CN106420629A - Branched chain amino acid preparation and preparation method and application thereof - Google Patents
Branched chain amino acid preparation and preparation method and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
Abstract
The invention relates to branched chain amino acid granules which comprise branched chain amino acid powder, a coating agent and a corrigent. As the outer layer of the branched chain amino acid powder is coated with the suitable coating agent and corrigent and the grain size of the branched chain amino acid granules ranges from 400 micrometers to 600 micrometers intensively, with the bitter taste hidden, the branched chain amino acid granules can dissolve in water rapidly and can be taken as a medicine or nutritious supplementary with good compliance. Besides, the branched chain amino acid granules can be prepared into other types of preparations and can be taken as medicine, food and health product.
Description
Technical field
The invention belongs to preparation technique field, it is specifically related to a kind of branched-amino acid supplement and preparation method thereof and answers
With.
Background technology
Branched-chain amino acid (BCAA) refers to the neutral amino acid containing branched aliphatic hydrocarbon chain on α-carbon, including leucine, different
Leucine and valine, belong to the essential amino acid of body.Branched-chain amino acid plays a significant role during muscle metabolism,
It is mainly reflected in the release promoting insulin and growth hormone.Branched-chain amino acid accounts for forming required amino in skeletal muscle protein
The 35% of acid content, can provide energy for muscle, also can promote myogenesis by Humoral immunity, can also protect flesh simultaneously
Group, prevents muscle mass.
Leucine is slightly molten in water, isoleucine and valine water soluble.The solubility of branched-chain amino acid with leucine,
Isoleucine is different with the proportioning of valine three and different.Branched-chain amino acid is odorless but has the white powder of special bitter taste.
At present, the main product of the branched-chain amino acid on market is mainly capsule, such as Optimum branched-chain amino acid
Capsule MEGA-SIZE BCAA and soft capsule MET-RX branched-chain amino acid capsule 2200, this two kinds of products are with the shape of capsule
Formula covers the bad bitter taste of branched-chain amino acid, increased the compliance taken, but is the failure to realize branched-chain amino acid quickly water-soluble
Property.
A kind of extrusion of Patent No. 201310507806.5 produces instant branched-chain amino acid.This patent is first by lecithin
Mix with branched-chain amino acid, then pelletized using twin-screw dry granulating machine, finally separate different size of with cyclone separator
Grain.The unstable lecithin of this method character of use and adopt dry granulation, can produce substantial amounts of heat because of friction in preparation process
Amount, causes tremendous influence to the stability of product.In addition, the particle diameter that the preparation method of this instant branched-chain amino acid is obtained particle divides
Cloth scope is larger, therefore needs to carry out gradation using cyclone separator further, and energy consumption is larger, and fails to solve branched-amino
The problem of the bad bitter taste of acid.
Content of the invention
Based on this, it is an object of the invention to provide a kind of being capable of branched-amino acid supplement that is quickly water-soluble and covering bitter taste
And its preparation method and application.
The concrete technical scheme realizing above-mentioned purpose is as follows：
A kind of branched-amino granulates, including branched-chain amino acid powder, coating agent and flavouring, described branched-chain amino acid powder
The mass ratio 0.8-1.2 of isoleucine, leucine and valine in end:2-2.2:1, described coating agent is selected from starch, gelatin, second
At least one in base cellulose, methylcellulose or HPMC, described branched-chain amino acid powder is coated with described
The mass ratio of agent is 40-80:1.
Wherein in an embodiment, described coating agent is at least in HPMC or methylcellulose
Kind.
Wherein in an embodiment, described coating agent is the mixture of HPMC E5 and methylcellulose,
The mass percent of described HPMC E5 and described methylcellulose is 70%-50%:30%-50%.
Wherein in an embodiment, described branched-chain amino acid powder is 55-65 with the mass ratio of described coating agent:1.
Wherein in an embodiment, the median particle diameter of described branched-chain amino acid powder is 20-75 μm.
Wherein in an embodiment, described flavouring is selected from least one in Aspartame or Sucralose.
The preparation method of above-mentioned branched-amino granulates, comprises the steps：
(1) preparation is coated liquid：Described coating agent and described flavouring are dissolved or is dispersed in solvent, obtain final product；
(2) preheat：Described branched-chain amino acid powder is splined in fluidisation cylinder, pre-heating technique parameter is set, is preheated；
(3) pelletize and be dried：The described liquid that is coated is splined in fluid bed, granulating process parameter is set, is coated described
Liquid is sprayed onto to be formed on branched-chain amino acid powder with the speed of homogeneous constant by top spray and is coated particle, and is dried simultaneously；
(4) medicine sieve whole grain, obtains final product described branched-amino granulates.
Wherein in an embodiment, described pre-heating technique parameter is 58-62 DEG C of EAT, fan delivery 58-62m3/
hr；
Described granulating process parameter is 58-62 DEG C of EAT, fan delivery 58-62m3/ hr, atomizing pressure 1.5-
2.0kg/m3, liquid supply speed 30-50rpm.
Application in preparing medicine, food or health products for the above-mentioned branched-amino granulates.
A kind of branched-chain amino acid tablet, is prepared from through compressing tablet by above-mentioned branched-amino granulates and disintegrant, lubricant；
Described disintegrant is sodium carboxymethyl starch, and described lubricant is magnesium stearate.
Branched-amino granulates of the present invention and preparation method thereof have advantages below and beneficial effect：
Branched-amino granulates of the present invention on the outer layer covers of branched-chain amino acid powder suitable coating agent and
Flavouring, particle diameter integrated distribution, at 400-600 μm, can effectively be sheltered the bitter taste of branched-chain amino acid, be capable of side chain simultaneously
Amino acid quickly water-soluble, directly can eat as medicine or nutritious supplementary pharmaceutical, compliance is good.Especially when fine using hydroxypropyl
When the one or two kinds of of dimension element and methylcellulose is as coating agent, the dissolution time of branched-amino granulates 89-97s it
Between, faster, its yield is up to 91%-96% to rate of dissolution simultaneously, and the mobility of particle might as well.
Branched-chain amino acid tablet of the present invention has higher hardness, can fater disintegration, can be used as nutrition pressure
Piece candy etc. is taken.
Specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
1st, test material
Leucine, isoleucine and valine, Wuxi Jinghai Amino Acid Co., Ltd.；
Starch, Liaoning Dongyuan County medicine company；
HPMC E5, Huzhou Zhanwang Pharmaceutical Co., Ltd.；
HPMC E15, Huzhou Zhanwang Pharmaceutical Co., Ltd.；
Methylcellulose, Dow Chemical Company；
Ethyl cellulose, ASHLAND company；
Gelatin, Shandong Yi Xin bio tech ltd；
Sucralose, JK Sucralose Inc；
Sodium carboxymethyl starch, Beilun In Ningbo Ya Xu Chemical Co., Ltd.；
Magnesium stearate, medicine company is looked forward in Huzhou；
95% ethanol, Hunan Er-kang Pharmaceutical Co., Ltd.；
Purified water, self-control.
2nd, the preparation of branched-amino granulates
Embodiment 1
By isoleucine, leucine and valine according to mass ratio 1:2.2:1 mixes formation branched-chain amino acid powder
(median particle diameter is 20-75 μm).Weigh branched-chain amino acid powder 1500g, HPMC E5 20g, Sucralose respectively
2.5g and purified water 450g.Purified water is heated to 80 DEG C, the HPMC E5 of recipe quantity and Sucralose side are stirred
Mixing side adds dissolving acquisition in hot purified water to be coated liquid, is cooled to room temperature, standby.
In multifunctional fluidized bed for the branched-chain amino acid powder addition of recipe quantity, pre-heating technique parameter, EAT are set
60 DEG C, fan delivery 62m3/ hr, preheats 5 minutes.To be coated liquid be splined on multifunctional fluidized bed in, setting multifunctional fluidized bed
Granulating process parameter, fan delivery 62m3/ hr, 60 DEG C of EAT, atomizing pressure 1.6kg/, liquid supply speed 40rpm, will
It is coated liquid and is sprayed onto to be formed on branched-chain amino acid powder with the speed of homogeneous constant and be coated particle, and be dried simultaneously, treat moisture
After content reaches less than 1%, sieve whole grain with 30 mesh pharmacopeia, obtain final product.
Embodiment 2
By isoleucine, leucine and valine according to mass ratio 0.9:2.1:1 mixes formation branched-chain amino acid powder
End (median particle diameter is 20-75 μm).Weigh branched-chain amino acid powder 1500g, HPMC E15 20g, trichlorine respectively
Sucrose 2.5g and purified water 450g.Purified water is heated to 80 DEG C, by the HPMC E15 of recipe quantity and Sucralose
Add dissolving acquisition in hot purified water to be coated liquid while stirring, be cooled to room temperature, standby.
In multifunctional fluidized bed for the branched-chain amino acid powder addition of recipe quantity, pre-heating technique parameter, EAT are set
60 DEG C, fan delivery 60m3/ hr, preheats 5 minutes.To be coated liquid be splined on multifunctional fluidized bed in, setting multifunctional fluidized bed
Granulating process parameter, fan delivery 60m3/ hr, 60 DEG C of EAT, atomizing pressure 1.6kg/, liquid supply speed 40rpm, will
It is coated liquid and is sprayed onto to be formed on branched-chain amino acid powder with the speed of homogeneous constant and be coated particle, and be dried simultaneously, treat moisture
After content reaches less than 1%, sieve whole grain with 30 mesh pharmacopeia, obtain final product.
Embodiment 3
By isoleucine, leucine and valine according to mass ratio 1:2.2:1 mixes formation branched-chain amino acid powder
(median particle diameter is 20-75 μm).Weigh respectively branched-chain amino acid powder 1500g, methylcellulose 30g, Sucralose 2.5g and
Purified water 500g.Purified water is heated to 80 DEG C, the methylcellulose of recipe quantity and Sucralose are added heat pure while stirring
Change in water and dissolve, dispersed acquisition is coated liquid, is cooled to room temperature, standby.
In multifunctional fluidized bed for the branched-chain amino acid powder addition of recipe quantity, pre-heating technique parameter, EAT are set
60 DEG C, fan delivery 60m3/ hr, preheats 5 minutes.To be coated liquid be splined on multifunctional fluidized bed in, setting multifunctional fluidized bed
Granulating process parameter, fan delivery 60m3/ hr, 60 DEG C of EAT, atomizing pressure 1.6kg/, liquid supply speed 40rpm, will
It is coated liquid and is sprayed onto to be formed on branched-chain amino acid powder with the speed of homogeneous constant and be coated particle, and be dried simultaneously, treat moisture
After content reaches less than 1%, sieve whole grain with 30 mesh pharmacopeia, obtain final product.
Embodiment 4
By isoleucine, leucine and valine according to mass ratio 1.1:2.1:1 mixes formation branched-chain amino acid powder
End (median particle diameter is 20-75 μm).Weigh branched-chain amino acid powder 1500g, HPMC E5 17.5g, methyl respectively
Cellulose 7.5g, Sucralose 2.5g and purified water 500g.Purified water is heated to 80 DEG C, by the hydroxypropyl methylcellulose of recipe quantity
Plain E5, methylcellulose and Sucralose add dissolving in hot purified water while stirring, and dispersed acquisition is coated liquid, is cooled to
Room temperature, standby.
In multifunctional fluidized bed for the branched-chain amino acid powder addition of recipe quantity, pre-heating technique parameter, EAT are set
60 DEG C, fan delivery 60m3/ hr, preheats 5 minutes.To be coated liquid be splined on multifunctional fluidized bed in, setting multifunctional fluidized bed
Granulating process parameter, fan delivery 60m3/ hr, 60 DEG C of EAT, atomizing pressure 1.6kg/, liquid supply speed 40rpm, will
It is coated liquid and is sprayed onto to be formed on branched-chain amino acid powder with the speed of homogeneous constant and be coated particle, and be dried simultaneously, treat moisture
After content reaches less than 1%, sieve whole grain with 30 mesh pharmacopeia, obtain final product.
Embodiment 5
By isoleucine, leucine and valine according to mass ratio 1:2:1 mix formation branched-chain amino acid powder (in
Value particle diameter is 20-75 μm).Weigh branched-chain amino acid powder 1500g, HPMC E5 12.5g, Methyl cellulose respectively
Plain 12.5g, Sucralose 2.5g and purified water 500g.Purified water is heated to 80 DEG C, by the HPMC of recipe quantity
E5, methylcellulose and Sucralose add dissolving in hot purified water while stirring, and dispersed acquisition is coated liquid, is cooled to room
Temperature, standby.
In multifunctional fluidized bed for the branched-chain amino acid powder addition of recipe quantity, pre-heating technique parameter, EAT are set
60 DEG C, fan delivery 59m3/ hr, preheats 5 minutes.To be coated liquid be splined on multifunctional fluidized bed in, setting multifunctional fluidized bed
Granulating process parameter, fan delivery 59m3/ hr, 60 DEG C of EAT, atomizing pressure 1.6kg/, liquid supply speed 40rpm, will
It is coated liquid and is sprayed onto to be formed on branched-chain amino acid powder with the speed of homogeneous constant and be coated particle, and be dried simultaneously, treat moisture
After content reaches less than 1%, sieve whole grain with 30 mesh pharmacopeia, obtain final product.
Embodiment 6
By isoleucine, leucine and valine according to mass ratio 0.9:2.1:1 mixes formation branched-chain amino acid powder
End (median particle diameter is 20-75 μm).Weigh branched-chain amino acid powder 1500g, starch 35g, Sucralose 2.5g and purifying respectively
Water 1200g.Purified water is heated to about 90 DEG C, the starch of recipe quantity and Sucralose is added in hot purified water, while stirring
Add, after being coated liquid and be dispersed, standby.
In multifunctional fluidized bed for the branched-chain amino acid powder addition of recipe quantity, pre-heating technique parameter, EAT are set
60 DEG C, fan delivery 60m3/ hr, preheats 5 minutes.To be coated liquid be splined on multifunctional fluidized bed in, setting multifunctional fluidized bed
Granulating process parameter, fan delivery 60m3/ hr, 60 DEG C of EAT, atomizing pressure 1.6kg/, liquid supply speed 40rpm, will
It is coated liquid and is sprayed onto to be formed on branched-chain amino acid powder with the speed of homogeneous constant and be coated particle, and be dried simultaneously, treat moisture
After content reaches less than 1%, sieve whole grain with 30 mesh pharmacopeia, obtain final product.
Embodiment 7
By isoleucine, leucine and valine according to mass ratio 1:2.1:1 mixes formation branched-chain amino acid powder
(median particle diameter is 20-75 μm).Weigh respectively branched-chain amino acid powder 1500g, ethyl cellulose 30g, Sucralose 2.5g and
95% ethanol 855g.The ethyl cellulose of recipe quantity and Sucralose are added in 95% ethanol, adds while stirring, uniformly divide
Obtain after dissipating and be coated liquid, standby.
In multifunctional fluidized bed for the branched-chain amino acid powder addition of recipe quantity, pre-heating technique parameter, EAT are set
60 DEG C, fan delivery 60m3/ hr, preheats 5 minutes.To be coated liquid be splined on multifunctional fluidized bed in, setting multifunctional fluidized bed
Granulating process parameter, fan delivery 60m3/ hr, 60 DEG C of EAT, atomizing pressure 1.6kg/, liquid supply speed 40rpm, will
It is coated liquid and is sprayed onto to be formed on branched-chain amino acid powder with the speed of homogeneous constant and be coated particle, and be dried simultaneously, treat moisture
After content reaches less than 1%, sieve whole grain with 30 mesh pharmacopeia, obtain final product.
Embodiment 8
By isoleucine, leucine and valine according to mass ratio 1.1:2.1:1 mixes formation branched-chain amino acid powder
End (median particle diameter is 20-75 μm).Weigh branched-chain amino acid powder 1500g, gelatin 35g, Sucralose 2.5g and purifying respectively
Water 620g.The gelatin of recipe quantity and Sucralose are added in purified water, adds while stirring, after being coated liquid clear,
Standby.
In multifunctional fluidized bed for the branched-chain amino acid powder addition of recipe quantity, pre-heating technique parameter, EAT are set
60 DEG C, fan delivery 60m3/ hr, preheats 5 minutes.To be coated liquid be splined on multifunctional fluidized bed in, setting multifunctional fluidized bed
Granulating process parameter, fan delivery 60m3/ hr, 60 DEG C of EAT, atomizing pressure 1.6kg/, liquid supply speed 40rpm, will
It is coated liquid and is sprayed onto to be formed on branched-chain amino acid powder with the speed of homogeneous constant and be coated particle, and be dried simultaneously, treat moisture
After content reaches less than 1%, sieve whole grain with 30 mesh pharmacopeia, obtain final product.
3rd, the performance test of branched-amino granulates
Branched-chain amino acid particle dissolution rates assay method：The branched-amino granulates 1g taking the various embodiments described above respectively adds
Enter in the purified water of 100mL, under the conditions of 25 DEG C, speed of agitator controls in 250 ± 10r/min, statistics is completely dissolved required time,
And attempt liquid taste.
Micromeritis is carried out to the branched-amino granulates of the various embodiments described above using BT-1001 intelligence Powder Physical tester
Test.
Dependence test result is as shown in table 1：
Table 1
Can be seen that all can effectively be coated after adopted coating agent and flavouring mixing according to experimental data in table 1 and prop up
Chain amino acid powder.Above-mentioned branched-amino granulates quickly can dissolve in water, can effectively shelter branched-chain amino acid
Bitter taste.Preferably, using HPMC and methylcellulose one or two kinds of as coating agent when, dissolution time
Between 89-97s, faster, the yield of branched-amino granulates is up to 91%-96%, and the flowing of particle to rate of dissolution simultaneously
Property is preferable.Especially, when being compounded from HPMC E5 and methylcellulose, the dissolution time of branched-amino granulates
Shorter, yield highest, mobility might as well simultaneously.
Particle is coated using the branched-chain amino acid of fluid bed top spray granulation preparation and sieves after whole grains by 30 mesh medicines, particle diameter is concentrated
400-600 μm, process stabilizing, product yield high it is adaptable to industrialized production.Furthermore it is also possible to will prepare in above-described embodiment
Good branched-chain amino acid is particles filled to make capsule it is adaptable to require supplementation with the colony of branched-chain amino acid in capsule shells, permissible
Directly as medicine, food or health products to improve organism physiology metabolic function.
4th, the preparation of branched-chain amino acid tablet and performance
Weigh branched-amino granulates 970g, disintegrant 25g and the lubricant 5g that above-described embodiment prepares.By side chain
Amino acid granular is mixed with sodium carboxymethyl starch, adds magnesium stearate and mixes, is pressed with rotary tablet machine
Piece, obtains final product branched-chain amino acid tablet.
After testing, hardness 5-7kg/cm of branched-chain amino acid tablet2, unilateral smooth clean and tidy, friability ＜ 0.1%, disintegration
2 minutes time limits.The branched-chain amino acid tablet of the method preparation, has higher hardness, can fater disintegration, supplementary product consumption is little,
Safe, can take as nutrition pressed candy etc..
In sum, branched-amino granulates of the present invention adopt fluid-bed marumerization method, in branched-chain amino acid
The outer layer covers of powder have upper suitable coating agent and flavouring, and particle diameter concentrates 400-600 μm, may be implemented in instant soon in water
Solution, and shelter its bitter taste, directly can eat as medicine or nutritious supplementary pharmaceutical, compliance is good.Above-described embodiment preparation simultaneously obtains
Branched-amino granulates there is good mobility and compressibility, even particle size distribution and relatively concentrating, one can be entered
Step is made into other preparation types, can take it is adaptable to industrialized production as medicine, food and health products.
Each technical characteristic of embodiment described above can arbitrarily be combined, for making description succinct, not to above-mentioned reality
The all possible combination of each technical characteristic applied in example is all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all it is considered to be the scope of this specification record.
Embodiment described above only have expressed the several embodiments of the present invention, and its description is more concrete and detailed, but simultaneously
Can not therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
Say, without departing from the inventive concept of the premise, some deformation can also be made and improve, these broadly fall into the protection of the present invention
Scope.Therefore, the protection domain of patent of the present invention should be defined by claims.
Claims (10)
1. a kind of branched-amino granulates are it is characterised in that include branched-chain amino acid powder, coating agent and flavouring, described
The mass ratio 0.8-1.2 of isoleucine, leucine and valine in chain amino acid powder:2-2.2:1, described coating agent is selected from and forms sediment
At least one in powder, gelatin, ethyl cellulose, methylcellulose or HPMC, described branched-chain amino acid powder
Mass ratio with described coating agent is 40-80:1.
2. branched-amino granulates according to claim 1 are it is characterised in that described coating agent is HPMC
Or at least one of methylcellulose.
3. branched-amino granulates according to claim 2 are it is characterised in that described coating agent is HPMC
E5 and the mixture of methylcellulose, the mass percent of described HPMC E5 and described methylcellulose is
70%-50%：30%-50%.
4. branched-amino granulates according to claim 3 are it is characterised in that described branched-chain amino acid powder and described bag
It is 55-65 by the mass ratio of agent:1.
5. branched-amino granulates according to claim 1 are it is characterised in that the average grain of described branched-chain amino acid powder
Footpath is 20-75 μm.
6. branched-amino granulates according to any one of claim 1 to 5 are it is characterised in that described flavouring is selected from
At least one in Aspartame or Sucralose.
7. the preparation method of the branched-amino granulates any one of claim 1 to 6 is it is characterised in that include as follows
Step：
(1) preparation is coated liquid：Described coating agent and described flavouring are dissolved or is dispersed in solvent, obtain final product；
(2) preheat：Described branched-chain amino acid powder is splined in fluidisation cylinder, pre-heating technique parameter is set, is preheated；
(3) pelletize and be dried：The described liquid that is coated is splined in fluid bed, granulating process parameter is set, the described liquid that is coated is led to
Cross top spray and be sprayed onto to be formed on branched-chain amino acid powder with the speed of homogeneous constant and be coated particle, and be dried simultaneously；
(4) medicine sieve whole grain, obtains final product described branched-amino granulates.
8. the preparation method of branched-amino granulates according to claim 7 is it is characterised in that described pre-heating technique parameter
For 58-62 DEG C of EAT, fan delivery 58-62m3/hr；
Described granulating process parameter is 58-62 DEG C of EAT, fan delivery 58-62m3/ hr, atomizing pressure 1.5-2.0kg/m3,
Liquid supply speed 30-50rpm.
9. the answering in preparing medicine, food or health products of the branched-amino granulates any one of claim 1 to 6
With.
10. a kind of branched-chain amino acid tablet is it is characterised in that by the branched-chain amino acid any one of claim 1 to 6
Grain is prepared from through compressing tablet with disintegrant, lubricant；Described disintegrant is sodium carboxymethyl starch, and described lubricant is stearic acid
Magnesium.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108244321A (en) * | 2017-12-29 | 2018-07-06 | 陕西思尔生物科技有限公司 | A kind of pressed candy for being effectively improved branched-chain amino acid bitter taste and preparation method thereof |
| CN108260788A (en) * | 2017-12-29 | 2018-07-10 | 陕西思尔生物科技有限公司 | A kind of jam for being effectively improved branched-chain amino acid bitter taste and preparation method thereof |
| CN108283314A (en) * | 2017-11-30 | 2018-07-17 | 新疆阜丰生物科技有限公司 | One kind containing L-Glutamine and three branched-chain amino acid compound health products and preparation method thereof |
| CN109619383A (en) * | 2018-12-13 | 2019-04-16 | 张家港中宝生物技术有限公司 | A kind of preparation method of compound amino acid |
| CN109846045A (en) * | 2019-01-23 | 2019-06-07 | 南京泛成生物科技有限公司 | Branched-chain amino acid instant powder formula and preparation method |
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| US20080305151A1 (en) * | 2005-09-20 | 2008-12-11 | Kyowa Hakko Kogyo Co., Ltd. | Dipeptide-Comprising Composition for Oral Administration |
| CN102772370A (en) * | 2007-07-31 | 2012-11-14 | 味之素株式会社 | Amino-acid-containing medicinal granular preparation highly easy to take |
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| US20080305151A1 (en) * | 2005-09-20 | 2008-12-11 | Kyowa Hakko Kogyo Co., Ltd. | Dipeptide-Comprising Composition for Oral Administration |
| CN102772370A (en) * | 2007-07-31 | 2012-11-14 | 味之素株式会社 | Amino-acid-containing medicinal granular preparation highly easy to take |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108283314A (en) * | 2017-11-30 | 2018-07-17 | 新疆阜丰生物科技有限公司 | One kind containing L-Glutamine and three branched-chain amino acid compound health products and preparation method thereof |
| CN108244321A (en) * | 2017-12-29 | 2018-07-06 | 陕西思尔生物科技有限公司 | A kind of pressed candy for being effectively improved branched-chain amino acid bitter taste and preparation method thereof |
| CN108260788A (en) * | 2017-12-29 | 2018-07-10 | 陕西思尔生物科技有限公司 | A kind of jam for being effectively improved branched-chain amino acid bitter taste and preparation method thereof |
| CN109619383A (en) * | 2018-12-13 | 2019-04-16 | 张家港中宝生物技术有限公司 | A kind of preparation method of compound amino acid |
| CN109846045A (en) * | 2019-01-23 | 2019-06-07 | 南京泛成生物科技有限公司 | Branched-chain amino acid instant powder formula and preparation method |
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