CN107744147A - A kind of cellulose base spacetabs type liposoluble vitamin piece and preparation method thereof - Google Patents
A kind of cellulose base spacetabs type liposoluble vitamin piece and preparation method thereof Download PDFInfo
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- CN107744147A CN107744147A CN201710987814.2A CN201710987814A CN107744147A CN 107744147 A CN107744147 A CN 107744147A CN 201710987814 A CN201710987814 A CN 201710987814A CN 107744147 A CN107744147 A CN 107744147A
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- Prior art keywords
- cellulose
- vitamin
- piece
- spacetabs type
- liposoluble
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- 229920002678 cellulose Polymers 0.000 title claims abstract description 51
- 229940088594 vitamin Drugs 0.000 title claims abstract description 47
- 229930003231 vitamin Natural products 0.000 title claims abstract description 47
- 235000013343 vitamin Nutrition 0.000 title claims abstract description 47
- 239000011782 vitamin Substances 0.000 title claims abstract description 47
- 239000001913 cellulose Substances 0.000 title claims abstract description 44
- 150000003722 vitamin derivatives Chemical class 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title abstract description 5
- -1 hexadecane epoxide Chemical class 0.000 claims abstract description 19
- DCAYPVUWAIABOU-UHFFFAOYSA-N alpha-n-hexadecene Natural products CCCCCCCCCCCCCCCC DCAYPVUWAIABOU-UHFFFAOYSA-N 0.000 claims abstract description 18
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 10
- 229920001249 ethyl cellulose Polymers 0.000 claims abstract description 10
- 235000019325 ethyl cellulose Nutrition 0.000 claims abstract description 10
- 239000008101 lactose Substances 0.000 claims abstract description 10
- 239000001856 Ethyl cellulose Substances 0.000 claims abstract description 4
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims abstract description 4
- 235000010980 cellulose Nutrition 0.000 claims description 48
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 22
- 239000002585 base Substances 0.000 claims description 20
- 239000002131 composite material Substances 0.000 claims description 16
- 239000000843 powder Substances 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- HNTGIJLWHDPAFN-UHFFFAOYSA-N 1-bromohexadecane Chemical compound CCCCCCCCCCCCCCCCBr HNTGIJLWHDPAFN-UHFFFAOYSA-N 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 10
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical class [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 10
- 235000019359 magnesium stearate Nutrition 0.000 claims description 8
- 235000020985 whole grains Nutrition 0.000 claims description 8
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 238000009413 insulation Methods 0.000 claims description 6
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 4
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 3
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 3
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 235000019155 vitamin A Nutrition 0.000 claims description 3
- 239000011719 vitamin A Substances 0.000 claims description 3
- 229940045997 vitamin a Drugs 0.000 claims description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- 229930003316 Vitamin D Natural products 0.000 claims description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 2
- 229930003427 Vitamin E Natural products 0.000 claims description 2
- 229930003448 Vitamin K Natural products 0.000 claims description 2
- 239000003513 alkali Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000006266 etherification reaction Methods 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 235000019166 vitamin D Nutrition 0.000 claims description 2
- 239000011710 vitamin D Substances 0.000 claims description 2
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 2
- 235000019165 vitamin E Nutrition 0.000 claims description 2
- 229940046009 vitamin E Drugs 0.000 claims description 2
- 239000011709 vitamin E Substances 0.000 claims description 2
- 235000019168 vitamin K Nutrition 0.000 claims description 2
- 239000011712 vitamin K Substances 0.000 claims description 2
- 150000003721 vitamin K derivatives Chemical class 0.000 claims description 2
- 229940046008 vitamin d Drugs 0.000 claims description 2
- 229940046010 vitamin k Drugs 0.000 claims description 2
- 238000005406 washing Methods 0.000 claims description 2
- 235000013305 food Nutrition 0.000 abstract description 13
- 235000016709 nutrition Nutrition 0.000 abstract description 5
- 238000013268 sustained release Methods 0.000 abstract description 5
- 239000012730 sustained-release form Substances 0.000 abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 5
- 239000008346 aqueous phase Substances 0.000 abstract description 4
- 239000011258 core-shell material Substances 0.000 abstract description 3
- 230000035764 nutrition Effects 0.000 abstract description 3
- 229940079593 drug Drugs 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract description 2
- 239000008104 plant cellulose Substances 0.000 abstract description 2
- 230000002269 spontaneous effect Effects 0.000 abstract description 2
- 230000008685 targeting Effects 0.000 abstract description 2
- 239000000428 dust Substances 0.000 abstract 1
- 238000004140 cleaning Methods 0.000 description 4
- 239000002893 slag Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 235000005152 nicotinamide Nutrition 0.000 description 2
- 239000011570 nicotinamide Substances 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000009881 electrostatic interaction Effects 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 239000011785 micronutrient Substances 0.000 description 1
- 235000013369 micronutrients Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 230000010148 water-pollination Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The present invention relates to a kind of cellulose base spacetabs type liposoluble vitamin piece and preparation method thereof, belong to technical field of food healthcare.The present invention is prepared using natural plant cellulose spontaneous the amphiphilic cellulosic micella with core-shell structure is formed in aqueous phase system, with good stability, amphiphilic cellulosic micella can significantly lift dispersiveness or solubility of the lyophobic dust in aqueous phase system simultaneously, and there is certain sustained release, targeted delivery function, progressively absorb water to form drug release skeleton by hexadecane epoxide cellulose, ethyl cellulose meets water and forms block layer, lactose dissolves rapidly, small delivery aperture is formed on slow-releasing system, three influences each other, control the release of vitamin, reach liposoluble vitamin sustained release, targeting is taken and nutrition, the purpose of Food fortification.
Description
Technical field
The present invention relates to a kind of cellulose base spacetabs type liposoluble vitamin piece and preparation method thereof, belong to health care of food skill
Art field.
Background technology
Vitamin is a kind of micro-content organism that humans and animals maintain normal physiological function and must obtained from food
Matter, played an important role in growth in humans, metabolism, growth course.Vitamin is a huge family, known today
Vitamin just has tens kinds, is broadly divided into fat-soluble and water-soluble two major class.Liposoluble vitamin mainly includes VA, VD, VE
And VK.VA and VD major storages are in liver, and VE is mainly stored in internal adipose tissue, and VK storages are less.They are human body institutes
The micro-nutrient composition needed, there is very important effect to the physiological activity of human body.
Food enrichment is to be added to the natural or people in food to increase the nutritional ingredient of food (value)
The nutrient and other nutritional ingredients of work synthesis.According to GB14880-2012《National food safety standard food enrichment
Use standard》, nutrition fortifier is broadly divided into the three major types such as vitamins, mineral matter class and amino acid and aliphatic acid.Dimension life
Element is that body maintains a kind of nutrient necessary to its normal life, and its species is a lot, and chemical constitution is different, molten generally according to its
Solution property is divided into fat-soluble and water-soluble two major class, and liposoluble vitamin has vitamin A, D, K, E etc.；Water soluble vitamin has dimension
Sheng Su B races (B1, B2, nicotinic acid and niacinamide usp, B6, pantothenic acid, biotin, folic acid, B12 etc.) and vitamin C etc..Vitamin is most not
It can synthesize in vivo, or synthetic quantity is little, storage capacity in vivo is also seldom, it is therefore necessary to often by food supply.It is fat-soluble
Vitamin dissolubility is poor, and stability is poor, and bioavailability is low, need to frequently take, and inconvenience is brought to user.If from outer
Vitamin intake deficiency in boundary's food, human body cannot normal development growth, or even specific diseases i.e. vitamin can occur and lack
Weary disease.Therefore, the fortification for how improving liposoluble vitamin in food is significant.
The content of the invention
The technical problems to be solved by the invention：Poor for liposoluble vitamin dissolubility, stability is poor, bioavailability
It is low, need to frequently it take, the problem of bringing inconvenience to user, there is provided a kind of cellulose base spacetabs type liposoluble vitamin
Piece and preparation method thereof.
In order to solve the above technical problems, the technical solution adopted by the present invention is：
A kind of cellulose base spacetabs type liposoluble vitamin piece, the multivitamin as described in following weight multivitamin by following
Raw material forms：100 ~ 200 parts of composite powders, 10 ~ 20 parts of liposoluble vitamins, 10 ~ 20 parts of magnesium stearates.
The composite powder is 50 ~ 60 parts by weight hexadecane epoxide celluloses, 20 ~ 30 parts by weight ethyl celluloses, 10 ~ 30
Parts by weight of lactose, ground 100 mesh sieve are made.
The hexadecane epoxide cellulose is that etherification reaction, filtering occur after alkali lye activates with bromohexadecane for cellulose
Washing is made after drying.
The mass ratio of the cellulose and bromohexadecane is 5：1~20：1.
The liposoluble vitamin is the one or more in vitamin A, vitamin D, vitamin E and vitamin K.
Described a kind of cellulose base spacetabs type liposoluble vitamin piece, it is characterised in that concretely comprise the following steps：
（1）Take cellulose to be immersed in sodium hydroxide solution, 20 ~ 30min stirred at 30 ~ 35 DEG C, adds bromohexadecane,
Filter, wash, dry after 3 ~ 5h of insulation reaction, obtain hexadecane epoxide cellulose；
（2）Hexadecane epoxide cellulose, ethyl cellulose, lactose are taken, is fitted into grinder and grinds, 100 mesh sieves is crossed, obtains composite powder
Material；
（3）Composite powder is dissolved in ethanol solution, adds liposoluble vitamin, 1 ~ 3h is dried after being well mixed, refills
Enter in kneader and pelletize, and cross 24 mesh sieve whole grains, be well mixed and be placed in tablet press machine with magnesium stearate after the completion of whole grain, suppress
Piece agent, obtain cellulose base spacetabs type liposoluble vitamin piece.
Compared with other method, advantageous effects are the present invention：
The present invention utilizes the features such as cheap natural plant cellulose, safety, good biocompatibility, fast and easily modified biodegradation
Prepare spontaneous can form the amphiphilic cellulosic micella with core-shell structure in aqueous phase system, and its kernel has hydrophobicity, outside
Shell has a hydrophily, unique structure assign hydrophobic interaction in core-shell structure cellulose micelle kernel between hydrophobic group,
It is quiet between hydrogen bond and electrostatic interaction and micella particle in shell between hydrophilic chain or between hydrophilic chain and hydrone
Electric interactions reach dynamic equilibrium, have good stability, at the same amphiphilic cellulosic micella can significantly be lifted it is thin
Dispersiveness or solubility of the aqueous substance in aqueous phase system, and with certain sustained release, targeted delivery function, pass through hexadecane
Epoxide cellulose progressively absorbs water to form drug release skeleton, and ethyl cellulose meets water and forms block layer, and lactose dissolves rapidly, in sustained release
Fasten to form small delivery aperture, three influences each other, and controls the release of vitamin, reaches liposoluble vitamin sustained release, targeting is taken
Purpose is obtained with nutrition, Food fortification.
Embodiment
100 ~ 200g celluloses are taken, it is in 10% sodium hydroxide solution, at 30 ~ 35 DEG C to add 400 ~ 800mL mass fractions
Under, 20 ~ 30min is stirred with 300 ~ 400r/min, 10 ~ 20g bromohexadecanes is added, 3 ~ 5h of insulation reaction, is cooled to room temperature
After filter to obtain filter residue, filter residue is washed with deionized to cleaning solution in neutrality, then is transferred in drying box, is done at 105 ~ 110 DEG C
It is dry to constant weight, obtain hexadecane epoxide cellulose, take 50 ~ 60g hexadecane epoxide celluloses, 20 ~ 30g ethyl celluloses, 10 ~ 30g
Lactose, it is fitted into grinder and grinds, cross 100 mesh sieves, obtain composite powder, take 1 ~ 2g composite powders, adding 4 ~ 8g mass fractions is
In 50 ~ 75% ethanol solutions, 30 ~ 40min is stirred with 200 ~ 300r/min, adds 100 ~ 200mg liposoluble vitamins, is mixed
It is placed in after uniformly in drying box, 1 ~ 3h is dried at 50 ~ 60 DEG C, is reloaded into kneader and pelletizes, and crosses 24 mesh sieve whole grains, then with
It is placed in after 0.1 ~ 0.2g magnesium stearates are well mixed in tablet press machine, it is tabletted, obtain the fat-soluble dimension life of cellulose base spacetabs type
Plain piece.
Example 1
100g celluloses are taken, it is in 10% sodium hydroxide solution to add 400mL mass fractions, at 30 DEG C, is stirred with 300r/min
20min, 10g bromohexadecanes are added, insulation reaction 3h, filter residue is filtered to obtain after being cooled to room temperature, filter is washed with deionized
Slag to cleaning solution is in neutrality, then is transferred in drying box, is dried at 105 DEG C to constant weight, obtains hexadecane epoxide cellulose, take 50g
Hexadecane epoxide cellulose, 20g ethyl celluloses, 10g lactose, it is fitted into grinder and grinds, crosses 100 mesh sieves, obtain composite powder,
1g composite powders are taken, it is in 50% ethanol solution to add 4g mass fractions, stirs 30min with 200r/min, adds 100mg fat
Soluble vitamin, it is placed in after well mixed in drying box, 1h is dried at 50 DEG C, is reloaded into kneader and pelletizes, and crosses 24 mesh
Whole grain is sieved, then is placed in after being well mixed with 0.1g magnesium stearates in tablet press machine, it is tabletted, obtain cellulose base spacetabs type liposoluble
Property multivitamin.
Example 2
150g celluloses are taken, it is in 10% sodium hydroxide solution to add 600mL mass fractions, at 32 DEG C, is stirred with 350r/min
25min, 15g bromohexadecanes are added, insulation reaction 4h, filter residue is filtered to obtain after being cooled to room temperature, filter is washed with deionized
Slag to cleaning solution is in neutrality, then is transferred in drying box, is dried at 107 DEG C to constant weight, obtains hexadecane epoxide cellulose, take 55g
Hexadecane epoxide cellulose, 25g ethyl celluloses, 20g lactose, it is fitted into grinder and grinds, crosses 100 mesh sieves, obtain composite powder,
1g composite powders are taken, it is in 63% ethanol solution to add 6g mass fractions, stirs 35min with 250r/min, adds 150mg fat
Soluble vitamin, it is placed in after well mixed in drying box, 2h is dried at 55 DEG C, is reloaded into kneader and pelletizes, and crosses 24 mesh
Whole grain is sieved, then is placed in after being well mixed with 0.15g magnesium stearates in tablet press machine, it is tabletted, obtain cellulose base spacetabs type fat
Soluble vitamin piece.
Example 3
200g celluloses are taken, it is in 10% sodium hydroxide solution to add 800mL mass fractions, at 35 DEG C, is stirred with 400r/min
30min, 20g bromohexadecanes are added, insulation reaction 5h, filter residue is filtered to obtain after being cooled to room temperature, filter is washed with deionized
Slag to cleaning solution is in neutrality, then is transferred in drying box, is dried at 110 DEG C to constant weight, obtains hexadecane epoxide cellulose, take 60g
Hexadecane epoxide cellulose, 30g ethyl celluloses, 30g lactose, it is fitted into grinder and grinds, crosses 100 mesh sieves, obtain composite powder
Material, 2g composite powders are taken, it is in 75% ethanol solution to add 8g mass fractions, stirs 40min with 300r/min, adds 200mg
Liposoluble vitamin, it is placed in after well mixed in drying box, 3h is dried at 60 DEG C, is reloaded into kneader and pelletizes, and crosses 24
Mesh sieve whole grain, then be placed in after being well mixed with 0.2g magnesium stearates in tablet press machine, it is tabletted, obtain cellulose base spacetabs type fat
Soluble vitamin piece.
Cellulose base spacetabs type liposoluble vitamin piece prepared by the present invention and the fat-soluble dimension of Guizhou company production
Raw plain piece is detected, specific testing result such as following table table 1：
The cellulose base spacetabs type liposoluble vitamin piece performance of table 1 characterizes
A kind of cellulose base spacetabs type liposoluble vitamin piece that as shown in Table 1 prepared by the present invention, stability is good, and loss late is low,
Solubility is low, and slow-release time length is not required to frequently take, and is brought convenience to user.
Claims (6)
1. a kind of cellulose base spacetabs type liposoluble vitamin piece, it is characterised in that the multivitamin is by following weight
Part raw material composition：100 ~ 200 parts of composite powders, 10 ~ 20 parts of liposoluble vitamins, 10 ~ 20 parts of magnesium stearates.
A kind of 2. cellulose base spacetabs type liposoluble vitamin piece as claimed in claim 1, it is characterised in that the composite powder
Expect for 50 ~ 60 parts by weight hexadecane epoxide celluloses, 20 ~ 30 parts by weight ethyl celluloses, 10 ~ 30 parts by weight of lactose it is ground
100 mesh sieves are made.
A kind of 3. cellulose base spacetabs type liposoluble vitamin piece as claimed in claim 2, it is characterised in that the hexadecane
Epoxide cellulose is that etherification reaction occurs after alkali lye activates with bromohexadecane for cellulose, and filtration washing is made after drying.
A kind of 4. cellulose base spacetabs type liposoluble vitamin piece as claimed in claim 3, it is characterised in that the cellulose
Mass ratio with bromohexadecane is 5：1~20：1.
5. a kind of cellulose base spacetabs type liposoluble vitamin piece as claimed in claim 1, it is characterised in that described fat-soluble
Vitamin is the one or more in vitamin A, vitamin D, vitamin E and vitamin K.
A kind of 6. cellulose base spacetabs type liposoluble vitamin piece as described in claim 1 ~ 5 any one, it is characterised in that
Concretely comprise the following steps：
（1）Take cellulose to be immersed in sodium hydroxide solution, 20 ~ 30min stirred at 30 ~ 35 DEG C, adds bromohexadecane,
Filter, wash, dry after 3 ~ 5h of insulation reaction, obtain hexadecane epoxide cellulose；
（2）Hexadecane epoxide cellulose, ethyl cellulose, lactose are taken, is fitted into grinder and grinds, 100 mesh sieves is crossed, obtains composite powder
Material；
（3）Composite powder is dissolved in ethanol solution, adds liposoluble vitamin, 1 ~ 3h is dried after being well mixed, refills
Enter in kneader and pelletize, and cross 24 mesh sieve whole grains, be well mixed and be placed in tablet press machine with magnesium stearate after the completion of whole grain, suppress
Piece agent, obtain cellulose base spacetabs type liposoluble vitamin piece.
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