CN107741400B - Sample detecting system of IVD external detection equipment - Google Patents
Sample detecting system of IVD external detection equipment Download PDFInfo
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- CN107741400B CN107741400B CN201711128470.6A CN201711128470A CN107741400B CN 107741400 B CN107741400 B CN 107741400B CN 201711128470 A CN201711128470 A CN 201711128470A CN 107741400 B CN107741400 B CN 107741400B
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- light
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- top cover
- optical fibers
- receiving
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- 238000001514 detection method Methods 0.000 title claims abstract description 23
- 239000013307 optical fiber Substances 0.000 claims abstract description 89
- 230000003287 optical effect Effects 0.000 claims abstract description 23
- 238000000338 in vitro Methods 0.000 claims abstract description 14
- 229910052736 halogen Inorganic materials 0.000 claims description 5
- 150000002367 halogens Chemical class 0.000 claims description 5
- 230000004544 DNA amplification Effects 0.000 abstract description 6
- 210000004369 blood Anatomy 0.000 abstract description 3
- 239000008280 blood Substances 0.000 abstract description 3
- 239000007788 liquid Substances 0.000 abstract description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000004543 DNA replication Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000002038 chemiluminescence detection Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 238000002331 protein detection Methods 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Plasma & Fusion (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The invention discloses a sample detection system of IVD in-vitro detection equipment, wherein an optical signal collection device comprises a top cover, a plurality of incident optical fibers which are arranged on the lower surface of the top cover at equal intervals in parallel, and a plurality of receiving optical fibers which are arranged above the top cover; a plurality of light-emitting cut openings which are arranged at equal intervals are arranged on each incident optical fiber, a light-receiving hole is respectively arranged on the top cover and positioned at the side edge of each light-emitting cut opening, and a reaction test tube is respectively and correspondingly arranged below each pair of light-emitting cut openings and the light-receiving hole; the bottom end of each receiving optical fiber is arranged in the corresponding receiving optical hole, the top ends of the receiving optical fibers are converged into an integrated optical fiber, and the light outlet of the integrated optical fiber is opposite to the upper photoelectric detector; meanwhile, two ends of the incident optical fiber extend out of the top cover and are converged into two integrated optical fibers, and the light inlets of the two integrated optical fibers and the light sources at the corresponding sides of the two integrated optical fibers are positioned on the same straight line; the invention has the advantage of solving the DNA amplification detection of clinical specimens such as blood, body cavity liquid, wash-rinse, hair, cells, living tissues and the like.
Description
Technical Field
The invention relates to a detection system, in particular to a sample detection system of IVD (IVD) in-vitro detection equipment.
Background
The biological polymerase chain reaction is a molecular biological technology for amplifying specific DNA fragments, can be regarded as special DNA replication outside organisms, has the greatest characteristics of PCR, can greatly increase trace DNA, and can react to a PC end in detail through optical fiber conduction and CCD imaging, but the temperature control of the traditional DNA amplification detection is not accurate enough.
Disclosure of Invention
The invention aims at: a sample detection system for an IVD in vitro detection device for resolving DNA amplification detection of clinical specimens such as blood, body fluids, wash-washes, hair, cells, living tissue and the like is provided.
The technical scheme of the invention is as follows: a sample detection system of IVD in-vitro detection equipment comprises two light sources, a photoelectric detector, a PC and an optical signal collecting device; the photoelectric detector is electrically connected with the PC, and the optical signal collecting device comprises a top cover, a plurality of incident optical fibers which are arranged on the lower surface of the top cover at equal intervals in parallel, and a plurality of receiving optical fibers which are arranged above the top cover;
a plurality of light-emitting notches which are arranged at equal intervals are formed in each incident optical fiber, a light-receiving hole is respectively formed in the side edge of each light-emitting notch on the top cover, and a reaction test tube is respectively and correspondingly placed below each pair of light-emitting notches and the light-receiving hole; the bottom end of each receiving optical fiber is arranged in the corresponding receiving optical hole, the top ends of the receiving optical fibers are converged into an integrated optical fiber, and the light outlet of the integrated optical fiber is opposite to the upper photoelectric detector; meanwhile, two ends of the incident optical fiber extend out of the top cover and are converged into two integrated optical fibers, and light inlets of the two integrated optical fibers and light sources on corresponding sides of the two integrated optical fibers are positioned on the same straight line.
As the preferable technical scheme, the light emergent notch is triangular, the depth is 0.1-0.5mm, and the included angle is 60-120 degrees.
As a preferable technical scheme, a first optical filter is arranged between the light inlets at the two ends of the incident optical fiber and the light source at the corresponding side of the incident optical fiber.
As an optimal technical scheme, a second optical filter is arranged between the light outlet of the receiving optical fiber and the photoelectric detector.
As a preferable technical scheme, the lower surface of the top cover is provided with optical fiber placing grooves which are longitudinally arranged, transversely arranged or grid-shaped arranged.
As a preferable technical scheme, the number of the light receiving holes on the top cover is 16, 48, 96 or 384.
As a preferable technical scheme, the device further comprises an optical fiber plate, and the reaction test tube is arranged on the reaction plate.
As a preferable technical scheme, the light source is an LED lamp or a halogen lamp.
As a preferred embodiment, the photodetector is a charge-coupled device or a photomultiplier.
The working process of the invention is as follows:
the two light sources (halogen lamps or LED lamps) emit light and respectively cut off wavelengths through the first optical filters, then respectively emit light into two ends of an incident optical fiber, emit light into the top of a corresponding reaction test tube below through a light outlet notch of the incident optical fiber and conduct the light into the reaction test tube, reflected light beams in the reaction test tube are emitted into a light receiving hole above and then received by a receiving optical fiber, cut off wavelengths through the second optical filters, conduct the light to a charge coupler or a photomultiplier for signal collection, and then feed back to a PC; finally, the DNA amplification change of the reagent in the reaction test tube is judged through the display of the PC end software.
The invention has the advantages that:
1. compared with the prior art, the invention is used for solving the problems of DNA amplification detection, protein detection, microfluidic detection, chemiluminescence detection, enzyme-free detection and the like of clinical specimens such as blood, body cavity liquid, wash liquid, hair, cells, living tissues and the like, and compared with the prior art, the invention emits light beams to the corresponding reaction test tubes below through the light-emitting incisions on the incident optical fibers, has better light intensity consistency, has lower requirement on the reaction volume of reagents in the reaction test tubes, and can be collected by 5-100 um;
2. the whole optical path system is arranged at the top of the reaction test tube, the reaction plate independently operates, the influence of the heat conduction of the incident and receiving optical fibers is avoided, the temperature uniformity is better, and the temperature control is more accurate.
Drawings
The invention is further described below with reference to the accompanying drawings and examples:
FIG. 1 is a schematic diagram of the structure of the present invention;
FIG. 2 is a top plan view of the top cover of the present invention;
FIG. 3 is a schematic illustration of an incident fiber in accordance with the present invention;
FIG. 4 is an enlarged view of a portion of I of FIG. 3 in accordance with the present invention;
FIG. 5 is a bottom view of the top cover and the fiber placement groove of the present invention arranged in a grid pattern;
FIG. 6 is a bottom view of the top cover and laterally aligned fiber optic housing of the present invention;
wherein: 1 reaction test tube, 2 incident optical fiber, 21 light outlet notch, 3 receiving optical fiber, 31 receiving light hole, 4 light source, 5 photoelectric detector, 6PC, 7 optical filter I, 8 optical filter II, 9 reaction plate, 10 top cover and 11 optical fiber placing groove.
Detailed Description
Examples: referring to fig. 1, a sample detection system of an IVD in vitro detection device includes two light sources 4, a photodetector 5, a pc 6, and an optical signal collecting device; the photoelectric detector 5 is electrically connected with the PC 6, and the optical signal collecting device comprises a top cover 10, a plurality of incident optical fibers 2 which are arranged on the lower surface of the top cover 10 at equal intervals in parallel, and a plurality of receiving optical fibers 3 which are arranged above the top cover 10; a plurality of light-emitting cut-outs 21 which are arranged at equal intervals are arranged on each incident optical fiber 2, a light-receiving hole 31 is respectively arranged on the top cover 10 and positioned at the side edge of each light-emitting cut-out 21, and a reaction test tube 1 is respectively and correspondingly arranged below each pair of light-emitting cut-outs 21 and the light-receiving hole 31; the bottom end of each receiving optical fiber 3 is arranged in the corresponding receiving light hole 31, the top ends of the receiving optical fibers 3 are converged into an integrated optical fiber, and the light outlet of the integrated optical fiber is opposite to the upper photoelectric detector 5; meanwhile, two ends of the incident optical fiber 2 extend out of the top cover 10 and are converged into two integrated optical fibers, and the light inlets of the two integrated optical fibers and the light sources 4 at the corresponding sides of the two integrated optical fibers are positioned on the same straight line.
Referring to fig. 3 to 4, the light-emitting slit 21 of the present invention has a triangular shape with a depth X of 0.1 to 0.5mm and an included angle Y of 60 to 120 °.
The invention is provided with a first optical filter 7 between the light inlets at the two ends of the incident optical fiber 2 and the light source 4 at the corresponding side, and a second optical filter 8 between the light outlet of the receiving optical fiber 3 and the photoelectric detector 5.
The optical fiber placing grooves 11 which are longitudinally arranged, transversely arranged (shown in fig. 6) or grid-shaped arranged (shown in fig. 5) are arranged on the lower surface of the top cover 10, and the number of the light receiving holes 31 on the top cover 10 is 16, 48, 96 or 384 as shown in fig. 2.
When the optical fiber placing grooves 11 on the lower surface of the top cover 10 are arranged in a grid shape and the incident optical fibers are longitudinally arranged, the number of the receiving holes 31 is 16, the corresponding number of the incident optical fibers 2 is 2, and the number of the receiving optical fibers 3 is 16; the number of the receiving holes 31 is 48, the number of the corresponding incident optical fibers 2 is 8, and the number of the receiving optical fibers 3 is 48; the number of the receiving holes 31 is 96, the number of the corresponding incident optical fibers 2 is 12, and the number of the receiving optical fibers 3 is 96; the number of the receiving holes 31 is 384, the number of the corresponding incident optical fibers 2 is 24, and the number of the receiving optical fibers 3 is 384.
When the optical fiber placing grooves 11 on the lower surface of the top cover 10 and the incident optical fibers thereof are transversely arranged, the number of the receiving light holes 31 is 16, the number of the corresponding incident optical fibers 8 is 16, and the number of the receiving optical fibers 3 is 16; the number of the receiving holes 31 is 48, the number of the corresponding incident optical fibers 8 is 16, and the number of the receiving optical fibers 3 is 48; the number of the receiving holes 31 is 96, the number of the corresponding incident optical fibers 8 is 16, and the number of the receiving optical fibers 3 is 96; the number of the receiving holes 31 is 384, the number of the corresponding incident optical fibers 2 is 16, and the number of the receiving optical fibers 3 is 384.
The invention further comprises an optical fiber plate 9, the reaction test tube 1 is arranged on the reaction plate 9, the light source 4 is an LED lamp or a halogen lamp, and the photoelectric detector 5 is a charge coupler or a photomultiplier for converting optical signals into electric signals.
The working process of the invention is as follows:
the two light sources 4 (halogen lamps or LED lamps) emit light and respectively cut off wavelengths through the first optical filters 7, then respectively enter two ends of the incident optical fiber 2, pass through the light outlet notch 21 of the incident optical fiber 2, then enter the top of the corresponding reaction cuvette 1 below, and are conducted into the reaction cuvette 1, after the reflected light beams in the reaction cuvette 1 enter the upper receiving light hole 31, the reflected light beams are received by the receiving optical fiber 3, cut off wavelengths are carried out through the second optical filters 8, and then are conducted to the charge coupler or the photomultiplier for signal collection, and then are fed back to the PC 6; finally, the DNA amplification change of the reagent in the reaction test tube is judged through the display of the software at the 6 end of the PC.
The above embodiments are merely illustrative of the principles of the present invention and its effectiveness, and are not intended to limit the invention. Modifications and variations may be made to the above-described embodiments by those skilled in the art without departing from the spirit and scope of the invention. Accordingly, it is intended that all equivalent modifications and variations of the invention be covered by the claims, which are within the ordinary skill of the art, be within the spirit and scope of the present disclosure.
Claims (9)
1. A sample detection system of IVD in-vitro detection equipment comprises two light sources (4), a photoelectric detector (5), a PC (6) and an optical signal collecting device; the photoelectric detector (5) is electrically connected with the PC (6), and is characterized in that: the optical signal collecting device comprises a top cover (10), a plurality of incidence optical fibers (2) which are arranged on the lower surface of the top cover (10) at equal intervals in parallel, and a plurality of receiving optical fibers (3) which are arranged above the top cover (10);
a plurality of light outlet notches (21) which are arranged at equal intervals are arranged on each incident optical fiber (2), a light receiving hole (31) is respectively arranged on the top cover (10) and positioned at the side edge of each light outlet notch (21), and a reaction test tube (1) is correspondingly arranged below each pair of light outlet notches (21) and the light receiving hole (31); the bottom end of each receiving optical fiber (3) is arranged in a corresponding receiving light hole (31), the top ends of the receiving optical fibers (3) are converged into an integrated optical fiber, and the light outlet of the integrated optical fiber is opposite to the upper photoelectric detector (5); meanwhile, two ends of the incident optical fiber (2) extend out of the top cover (10) and are converged into two integrated optical fibers, and the light inlets of the two integrated optical fibers and the light sources (4) at the corresponding sides of the two integrated optical fibers are positioned on the same straight line.
2. The sample testing system of an IVD in vitro testing device according to claim 1, wherein: the light emergent notch (21) is triangular, the depth of the light emergent notch is 0.1-0.5mm, and the included angle of the light emergent notch is 60-120 degrees.
3. The sample testing system of an IVD in vitro testing device according to claim 1, wherein: and a first optical filter (7) is arranged between the light inlets at the two ends of the incident optical fiber (2) and the light source (4) at the corresponding side of the incident optical fiber.
4. The sample testing system of an IVD in vitro testing device according to claim 1, wherein: and a second optical filter (8) is arranged between the light outlet of the receiving optical fiber (3) and the photoelectric detector (5).
5. Sample detection system of an IVD in vitro detection device according to claim 1, wherein the top cover (10) is provided with optical fiber placement grooves (11) arranged longitudinally, transversely or in a grid-like arrangement on the lower surface.
6. The sample testing system of an IVD in vitro testing device according to claim 1, wherein: the number of the light receiving holes (31) on the top cover (10) is 16, 48, 96 or 384.
7. The sample testing system of an IVD in vitro testing device according to claim 1, wherein: the reaction tube (1) is arranged on the reaction plate (9).
8. The sample testing system of an IVD in vitro testing device according to claim 1, wherein: the light source (4) is an LED lamp or a halogen lamp.
9. The sample testing system of an IVD in vitro testing device according to claim 1, wherein: the photodetector (5) is a charge-coupled device or a photomultiplier.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711128470.6A CN107741400B (en) | 2017-11-15 | 2017-11-15 | Sample detecting system of IVD external detection equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711128470.6A CN107741400B (en) | 2017-11-15 | 2017-11-15 | Sample detecting system of IVD external detection equipment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107741400A CN107741400A (en) | 2018-02-27 |
| CN107741400B true CN107741400B (en) | 2024-01-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711128470.6A Active CN107741400B (en) | 2017-11-15 | 2017-11-15 | Sample detecting system of IVD external detection equipment |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111289434B (en) * | 2020-02-25 | 2020-12-15 | 杭州博日科技股份有限公司 | Light path position calibration method, calibration tool and fluorescent quantitative detection system |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2775652Y (en) * | 2004-09-14 | 2006-04-26 | 聂智明 | Multiple PCR quantitative detector |
| CN102341694A (en) * | 2009-01-08 | 2012-02-01 | It-Is国际有限公司 | Optical system for chemical and/or biochemical reactions |
| CN102618439A (en) * | 2012-03-01 | 2012-08-01 | 胡惠平 | Deoxyribonucleic acid (DNA) fragment amplification and quantitative detection system based on closed reactors |
| CN106929388A (en) * | 2015-12-31 | 2017-07-07 | 苏州百源基因技术有限公司 | A kind of real-time fluorescence quantitative PCR instrument |
| CN207528619U (en) * | 2017-11-15 | 2018-06-22 | 苏州雅睿生物技术有限公司 | A kind of pattern detection system of IVD vitro detections equipment |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130158413A1 (en) * | 2011-12-15 | 2013-06-20 | Nellcor Puritan Bennett Llc | Optical measurement of physiological blood parameters |
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2017
- 2017-11-15 CN CN201711128470.6A patent/CN107741400B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2775652Y (en) * | 2004-09-14 | 2006-04-26 | 聂智明 | Multiple PCR quantitative detector |
| CN102341694A (en) * | 2009-01-08 | 2012-02-01 | It-Is国际有限公司 | Optical system for chemical and/or biochemical reactions |
| CN102618439A (en) * | 2012-03-01 | 2012-08-01 | 胡惠平 | Deoxyribonucleic acid (DNA) fragment amplification and quantitative detection system based on closed reactors |
| CN106929388A (en) * | 2015-12-31 | 2017-07-07 | 苏州百源基因技术有限公司 | A kind of real-time fluorescence quantitative PCR instrument |
| CN207528619U (en) * | 2017-11-15 | 2018-06-22 | 苏州雅睿生物技术有限公司 | A kind of pattern detection system of IVD vitro detections equipment |
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| CN107741400A (en) | 2018-02-27 |
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Address after: 215000 rooms 101 and 201, C7 building, biomedical industrial park, 218 Xinghu street, Suzhou Industrial Park, Jiangsu Province Applicant after: Suzhou Yarui Biotechnology Co.,Ltd. Address before: 215000 rooms 101 and 201, C7 building, bio nano technology park, 218 Xinghu street, Suzhou Industrial Park, Jiangsu Province Applicant before: SUZHOU MOLARRAY BIOTECHNOLOGY Co.,Ltd. |
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