41, and taking out the pre-filled capsule tray assembly 156; and ending the complete capsule subpackaging process.
In one embodiment of the present application, the power device may be a pump set consisting of one or several peristaltic pumps 154 to provide power for pumping the mother liquid from the mother liquid bottle into the dispensing device; in this application, the power means may consist of a peristaltic pump 154.
In one embodiment of the present application, the mother liquor circulating device 153 may be composed of a mother liquor bottle 1534, a mother liquor shielding tank 1535 for placing the mother liquor bottle, a liquid extraction needle 1531 inserted on the mother liquor bottle, a reflux needle 1532 and a gas exhaust needle 1533; wherein, the liquid-taking needle 1531 is connected with the peristaltic pump 154 through a pipeline, the reflux needle 1532 is connected with the sub-packaging device 152, and the air-discharging needle 1533 is an empty needle and is not connected with any equipment; at the time of production, the mother liquor shield tank 1535 enters the shielded hot cell 1 through the shield transfer drawer 3.
In one embodiment of the present application, pre-filled capsule tray assembly 156 is comprised of a tray 1563, a number of shield cans 1562 disposed on the tray, a shield can plug 1561, and a number of pre-filled capsules; in production, the pre-filled capsule tray assembly 156 enters the shielded hot chamber 1 through the shielded transfer chamber 4.
Based on the specific structure of the mother liquor circulating device 153 and the pre-filled capsule tray assembly 156, when automatic sub-packaging is performed, the specific operation process is as follows:
pulling out the shielding transmission drawer 3, putting the mother liquor shielding tank 1535 with the mother liquor bottle 1534 into the drawer, and closing the shielding transmission drawer 3; opening the side compartment shielding door 41, placing the pre-filled capsule tray assembly 156 in, and closing the side compartment shielding door 41; opening a shielding door 12 of the hot chamber, opening a shielding drawer cover plate 31 through the operation of a glove hole on an organic glass door 13 with the glove hole, taking out the mother liquid shielding tank 1535, then covering the shielding drawer cover plate 31, inserting a liquid taking needle 1531, a reflux needle 1532 and an exhaust needle 1533 into the mother liquid bottle 1534, and straightening the pipeline; the side compartment isolation door 14 is opened, the pre-filled capsule tray assembly 156 is removed, slid to a predetermined position for securing, the side compartment isolation door 14 is closed, and the thermal compartment shielding door 41 is closed, ready for use.
Example 2: automatic subpackaging method of automatic subpackaging system for radioactive isotope liquid medicine capsules
The automatic subpackaging method of the automatic subpackaging system for the radioactive isotope capsules can be divided into working processes in a high-efficiency mode and an economic mode, and the working processes are as follows:
1. working process in efficient mode
Calculating to obtain data such as required dosage and volume of the liquid medicine subpackage according to the isotope liquid medicine mother liquor and the patient data, and outputting the data to the controller 7; the controller 7 calls data and then controls the robot and the cooperative equipment (such as the manipulator 1551, the lifting device 151, the power device, the mother liquor circulating device 153, the subpackaging device 152 and the like) of the relevant I \ O interface end to subpackage and measure, the measured data is measured by the activity measuring equipment, the measured data is judged, and then relevant operations such as correction or shipment are controlled, when a batch of capsules are produced, the pre-filled capsule tray assembly 156 is taken out from the shielding transfer chamber 4, then the process is ended, and the specific process is as follows:
pulling out the shielding transfer drawer 3, placing the mother liquor bottle 1534 into the mother liquor shielding tank 1535, placing the mother liquor shielding tank 1535 into the above drawer, and closing the shielding transfer drawer 3; opening the side compartment shielding door 41, placing the pre-filled capsule tray assembly 156 in, and closing the side compartment shielding door 41; opening a shielding door 12 of the hot chamber, opening a shielding drawer cover plate 31 through the operation of a glove hole on an organic glass door 13 with the glove hole, taking out the mother liquid shielding tank 1535, then covering the shielding drawer cover plate 31, inserting a liquid taking needle 1531, a reflux needle 1532 and an exhaust needle 1533 into the mother liquid bottle 1534, and straightening the pipeline; the side compartment isolation door 14 is opened, the pre-filled capsule tray assembly 156 is removed, slid into a predetermined position for securement, and then the side compartment isolation door 14 is closed and the thermal compartment shielding door 12 is closed.
The manipulator 1551 clamps the pre-filled capsule from the pre-filled capsule tray assembly 156 and moves the pre-filled capsule to the station of the sub-packaging device 152, the manipulator 1551 places the pre-filled capsule in the capsule positioning hole 1524 for positioning, the manipulator leaves, the clamping part 1523 clamps and fixes the pre-filled capsule, and the inserting needle driving device 1521 drives the sub-packaging needle base 1526 and the sub-packaging needle 1525 to insert into the pre-filled capsule; based on the calculation, the peristaltic pump 154 injects a metered amount of solution through the dispensing needle 1525 into the pre-filled capsule;
after the injection is finished, the needle inserting driving device 1521 drives the sub-packaging needle base 1526 and the sub-packaging needle 1525 to be pulled out of the filled capsule and reset;
after the holding member 1523 releases the filled capsule, the manipulator 1551 holds the filled capsule to the lifting device 151 station; the manipulator 1551 places the filled capsules in the positioning holes 1513 of the lifting device bracket 1511, the manipulator 1551 leaves, and the lifting device bracket 1511 carries the filled capsules to descend into the ionization well 6 for measurement; the lifting device cradle 1511 lifts the filled capsule to the initial position;
judging the measurement result, if the split charging is not accurate, the manipulator 1551 needs to be corrected to clamp the filled capsule to be placed to the initial position on the pre-filled capsule tray assembly 156, and correction operation is performed after the split charging of all capsules is finished; if the capsule is not needed to be corrected, the manipulator clamp 1551 holds the filled capsule and puts the filled capsule into the shielding can 1562, and the manipulator 1551 clamps the shielding can plug 1561 to plug the container opening of the shielding can 1562; stopping the machine until all capsules in the pre-filled capsule tray assembly 156 are completely filled, opening the hot chamber shielding door 12, opening the side chamber isolation door 14 through a glove hole on the organic glass door 13 with a glove hole, conveying the pre-filled capsule tray assembly 156 into the shielding transfer chamber 4, closing the side chamber isolation door 14, opening the side chamber shielding door 41, and taking out the pre-filled capsule tray assembly 156; and ending the complete capsule subpackaging process.
2. Working process in economic mode
The operation in the economy mode is substantially the same as that in the high efficiency mode, the only difference being the difference in the operation due to the difference in the configuration of the dispensing apparatus, which has been explained in the description of the system of embodiment 1, and which is not repeated here.
In conclusion, the invention provides a set of isotope liquid medicine capsule automatic subpackaging system and a subpackaging method which have the advantages of high automation degree, high production efficiency, high subpackaging precision, simplicity and convenience in operation and good shielding performance, and meanwhile, the system can select an economic mode or an efficient mode, provides a larger selection space for users with different requirements, and has great application value.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (10)
1. The automatic sub-packaging system for the radioactive isotope liquid medicine capsule is characterized by comprising a support table and a shielding hot chamber arranged on the support table;
a subpackaging platform is arranged in the hot chamber, and a manipulator, a subpackaging device, a pre-filled capsule tray assembly and a mother liquor circulating device connected with the subpackaging device through a power device are arranged on the subpackaging platform;
the manipulator, the split charging device and the power device are all connected with a controller, and the controller controls the manipulator, the split charging device and the power device to act according to the liquid medicine and the patient condition so as to realize automatic quantitative split charging of the liquid medicine capsules;
the pre-filled capsule tray assembly comprises a tray and a number of pre-filled capsules placed on the tray, the pre-filled capsule tray assembly further comprising a shielded canister and a shielded canister plug;
two shielding transmission devices are respectively arranged at one side and the lower end of the shielding hot chamber, and the shielding transmission devices are a shielding transmission chamber and a shielding transmission drawer; a side chamber shielding door is arranged on the shielding transfer chamber, a shielding drawer cover plate is arranged on the shielding transfer drawer, a hot chamber shielding door and an organic glass door with a glove hole are also arranged on the shielding hot chamber, and a shielding type peeping window is arranged on the hot chamber shielding door;
the split charging device comprises a split charging device main body, a split charging needle base arranged in the split charging device main body and a split charging needle fixed on the split charging needle base; the sub-packaging device also comprises a contact pin driving device which is arranged on the sub-packaging device main body and is used for driving the sub-packaging needle base to move, and a clamping component which is arranged on the lower base of the sub-packaging device main body and is used for clamping and fixing the capsule;
the manipulator clamps the pre-filled capsule from the pre-filled capsule tray assembly and moves the pre-filled capsule to a station of the split charging device, the manipulator places the pre-filled capsule in a capsule positioning hole for positioning, the clamping device clamps and fixes the pre-filled capsule, and the contact pin driving device drives the split charging needle base and the split charging needle to insert the pre-filled capsule; or the manipulator clamps the pre-filled capsule from the pre-filled capsule tray assembly and moves the pre-filled capsule to a station of the split charging device, and the manipulator clamps the pre-filled capsule and moves the pre-filled capsule vertically upwards until the pre-filled capsule is pierced by the split charging needle;
the controller controls the manipulator to clamp the filled isotope capsules to the lifting device, and the lifting device conveys the filled isotope capsules to the activity measuring equipment for measurement;
and comparing the measurement result with the initially calculated required dosage data of the liquid medicine subpackage, and if the subpackage is correct, controlling the manipulator to directly clamp the capsule to a shielding tank of the pre-filled capsule tray assembly and cover a shielding plug.
2. An automatic sub-packaging system for radioisotope liquid medicine capsules as claimed in claim 1,
the subpackaging platform is also provided with a lifting device connected with the controller, and the lifting device is matched and connected with the activity measuring equipment;
the activity measuring apparatus includes an ionization well and an activity meter connected to the ionization well.
3. The automatic sub-packaging system for radioisotope liquid medicine capsules as claimed in claim 2, wherein: the lifting device comprises a lifting device bracket and a lifting device bracket vertically connected to the lifting device bracket; at least one positioning hole is arranged in the lifting device bracket.
4. The automatic sub-packaging system of a radioisotope liquid medicine capsule as claimed in claim 1, wherein said mother liquid circulating means comprises a mother liquid bottle, a mother liquid shielding can for housing the mother liquid bottle, and a liquid taking needle, a return needle and an exhaust needle inserted in the mother liquid bottle; the liquid taking needle is connected with the power device through a pipeline and then connected to the split charging device; the reflux needle is connected with the split charging device.
5. An automatic sub-packaging system for radioisotope liquid medicine capsules as claimed in claim 1, wherein said power means is a pump unit comprising one or more peristaltic pumps.
6. An automatic separate-charging method for an automatic separate-charging system for a radioisotope liquid medicine capsule as claimed in any one of claims 1 to 5, comprising:
calculating to obtain required dosage data of the liquid medicine subpackage according to the isotope liquid medicine mother liquor and the patient data, and outputting the data to a controller;
respectively arranging the mother liquor circulating device and the pre-filled capsule tray assembly to prepare the radioisotope liquid medicine mother liquor and the pre-filled capsule in place;
the controller controls the manipulator to clamp the pre-filled capsule from the pre-filled capsule tray assembly and move the pre-filled capsule tray assembly to a sub-packaging device for sub-packaging so as to quantitatively inject the isotope liquid medicine into the pre-filled capsule; or
The controller controls the manipulator to clamp the pre-filled capsule from the pre-filled capsule tray assembly and move to the sub-packaging device, and the power device is controlled in a linkage mode to perform sub-packaging, so that the isotope liquid medicine is quantitatively injected into the pre-filled capsule.
7. The automatic separate-charging method of an automatic separate-charging system for a radioisotope liquid medicine capsule as claimed in claim 6, further comprising:
and if the measurement result of the filled isotope capsule is compared with the liquid medicine subpackaging dose data obtained by initial calculation and the subpackaging is incorrect, controlling the manipulator to clamp the capsule to the initial position of the prefilled capsule in the prefilled capsule tray assembly, and correcting after the subpackaging of all the capsules is finished.
8. The automatic dispensing method of an automatic radioisotope liquid medicine capsule dispensing system as claimed in claim 6, wherein said specific method of arranging said mother liquor circulating means and pre-filling said capsule tray assembly comprises:
pulling out the shielding transfer drawer, putting the mother liquor shielding tank in, and closing the shielding transfer drawer; opening the side chamber shield door, placing the pre-filled capsule tray assembly into the shielded transfer chamber, and closing the side chamber shield door; opening a shielding door of the hot chamber, opening a shielding drawer cover plate through a glove hole in an organic glass door with the glove hole, taking out the mother liquor shielding tank, then covering the shielding drawer cover plate, and inserting a liquor taking needle, a reflux needle and an exhaust needle into a mother liquor bottle; the pre-filled capsule tray assembly is then removed, slid to a predetermined position for securement, and the hot chamber shield door is then closed.
9. The automatic separate loading method of an automatic separate loading system for a radioisotope liquid medicine capsule as claimed in claim 6, wherein the specific method of separate loading by the separate loading means comprises:
according to the required dosage data of the split charging of the liquid medicine obtained by the initial calculation, the power device injects a quantitative solution into the pre-filled capsule through the split charging needle; after the injection is finished, the contact pin driving device drives the sub-packaging needle base and the sub-packaging needle to be pulled out of the pre-filled capsule and reset.
10. The automatic separate loading method of an automatic separate loading system for a radioisotope liquid medicine capsule as claimed in claim 6, wherein the specific method of separate loading by the separate loading means comprises:
according to the required dosage data of the liquid medicine subpackaging obtained by initial calculation, a power device injects the quantitative isotope liquid medicine into the prefilled capsule through a subpackaging needle; and after the injection is finished, the manipulator clamps the prefilled capsule and pulls out the prefilled capsule from the split charging needle.
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| CN108542780B (en) * | 2018-05-22 | 2024-04-09 | 原子高科股份有限公司 | Automatic dripping preparation device for radiotherapy capsules |
| CN110600155B (en) * | 2018-08-21 | 2020-10-27 | 河南双辐科技股份有限公司 | Logging isotope capsule and split charging device used for same |
| CN111965687B (en) * | 2020-08-26 | 2022-08-05 | 山西医科大学 | Activity detection station |
| CN112817037A (en) * | 2020-12-28 | 2021-05-18 | 江苏万略医药科技有限公司 | Device and method for rapidly measuring and calculating activity of radioactive drug |
| CN113484903B (en) * | 2021-07-26 | 2023-07-14 | 天津核安科技有限公司 | Movable ionization well protection operating means of activity meter |
| CN113860241B (en) * | 2021-09-30 | 2022-10-18 | 江苏超敏科技有限公司 | Nuclide partial shipment device |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201594401U (en) * | 2009-12-30 | 2010-09-29 | 上海欣科医药有限公司 | Purifying and ventilating cabinet for operating radioactive substance |
| CN104554841A (en) * | 2014-11-21 | 2015-04-29 | 程鹏志 | Radiopharmaceutical automatic split charging process method and system |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002311526A (en) * | 2001-04-11 | 2002-10-23 | Canon Inc | X-ray image photographing device |
| WO2007112413A2 (en) * | 2006-03-27 | 2007-10-04 | Neology, Inc. | Systems and methods for managing inventory of items held in a cabinet using radio frequency identification (rfid) |
| US7750328B2 (en) * | 2006-10-27 | 2010-07-06 | Draximage General Partnership | Filling system for potentially hazardous materials |
| CN103416998A (en) * | 2012-05-19 | 2013-12-04 | 陈新明 | Household medicine cabinet |
| CN104095405A (en) * | 2013-04-08 | 2014-10-15 | 葛乐恒 | Novel desk |
| CN204022834U (en) * | 2014-08-16 | 2014-12-17 | 宋涛 | New virus detector |
-
2016
- 2016-08-29 CN CN201610742473.8A patent/CN107744468B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201594401U (en) * | 2009-12-30 | 2010-09-29 | 上海欣科医药有限公司 | Purifying and ventilating cabinet for operating radioactive substance |
| CN104554841A (en) * | 2014-11-21 | 2015-04-29 | 程鹏志 | Radiopharmaceutical automatic split charging process method and system |
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